{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:24:58Z","timestamp":1789068298539,"version":"build-2803163510"},"reference-count":124,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wuhan University of Science and Technology startup fund (Chu Tian Scholars Program)","award":["X22020024"],"award-info":[{"award-number":["X22020024"]}]},{"name":"Wuhan University of Science and Technology startup fund (Chu Tian Scholars Program)","award":["2022kqhm005"],"award-info":[{"award-number":["2022kqhm005"]}]},{"name":"Wuhan University of Science and Technology startup fund (Chu Tian Scholars Program)","award":["U22A20314"],"award-info":[{"award-number":["U22A20314"]}]},{"name":"Wuhan University of Science and Technology startup fund (Chu Tian Scholars Program)","award":["WJ2023M121"],"award-info":[{"award-number":["WJ2023M121"]}]},{"name":"open laboratory fund of the Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration","award":["X22020024"],"award-info":[{"award-number":["X22020024"]}]},{"name":"open laboratory fund of the Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration","award":["2022kqhm005"],"award-info":[{"award-number":["2022kqhm005"]}]},{"name":"open laboratory fund of the Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration","award":["U22A20314"],"award-info":[{"award-number":["U22A20314"]}]},{"name":"open laboratory fund of the Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration","award":["WJ2023M121"],"award-info":[{"award-number":["WJ2023M121"]}]},{"name":"National Natural Science Foundation of China","award":["X22020024"],"award-info":[{"award-number":["X22020024"]}]},{"name":"National Natural Science Foundation of China","award":["2022kqhm005"],"award-info":[{"award-number":["2022kqhm005"]}]},{"name":"National Natural Science Foundation of China","award":["U22A20314"],"award-info":[{"award-number":["U22A20314"]}]},{"name":"National Natural Science Foundation of China","award":["WJ2023M121"],"award-info":[{"award-number":["WJ2023M121"]}]},{"name":"Hubei Provincial Health and Health Commission Research Project","award":["X22020024"],"award-info":[{"award-number":["X22020024"]}]},{"name":"Hubei Provincial Health and Health Commission Research Project","award":["2022kqhm005"],"award-info":[{"award-number":["2022kqhm005"]}]},{"name":"Hubei Provincial Health and Health Commission Research Project","award":["U22A20314"],"award-info":[{"award-number":["U22A20314"]}]},{"name":"Hubei Provincial Health and Health Commission Research Project","award":["WJ2023M121"],"award-info":[{"award-number":["WJ2023M121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Repairing and regenerating tissue barriers is a key challenge in regenerative medicine. Stem cells play a crucial role in restoring the structural and functional integrity of key epithelial barrier surfaces, including the skin and mucosa. This review analyzes the role of dental pulp stem cells (DPSCs) and their derivatives, including extracellular vesicles, conditioned medium, and intracellular factors, in accelerating skin wound healing. The key mechanisms include: (1) DPSCs regulating inflammatory microenvironments by promoting anti-inflammatory M2 macrophage polarization; (2) DPSCs activating vascular endothelial growth factor (VEGF) to drive angiogenesis; (3) DPSCs optimizing extracellular matrix (ECM) spatial structure through matrix metalloproteinase\/tissue inhibitor of metalloproteinase (MMP\/TIMP) balance; and (4) DPSCs enhancing transforming growth factor-\u03b2 (TGF-\u03b2) secretion to accelerate granulation tissue formation. Collectively, these processes promote wound healing. In addition, we explored potential factors that accelerate wound healing in DPSCs, such as oxidative stress, mechanical stimulation, hypertension, electrical stimulation, and organoid modeling. In addition to demonstrating the great potential of DPSCs for skin repair, this review explores their translational prospects in mucosal regenerative medicine. It covers the oral cavity, esophagus, colon, and fallopian tube. Some studies have found that combining DPSCs and their derivatives with drugs can significantly enhance their biological effects. By integrating insights from skin and mucosal models, this review offers novel ideas and strategies for treating chronic wounds, inflammatory bowel disease, and mucosal injuries. It also lays the foundation for connecting basic research results with clinical practice. This represents a significant step forward in tackling these complex medical challenges and lays a solid scientific foundation for developing more targeted and efficient regenerative therapies.<\/jats:p>","DOI":"10.3390\/cimb47070509","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:55:43Z","timestamp":1751442943000},"page":"509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tissue Repair Mechanisms of Dental Pulp Stem Cells: A Comprehensive Review from Cutaneous Regeneration to Mucosal Healing"],"prefix":"10.3390","volume":"47","author":[{"given":"Jihui","family":"He","sequence":"first","affiliation":[{"name":"First Clinical College of the Ministry of Medicine, Wuhan University of Science and Technology, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Fu","sequence":"additional","affiliation":[{"name":"First Clinical College of the Ministry of Medicine, Wuhan University of Science and Technology, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"First Clinical College of the Ministry of Medicine, Wuhan University of Science and Technology, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8887-2298","authenticated-orcid":false,"given":"Xiaojing","family":"Liu","sequence":"additional","affiliation":[{"name":"First Clinical College of the Ministry of Medicine, Wuhan University of Science and Technology, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juming","family":"Yao","sequence":"additional","affiliation":[{"name":"First Clinical College of the Ministry of Medicine, Wuhan University of Science and Technology, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Xing","sequence":"additional","affiliation":[{"name":"First Clinical College of the Ministry of Medicine, Wuhan University of Science and Technology, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Wang","sequence":"additional","affiliation":[{"name":"First Clinical College of the Ministry of Medicine, Wuhan University of Science and Technology, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[{"name":"First Clinical College of the Ministry of Medicine, Wuhan University of Science and Technology, Wuhan 430064, China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"ref_1","unstructured":"GBD 2021 Diabetes Collaborators (2023). 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