{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:15:47Z","timestamp":1780337747895,"version":"3.54.1"},"reference-count":182,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>JUNB and JUND are two transcriptional factors (TFs) of increased interest in cancer, regulating the expression of genes associated with survival, proliferation, differentiation, migration, invasion, angiogenesis, adhesion, apoptosis, and cell cycle regulation. Together with c-JUN, they constitute the JUN family of TFs, acting as downstream effectors of the MAPKs, with established roles in carcinogenesis, disease progression, metastasis, and therapy resistance. Their phosphorylation leads to the formation of dimeric complexes with other TFs (from the JUN, FOS, or ATF families), thereby assembling the AP-1 complex, which exerts multifaceted influences on both normal and cancerous cells. JUNB and JUND are credited with both tumor-suppressing and oncogenic roles, since the outcome of their activation relies on the specific cancer type, disease stage, intracellular localization, and the expression of interacting cofactors. This narrative review explores the current understanding of JUNB and JUND roles within urological cancers (prostate, bladder, renal, and testicular cancer) as these malignancies, while distinct, share common genetic and\/or environmental risk factors and varying degrees of androgen receptor (AR) dependency. The study discusses commonalities and differences in the expression patterns, mechanisms, and clinical implications of JUNB and JUND across urological cancers, thus highlighting their potential as prevention, diagnosis, prognosis, and treatment targets.<\/jats:p>","DOI":"10.3390\/cimb47090741","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T14:14:55Z","timestamp":1757513695000},"page":"741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["JUNB and JUND in Urological Cancers: A Literature Review"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7096-6957","authenticated-orcid":false,"given":"Georgios","family":"Kalampounias","sequence":"first","affiliation":[{"name":"Laboratory of Cell Biology, Division of Genetics, Cell and Developmental Biology, Department of Biology, School of Natural Sciences, University of Patras, 26504 Patras, Greece"},{"name":"Institute for Bioinnovation, Biomedical Sciences Research Centre \u201cAlexander Fleming\u201d, 16672 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-2225","authenticated-orcid":false,"given":"Theodosia","family":"Androutsopoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology, Division of Genetics, Cell and Developmental Biology, Department of Biology, School of Natural Sciences, University of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2057-9475","authenticated-orcid":false,"given":"Panagiotis","family":"Katsoris","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology, Division of Genetics, Cell and Developmental Biology, Department of Biology, School of Natural Sciences, University of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kucharz, E.J. (1992). Urinary and Reproductive Systems. The Collagens: Biochemistry and Pathophysiology, Springer.","DOI":"10.1007\/978-3-642-76197-3"},{"key":"ref_2","unstructured":"Libretti, S., and Aeddula, N.R. (2025). Genitourinary. StatPearls, StatPearls Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10555-009-9189-4","article-title":"Biology of Urothelial Tumorigenesis: Insights from Genetically Engineered Mice","volume":"28","author":"Wu","year":"2009","journal-title":"Cancer Metastasis Rev."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Peng, Z., Zhuang, J., and Shen, B. (2024). The Role of Microbiota in Tumorigenesis, Progression and Treatment of Bladder Cancer. Microbiome Res. Rep., 3.","DOI":"10.20517\/mrr.2023.47"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Webster, B.R., Gopal, N., and Ball, M.W. (2022). Tumorigenesis Mechanisms Found in Hereditary Renal Cell Carcinoma: A Review. Genes, 13.","DOI":"10.3390\/genes13112122"},{"key":"ref_6","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA A Cancer J. Clin."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bilim, V., Kuroki, H., Shirono, Y., Murata, M., Hiruma, K., and Tomita, Y. (2022). Advanced Bladder Cancer: Changing the Treatment Landscape. J. Pers. Med., 12.","DOI":"10.3390\/jpm12101745"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hushmandi, K., Farahani, N., Einollahi, B., Salimimoghadam, S., Alimohammadi, M., Liang, L., Liu, L., and Sethi, G. (2025). Deciphering Molecular Pathways in Urological Cancers: A Gateway to Precision Therapeutics. J. Adv. Res., in press.","DOI":"10.1016\/j.jare.2025.06.009"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mallah, H., Diabasana, Z., Soultani, S., Idoux-Gillet, Y., and Massfelder, T. (2025). Prostate Cancer: A Journey Through Its History and Recent Developments. Cancers, 17.","DOI":"10.3390\/cancers17020194"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gill, E., and Perks, C.M. (2024). Mini-Review: Current Bladder Cancer Treatment\u2014The Need for Improvement. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031557"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Manini, C., L\u00f3pez-Fern\u00e1ndez, E., L\u00f3pez, J.I., and Angulo, J.C. (2023). Advances in Urological Cancer in 2022, from Basic Approaches to Clinical Management. Cancers, 15.","DOI":"10.3390\/cancers15051422"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/jama.2024.12848","article-title":"Renal Cell Carcinoma","volume":"332","author":"Rose","year":"2024","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.annonc.2024.05.537","article-title":"Renal Cell Carcinoma: ESMO Clinical Practice Guideline for Diagnosis, Treatment and Follow-Up\u2606","volume":"35","author":"Powles","year":"2024","journal-title":"Ann. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2279235","DOI":"10.1080\/07853890.2023.2279235","article-title":"Molecular Classifications of Prostate Cancer: Basis for Individualized Risk Stratification and Precision Therapy","volume":"55","author":"Ge","year":"2023","journal-title":"Ann. