{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:14:29Z","timestamp":1792019669165,"version":"4.4.0"},"reference-count":63,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Estrogen-dependent conditions, such as endometriosis, adenomyosis, lipedema, polycystic ovary syndrome, and breast cancer, are intimately involved with hormonal changes related to estrogen and their receptors. These conditions can be expressed mainly during hormonal changes such as pregnancy, puberty, and menopause. They are associated with alterations in estrogen function and inflammatory mechanisms, leading to significant discomfort and a marked decrease in self-esteem in women. Resveratrol has been studied in the treatment of inflammatory diseases like obesity, metabolic syndrome, and endometriosis. The research suggests potential pathways through which resveratrol may also be beneficial in treating metabolic and estrogen-dependent conditions. We reviewed 63 articles from 2000 to 2025, prioritizing systematic reviews, meta-analyses, and randomized controlled trials in the PubMed, ScienceDirect, and SciELO databases. Our results suggest that resveratrol may benefit metabolic and estrogen-dependent conditions by modulating anti-inflammatory factors that regulate estrogen receptor activity, increasing lipolysis, decreasing insulin resistance, and mitigating oxidative stress. Future research should evaluate the long-term safety and potential therapeutic effects of resveratrol in metabolic conditions.<\/jats:p>","DOI":"10.3390\/cimb47090692","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:14:05Z","timestamp":1756286045000},"page":"692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New Perspectives on the Use of Resveratrol in the Treatment of Metabolic and Estrogen-Dependent Conditions Through Hormonal Modulation and Anti-Inflammatory Effects"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7940-3667","authenticated-orcid":false,"given":"Guilherme","family":"Renke","sequence":"first","affiliation":[{"name":"Nutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o, Instituto de Nutri\u00e7\u00e3o Josu\u00e9 de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Fuschini","sequence":"additional","affiliation":[{"name":"Nutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Clivati","sequence":"additional","affiliation":[{"name":"Nutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Mocellin","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Nutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Cuyabano","sequence":"additional","affiliation":[{"name":"Nutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-8967","authenticated-orcid":false,"given":"C. Tamer","family":"Erel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul 34320, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0889-4662","authenticated-orcid":false,"given":"Eliane Lopes","family":"Rosado","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o, Instituto de Nutri\u00e7\u00e3o Josu\u00e9 de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bpobgyn.2007.07.005","article-title":"Hormone-dependent gynaecological disorders: A pathophysiological perspective for appropriate treatment","volume":"22","author":"Petraglia","year":"2008","journal-title":"Best Pract. 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