{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:31:03Z","timestamp":1778567463159,"version":"3.51.4"},"reference-count":158,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Approximately 7% of males globally suffer from male infertility, which is becoming more widely acknowledged as a clinical indicator of potential health hazards as well as a cause of reproductive failure. Among these, cancer has become a significant worry due to mounting evidence that spermatogenesis impairment is associated with increased risk of prostate, testicular, and other cancers. Male infertility may be an early clinical manifestation of systemic genomic instability due to shared biological pathways, such as Y-chromosome microdeletions (AZF regions), germline DNA repair defects, mutations in tumor suppressor genes (e.g., BRCA1\/2, TP53), mismatch repair gene mutations (e.g., MLH1, MSH2), and dysregulated epigenetic profiles. This narrative review covers the most recent research on prognostic markers of cancer in infertile men. These include molecular biomarkers such as genetic, epigenetic, and proteomic signatures; endocrine and hormonal profiles; and clinical predictors such as azoospermia, severe oligozoospermia, and a history of cryptorchidism. The possibility of incorporating these indicators into risk stratification models for precision medicine and early cancer surveillance is highlighted. For this high-risk group, bridging the domains of andrology and oncology may allow for better counseling, earlier detection, and focused therapies.<\/jats:p>","DOI":"10.3390\/cimb47110930","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T17:45:34Z","timestamp":1762796734000},"page":"930","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-4450","authenticated-orcid":false,"given":"Athanasios","family":"Zachariou","sequence":"first","affiliation":[{"name":"Department of Urology, School of Medicine, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3333-2620","authenticated-orcid":false,"given":"Efthalia","family":"Moustakli","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Health Sciences, University of Ioannina, 4th Kilometer National Highway Str. Ioannina-Athens, 45500 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9553-6803","authenticated-orcid":false,"given":"Athanasios","family":"Zikopoulos","sequence":"additional","affiliation":[{"name":"Torbay and South Devon NHS Foundation Trust, Lowes Brg, Torquay TQ2 7AA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5119-9072","authenticated-orcid":false,"given":"Maria","family":"Filiponi","sequence":"additional","affiliation":[{"name":"Urology Outpatient Department, KENTAVROS Rehabilitation Centre, 38222 Volos, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7716-1521","authenticated-orcid":false,"given":"Anastasios","family":"Potiris","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-809X","authenticated-orcid":false,"given":"Nikolaos","family":"Kathopoulis","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-8775","authenticated-orcid":false,"given":"Themos","family":"Grigoriadis","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tzeli","sequence":"additional","affiliation":[{"name":"Department of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, 12243 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-9709","authenticated-orcid":false,"given":"Nikolaos","family":"Machairiotis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8899-3040","authenticated-orcid":false,"given":"Ekaterini","family":"Domali","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Thomakos","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofoklis","family":"Stavros","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"ref_1","unstructured":"Leslie, S.W., Soon-Sutton, T.L., and Khan, M.A. (2024, August 12). Male Infertility, StatPearls [Internet], Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK562258\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.5534\/wjmh.230232","article-title":"Male Infertility: New Developments, Current Challenges, and Future Directions","volume":"42","author":"Russo","year":"2024","journal-title":"World J. Men\u2019s Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4103\/aja20256","article-title":"Health risks associated with infertility and non-obstructive azoospermia","volume":"27","author":"Huyghe","year":"2025","journal-title":"Asian J. Androl."},{"key":"ref_4","first-page":"S3","article-title":"Risk factors for prostate cancer","volume":"4","author":"Gann","year":"2002","journal-title":"Rev. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1667\/RR13515.1","article-title":"DNA damage response genes and the development of cancer metastasis","volume":"181","author":"Broustas","year":"2014","journal-title":"Radiat. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/ped.12185","article-title":"DNA methylation errors in imprinting disorders and assisted reproductive technology","volume":"55","author":"Chiba","year":"2013","journal-title":"Pediatr. Int."