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Posdzich, P., Darr, C., Hilser, T., Wahl, M., Herrmann, K., Hadaschik, B., and Gr\u00fcnwald, V. (2023). Metastatic Prostate Cancer\u2014A Review of Current Treatment Options and Promising New Approaches. Cancers, 15.","DOI":"10.3390\/cancers15020461"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kalampounias, G., Zafeiropoulou, K., Androutsopoulou, T., Alexis, S., Symeonidis, A., and Katsoris, P. (2025). The Transcription Axes ERK-Elk1, JNK-cJun, and JAK-STAT Promote Autophagy Activation and Proteasome Inhibitor Resistance in Prostate Cancer Cells. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47050352"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107355","DOI":"10.1016\/j.phrs.2024.107355","article-title":"ATF Family Members as Therapeutic Targets in Cancer: From Mechanisms to Pharmacological Interventions","volume":"208","author":"Zhang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"155381","DOI":"10.1016\/j.prp.2024.155381","article-title":"Implications of C-Myc in the Pathogenesis and Treatment Efficacy of Urological Cancers","volume":"259","author":"Hushmandi","year":"2024","journal-title":"Pathol.\u2014Res. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41419-024-06446-7","article-title":"USP43 Stabilizes C-Myc to Promote Glycolysis and Metastasis in Bladder Cancer","volume":"15","author":"Li","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zafeiropoulou, K., Kalampounias, G., Alexis, S., Anastasopoulos, D., Symeonidis, A., and Katsoris, P. (2024). Autophagy and Oxidative Stress Modulation Mediate Bortezomib Resistance in Prostate Cancer. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0289904"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s00120-023-02119-z","article-title":"Precision oncology options in urological cancers","volume":"62","author":"Franz","year":"2023","journal-title":"Urologie"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/CU9.0000000000000053","article-title":"Expression of Proto-Oncogene c-Myc in Patients with Urinary Bladder Transitional Cell Carcinoma","volume":"15","author":"Fragkoulis","year":"2021","journal-title":"Curr. Urol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Udayappan, U.K., and Casey, P.J. (2017). C-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells. Molecules, 22.","DOI":"10.3390\/molecules22040612"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17964","DOI":"10.1074\/jbc.M116.714899","article-title":"JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-\u03b2 (TGF-\u03b2)-Induced Inhibition of Cell Proliferation","volume":"291","author":"Millena","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kalampounias, G., Androutsopoulou, T., and Katsoris, P. (2025). Mechanistic Insights and Clinical Implications of ELK1 in Solid Tumors: A Narrative Review. Cells, 14.","DOI":"10.3390\/cells14161257"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41571-023-00826-2","article-title":"Progress in Systemic Therapy for Advanced-Stage Urothelial Carcinoma","volume":"21","author":"Nadal","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Moreira-Silva, F., Henrique, R., and Jer\u00f3nimo, C. (2022). From Therapy Resistance to Targeted Therapies in Prostate Cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.877379"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ajur.2018.11.005","article-title":"Metastatic Prostate Cancer Remains Incurable, Why?","volume":"6","author":"Dong","year":"2019","journal-title":"Asian J. Urol."},{"key":"ref_29","first-page":"267","article-title":"Castration-Resistant Prostate Cancer: Potential Targets and Therapies","volume":"6","author":"Parray","year":"2012","journal-title":"Biologics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbcan.2019.04.003","article-title":"The AP-1 Transcriptional Complex: Local Switch or Remote Command?","volume":"1872","author":"Bejjani","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Rev. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Song, D., Lian, Y., and Zhang, L. (2023). The Potential of Activator Protein 1 (AP-1) in Cancer Targeted Therapy. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1224892"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.cellsig.2009.12.008","article-title":"AP-1\u2014The Jun Proteins: Oncogenes or Tumor Suppressors in Disguise?","volume":"22","author":"Shaulian","year":"2010","journal-title":"Cell. Signal."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.18632\/oncotarget.27997","article-title":"Targeting AP-1 Transcription Factors by CRISPR in the Prostate","volume":"12","author":"Riedel","year":"2021","journal-title":"Oncotarget"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrc1209","article-title":"AP-1: A Double-Edged Sword in Tumorigenesis","volume":"3","author":"Eferl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ren, F., Cai, X., Yao, Y., and Fang, G. (2023). JunB: A Paradigm for Jun Family in Immune Response and Cancer. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1222265"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/sj.onc.1210690","article-title":"Targeting C-Jun and JunB Proteins as Potential Anticancer Cell Therapy","volume":"27","author":"Gurzov","year":"2008","journal-title":"Oncogene"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.cellsig.2016.05.016","article-title":"Itch Promotes the Neddylation of JunB and Regulates JunB-Dependent Transcription","volume":"28","author":"Li","year":"2016","journal-title":"Cell. Signal"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.4049\/jimmunol.180.9.5983","article-title":"SUMOylation Regulates the Transcriptional Activity of JunB in T Lymphocytes","volume":"180","author":"Garaude","year":"2008","journal-title":"J. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.1158\/0008-5472.CAN-05-4466","article-title":"COOH-Terminal Src Kinase\u2013Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation","volume":"66","author":"Zhu","year":"2006","journal-title":"Cancer Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1093\/emboj\/19.9.2056","article-title":"Cell Cycle-Dependent Variations in c-Jun and JunB Phosphorylation: A Role in the Control of Cyclin D1 Expression","volume":"19","author":"Bakiri","year":"2000","journal-title":"EMBO J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/mc.20348","article-title":"The Functional Contrariety of JNK","volume":"46","author":"Bode","year":"2007","journal-title":"Mol. Carcinog."