{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:35:16Z","timestamp":1790184916698,"version":"4.1.0"},"reference-count":144,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Program for Basic Research in the Russian Federation","award":["122022800499-5"],"award-info":[{"award-number":["122022800499-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>In recent decades, there has been a significant amount of research on the biological role of non-coding RNAs (ncRNAs) in both normal and pathological conditions. Specifically, a growing body of evidence suggests that ncRNAs play a crucial role in maintaining epidermal homeostasis. These ncRNAs are involved in regulating epidermal differentiation and wound healing, as well as in pathological skin conditions, such as psoriasis and chronic wounds. The discovery of mechanisms such as RNA interference and other modes of action of ncRNAs has led to the development of novel therapeutic strategies, where ncRNAs could serve as targets, therapeutic agents, or diagnostic markers. This review explores the role of different classes of ncRNAs in the epidermis under normal and abnormal conditions, the mechanisms by which ncRNAs interact with other modulators of epidermal homeostasis, and the current state of ncRNA-based therapy.<\/jats:p>","DOI":"10.3390\/cimb47110924","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:02:03Z","timestamp":1762419723000},"page":"924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Non-Coding RNAs and Their Role in Maintaining Epidermal Homeostasis"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0311-5826","authenticated-orcid":false,"given":"Daniil D.","family":"Romashin","sequence":"first","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow 119121, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-6551","authenticated-orcid":false,"given":"Tatiana V.","family":"Tolstova","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow 119121, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-5330","authenticated-orcid":false,"given":"Alexander L.","family":"Rusanov","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow 119121, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia G.","family":"Luzgina","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow 119121, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mahanty, S., and Setty, S.R.G. (2021). Epidermal Lamellar Body Biogenesis: Insight Into the Roles of Golgi and Lysosomes. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.701950"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ceb.2020.09.004","article-title":"Advances in Resolving the Heterogeneity and Dynamics of Keratinocyte Differentiation","volume":"67","author":"Rice","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1083\/jcb.200708185","article-title":"Skin Stem Cells: Rising to the Surface","volume":"180","author":"Fuchs","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhang, X., Yin, M., and Zhang, L. (2019). Keratin 6, 16 and 17\u2014Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis. Cells, 8.","DOI":"10.3390\/cells8080807"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"dev194100","DOI":"10.1242\/dev.194100","article-title":"Regulatory Mechanisms Governing Epidermal Stem Cell Function during Development and Homeostasis","volume":"147","author":"Flora","year":"2020","journal-title":"Development"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.jid.2021.09.033","article-title":"NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair","volume":"142","author":"Yan","year":"2022","journal-title":"J. Investig. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jid.2023.12.017","article-title":"AP-2\u03b1\/AP-2\u03b2 Transcription Factors Are Key Regulators of Epidermal Homeostasis","volume":"144","author":"Zhang","year":"2024","journal-title":"J. Investig. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/bjd.14048","article-title":"P53 Activity Contributes to Defective Interfollicular Epidermal Differentiation in Hyperproliferative Murine Skin","volume":"174","author":"Cottle","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"a015248","DOI":"10.1101\/cshperspect.a015248","article-title":"P53\/P63\/P73 in the Epidermis in Health and Disease","volume":"4","author":"Botchkarev","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41422-024-00975-8","article-title":"Coding, or Non-Coding, That Is the Question","volume":"34","author":"Poliseno","year":"2024","journal-title":"Cell Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Jacovetti, C., Bayazit, M.B., and Regazzi, R. (2021). Emerging Classes of Small Non-Coding RNAs With Potential Implications in Diabetes and Associated Metabolic Disorders. