{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:52:32Z","timestamp":1787730752945,"version":"build-2784847793"},"reference-count":112,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Social Development Project of Jiangsu Province","award":["BE2023757"],"award-info":[{"award-number":["BE2023757"]}]},{"name":"Social Development Project of Jiangsu Province","award":["BK20231251"],"award-info":[{"award-number":["BK20231251"]}]},{"name":"Social Development Project of Jiangsu Province","award":["BRA2022008"],"award-info":[{"award-number":["BRA2022008"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["BE2023757"],"award-info":[{"award-number":["BE2023757"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["BK20231251"],"award-info":[{"award-number":["BK20231251"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["BRA2022008"],"award-info":[{"award-number":["BRA2022008"]}]},{"name":"sixth phase 333 second level talent training project of Jiangsu Province (tackling bottleneck technology)","award":["BE2023757"],"award-info":[{"award-number":["BE2023757"]}]},{"name":"sixth phase 333 second level talent training project of Jiangsu Province (tackling bottleneck technology)","award":["BK20231251"],"award-info":[{"award-number":["BK20231251"]}]},{"name":"sixth phase 333 second level talent training project of Jiangsu Province (tackling bottleneck technology)","award":["BRA2022008"],"award-info":[{"award-number":["BRA2022008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Fyn is widely involved in diverse cellular physiological processes, including cell growth and survival, and has been implicated in the regulation of energy metabolism and the pathogenesis of diabetes mellitus through multiple pathways. Fyn plays a role in increasing fat accumulation and promoting insulin resistance, and it also contributes to the development of diabetic complications such as diabetic kidney disease and diabetic retinopathy. The primary mechanism by which Fyn modulates lipid metabolism is that it inhibits AMP-activated protein kinase (AMPK). Additionally, it affects energy homeostasis through regulating specific signal pathways affecting lipid metabolism including pathways related to CD36, through enhancement of adipocyte differentiation, and through modulating insulin signal transduction. Inflammatory stress is one of the fundamental mechanisms in diabetes mellitus and its complications. Fyn also plays a role in inflammatory stress-related signaling cascades such as the Akt\/GSK-3\u03b2\/Fyn\/Nrf2 pathway, exacerbating inflammation in diabetes mellitus. Therefore, Fyn emerges as a promising therapeutic target for regulating glucolipid metabolism and alleviating type 2 diabetes mellitus. This review synthesizes research on the role of Fyn in the regulation of energy metabolism and the development of diabetes mellitus, while exploring its specific regulatory mechanisms.<\/jats:p>","DOI":"10.3390\/cimb47080623","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T14:23:19Z","timestamp":1754403799000},"page":"623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fyn Kinase: A Potential Target in Glucolipid Metabolism and Diabetes Mellitus"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3276-2831","authenticated-orcid":false,"given":"Ruifeng","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of Jiangsu University, Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of Jiangsu University, Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of Jiangsu University, Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of Jiangsu University, Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-9041","authenticated-orcid":false,"given":"Xia","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of Jiangsu University, Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of Jiangsu University, Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Affiliated Hospital of Jiangsu University, Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ruze, R., Liu, T., Zou, X., Song, J., Chen, Y., Xu, R., Yin, X., and Xu, Q. 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