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.semcancer.2004.04.006","article-title":"Stress-Activated Protein Kinases\u2014Tumor Suppressors or Tumor Initiators?","volume":"14","author":"Engelberg","year":"2004","journal-title":"Semin. Cancer Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1128\/MCB.01620-07","article-title":"JunB Breakdown in Mid-\/Late G2 Is Required for Down-Regulation of Cyclin A2 Levels and Proper Mitosis","volume":"28","author":"Baldin","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/j.biocel.2007.06.013","article-title":"The Mitogen-Activated Protein Kinase P38 Regulates Activator Protein 1 by Direct Phosphorylation of c-Jun","volume":"39","author":"Humar","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1074\/jbc.M110376200","article-title":"Green Tea Polyphenol Stimulates a Ras, MEKK1, MEK3, and P38 Cascade to Increase Activator Protein 1 Factor-Dependent Involucrin Gene Expression in Normal Human Keratinocytes *","volume":"277","author":"Balasubramanian","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Courcelles, M., Fr\u00e9min, C., Voisin, L., Lemieux, S., Meloche, S., and Thibault, P. (2013). Phosphoproteome Dynamics Reveal Novel ERK1\/2 MAP Kinase Substrates with Broad Spectrum of Functions. Mol. Syst. Biol., 9.","DOI":"10.1038\/msb.2013.25"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ydbio.2010.01.036","article-title":"Phosphorylation of Junb Family Proteins by the Jun N-Terminal Kinase Supports Tissue Regeneration in Zebrafish","volume":"340","author":"Ishida","year":"2010","journal-title":"Dev. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cyto.2018.09.014","article-title":"JNK Facilitates IL-1\u03b2-Induced Hepcidin Transcription via JunB Activation","volume":"111","author":"Kanamori","year":"2018","journal-title":"Cytokine"},{"key":"ref_49","first-page":"4694","article-title":"Jun Is Phosphorylated by Several Protein Kinases at the Same Sites That Are Modified in Serum-Stimulated Fibroblasts","volume":"12","author":"Baker","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0092-8674(91)90241-P","article-title":"Activation of Protein Kinase C Decreases Phosphorylation of C-Jun at Sites That Negatively Regulate Its DNA-Binding Activity","volume":"64","author":"Boyle","year":"1991","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/carcin\/bgq271","article-title":"P21-Activated Protein Kinase (PAK2)-Mediated c-Jun Phosphorylation at 5 Threonine Sites Promotes Cell Transformation","volume":"32","author":"Li","year":"2011","journal-title":"Carcinogenesis"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8950","DOI":"10.1038\/sj.onc.1208015","article-title":"C-Jun Phosphorylation by the Human Vaccinia-Related Kinase 1 (VRK1) and Its Cooperation with the N-Terminal Kinase of c-Jun (JNK)","volume":"23","author":"Sevilla","year":"2004","journal-title":"Oncogene"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0092-8674(94)90380-8","article-title":"JNK1: A Protein Kinase Stimulated by UV Light and Ha-Ras That Binds and Phosphorylates the c-Jun Activation Domain","volume":"76","author":"Hibi","year":"1994","journal-title":"Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e852","DOI":"10.1038\/cddis.2013.381","article-title":"Multisite Phosphorylation of C-Jun at Threonine 91\/93\/95 Triggers the Onset of c-Jun pro-Apoptotic Activity in Cerebellar Granule Neurons","volume":"4","author":"Reddy","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1038\/sj.onc.1210888","article-title":"Calcineurin-Mediated Dephosphorylation of c-Jun Ser-243 Is Required for c-Jun Protein Stability and Cell Transformation","volume":"27","author":"Huang","year":"2008","journal-title":"Oncogene"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"W420","DOI":"10.1093\/nar\/gkac373","article-title":"IBS 2.0: An Upgraded Illustrator for the Visualization of Biological Sequences","volume":"50","author":"Xie","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1042\/BST0360864","article-title":"Regulation and Function of JunB in Cell Proliferation","volume":"36","author":"Piechaczyk","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/jid.2011.1","article-title":"C-Jun Promotes Whereas JunB Inhibits Epidermal Neoplasia","volume":"131","author":"Jin","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0092-8674(00)00178-1","article-title":"C-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal\u2013Epidermal Interaction in Skin","volume":"103","author":"Szabowski","year":"2000","journal-title":"Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1038\/s41418-021-00765-4","article-title":"The AP-1 Transcription Factors c-Jun and JunB Are Essential for CD8\u03b1 Conventional Dendritic Cell Identity","volume":"28","author":"Novoszel","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zhang, J., Wu, Z., Savin, A., Yang, M., Hsu, Y.-H.R., Jantuan, E., Bacani, J.T.C., and Ingham, R.J. (2018). The C-Jun and JunB Transcription Factors Facilitate the Transit of Classical Hodgkin Lymphoma Tumour Cells through G1. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-34199-9"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1038\/leu.2015.127","article-title":"Constitutive Control of AKT1 Gene Expression by JUNB\/CJUN in ALK+ Anaplastic Large-Cell Lymphoma: A Novel Crosstalk Mechanism","volume":"29","author":"Atsaves","year":"2015","journal-title":"Leukemia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13046-024-03200-x","article-title":"NAT10\/ac4C\/JunB Facilitates TNBC Malignant Progression and Immunosuppression by Driving Glycolysis Addiction","volume":"43","author":"Li","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/carcin\/21.7.1313","article-title":"Expression of Jun Family Members in Human Colorectal Adenocarcinoma","volume":"21","author":"Wang","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1101\/gad.7.3.479","article-title":"JunB Differs from C-Jun in Its DNA-Binding and Dimerization Domains, and Represses c-Jun by Formation of Inactive Heterodimers","volume":"7","author":"Deng","year":"1993","journal-title":"Genes Dev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11010-009-0285-0","article-title":"C-Jun-NH2 Terminal Kinase (JNK)-Mediates AP-1 Activation by Thioredoxin: Phosphorylation of cJun, JunB, and Fra-1","volume":"337","author":"Das","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/emboj\/18.2.420","article-title":"Regulation of IL-4 Expression by the Transcription Factor JunB during T Helper Cell Differentiation","volume":"18","author":"Li","year":"1999","journal-title":"EMBO J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1042\/BJ20150372","article-title":"C-Abl-Mediated Tyrosine Phosphorylation of JunB Is Required for Adriamycin-Induced Expression of P21","volume":"471","author":"Yamaguchi","year":"2015","journal-title":"Biochem. