{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:53:07Z","timestamp":1787241187854,"version":"build-2736575974"},"reference-count":54,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Busan Metropolitan City and Busan Techno Park"},{"name":"Korean government","award":["NRF-2022R1F1A1074419"],"award-info":[{"award-number":["NRF-2022R1F1A1074419"]}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education of the Republic of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2022S1A5C2A04093562"],"award-info":[{"award-number":["NRF-2022S1A5C2A04093562"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["CIMB"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurological condition with limited effective pharmaceutical treatments, often accompanied by side effects. This has increased interest in plant-based alternatives. This study examined the cognitive effects of a Natural Polyherbal Extract (NPX) on scopolamine-induced memory deficits in mice. Male C57BL\/6 mice (10 weeks old, n = 36) were divided into four groups: control (saline), scopolamine (1 mg\/kg, i.p.), tacrine (10 mg\/kg, oral), and NPX (1000 mg\/kg, oral). NPX and tacrine were administered daily by oral gavage for two weeks. Cognitive function was assessed weekly using the Y-maze task. Brain tissues were collected for biochemical analysis, including AChE activity and immunohistochemical detection of neurodegeneration-related markers. Results: Mice treated with NPX demonstrated improved spontaneous alternation behavior compared to the scopolamine group. NPX also significantly reduced acetylcholinesterase activity. Immunohistochemistry revealed decreased expression of amyloid-beta (A\u03b2) and caspase-3, with enhanced choline acetyltransferase levels. These outcomes were comparable to those observed in the tacrine-treated group. Conclusions: NPX alleviated scopolamine-induced memory impairment through enhancement of cholinergic signaling and mitigation of neurodegenerative markers. The findings suggest that NPX may serve as a promising plant-derived candidate for managing memory-related disorders, including AD.<\/jats:p>","DOI":"10.3390\/cimb47100817","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:18:33Z","timestamp":1759421913000},"page":"817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of a Natural Polyherbal Extract on Alleviating Scopolamine-Induced Memory Deficits in C57BL\/6 Mice via Enhancing Cholinergic Function"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-4487","authenticated-orcid":false,"given":"Hyeokjin","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea"},{"name":"Next-Generation Industrial Field-Based Specialist Program for Molecular Diagnostics, Brain Busan 21 Plus Project, Graduate School, Catholic University of Pusan, Busan 46252, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ho","family":"Kwon","sequence":"additional","affiliation":[{"name":"Basic Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China"},{"name":"Miion Bio Co., Ltd., Seoul 08591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-1672","authenticated-orcid":false,"given":"Myeongguk","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea"},{"name":"Next-Generation Industrial Field-Based Specialist Program for Molecular Diagnostics, Brain Busan 21 Plus Project, Graduate School, Catholic University of Pusan, Busan 46252, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-5709","authenticated-orcid":false,"given":"Yeeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedical Sciences, Graduate School of Dong-A University, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Gyung","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of General Education, Dong-Eui University, Busan 46252, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeongdon","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, Gimcheon University, Gimcheon 39528, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Yae","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, Dong-Eui University, Busan 46252, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0800-2919","authenticated-orcid":false,"given":"Go-Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea"},{"name":"Next-Generation Industrial Field-Based Specialist Program for Molecular Diagnostics, Brain Busan 21 Plus Project, Graduate School, Catholic University of Pusan, Busan 46252, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"(2025). 2025 Alzheimer\u2019s disease facts and figures. 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