{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:25:38Z","timestamp":1781281538596,"version":"3.54.1"},"reference-count":61,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Research and Innovation at University of Hafr Al Batin","award":["0144-1446-S"],"award-info":[{"award-number":["0144-1446-S"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>In left ventricular hypertrophy (LVH), the combined external administration of hydrogen sulfide (H2S) and nitric oxide (NO) has been shown to reverse LVH by activating the endothelial nitric oxide synthase pathway (eNOS\/NO), independent of the cystathionine \u03b3-lyase (CSE\/H2S) pathway. Individually, both H2S and NO have also been reported to significantly improve RCBP, restore renal excretory performance, and enhance \u03b1-adrenergic receptor responsiveness in rats. The induction of LVH was performed over a period of two weeks using drinking water with caffeine and isoprenaline. Five weeks later, the rats were fed with L-arginine (1.25 g\/L) as a nitrogen oxide donor. Vascular reactions to methoxamine, phenylephrine, and noradrenaline were assessed in presences and absence of 5-methylurapidil (5-MeU), BMY7378, and chloroethylclonidine (CeC) and \u03b11-adrenoceptor antagonists. In both the Control WKY and LVH-WKY groups, combined H2S+NO therapy significantly (p &lt; 0.05) upregulated the renal mRNA of CSE and eNOS when compared with untreated LVH rats. The treatment also markedly increased RCBP in LVH-H2S+NO rats relative to LVH controls. Furthermore, H2S+NO administration enhanced the activity of \u03b11A, \u03b11B, and \u03b11D adrenergic receptors in mediating renal vasoconstriction. Even under receptor blockade with high doses (HDs) of 5-MeU, CeC, and BMY 7378, renal vasoconstriction responses to adrenergic agonists like NA, PE, and ME in the LVH-H2S+NO group remained comparable to those observed in the counterpart Control-H2S+NO group. The findings of current study suggest that simultaneous exogenous administration of H2S and NO donors improve renal cortical blood flow, support renal function, and augment \u03b11A, \u03b11B, and \u03b11D adrenergic receptor responsiveness to adrenergic agonists like NA, PE, and ME in LVH rats. This effect appears to rely primarily on the eNOS\/NO pathway, with partial contribution from the CSE\/H2S pathway.<\/jats:p>","DOI":"10.3390\/cimb47100848","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:04:02Z","timestamp":1760537042000},"page":"848","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hydrogen Sulfide and Nitric Oxide Improve Renal Function and \u03b1-Adrenergic Responsiveness in Rats with Left Ventricular Hypertrophy"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-9336","authenticated-orcid":false,"given":"Tabinda","family":"Fatima","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0838-2301","authenticated-orcid":false,"given":"Latifah Al","family":"Shammari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ibrahim","family":"Lazhari","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Faculty of Medical Technology, University of Tripoli, Tripoli 13932, Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waad","family":"Alrohily","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-6950","authenticated-orcid":false,"given":"Tan","family":"Yong Chia","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University Sains Malaysia, Penang 11800, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9081-2113","authenticated-orcid":false,"given":"Nimer","family":"Alsabeelah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eid Fahad","family":"Alanazi","sequence":"additional","affiliation":[{"name":"Pharm D Program, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid Abdulrahman","family":"Almutairi","sequence":"additional","affiliation":[{"name":"Pharm D Program, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan Mujahid","family":"Alhabradi","sequence":"additional","affiliation":[{"name":"Pharm D Program, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naif Saleh","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Pharm D Program, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-4639","authenticated-orcid":false,"given":"Ashfaq","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/01.CIR.102.4.470","article-title":"Left ventricular hypertrophy: Pathogenesis, detection, and prognosis","volume":"102","author":"Lorell","year":"2000","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pcad.2019.11.009","article-title":"Left ventricular hypertrophy and hypertension","volume":"63","author":"Yildiz","year":"2020","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_3","first-page":"1015","article-title":"Impact of Isoprenaline and Caffeine on Development of Left Ventricular Hypertrophy and Renal Hemodynamic In Wistar Kyoto Rats","volume":"72","author":"Ahmad","year":"2015","journal-title":"Acta Pol. Pharm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/bjp.2008.13","article-title":"Influence of combined hypertension and renal failure on functional alpha(1)-adrenoceptor subtypes in the rat kidney","volume":"153","author":"Sattar","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1017\/S0007114511002716","article-title":"High-fructose feeding impacts on the adrenergic control of renal haemodynamics in the rat","volume":"107","author":"Abdulla","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_6","first-page":"253","article-title":"Cisplatin-induced nephrotoxicity causes altered renal hemodynamics in Wistar Kyoto and spontaneously hypertensive rats: Role of augmented renal alpha-adrenergic responsiveness","volume":"59","author":"Abdullah","year":"2007","journal-title":"Exp. Toxicol. Pathol. Off. J. Ges. Fur Toxikol. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1139\/cjpp-2014-0236","article-title":"Functional contribution of \u03b11D-adrenoceptors in the renal vasculature of left ventricular hypertrophy induced with isoprenaline and caffeine in Wistar-Kyoto rats","volume":"92","author":"Ahmad","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.CIR.0000081775.72651.B6","article-title":"Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy","volume":"108","author":"Schlaich","year":"2003","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1161\/CIRCULATIONAHA.106.668863","article-title":"Relationship between central sympathetic drive and magnetic resonance imaging-determined left ventricular mass in essential hypertension","volume":"115","author":"Burns","year":"2007","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000137886","article-title":"Vascular reactivity to adrenergic agents and neuronal and vascular catecholamine levels in spontaneously hypertensive rats","volume":"27","author":"Sun","year":"1983","journal-title":"Pharmacology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/sj.bjp.0705842","article-title":"The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats","volume":"142","author":"Armenia","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two\u2019s company, three\u2019s a crowd: Can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ahmad, A., Sattar, M.A., Azam, M., Khan, S.A., Bhatt, O., and Johns, E.J. (2018). Interaction between nitric oxide and renal \u03b11-adrenoreceptors mediated vasoconstriction in rats with left ventricular hypertrophyin Wistar Kyoto rats. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0189386"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF03179855","article-title":"The nitric oxide pathway in the cardiovascular system","volume":"58","author":"Llorens","year":"2002","journal-title":"J. Physiol. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cardiores.2006.02.002","article-title":"Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation","volume":"70","author":"Martin","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_16","first-page":"31","article-title":"Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated Wistar-Kyoto rats","volume":"67","author":"Ahmad","year":"2016","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ahmad, A., Sattar, M.A., Azam, M., Abdulla, M.H., Khan, S.A., Hashmi, F., Abdullah, N.A., and Johns, E.J. (2016). Cystathione gamma lyase\/Hydrogen Sulphide Pathway Up Regulation Enhances the Responsiveness of \u03b11A and \u03b11B-Adrenoreceptors in the Kidney of Rats with Left Ventricular Hypertrophy. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154995"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2003.10.007","article-title":"Hydrogen sulfide: From the smell of the past to the mediator of the future?","volume":"24","author":"Moore","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1582-4934.2009.00645.x","article-title":"Hydrogen sulfide and the vasculature: A novel vasculoprotective entity and regulator of nitric oxide bioavailability?","volume":"13","author":"Whiteman","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ahmad, A. (2022). Physiological, Pathological and Pharmacological Interactions of Hydrogen Sulphide and Nitric Oxide in the Myocardium of Rats with Left Ventricular Hypertrophy. Curr. Issues Mol. Biol., 44.","DOI":"10.3390\/cimb44010030"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ahmad, A., Sattar, M.A., Rathore, H.A., Abdulla, M.H., Khan, S.A., Azam, M., Abdullah, N.A., and Johns, E.J. (2016). Up Regulation of cystathione \u03b3 lyase and Hydrogen Sulphide in the Myocardium Inhibits the Progression of Isoproterenol\u2013Caffeine Induced Left Ventricular Hypertrophy in Wistar Kyoto Rats. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150137"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2003.11.081","article-title":"The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats","volume":"313","author":"Yan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1172\/JCI119191","article-title":"Nitric oxide (NO) modulates the neurogenic control of blood pressure in rats with chronic renal failure (CRF)","volume":"99","author":"Ye","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"H1484","DOI":"10.1152\/ajpheart.00382.2013","article-title":"Caveolin-1 scaffolding domain promotes leukocyte adhesion by reduced basal endothelial nitric oxide-mediated ICAM-1 phosphorylation in rat mesenteric venules","volume":"305","author":"Xu","year":"2013","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.mito.2009.08.007","article-title":"Proteins participating to the post-transcriptional regulation of the mitochondrial cytochrome c oxidase subunit IV via elements located in the 3\u2032UTR","volume":"9","author":"Cannino","year":"2009","journal-title":"Mitochondrion"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ahmad, A. (2022). Prophylactic Treatment with Hydrogen Sulphide Can Prevent Renal Ischemia-Reperfusion Injury in L-NAME Induced Hypertensive Rats with Cisplatin-Induced Acute Renal Failure. Life, 12.","DOI":"10.3390\/life12111819"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0014-2999(88)90819-9","article-title":"5-Methyl-urapidil discriminates between subtypes of the alpha 1-adrenoceptor","volume":"151","author":"Gross","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/BF00169154","article-title":"Chloroethylclonidine irreversibly activates postjunctional alpha 2-adrenoceptors in the dog saphenous vein","volume":"348","author":"Nunes","year":"1993","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1016\/0014-2999(94)00751-R","article-title":"BMY 7378 is a selective antagonist of the D subtype of \u03b11-adrenoceptors","volume":"272","author":"Goetz","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0031-6997(25)06845-0","article-title":"International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: Consensus update","volume":"47","author":"Hieble","year":"1995","journal-title":"Pharmacol. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1152\/physrev.1997.77.1.75","article-title":"Neural control of renal function","volume":"77","author":"Dibona","year":"1997","journal-title":"Physiol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00394-010-0133-8","article-title":"The contribution of \u03b11B-adrenoceptor subtype in the renal vasculature of fructose-fed Sprague\u2013Dawley rats","volume":"50","author":"Abdulla","year":"2011","journal-title":"Eur. J. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1152\/japplphysiol.00139.2002","article-title":"Myotoxic effects of clenbuterol in the rat heart and soleus muscle","volume":"93","author":"Burniston","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0163-7258(82)90016-X","article-title":"Diet-induced thermogenesis","volume":"17","author":"Rothwell","year":"1982","journal-title":"Pharmacol. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1440-1681.1992.tb00514.x","article-title":"L-Arginine Infusion Induces Hypotension and Diuresis\/Natriuresis with Concomitant Increased Urinary Excretion of Nitrite\/Nitrate and Cyclic Gmp in Humans","volume":"19","author":"Kanno","year":"1992","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1042\/cs0720749","article-title":"Renal and cardiovascular effects of caffeine: A dose-response study","volume":"72","author":"Passmore","year":"1987","journal-title":"Clin Sci"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1139\/y03-077","article-title":"Modulation of endogenous production of H2S in rat tissues","volume":"81","author":"Zhao","year":"2003","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00041552-200401000-00013","article-title":"Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertension","volume":"13","author":"Vaziri","year":"2004","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/00005768-200108000-00024","article-title":"Effect of caffeine and ephedrine ingestion on anaerobic exercise performance","volume":"33","author":"Bell","year":"2001","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1055\/s-2007-1024710","article-title":"Effects of caffeine ingestion on performance and anaerobic metabolism during the Wingate test","volume":"12","author":"Collomp","year":"1991","journal-title":"Int. J. Sports Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"17985","DOI":"10.1073\/pnas.0605545103","article-title":"Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney","volume":"103","author":"Crowley","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1056\/NEJM197801262980403","article-title":"Effects of caffeine on plasma renin activity, catecholamines and blood pressure","volume":"298","author":"Robertson","year":"1978","journal-title":"N. Engl. J. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/sj.bjp.0706906","article-title":"Regulation of vascular nitric oxide wasro and in vivo; a new role for endogenous hydrogen sulphide?","volume":"149","author":"Ali","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_46","first-page":"245","article-title":"Antioxidant activity and free radical scavenging capacity of L-arginine and NaHS: A comparative in vitro study","volume":"72","author":"Ahmad","year":"2015","journal-title":"Acta Pol. Pharm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/ki.2009.221","article-title":"Hydrogen sulfide: A new EDRF","volume":"76","author":"Wang","year":"2009","journal-title":"Kidney Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/327524a0","article-title":"Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor","volume":"327","author":"Palmer","year":"1987","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"H1030","DOI":"10.1152\/ajpheart.1989.256.4.H1030","article-title":"Release of NO and EDRF from cultured bovine aortic endothelial cells","volume":"256","author":"Myers","year":"1989","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-4159.2004.02617.x","article-title":"The novel neuromodulator hydrogen sulfide: An endogenous peroxynitrite \u2018scavenger\u2019?","volume":"90","author":"Whiteman","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/cvr\/cvq248","article-title":"Hydrogen sulfide interacts with nitric oxide in the heart: Possible involvement of nitroxyl","volume":"88","author":"Yong","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0014-2999(03)01305-0","article-title":"Preventive effect of zelandopam, a dopamine D1 receptor agonist, on cisplatin-induced acute renal failure in rats","volume":"461","author":"Yatsu","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0014-2999(91)90491-8","article-title":"Evidence for a complex interaction between the subtypes of the alpha 1-adrenoceptor","volume":"199","author":"Piascik","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1537-1891(02)00336-1","article-title":"Evidence for the role of alpha1D- and alpha1A-adrenoceptors in contraction of the rat mesenteric artery","volume":"40","year":"2003","journal-title":"Vasc. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0898-6568(93)90049-R","article-title":"Alpha 1-adrenergic action: Receptor subtypes, signal transduction and regulation","volume":"5","year":"1993","journal-title":"Cell Signal"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1745-7254.2008.00727.x","article-title":"Alpha1B-adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairment","volume":"29","author":"Khan","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/01.RES.70.3.607","article-title":"NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?","volume":"70","author":"Sakuma","year":"1992","journal-title":"Circ. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Ahmad, A., Dempsey, S.K., Daneva, Z., Azam, M., Li, N., Li, P.L., and Ritter, J.K. (2018). Role of Nitric Oxide in the Cardiovascular and Renal Systems. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092605"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1097\/00004872-200310000-00015","article-title":"The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase","volume":"21","author":"Zhong","year":"2003","journal-title":"J. Hypertens."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"H778","DOI":"10.1152\/ajpheart.1992.263.3.H778","article-title":"Aging-and training-induced alterations in collagen characteristics of rat left ventricle and papillary muscle","volume":"263","author":"Thomas","year":"1992","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1291\/hypres.31.1619","article-title":"Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats","volume":"31","author":"Zhao","year":"2008","journal-title":"Hypertens. Res."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/10\/848\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:37:26Z","timestamp":1760539046000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/10\/848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":61,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["cimb47100848"],"URL":"https:\/\/doi.org\/10.3390\/cimb47100848","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]}}}