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0092-8674(00)81999-6","article-title":"C-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions","volume":"87","author":"Kallunki","year":"1996","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0898-6568(99)00037-6","article-title":"Genomic Organisation of the Human Cyclic AMP-Specific Phosphodiesterase PDE4C Gene and Its Chromosomal Localisation to 19p13.1, between RAB3A and JUND","volume":"11","author":"Sullivan","year":"1999","journal-title":"Cell. Signal"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1002\/j.1460-2075.1996.tb00636.x","article-title":"Selective Interaction of JNK Protein Kinase Isoforms with Transcription Factors","volume":"15","author":"Gupta","year":"1996","journal-title":"EMBO J."},{"key":"ref_72","first-page":"916","article-title":"Differential Binding of the Menin Tumor Suppressor Protein to JunD Isoforms","volume":"61","author":"Yazgan","year":"2001","journal-title":"Cancer Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"9634","DOI":"10.1074\/jbc.M308721200","article-title":"Differential Phosphorylation of C-Jun and JunD in Response to the Epidermal Growth Factor Is Determined by the Structure of MAPK Targeting Sequences *","volume":"279","author":"Vinciguerra","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"38544","DOI":"10.1074\/jbc.M504202200","article-title":"A Novel Role for GADD45beta as a Mediator of MMP-13 Gene Expression during Chondrocyte Terminal Differentiation","volume":"280","author":"Ijiri","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_75","first-page":"2639","article-title":"JunD Phosphorylation, and Expression of AP-1 DNA Binding Activity Modulated by Serum Growth Factors in Quiescent Murine 3T3T Cells","volume":"13","author":"Wang","year":"1996","journal-title":"Oncogene"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"15992","DOI":"10.1074\/jbc.M107340200","article-title":"Mitogen-Activated Protein Kinases and Activator Protein 1 Are Required for Proliferation and Cardiomyocyte Differentiation of P19 Embryonal Carcinoma Cells","volume":"277","author":"Eriksson","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/bbrc.1998.9331","article-title":"Two Proteins Translated by Alternative Usage of Initiation Codons in mRNA Encoding a JunD Transcriptional Regulator","volume":"250","author":"Okazaki","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1038\/sj.onc.1205822","article-title":"Menin Uncouples Elk-1, JunD and c-Jun Phosphorylation from MAP Kinase Activation","volume":"21","author":"Gallo","year":"2002","journal-title":"Oncogene"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1038\/onc.2008.120","article-title":"Multiple Facets of junD Gene Expression Are Atypical among AP-1 Family Members","volume":"27","author":"Hernandez","year":"2008","journal-title":"Oncogene"},{"key":"ref_80","first-page":"619","article-title":"Differential Regulation of C-Jun and JunD by Ubiquitin-Dependent Protein Degradation","volume":"377","author":"Musti","year":"1996","journal-title":"Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1158\/1078-0432.CCR-07-4120","article-title":"Function of JunB in Transient Amplifying Cell Senescence and Progression of Human Prostate Cancer","volume":"14","author":"Konishi","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/cdd.2014.213","article-title":"Loss of JUNB\/AP-1 Promotes Invasive Prostate Cancer","volume":"22","author":"Thomsen","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/cdd.2014.232","article-title":"JunB and PTEN in Prostate Cancer: \u201cLoss Is Nothing Else than Change\u201d","volume":"22","author":"Birner","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.bbrc.2019.11.145","article-title":"Promotion of Cellular Senescence by THG-1\/TSC22D4 Knockout through Activation of JUNB","volume":"522","author":"Zhang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"109634","DOI":"10.1016\/j.celrep.2021.109634","article-title":"Persistent JunB Activation in Fibroblasts Disrupts Stem Cell Niche Interactions Enforcing Skin Aging","volume":"36","author":"Maity","year":"2021","journal-title":"Cell Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1038\/sj.onc.1210285","article-title":"JunB Is a Gatekeeper for B-Lymphoid Leukemia","volume":"26","author":"Ott","year":"2007","journal-title":"Oncogene"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Sadeghi, M., Ranjbar, B., Ganjalikhany, M.R., Khan, F.M., Schmitz, U., Wolkenhauer, O., and Gupta, S.K. (2016). MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0168760"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/978-1-4939-7456-6_12","article-title":"A Network-Based Integrative Workflow to Unravel Mechanisms Underlying Disease Progression","volume":"1702","author":"Khan","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"18949","DOI":"10.1074\/jbc.M111.232637","article-title":"KAI1 Gene Is Engaged in NDRG1 Gene-Mediated Metastasis Suppression through the ATF3-NFkappaB Complex in Human Prostate Cancer","volume":"286","author":"Liu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/sj.onc.1208216","article-title":"KAI1 Promoter Activity Is Dependent on P53, junB and AP2: Evidence for a Possible Mechanism Underlying Loss of KAI1 Expression in Cancer Cells","volume":"24","author":"Marreiros","year":"2005","journal-title":"Oncogene"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e1010948","DOI":"10.1080\/23723556.2015.1010948","article-title":"Emerging Roles of ATF3 in the Suppression of Prostate Cancer","volume":"3","author":"Wang","year":"2015","journal-title":"Mol. Cell. Oncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1038\/onc.2014.426","article-title":"Loss of ATF3 Promotes Akt Activation and Prostate Cancer Development in a Pten Knockout Mouse Model","volume":"34","author":"Wang","year":"2015","journal-title":"Oncogene"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Ku, H.