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.670719"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41420-022-01056-8","article-title":"snoRNAs: Functions and Mechanisms in Biological Processes, and Roles in Tumor Pathophysiology","volume":"8","author":"Huang","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1093\/hmg\/ddl046","article-title":"Non-Coding RNA","volume":"15","author":"Mattick","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/s41594-024-01287-6","article-title":"Mammalian PIWI-piRNA-Target Complexes Reveal Features for Broad and Efficient Target Silencing","volume":"31","author":"Li","year":"2024","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.gendis.2019.09.009","article-title":"RISC Assembly and Post-Transcriptional Gene Regulation in Hepatocellular Carcinoma","volume":"7","author":"Santhekadur","year":"2020","journal-title":"Genes. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene Regulation by Long Non-Coding RNAs and Its Biological Functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41576-023-00611-y","article-title":"microRNAs in Action: Biogenesis, Function and Regulation","volume":"24","author":"Shang","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"ref_18","unstructured":"Xiao, J. (2022). Chapter 3-MicroRNA Interference. MicroRNA, Academic Press."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1042\/BST20140142","article-title":"Regulation of miRNA Strand Selection: Follow the Leader?","volume":"42","author":"Meijer","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Rubina, K., Maier, A., Klimovich, P., Sysoeva, V., Romashin, D., Semina, E., and Tkachuk, V. (2025). T-Cadherin (CDH13) and Non-Coding RNAs: The Crosstalk Between Health and Disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136127"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long Non-Coding RNAs: Definitions, Functions, Challenges and Recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkad829","article-title":"FL-circAS: An Integrative Resource and Analysis for Full-Length Sequences and Alternative Splicing of Circular RNAs with Nanopore Sequencing","volume":"52","author":"Chiang","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/2211-5463.12397","article-title":"Profiling Expression of Coding Genes, Long Noncoding RNA, and Circular RNA in Lung Adenocarcinoma by Ribosomal RNA-Depleted RNA Sequencing","volume":"8","author":"Ding","year":"2018","journal-title":"FEBS Open Bio"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41418-022-00948-7","article-title":"Specific Expression and Functions of Circular RNAs","volume":"29","author":"Misir","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhu, H., Fu, L., and Xu, T. (2021). Investigating the Underlying Mechanisms of Circular RNAs and Their Application in Clinical Research of Cervical Cancer. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.653051"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Catanzaro, G. (2022). Non-Coding RNAs in Health and Disease: Editorial. Biomedicines, 11.","DOI":"10.3390\/biomedicines11010014"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Good, D.J. (2023). Non-Coding RNAs in Human Health and Diseases. Genes, 14.","DOI":"10.3390\/genes14071429"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e435","DOI":"10.1038\/cddis.2012.174","article-title":"MicroRNA-203 Contributes to Skin Re-Epithelialization","volume":"3","author":"Lena","year":"2012","journal-title":"Cell Death Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.jid.2024.10.613","article-title":"Identification of miR-141 as a Regulator of Epidermal Homeostasis","volume":"145","author":"Vieu","year":"2025","journal-title":"J. Investig. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/cdd.2008.69","article-title":"miR-203 Represses \u201cstemness\u201d by Repressing DeltaNp63","volume":"15","author":"Lena","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1038\/oncsis.2012.3","article-title":"MicroRNA-203 Functions as a Tumor Suppressor in Basal Cell Carcinoma","volume":"1","author":"Sonkoly","year":"2012","journal-title":"Oncogenesis"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"10644","DOI":"10.1128\/JVI.00703-10","article-title":"MicroRNA 203 Expression in Keratinocytes Is Dependent on Regulation of P53 Levels by E6","volume":"84","author":"McKenna","year":"2010","journal-title":"J. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/bjc.2013.697","article-title":"Expression of Nuclear Survivin in Normal Skin and Squamous Cell Carcinoma: A Possible Role in Tumour Invasion","volume":"110","author":"Dallaglio","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6100","DOI":"10.1111\/jocd.15147","article-title":"miR-203 Represses Keratinocyte Stemness by Targeting Survivin","volume":"21","author":"Labarrade","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"17018","DOI":"10.3390\/ijms160817018","article-title":"miR-198 Represses the Proliferation of HaCaT Cells by Targeting Cyclin D2","volume":"16","author":"Wang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.stemcr.2017.10.030","article-title":"microRNA-184 Induces a Commitment Switch to Epidermal Differentiation","volume":"9","author":"Nagosa","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jid.2022.06.028","article-title":"MicroRNA-148a Controls Epidermal and Hair Follicle Stem\/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5","volume":"143","author":"Pickup","year":"2023","journal-title":"J. Investig. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e3174","DOI":"10.1038\/cddis.2017.516","article-title":"H19 lncRNA Regulates Keratinocyte Differentiation by Targeting miR-130b-3p","volume":"8","author":"Li","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.devcel.2015.01.028","article-title":"A LncRNA-MAF:MAFB Transcription Factor Network Regulates Epidermal Differentiation","volume":"32","author":"Qu","year":"2015","journal-title":"Dev. Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1007\/s00018-020-03554-3","article-title":"Long Non-Coding RNAs in Cutaneous Biology and Keratinocyte Carcinomas","volume":"77","author":"Piipponen","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e46612","DOI":"10.15252\/embr.201846612","article-title":"The Long Non-coding RNA LINC00941 and SPRR5 Are Novel Regulators of Human Epidermal Homeostasis","volume":"20","author":"Ziegler","year":"2019","journal-title":"EMBO Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e106276","DOI":"10.15252\/embj.2020106276","article-title":"N6-methyladenosine Modification of lncRNA Pvt1 Governs Epidermal Stemness","volume":"40","author":"Lee","year":"2021","journal-title":"EMBO J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e202302475","DOI":"10.26508\/lsa.202302475","article-title":"lncRNA LINC00941 Modulates MTA2\/NuRD Occupancy to Suppress Premature Human Epidermal Differentiation","volume":"7","author":"Morgenstern","year":"2024","journal-title":"Life Sci. Alliance"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/15476286.2017.1409931","article-title":"Circular RNAs Are Abundantly Expressed and Upregulated during Human Epidermal Stem Cell Differentiation","volume":"15","author":"Kristensen","year":"2017","journal-title":"RNA Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/exd.13119","article-title":"MicroRNA-23b-3p Regulates Human Keratinocyte Differentiation through Repression of TGIF1 and Activation of the TGF-\u00df-SMAD2 Signalling Pathway","volume":"26","author":"Metral","year":"2017","journal-title":"Exp. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbrc.2022.04.022","article-title":"P63 in Corneal and Epidermal Differentiation","volume":"610","author":"Novelli","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jid.2023.07.005","article-title":"\u0394Np63 Regulates Homeostasis, Stemness, and Suppression of Inflammation in the Adult Epidermis","volume":"144","author":"Eyermann","year":"2024","journal-title":"J. Investig. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41420-023-01716-3","article-title":"Epigenetic Priming of an Epithelial Enhancer by P63 and CTCF Controls Expression of a Skin-Restricted Gene XP33","volume":"9","author":"Smirnov","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1038\/s41467-023-39011-5","article-title":"The Long Non-Coding RNA NEAT1 Is a \u0394Np63 Target Gene Modulating Epidermal Differentiation","volume":"14","author":"Fierro","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s12672-025-02510-6","article-title":"Defining the Transcriptional Routes Controlling lncRNA NEAT1 Expression: Implications in Cellular Stress Response, Inflammation, and Differentiation","volume":"16","author":"Nicolai","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1038\/s41388-023-02859-4","article-title":"P63: A Crucial Player in Epithelial Stemness Regulation","volume":"42","author":"Li","year":"2023","journal-title":"Oncogene"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Tanis, S.E.J., K\u00f6ksal, E.S., van Buggenum, J.A.G.L., and Mulder, K.W. (2019). BLNCR Is a Long Non-Coding RNA Adjacent to Integrin Beta-1 That Is Rapidly Lost during Epidermal Progenitor Cell Differentiation. Sci. Rep., 9.","DOI":"10.1038\/s41598-018-37251-w"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/cdd.2014.113","article-title":"MicroRNAs and P63 in Epithelial Stemness","volume":"22","author":"Candi","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Woodstock, D.L., Sammons, M.A., and Fischer, M. (2021). P63 and P53: Collaborative Partners or Dueling Rivals?. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.701986"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1128\/MCB.23.7.2264-2276.2003","article-title":"The Delta Np63 Alpha Phosphoprotein Binds the P21 and 14-3-3 Sigma Promoters in Vivo and Has Transcriptional Repressor Activity That Is Reduced by Hay-Wells Syndrome-Derived Mutations","volume":"23","author":"Westfall","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2007.05.010","article-title":"Transactivation of miR-34a by P53 Broadly Influences Gene Expression and Promotes Apoptosis","volume":"26","author":"Chang","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/jid.2009.438","article-title":"Transcriptional Repression of miR-34 Family Contributes to P63-Mediated Cell Cycle Progression in Epidermal Cells","volume":"130","author":"Antonini","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Dom\u00edguez-H\u00fcttinger, E., Flores-Garza, E., Cald\u00fa-Primo, J.L., Day, H., Ram\u00edrez, A.R., and Tanaka, R.J. (2025). History-Dependent Switch-like Differentiation of Keratinocytes in Response to Skin Barrier Damage. PLoS Comput. Biol., 21.","DOI":"10.1371\/journal.pcbi.1013162"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.3390\/cimb46080508","article-title":"Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings","volume":"46","author":"Romashin","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Sass, P.A., D\u0105browski, M., Charzy\u0144ska, A., and Sachadyn, P. (2017). Transcriptomic Responses to Wounding: Meta-Analysis of Gene Expression Microarray Data. BMC Genom., 18.","DOI":"10.1186\/s12864-017-4202-8"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.stem.2024.11.013","article-title":"Spatiotemporal Single-Cell Roadmap of Human Skin Wound Healing","volume":"32","author":"Liu","year":"2025","journal-title":"Cell Stem Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jid.2019.07.694","article-title":"MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4","volume":"140","author":"Wu","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.jid.2018.03.1521","article-title":"MiR-31 Mediates Inflammatory Signaling to Promote Re-Epithelialization during Skin Wound Healing","volume":"138","author":"Shi","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Li, Q., Zhao, H., Chen, W., Huang, P., and Bi, J. (2019). Human Keratinocyte-Derived Microvesicle miRNA-21 Promotes Skin Wound Healing in Diabetic Rats through Facilitating Fibroblast Function and Angiogenesis. Int. J. Biochem. Cell Biol., 114.","DOI":"10.1016\/j.biocel.2019.105570"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s10753-023-01930-2","article-title":"miR-21 Expressed by Dermal Fibroblasts Enhances Skin Wound Healing Through the Regulation of Inflammatory Cytokine Expression","volume":"47","author":"Liu","year":"2024","journal-title":"Inflammation"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Zhang, L., Hung, G.C.-C., Meng, S., Evans, R., and Xu, J. (2023). LncRNA MALAT1 Regulates Hyperglycemia Induced EMT in Keratinocyte via miR-205. Noncoding RNA, 9.","DOI":"10.3390\/ncrna9010014"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhang, L., Hu, J., Meshkat, B.I., Liechty, K.W., and Xu, J. (2021). LncRNA MALAT1 Modulates TGF-\u03921-Induced EMT in Keratinocyte. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111816"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/s41418-023-01142-z","article-title":"Human Skin Specific Long Noncoding RNA HOXC13-AS Regulates Epidermal Differentiation by Interfering with Golgi-ER Retrograde Transport","volume":"30","author":"Zhang","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jid.2018.11.033","article-title":"WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines","volume":"139","author":"Herter","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.1038\/s41467-024-52783-8","article-title":"The lncRNA SNHG26 Drives the Inflammatory-to-Proliferative State Transition of Keratinocyte Progenitor Cells during Wound Healing","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/jbcr\/irad145","article-title":"LncRNA H19 Inhibits Keratinocyte Cell Proliferation and Migration by Targeting miR-17-5p\/RUNX1 Axis in Chronic Wounds","volume":"45","author":"Ji","year":"2024","journal-title":"J. Burn. Care Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1016\/j.jid.2022.03.024","article-title":"Circular RNA Signatures of Human Healing and Nonhealing Wounds","volume":"142","author":"Toma","year":"2022","journal-title":"J. Investig. Dermatol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/bjd\/ljae405","article-title":"Circular RNA circASH1L(4,5) Protects microRNA-129-5p from Target-Directed microRNA Degradation in Human Skin Wound Healing","volume":"192","author":"Wang","year":"2025","journal-title":"Br. J. Dermatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e2416784","DOI":"10.1002\/advs.202416784","article-title":"Collaborative Duality of CircGLIS3(2) RNA and Protein in Human Wound Repair","volume":"12","author":"Niu","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Ban, E., Jeong, S., Park, M., Kwon, H., Park, J., Song, E.J., and Kim, A. (2020). Accelerated Wound Healing in Diabetic Mice by miRNA-497 and Its Anti-Inflammatory Activity. Biomed. Pharmacother., 121.","DOI":"10.1016\/j.biopha.2019.109613"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1007\/s10528-023-10551-1","article-title":"MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by Targeting PDGFD in Diabetic Foot Ulcer","volume":"62","author":"Wang","year":"2024","journal-title":"Biochem. Genet."