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This study examined whether CO and H2S exert similar effects by treating PC12 cells with a CO donor (CORM-2) or an H2S donor (NaHS), with or without glucocorticoid stimulation. Gene expression of tyrosine hydroxylase (Th), dopamine \u03b2-hydroxylase (Dbh), and phenylethanolamine N-methyltransferase (Pnmt) was assessed by RT-qPCR, and catecholamine release was measured by ELISA. We found that exogenous CO decreased Th and Dbh expression, attenuated glucocorticoid-induced upregulation of catecholamine biosynthesis genes, and differentially modulated dopamine and norepinephrine release. In contrast, exogenous H2S treatment had no significant effect. These findings identify CO as a novel regulator of catecholamine biosynthesis and highlight important differences among gas transmitters in stress-related signaling.<\/jats:p>","DOI":"10.3390\/cimb47090725","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T09:51:21Z","timestamp":1757065881000},"page":"725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Regulation of Catecholamine Biosynthesis by the Gas Transmitters Carbon Monoxide and Hydrogen Sulfide"],"prefix":"10.3390","volume":"47","author":[{"given":"Robert","family":"Dingley","sequence":"first","affiliation":[{"name":"Medical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON P3E 2C6, Canada"},{"name":"School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Hourtovenko","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON P3E 2C6, Canada"},{"name":"School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON P3E 2C6, Canada"},{"name":"School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujeenthar","family":"Tharmalingam","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON P3E 2C6, Canada"},{"name":"School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada"},{"name":"Health Sciences North Research Institute, Sudbury, ON P3E 2H2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. C.","family":"Tai","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON P3E 2C6, Canada"},{"name":"School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada"},{"name":"Health Sciences North Research Institute, Sudbury, ON P3E 2H2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pocock, G., Richards, C.D., and Richards, D.A. (2018). Human Physiology, Oxford University Press.","DOI":"10.1093\/hesc\/9780198737223.001.0001"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.2040-4603.2015.tb00599.x","article-title":"Peripheral and Central Effects of Circulating Catecholamines","volume":"5","author":"Tank","year":"2015","journal-title":"Compr. 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