-C., and Cheng, C.-F. (2020). Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00556"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10585-010-9356-6","article-title":"Endoglin Suppresses Human Prostate Cancer Metastasis","volume":"28","author":"Lakshman","year":"2011","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Roumeliotou, A., Strati, A., Chamchougia, F., Xagara, A., Tserpeli, V., Smilkou, S., Lagopodi, E., Christopoulou, A., Kontopodis, E., and Drositis, I. (2024). Comprehensive Analysis of CXCR4, JUNB, and PD-L1 Expression in Circulating Tumor Cells (CTCs) from Prostate Cancer Patients. Cells, 13.","DOI":"10.3390\/cells13090782"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1074\/jbc.M307608200","article-title":"The C-Jun Dimerization Protein 2 Inhibits Cell Transformation and Acts as a Tumor Suppressor Gene","volume":"279","author":"Heinrich","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s10517-016-3358-6","article-title":"MicroRNA Hsa-miR-4674 in Hemolysis-Free Blood Plasma Is Associated with Distant Metastases of Prostatic Cancer","volume":"161","author":"Knyazev","year":"2016","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9729","DOI":"10.1002\/jcp.29784","article-title":"Tumor-Associated Macrophages Promote Prostate Cancer Progression via Exosome-Mediated miR-95 Transfer","volume":"235","author":"Guan","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1128\/MCB.00982-14","article-title":"Extracellular Signal-Regulated Kinase Signaling Regulates the Opposing Roles of JUN Family Transcription Factors at ETS\/AP-1 Sites and in Cell Migration","volume":"35","author":"Selvaraj","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"E975","DOI":"10.1152\/ajpendo.00615.2012","article-title":"Cyclin-Dependent Kinase 5 Modulates STAT3 and Androgen Receptor Activation through Phosphorylation of Ser727 on STAT3 in Prostate Cancer Cells","volume":"305","author":"Hsu","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41419-020-02973-1","article-title":"Immune Signature Driven by ADT-Induced Immune Microenvironment Remodeling in Prostate Cancer Is Correlated with Recurrence-Free Survival and Immune Infiltration","volume":"11","author":"Long","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15430\/JCP.2018.23.1.1","article-title":"Identification of Epithelial-Mesenchymal Transition-Related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation","volume":"23","author":"Park","year":"2018","journal-title":"J. Cancer Prev."},{"key":"ref_103","first-page":"5271","article-title":"Gene Amplifications Associated with the Development of Hormone-Resistant Prostate Cancer","volume":"9","author":"Edwards","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Sharma, N.V., Pellegrini, K.L., Ouellet, V., Giuste, F.O., Ramalingam, S., Watanabe, K., Adam-Granger, E., Fossouo, L., You, S., and Freeman, M.R. (2018). Identification of the Transcription Factor Relationships Associated with Androgen Deprivation Therapy Response and Metastatic Progression in Prostate Cancer. Cancers, 10.","DOI":"10.3390\/cancers10100379"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1210\/en.2005-0942","article-title":"Androgens Regulate the Immune\/Inflammatory Response and Cell Survival Pathways in Rat Ventral Prostate Epithelial Cells","volume":"147","author":"Asirvatham","year":"2006","journal-title":"Endocrinology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/ijc.33584","article-title":"A Rare Variant in EZH2 Is Associated with Prostate Cancer Risk","volume":"149","author":"Raspin","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.5534\/wjmh.240298","article-title":"Single-Cell Analysis Combined with Mendelian Randomization Identifies Genes Associated with Prostate Cancer Cells","volume":"43","author":"Wang","year":"2025","journal-title":"World J. Men\u2019s Health"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Adir, O., Sagi-Assif, O., Meshel, T., Ben-Menachem, S., Pasmanik-Chor, M., Hoon, D.S.B., Witz, I.P., and Izraely, S. (2023). Heterogeneity in the Metastatic Microenvironment: JunB-Expressing Microglia Cells as Potential Drivers of Melanoma Brain Metastasis Progression. Cancers, 15.","DOI":"10.3390\/cancers15204979"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"jcs261323","DOI":"10.1242\/jcs.261323","article-title":"Shock Drives a STAT3 and JunB-Mediated Coordinated Transcriptional and DNA Methylation Response in the Endothelium","volume":"136","author":"Ramos","year":"2023","journal-title":"J. Cell Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1096\/fj.99-0810com","article-title":"Role of Suppressors of Cytokine Signaling (Socs) in Leukemia Inhibitory Factor (LIF)\u2014Dependent Embryonic Stem Cell Survival","volume":"14","author":"Duval","year":"2000","journal-title":"FASEB J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e167728","DOI":"10.1172\/JCI167728","article-title":"CRISPR Screening Identifies the Deubiquitylase ATXN3 as a PD-L1-Positive Regulator for Tumor Immune Evasion","volume":"133","author":"Wang","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Singh, T., Chhokar, A., Thakur, K., Aggarwal, N., Pragya, P., Yadav, J., Tripathi, T., Jadli, M., Bhat, A., and Gupta, P. (2021). Targeting Aberrant Expression of STAT3 and AP-1 Oncogenic Transcription Factors and HPV Oncoproteins in Cervical Cancer by Berberis Aquifolium. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.757414"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e67312","DOI":"10.7554\/eLife.67312","article-title":"YAP and TAZ Are Transcriptional Co-Activators of AP-1 Proteins and STAT3 during Breast Cellular Transformation","volume":"10","author":"He","year":"2021","journal-title":"Elife"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Moon, Y.-M., Lee, S.-Y., Kwok, S.-K., Lee, S.H., Kim, D., Kim, W.K., Her, Y.-M., Son, H.-J., Kim, E.-K., and Ryu, J.-G. (2017). The Fos-Related Antigen 1-JUNB\/Activator Protein 1 Transcription Complex, a Downstream Target of Signal Transducer and Activator of Transcription 3, Induces T Helper 17 Differentiation and Promotes Experimental Autoimmune Arthritis. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01793"},{"key":"ref_115","first-page":"347","article-title":"JUND Promotes Tumorigenesis via Specifically Binding on Enhancers of Multiple Oncogenes in Cervical Cancer","volume":"16","author":"Zhou","year":"2023","journal-title":"OncoTargets Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"102010","DOI":"10.1016\/j.tice.2022.102010","article-title":"JUND Facilitates Proliferation and Angiogenesis of Esophageal Squamous Cell Carcinoma Cell via MAPRE2 Up-Regulation","volume":"81","author":"Zhang","year":"2023","journal-title":"Tissue Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1038\/onc.2008.145","article-title":"JunD Is Involved in the Antiproliferative Effect of \u03949-Tetrahydrocannabinol on Human Breast Cancer Cells","volume":"27","author":"Caffarel","year":"2008","journal-title":"Oncogene"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e124985","DOI":"10.1172\/jci.insight.124985","article-title":"JunD, Not c-Jun, Is the AP-1 Transcription Factor Required for Ras-Induced Lung Cancer","volume":"6","author":"Ruiz","year":"2021","journal-title":"JCI Insight"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.cell.2004.08.025","article-title":"JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress","volume":"118","author":"Gerald","year":"2004","journal-title":"Cell"},{"key":"ref_120","first-page":"312","article-title":"Curcumin Induces the Novel Tumor Suppressor, HLJ1, through JunD Pathway and Inhibits Lung Cancer Cell Invasion","volume":"66","author":"Chen","year":"2006","journal-title":"Cancer Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5619","DOI":"10.1038\/sj.onc.1206644","article-title":"AP-1 Complexes Containing cJun and JunB Cause Cellular Transformation of Rat1a Fibroblasts and Share Transcriptional Targets","volume":"22","author":"Leaner","year":"2003","journal-title":"Oncogene"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"7763","DOI":"10.1074\/jbc.RA119.012005","article-title":"The mRNA Encoding the JUND Tumor Suppressor Detains Nuclear RNA-Binding Proteins to Assemble Polysomes That Are Unaffected by mTOR","volume":"295","author":"Singh","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"10770","DOI":"10.1073\/pnas.1834524100","article-title":"Transcription Factor JunD, Deprived of Menin, Switches from Growth Suppressor to Growth Promoter","volume":"100","author":"Agarwal","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","first-page":"726","article-title":"Menin Represses Tumorigenesis via Repressing Cell Proliferation","volume":"1","author":"Wu","year":"2011","journal-title":"Am. J. Cancer Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/cdd.2010.22","article-title":"Jun and JunD-Dependent Functions in Cell Proliferation and Stress Response","volume":"17","author":"Meixner","year":"2010","journal-title":"Cell Death Differ."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/(SICI)1097-4644(199705)65:2<245::AID-JCB9>3.0.CO;2-U","article-title":"Differential Expression of C-Jun and junD in End-Stage Human Cardiomyopathy","volume":"65","author":"Pollack","year":"1997","journal-title":"J. Cell. Biochem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0092-8674(94)90513-4","article-title":"Mouse JunD Negatively Regulates Fibroblast Growth and Antagonizes Transformation by Ras","volume":"76","author":"Pfarr","year":"1994","journal-title":"Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"216731","DOI":"10.1016\/j.canlet.2024.216731","article-title":"JunD-miR494-CUL3 Axis Promotes Radioresistance and Metastasis by Facilitating EMT and Restraining PD-L1 Degradation in Esophageal Squamous Cell Carcinoma","volume":"587","author":"Li","year":"2024","journal-title":"Cancer Lett."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Odaka, T., Sakamoto, R., Kumagai, K., Okuma, K., Nishizawa, M., and Kimura, T. (2024). Ephrin Type-A Receptor 2-Antisense RNA1\/2 Promote Proliferation and Migration of MDA-MB-231 Cells through EPHA2-Dependent Ras Signaling Pathway Mediated by MAPK8\/JNK1, MAPK9\/JNK2-NFATC2\/NFAT1 and JUND. Front. Mol. Biosci., 11.","DOI":"10.3389\/fmolb.2024.1402354"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/s41419-022-05412-5","article-title":"JUND\/Linc00976 Promotes Cholangiocarcinoma Progression and Metastasis, Inhibits Ferroptosis by Regulating the miR-3202\/GPX4 Axis","volume":"13","author":"Lei","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.18632\/oncotarget.28026","article-title":"JunD Accentuates Arecoline-Induced Disruption of Tight Junctions and Promotes Epithelial-to-Mesenchymal Transition by Association with NEAT1 lncRNA","volume":"12","author":"Ghosh","year":"2021","journal-title":"Oncotarget"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Xu, X., Zhang, M., Wang, X., Bai, X., Li, H., Kan, L., Zhou, Y., Niu, H., and He, P. (2016). MicroRNA-663a Is Downregulated in Non-Small Cell Lung Cancer and Inhibits Proliferation and Invasion by Targeting JunD. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2350-x"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/pros.20172","article-title":"Induction of AP-1 Activity by Androgen Activation of the Androgen Receptor in LNCaP Human Prostate Carcinoma Cells","volume":"63","author":"Church","year":"2005","journal-title":"Prostate"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/pros.20691","article-title":"JunD Mediates Androgen-Induced Oxidative Stress in Androgen Dependent LNCaP Human Prostate Cancer Cells","volume":"68","author":"Lee","year":"2008","journal-title":"Prostate"},{"key":"ref_135","first-page":"2206","article-title":"Constitutive Activation of Nuclear Factor kappaB P50\/P65 and Fra-1 and JunD Is Essential for Deregulated Interleukin 6 Expression in Prostate Cancer","volume":"63","author":"Zerbini","year":"2003","journal-title":"Cancer Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"40428","DOI":"10.1074\/jbc.M505120200","article-title":"Hydrogen Peroxide Stimulates Proliferation and Migration of Human Prostate Cancer Cells through Activation of Activator Protein-1 and up-Regulation of the Heparin Affin Regulatory Peptide Gene","volume":"280","author":"Polytarchou","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_137","first-page":"1175","article-title":"Transcription Factor AP-1 Promotes Growth and