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Sakshi, S., Jayasuriya, R., Sathish Kumar, R.C., Umapathy, D., Gopinathan, A., Balamurugan, R., Ganesan, K., and Ramkumar, K.M. (2023). MicroRNA-27b Impairs Nrf2-Mediated Angiogenesis in the Progression of Diabetic Foot Ulcer. J. Clin. Med., 12.","DOI":"10.3390\/jcm12134551"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1038\/ncomms6099","article-title":"A Novel Nrf2-miR-29-Desmocollin-2 Axis Regulates Desmosome Function in Keratinocytes","volume":"5","author":"Kurinna","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/1873-3468.70051","article-title":"miRNA-29 Regulates Epidermal and Mesenchymal Functions in Skin Repair","volume":"599","author":"Thiagarajan","year":"2025","journal-title":"FEBS Lett."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.2147\/DMSO.S410986","article-title":"Role of Increased miR-222-3p Expression in Peripheral Blood and Wound Marginal Tissues of Type 2 Diabetes Mellitus Patients with Diabetic Foot Ulcer","volume":"16","author":"Jie","year":"2023","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/iwj.13895","article-title":"Changes in miroRNA-103 Expression in Wound Margin Tissue Are Related to Wound Healing of Diabetes Foot Ulcers","volume":"20","author":"Zhao","year":"2022","journal-title":"Int. Wound J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/wound.2019.0956","article-title":"Circular RNA Hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation","volume":"9","author":"Wang","year":"2020","journal-title":"Adv. Wound Care"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Shi, R., Jin, Y., Zhao, S., Yuan, H., Shi, J., and Zhao, H. (2022). Hypoxic ADSC-Derived Exosomes Enhance Wound Healing in Diabetic Mice via Delivery of Circ-Snhg11 and Induction of M2-like Macrophage Polarization. Biomed. Pharmacother., 153.","DOI":"10.1016\/j.biopha.2022.113463"},{"key":"ref_84","unstructured":"Nair, P.A., and Badri, T. (2025). Psoriasis. StatPearls, StatPearls Publishing."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e70054","DOI":"10.1111\/exd.70054","article-title":"RNA Sequencing Reveals the Long Non-Coding RNA Signature in Psoriasis Keratinocytes and Identifies CYDAER as a Long Non-Coding RNA Regulating Epidermal Differentiation","volume":"34","author":"Freisenhausen","year":"2025","journal-title":"Exp. Dermatol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Teo, L.T.K., Juantuah-Kusi, N., Subramanian, G., and Sampath, P. (2025). Psoriasis Treatments: Emerging Roles and Future Prospects of MicroRNAs. Non-Coding RNA, 11.","DOI":"10.3390\/ncrna11010016"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"678","DOI":"10.4049\/jimmunol.1202695","article-title":"MicroRNA-31 Is Overexpressed in Psoriasis and Modulates Inflammatory Cytokine and Chemokine Production in Keratinocytes via Targeting Serine\/Threonine Kinase 40","volume":"190","author":"Xu","year":"2013","journal-title":"J. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e15674","DOI":"10.15252\/emmm.202215674","article-title":"Metabolic Rewiring in Keratinocytes by miR-31-5p Identifies Therapeutic Intervention for Psoriasis","volume":"15","author":"Wang","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Tu, Y., Wang, L., An, L., and He, L. (2025). Hsa-miR-31-3p Targets CLDN8 to Compromise Skin Barrier Integrity in Psoriasis. Biochem. Biophys. Rep., 42.","DOI":"10.1016\/j.bbrep.2025.101976"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Guzm\u00e1n-Mart\u00edn, C.A., Jim\u00e9nez-Ortega, R.F., Ortega-Springall, M.F., Pe\u00f1a-Pe\u00f1a, M., Guerrero-Ponce, A.E., Vega-Memije, M.E., Amezcua-Guerra, L.M., S\u00e1nchez-Mu\u00f1oz, F., and Springall, R. (2025). miR-16-5p, miR-21-5p, and miR-155-5p in Circulating Vesicles as Psoriasis Biomarkers. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-91532-9"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1083\/jcb.201708173","article-title":"The microRNA-200 Family Coordinately Regulates Cell Adhesion and Proliferation in Hair Morphogenesis","volume":"217","author":"Hoefert","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/exd.14497","article-title":"MicroRNA Profiling of Psoriatic Skin Identifies 11 miRNAs Associated with Disease Severity","volume":"31","author":"Solvin","year":"2022","journal-title":"Exp. Dermatol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Chicharro, P., Rodr\u00edguez-Jim\u00e9nez, P., Llamas-Velasco, M., Montes, N., Sanz-Garc\u00eda, A., Cibrian, D., Vara, A., G\u00f3mez, M.J., Jim\u00e9nez-Fern\u00e1ndez, M., and Mart\u00ednez-Fleta, P. (2020). Expression of miR-135b in Psoriatic Skin and Its Association with Disease Improvement. Cells, 9.","DOI":"10.3390\/cells9071603"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41419-023-05790-4","article-title":"LncRNA UCA1 Promotes Keratinocyte-Driven Inflammation via Suppressing METTL14 and Activating the HIF-1\u03b1\/NF-\u03baB Axis in Psoriasis","volume":"14","author":"Hu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_95","first-page":"367","article-title":"Possible Role of lncRNA MEG3-microRNA-21 and Endoplasmic Reticulum (ER) Stress Proteins in the Pathogenesis of Psoriasis Vulgaris","volume":"11","author":"Elwan","year":"2022","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Trufin, I.I., Ungureanu, L., Halm\u00e1gyi, S.-R., Apostu, A.P., and \u0218enil\u0103, S.C. (2025). Long Non-Coding RNAs in Psoriasis and Cutaneous Squamous Cell Carcinoma. J. Clin. Med., 14.","DOI":"10.3390\/jcm14145081"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Wang, W., Sun, L., Wang, L., Zhao, J., She, S., Hou, P., and He, M. (2025). Using 0.1 THz Radiation Regulates Collagen Synthesis Through TGF-\u03b2\/Smad Signaling Pathway in Human Fetal Scleral Fibroblasts. Cells, 14.","DOI":"10.3390\/cells14191512"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.devcel.2016.07.022","article-title":"Keratins Are Going Nuclear","volume":"38","author":"Hobbs","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"jcs254094","DOI":"10.1242\/jcs.254094","article-title":"Keratin 17 Regulates Nuclear Morphology and Chromatin Organization","volume":"133","author":"Jacob","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/med.21291","article-title":"Keratin 17: A Critical Player in the Pathogenesis of Psoriasis","volume":"34","author":"Jin","year":"2014","journal-title":"Med. Res. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.jid.2017.06.005","article-title":"TGF\u03b2\/SMAD\/microRNA-486-3p Signaling Axis Mediates Keratin 17 Expression and Keratinocyte Hyperproliferation in Psoriasis","volume":"137","author":"Jiang","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Jang, T.-H., Huang, W.-C., Tung, S.-L., Lin, S.-C., Chen, P.-M., Cho, C.-Y., Yang, Y.-Y., Yen, T.-C., Lo, G.-H., and Chuang, S.-E. (2022). MicroRNA-485-5p Targets Keratin 17 to Regulate Oral Cancer Stemness and Chemoresistance via the Integrin\/FAK\/Src\/ERK\/\u03b2-Catenin Pathway. J. Biomed. Sci., 29.","DOI":"10.1186\/s12929-022-00824-z"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.7150\/jca.90689","article-title":"MicroRNA-485-5p Targets Keratin17 to Regulate Pancreatic Cancer Cell Proliferation and Invasion via the FAK\/SRC\/ERK Pathway","volume":"15","author":"Chen","year":"2024","journal-title":"J. Cancer"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.4314\/tjpr.v19i12.10","article-title":"MicroRNA-485-5p Reduces Keratinocyte Proliferation and Migration by Regulating ITGA5 Expression in Skin Wound Healing","volume":"19","author":"Yuan","year":"2020","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e70719","DOI":"10.1111\/jcmm.70719","article-title":"LncRNA LINC01026 Is Overexpressed in Psoriasis and Enhances Keratinocyte Cell Cycle Progression by Regulating the Ets Homologous Factor (EHF)","volume":"29","author":"Lin","year":"2025","journal-title":"J. Cell Mol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9846","DOI":"10.18632\/aging.205902","article-title":"LncRNA MIR181A2HG Inhibits Keratinocytes Proliferation through miR-223-3p\/SOX6 Axis","volume":"16","author":"Li","year":"2024","journal-title":"Aging"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Gao, J., Chen, F., Hua, M., Guo, J., Nong, Y., Tang, Q., Zhong, F., and Qin, L. (2018). Knockdown of lncRNA MIR31HG Inhibits Cell Proliferation in Human HaCaT Keratinocytes. Biol. Res., 51.","DOI":"10.1186\/s40659-018-0181-8"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Liu, X., Frost, J., Bowcock, A., and Zhang, W. (2021). Canonical and Interior Circular RNAs Function as Competing Endogenous RNAs in Psoriatic Skin. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105182"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"109766","DOI":"10.1016\/j.clim.2023.109766","article-title":"Circular RNA Sequencing Identified circARNTL2 as a Pathogenic Factor in Psoriasis by Facilitating Proliferation and Cell Cycle Progression of Keratinocytes","volume":"255","author":"Zhang","year":"2023","journal-title":"Clin. Immunol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"He, Q., Liu, N., Hu, F., Shi, Q., Pi, X., Chen, H., Li, J., and Zhang, B. (2021). Circ_0061012 Contributes to IL-22-Induced Proliferation, Migration and Invasion in Keratinocytes through miR-194-5p\/GAB1 Axis in Psoriasis. Biosci. Rep., 41.","DOI":"10.1042\/BSR20203130"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4103\/ejdv.ejdv_36_21","article-title":"An Insight into the Value of Circular RNA in Psoriasis Pathogenesis and Its Correlation with PASI Score","volume":"42","author":"Naguib","year":"2022","journal-title":"Egypt. J. Dermatol. Venerol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Seeler, S., Moldovan, L.-I., Bertelsen, T., Hager, H., Iversen, L., Johansen, C., Kjems, J., and Kristensen, L.S. (2022). Global circRNA Expression Changes Predate Clinical and Histological Improvements of Psoriasis Patients upon Secukinumab Treatment. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0275219"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and Specific Genetic Interference by Double-Stranded RNA in Caenorhabditis Elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1111\/jcmm.17473","article-title":"circRNA: Regulatory Factors and Potential Therapeutic Targets in Inflammatory Dermatoses","volume":"26","author":"Liu","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.ncrna.2024.01.021","article-title":"LncRNA MALAT1 in Keratinocyte Function: A Review of Recent Advances","volume":"9","author":"Springall","year":"2024","journal-title":"Noncoding RNA Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/15476286.2023.2223486","article-title":"Implications of LncRNAs and CircRNAs in Psoriasis: A Review","volume":"20","author":"Shi","year":"2023","journal-title":"RNA Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.4081\/ejh.2022.3275","article-title":"MicroRNA-17-3p Is Upregulated in Psoriasis and Regulates Keratinocyte Hyperproliferation and pro-Inflammatory Cytokine Secretion by Targeting CTR9","volume":"66","author":"Li","year":"2022","journal-title":"Eur. J. Histochem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"107587","DOI":"10.1016\/j.intimp.2021.107587","article-title":"miR-383 Reduces Keratinocyte Proliferation and Induces the Apoptosis in Psoriasis via Disruption of LCN2-Dependent JAK\/STAT Pathway Activation","volume":"96","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Beer, L., Kalinina, P., K\u00f6cher, M., Laggner, M., Jeitler, M., Abbas Zadeh, S., Copic, D., Tschachler, E., and Mildner, M. (2020). miR-155 Contributes to Normal Keratinocyte Differentiation and Is Upregulated in the Epidermis of Psoriatic Skin Lesions. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239288"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10616-024-00621-6","article-title":"LncRNA MIR181A2HG Negatively Regulates Human Keratinocytes Proliferation by Binding SRSF1","volume":"76","author":"Fan","year":"2024","journal-title":"Cytotechnology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.2147\/JIR.S521553","article-title":"Identification of PRKCQ-AS1 as a Keratinocyte-Derived Exosomal lncRNA That Promotes Th17 Differentiation and IL-17 Secretion in Psoriasis Through Bioinformatics, Machine Learning Algorithms, and Cell Experiments","volume":"18","author":"Gao","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jconrel.2023.12.009","article-title":"Transdermal Delivery of Fn14 siRNA Using a Novel Composite Ionic Liquid for Treatment of Psoriasis-like Skin Lesions","volume":"365","author":"Li","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2147\/ITT.S458800","article-title":"Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments","volume":"13","author":"Zhao","year":"2024","journal-title":"Immunotargets Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.ncrna.2024.05.012","article-title":"The Role of microRNAs in Atopic Dermatitis","volume":"9","author":"Khosrojerdi","year":"2024","journal-title":"Noncoding RNA Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1111\/all.13849","article-title":"miR-10a-5p Is Increased in Atopic Dermatitis and Has Capacity to Inhibit Keratinocyte Proliferation","volume":"74","author":"Vaher","year":"2019","journal-title":"Allergy"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jaci.2016.07.025","article-title":"MicroRNA-146a Suppresses IL-17\u2013Mediated Skin Inflammation and Is Genetically Associated with Psoriasis","volume":"139","author":"Srivastava","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Bai, X., Shen, K., Luo, L., Zhao, M., Xu, C., Jia, Y., Xiao, D., Li, Y., and Gao, X. (2022). Exosomes Derived from Adipose Mesenchymal Stem Cells Promote Diabetic Chronic Wound Healing through SIRT3\/SOD2. Cells, 11.","DOI":"10.3390\/cells11162568"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41392-022-01263-w","article-title":"MiR146a-Loaded Engineered Exosomes Released from Silk Fibroin Patch Promote Diabetic Wound Healing by Targeting IRAK1","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1021\/acs.molpharmaceut.1c00669","article-title":"Mesenchymal Stem Cell-Derived Exosomes Loaded with miR-155 Inhibitor Ameliorate Diabetic Wound Healing","volume":"19","author":"Gondaliya","year":"2022","journal-title":"Mol. Pharm."