Radioresistance in Prostate Cancer Cells","volume":"35","author":"Kajanne","year":"2009","journal-title":"Int. J. Oncol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1038\/onc.2009.496","article-title":"Wnt5a Signaling Is Involved in the Aggressiveness of Prostate Cancer and Expression of Metalloproteinase","volume":"29","author":"Yamamoto","year":"2010","journal-title":"Oncogene"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.4161\/cc.10.15.16057","article-title":"JunD-Mediated Repression of GADD45\u03b1 and \u03b3 Regulates Escape from Cell Death in Prostate Cancer","volume":"10","author":"Zerbini","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2019.02.005","article-title":"Essential Role of JunD in Cell Proliferation Is Mediated via MYC Signaling in Prostate Cancer Cells","volume":"448","author":"Elliott","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s13046-021-02058-7","article-title":"MEN1 Silencing Aggravates Tumorigenic Potential of AR-Independent Prostate Cancer Cells through Nuclear Translocation and Activation of JunD and \u03b2-Catenin","volume":"40","author":"Luo","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Xu, M., Gong, S., Li, Y., Zhou, J., Du, J., Yang, C., Yang, M., Zhang, F., Liang, C., and Tong, Z. (2020). Identifying Long Non-Coding RNA of Prostate Cancer Associated with Radioresponse by Comprehensive Bioinformatics Analysis. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00498"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Tang, L., Li, W., Xu, H., Zheng, X., Qiu, S., He, W., Wei, Q., Ai, J., Yang, L., and Liu, J. (2022). Mutator-Derived lncRNA Landscape: A Novel Insight into the Genomic Instability of Prostate Cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.876531"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1158\/0008-5472.CAN-09-3596","article-title":"Androgen Receptor Requires JunD as a Coactivator to Switch on an Oxidative Stress Generation Pathway in Prostate Cancer Cells","volume":"70","author":"Basu","year":"2010","journal-title":"Cancer Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/pros.22800","article-title":"Targeting Androgen Receptor and JunD Interaction for Prevention of Prostate Cancer Progression","volume":"74","author":"Kegel","year":"2014","journal-title":"Prostate"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.4161\/cc.10.20.17668","article-title":"Targeting JunD: A Potential Strategy to Counteract Hormone-Refractory Prostate Cancer","volume":"10","author":"Sarkar","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.4161\/cc.10.20.17528","article-title":"Prostate Cancer: JunD, Gadd45a and Gadd45g as Therapeutic Targets","volume":"10","author":"Liebermann","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_148","first-page":"318","article-title":"Alterations in TGF\u03b2 Signaling during Prostate Cancer Progression","volume":"9","author":"Johnson","year":"2021","journal-title":"Am. J. Clin. Exp. Urol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s13258-024-01578-8","article-title":"Granzyme mRNA-miRNA Interaction and Its Implication to Functional Impact","volume":"46","author":"Kim","year":"2024","journal-title":"Genes Genom."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/cbf.3532","article-title":"microRNA-124-3p Inhibits Tumourigenesis by Targeting Mitogen-Activated Protein Kinase 4 in Papillary Thyroid Carcinoma","volume":"38","author":"Sun","year":"2020","journal-title":"Cell Biochem. Funct."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41467-019-14083-4","article-title":"Enhanced JunD\/RSK3 Signalling Due to Loss of BRD4\/FOXD3\/miR-548d-3p Axis Determines BET Inhibition Resistance","volume":"11","author":"Tai","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1349-7006.2009.01379.x","article-title":"Role of Syndecan-1 (CD138) in Cell Survival of Human Urothelial Carcinoma","volume":"101","author":"Shimada","year":"2010","journal-title":"Cancer Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1096\/fj.02-0287fje","article-title":"Differential Activation of AP-1 in Human Bladder Epithelial Cells by Inorganic and Methylated Arsenicals","volume":"17","author":"Jaspers","year":"2003","journal-title":"FASEB J."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/jcb.21667","article-title":"Modulation of Several Waves of Gene Expression during FGF-1 Induced Epithelial-Mesenchymal Transition of Carcinoma Cells","volume":"104","author":"Billottet","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e1800203","DOI":"10.1002\/pmic.201800203","article-title":"FGF2 Antiproliferative Stimulation Induces Proteomic Dynamic Changes and High Expression of FOSB and JUNB in K-Ras-Driven Mouse Tumor Cells","volume":"18","author":"Montoni","year":"2018","journal-title":"Proteomics"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Chen, H., and Chen, G. (2022). Dissecting Immunosuppressive Cell Communication Patterns Reveals JunB Proto-Oncogene (JUNB) Shaping a Non-Inflamed Tumor Microenvironment. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.883583"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Gu, X., Zhu, Y., Su, J., Wang, S., Su, X., Ding, X., Jiang, L., Fei, X., and Zhang, W. (2024). Lactate-Induced Activation of Tumor-Associated Fibroblasts and IL-8-Mediated Macrophage Recruitment Promote Lung Cancer Progression. Redox Biol., 74.","DOI":"10.1016\/j.redox.2024.103209"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Habanjar, O., Bingula, R., Decombat, C., Diab-Assaf, M., Caldefie-Chezet, F., and Delort, L. (2023). Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24044002"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.bbagrm.2019.05.007","article-title":"Transcriptionally Elevation of miR-494 by New ChlA-F Compound via a HuR\/JunB Axis Inhibits Human Bladder Cancer Cell Invasion","volume":"1862","author":"Tian","year":"2019","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Sobolewski, C., Dubuquoy, L., and Legrand, N. (2022). MicroRNAs, Tristetraprolin Family Members and HuR: A Complex Interplay Controlling Cancer-Related Processes. Cancers, 14.","DOI":"10.3390\/cancers14143516"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jb\/mvaa027","article-title":"JUND-Dependent up-Regulation of HMOX1 Is Associated with Cisplatin Resistance in Muscle-Invasive Bladder Cancer","volume":"168","author":"Peng","year":"2020","journal-title":"J. Biochem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"115545","DOI":"10.1016\/j.celrep.2025.115545","article-title":"High-Glucose-Associated YTHDC1 Lactylation Reduces the Sensitivity of Bladder Cancer to Enfortumab Vedotin Therapy","volume":"44","author":"Xing","year":"2025","journal-title":"Cell Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"217681","DOI":"10.1016\/j.canlet.2025.217681","article-title":"Nectin-4 Expression Patterns and Therapeutics in Oncology","volume":"622","author":"Nikanjam","year":"2025","journal-title":"Cancer Lett."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Filon, M., and Schmidt, B. (2025). The Future of Novel Antibody-Drug Conjugates in Localized Urothelial Cancer. Eur. Urol. Focus.","DOI":"10.1016\/j.euf.2025.07.016"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"110428","DOI":"10.1016\/j.ygeno.2022.110428","article-title":"LINC00702-Mediated DUSP1 Transcription in the Prevention of Bladder Cancer Progression: Implications in Cancer Cell Proliferation and Tumor Inflammatory Microenvironment","volume":"114","author":"Pan","year":"2022","journal-title":"Genomics"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"105508","DOI":"10.1016\/j.tiv.2022.105508","article-title":"Molecular Mechanism of Di-n-Butyl Phthalate Promotion of Bladder Cancer Development","volume":"86","author":"Li","year":"2023","journal-title":"Toxicol. Vitr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/S0022-5347(17)36899-4","article-title":"The Expression of C-Jun and junB mRNA in Renal Cell Cancer and in Vitro Regulation by Transforming Growth Factor Beta 1 and Tumor Necrosis Factor Alpha 1","volume":"148","author":"Koo","year":"1992","journal-title":"J. Urol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/bbrc.1997.7731","article-title":"Overexpression of Members of the AP-1 Transcriptional Factor Family from an Early Stage of Renal Carcinogenesis and Inhibition of Cell Growth by AP-1 Gene Antisense Oligonucleotides in the Tsc2 Gene Mutant (Eker) Rat Model","volume":"241","author":"Urakami","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"He, H., Wang, L., Zhou, W., Zhang, Z., Wang, L., Xu, S., Wang, D., Dong, J., Tang, C., and Tang, H. (2015). MicroRNA Expression Profiling in Clear Cell Renal Cell Carcinoma: Identification and Functional Validation of Key miRNAs. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125672"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1083\/jcb.201109045","article-title":"JunB Contributes to Id2 Repression and the Epithelial-Mesenchymal Transition in Response to Transforming Growth Factor-\u03b2","volume":"196","author":"Gervasi","year":"2012","journal-title":"J. Cell Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1002\/cam4.886","article-title":"CCL2 as a Potential Therapeutic Target for Clear Cell Renal Cell Carcinoma","volume":"5","author":"Arakaki","year":"2016","journal-title":"Cancer Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ccr.2005.06.015","article-title":"Neuronal Apoptosis Linked to EglN3 Prolyl Hydroxylase and Familial Pheochromocytoma Genes: Developmental Culling and Cancer","volume":"8","author":"Lee","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1038\/onc.2011.475","article-title":"JunB Promotes Cell Invasion and Angiogenesis in VHL-Defective Renal Cell Carcinoma","volume":"31","author":"Kanno","year":"2012","journal-title":"Oncogene"},{"key":"ref_174","first-page":"217","article-title":"Inductions of Immediate Early Genes (IEGS) and Ref-1 by Human Chorionic Gonadotropin in Murine Leydig Cell Line (MA-10)","volume":"44","author":"Suzuki","year":"1998","journal-title":"Biochem. Mol. Biol. Int."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1101\/sqb.2005.70.001","article-title":"The von Hippel-Lindau Tumor Suppressor Protein: Roles in Cancer and Oxygen Sensing","volume":"70","author":"Kaelin","year":"2005","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Gurzov, E.N., Ortis, F., Bakiri, L., Wagner, E.F., and Eizirik, D.L. (2008). JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003030"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5483\/BMBRep.2010.43.1.057","article-title":"Over-Expression of JunB Inhibits Mitochondrial Stress and Cytotoxicity in Human Lymphoma Cells Exposed to Chronic Oxidative Stress","volume":"43","author":"Son","year":"2010","journal-title":"BMB Rep."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/cdd.2014.53","article-title":"JunB Protects \u03b2-Cells from Lipotoxicity via the XBP1\u2013AKT Pathway","volume":"21","author":"Cunha","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Hsieh, T., Sasaki, D., Taira, N., Chien, H., Sarkar, S., Seto, Y., Miyagi, M., and Ishikawa, H. (2022). JunB Is Critical for Survival of T Helper Cells. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.901030"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Ren, X., Cui, Z., Zhang, Q., Su, Z., Xu, W., Wu, J., and Jiang, H. (2023). JunB Condensation Attenuates Vascular Endothelial Damage under Hyperglycemic Condition. J. Mol. Cell. Biol., 15.","DOI":"10.1093\/jmcb\/mjad072"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Fiore, M., Taddia, A., Indio, V., Bertuccio, S.N., Messelodi, D., Serravalle, S., Bandini, J., Spreafico, F., Perotti, D., and Collini, P. (2023). Molecular Signature of Biological Aggressiveness in Clear Cell Sarcoma of the Kidney (CCSK). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043743"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1095\/biolreprod.108.072108","article-title":"Impact of the Chemotherapy Cocktail Used to Treat Testicular Cancer on the Gene Expression Profile of Germ Cells from Male Brown-Norway Rats","volume":"80","author":"Chan","year":"2009","journal-title":"Biol. Reprod."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/9\/741\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:43:25Z","timestamp":1760035405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/9\/741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,10]]},"references-count":182,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["cimb47090741"],"URL":"https:\/\/doi.org\/10.3390\/cimb47090741","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,10]]}}}