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e1902232","DOI":"10.1002\/smll.201902232","article-title":"Local Immunomodulation Using an Adhesive Hydrogel Loaded with miRNA-Laden Nanoparticles Promotes Wound Healing","volume":"15","author":"Saleh","year":"2019","journal-title":"Small"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Jia, H.-Y., Zhang, K., Lu, W.-J., Xu, G.-W., Zhang, J.-F., and Tang, Z.-L. (2019). LncRNA MEG3 Influences the Proliferation and Apoptosis of Psoriasis Epidermal Cells by Targeting miR-21\/Caspase-8. BMC Mol. Cell Biol., 20.","DOI":"10.1186\/s12860-019-0229-9"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1016\/j.jid.2019.04.022","article-title":"Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes during Skin Aging","volume":"139","author":"Ahmed","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Abdallah, F., Henriet, E., Suet, A., Arar, A., Clemen\u00e7on, R., Malinge, J.-M., Lecellier, G., Baril, P., and Pichon, C. (2021). miR-21-3p\/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response. Cells, 10.","DOI":"10.3390\/cells10102547"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Conley, J., Genenger, B., Ashford, B., and Ranson, M. (2024). Micro RNA Dysregulation in Keratinocyte Carcinomas: Clinical Evidence, Functional Impact, and Future Directions. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202407.1323.v1"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1007\/s13346-025-01800-4","article-title":"Topical Delivery of siRNA to Psoriatic Skin Model Using High Molecular Weight Chitosan Derivatives: In Vitro and in Vivo Studies","volume":"15","author":"Ruiz","year":"2025","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Zhou, Y., Ma, X., Duan, Z., Xu, H., Li, Y., Kong, Y., Yang, L., and Xin, X. (2025). Topical Therapy in Psoriasis: Clinical Benefits, Advances in Novel Drug Delivery Strategies, and Gene Therapy Regimen. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17030283"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2147\/DDDT.S447780","article-title":"RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models","volume":"18","author":"Lin","year":"2024","journal-title":"DDDT"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2405983","DOI":"10.1002\/advs.202405983","article-title":"Design Principles and Applications of Ionic Liquids for Transdermal Drug Delivery","volume":"11","author":"Gao","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Wang, J., Huang, Y., Wu, X., and Li, D. (2024). MicroRNA-939 Amplifies Staphylococcus Aureus-Induced Matrix Metalloproteinase Expression in Atopic Dermatitis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1354154"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Nappi, F. (2024). Non-Coding RNA-Targeted Therapy: A State-of-the-Art Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073630"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"4","DOI":"10.29245\/2767-5092\/2023\/1.1168","article-title":"The Dawning of a New Enterprise: RNA Therapeutics for the Skin","volume":"5","author":"Kieser","year":"2023","journal-title":"J. Dermatol. Ski. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"102305","DOI":"10.1016\/j.rechem.2025.102305","article-title":"Advanced Strategies for Screening and Identifying RNA-Targeted Small Molecules: Bridging Therapeutic Potential and Innovation","volume":"15","author":"Ruzi","year":"2025","journal-title":"Results Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jconrel.2015.09.017","article-title":"Nucleic Acid Delivery into Skin for the Treatment of Skin Disease: Proofs-of-Concept, Potential Impact, and Remaining Challenges","volume":"219","author":"Zakrewsky","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41573-020-0075-7","article-title":"Advances in Oligonucleotide Drug Delivery","volume":"19","author":"Roberts","year":"2020","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/11\/924\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T10:15:23Z","timestamp":1762424123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/11\/924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":144,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["cimb47110924"],"URL":"https:\/\/doi.org\/10.3390\/cimb47110924","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]}}}