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Adetunji, A.O., Owusu, H., Adewale, E.F., Adesina, P.A., Xedzro, C., Saliu, T.P., Islam, S., Zhu, Z., and Morenikeji, O.B. (2025). DNA Methylation: A Key Regulator in Male and Female Reproductive Outcomes. Life, 15.","DOI":"10.3390\/life15071109"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1521-6934(02)00128-1","article-title":"Cancer risks associated with the diagnosis of infertility","volume":"17","author":"Venn","year":"2003","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/GCO.0000000000000370","article-title":"Use of fertility medications and cancer risk: A review and update","volume":"29","author":"Kroener","year":"2017","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.21037\/tau.2019.10.20","article-title":"Future diagnostics in male infertility: Genomics, epigenetics, metabolomics and proteomics","volume":"9","author":"Krzastek","year":"2020","journal-title":"Transl. Androl. Urol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Behboudi-Gandevani, S., Bidhendi-Yarandi, R., Panahi, M.H., and Vaismoradi, M. (2021). A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.696702"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Maiolino, G., Fern\u00e1ndez-Pascual, E., Ochoa Arvizo, M.A., Vishwakarma, R., and Mart\u00ednez-Salamanca, J.I. (2023). Male Infertility and the Risk of Developing Testicular Cancer: A Critical Contemporary Literature Review. Medicina, 59.","DOI":"10.3390\/medicina59071305"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.fertnstert.2017.11.005","article-title":"Male infertility: A biomarker of individual and familial cancer risk","volume":"109","author":"Hanson","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.fertnstert.2017.10.028","article-title":"Genetic intersection of male infertility and cancer","volume":"109","author":"Nagirnaja","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_15","unstructured":"Feingold, K.R., Ahmed, S.F., Anawalt, B., Blackman, M.R., Boyce, A., and Chrousos, G. (2025, October 03). Testicular Cancer: Pathogenesis, Diagnosis and Management with Focus on Endocrine Aspects, Endotext [Internet], Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK278992\/."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/bmj.321.7264.789","article-title":"Risk of testicular cancer in men with abnormal semen characteristics: Cohort study","volume":"321","author":"Jacobsen","year":"2000","journal-title":"BMJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tem.2008.12.001","article-title":"Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence","volume":"20","author":"Hu","year":"2009","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.fertnstert.2007.12.026","article-title":"Testicular dysgenesis syndrome: Mechanistic insights and potential new downstream effects","volume":"89","author":"Sharpe","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/ijc.28057","article-title":"Fatherhood status and risk of prostate cancer: Nationwide, population-based case-control study","volume":"133","author":"Drevin","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/cncr.25075","article-title":"Increased risk of high-grade prostate cancer among infertile men","volume":"116","author":"Walsh","year":"2010","journal-title":"Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/MOU.0000000000000886","article-title":"Association between male infertility and prostate cancer: A systematic review and meta-analysis","volume":"31","author":"Laukhtina","year":"2021","journal-title":"Curr. Opin. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1210\/er.2018-00178","article-title":"Aging and the Male Reproductive System","volume":"40","author":"Kaufman","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1007\/s00277-025-06426-7","article-title":"Semen quality in acute leukemia patients: A retrospective study","volume":"104","author":"Buonacquisto","year":"2025","journal-title":"Ann. Hematol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e70984","DOI":"10.1002\/cam4.70984","article-title":"Incidence, Risk and Trends of Multiple Primary Cancers in Patients With Colorectal Cancer: Evidence From the South Australian Cancer Registry","volume":"14","author":"Melku","year":"2025","journal-title":"Cancer Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1089\/thy.2011.0406","article-title":"The risk of second cancers after diagnosis of primary thyroid cancer is elevated in thyroid microcarcinomas","volume":"23","author":"Kim","year":"2013","journal-title":"Thyroid Off. J. Am. Thyroid Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"hoaf008","DOI":"10.1093\/hropen\/hoaf008","article-title":"Significantly increased load of hereditary cancer-linked germline variants in infertile men","volume":"2025","author":"Valkna","year":"2025","journal-title":"Hum. Reprod. Open"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"102337","DOI":"10.1016\/j.ctrv.2021.102337","article-title":"Therapeutic implications of germline vulnerabilities in DNA repair for precision oncology","volume":"104","author":"Shah","year":"2022","journal-title":"Cancer Treat. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Rotondo, J.C., Lanzillotti, C., Mazziotta, C., Tognon, M., and Martini, F. (2021). Epigenetics of Male Infertility: The Role of DNA Methylation. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.689624"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Nicu, A.T., Medar, C., Chifiriuc, M.C., Gradisteanu Pircalabioru, G., and Burlibasa, L. (2022). Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.861995"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"490","DOI":"10.21037\/tau.2018.05.17","article-title":"Endocrine disrupting chemicals and impact on male reproductive health","volume":"7","author":"Rehman","year":"2018","journal-title":"Transl. Androl. Urol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sciorio, R., Greco, P.F., Greco, E., Tramontano, L., Elshaer, F.M., and Fleming, S. (2025). Potential effects of environmental toxicants on sperm quality and potential risk for fertility in humans. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1545593"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12020-022-03171-z","article-title":"Environmental disruptors and testicular cancer","volume":"78","author":"Faja","year":"2022","journal-title":"Endocrine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"25168657231199893","DOI":"10.1177\/25168657231199893","article-title":"DNA Methylation in Cancer: Epigenetic View of Dietary and Lifestyle Factors","volume":"16","author":"Maleknia","year":"2023","journal-title":"Epigenet. Insights"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.envint.2015.07.017","article-title":"Human exposure to endocrine disrupting chemicals and fertility: A case-control study in male subfertility patients","volume":"84","author":"Tournaye","year":"2015","journal-title":"Environ. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.urology.2021.02.041","article-title":"The Association between Mortality and Male Infertility: Systematic Review and Meta-analysis","volume":"154","author":"Kasman","year":"2021","journal-title":"Urology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.fertnstert.2013.05.022","article-title":"Increased risk of cancer among azoospermic men","volume":"100","author":"Eisenberg","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Gil, L., Pascual-Ahuir, A., and Proft, M. (2023). Genomic Instability and Epigenetic Changes during Aging. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241814279"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Requesens, M., Foijer, F., Nijman, H.W., and de Bruyn, M. (2024). Genomic instability as a driver and suppressor of anti-tumor immunity. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1462496"},{"key":"ref_39","first-page":"e20240052","article-title":"Male aging in germ cells: What are we inheriting?","volume":"47","author":"Lira","year":"2025","journal-title":"Genet. Mol. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Borbiev, T., Babcock, K., Sinopole, K., Chesnut, G.T., and Petrovics, G. (2025). Ancestry-Specific DNA Damage Repair Gene Mutations and Prostate Cancer. Cancers, 17.","DOI":"10.3390\/cancers17040682"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1549416","DOI":"10.3389\/or.2025.1549416","article-title":"A brief review of Lynch syndrome: Understanding the dual cancer risk between endometrial and colorectal cancer","volume":"19","author":"Pallatt","year":"2025","journal-title":"Oncol. Rev."},{"key":"ref_42","unstructured":"Bhattacharya, P., Leslie, S.W., and McHugh, T.W. (2025, October 03). Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer), StatPearls [Internet], Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK431096\/."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Ibrahim, M., Yadav, S., Ogunleye, F., and Zakalik, D. (2018). Male BRCA mutation carriers: Clinical characteristics and cancer spectrum. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4098-y"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.eururo.2019.08.025","article-title":"Prostate Cancer Risks for Male BRCA1 and BRCA2 Mutation Carriers: A Prospective Cohort Study","volume":"77","author":"Nyberg","year":"2020","journal-title":"Eur. Urol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e582","DOI":"10.1002\/mco2.582","article-title":"Oncogenes and tumor suppressor genes: Functions and roles in cancers","volume":"5","author":"Dakal","year":"2024","journal-title":"MedComm"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Stojchevski, R., Sutanto, E.A., Sutanto, R., Hadzi-Petrushev, N., Mladenov, M., Singh, S.R., Verma, P., Sengupta, S., Bhaskar, R., and Avtanski, D. (2025). Translational Advances in Oncogene and Tumor-Suppressor Gene Research. Cancers, 17.","DOI":"10.3390\/cancers17061008"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Singh, S.R., Bhaskar, R., Ghosh, S., Yarlagadda, B., Singh, K.K., Verma, P., Sengupta, S., Mladenov, M., Hadzi-Petrushev, N., and Stojchevski, R. (2025). Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes. Cancers, 17.","DOI":"10.3390\/cancers17071082"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Olivier, M., Hollstein, M., and Hainaut, P. (2010). TP53 mutations in human cancers: Origins, consequences, and clinical use. Cold Spring Harb. Perspect. Biol., 2.","DOI":"10.1101\/cshperspect.a001008"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1002\/cncr.31667","article-title":"Klinefelter syndrome in males with germ cell tumors: A report from the Children\u2019s Oncology Group","volume":"124","author":"Williams","year":"2018","journal-title":"Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/cen.15200","article-title":"Klinefelter Syndrome: A Review","volume":"102","author":"Blackburn","year":"2025","journal-title":"Clin. Endocrinol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12522-010-0055-4","article-title":"Azoospermia factor and male infertility","volume":"9","author":"Koh","year":"2010","journal-title":"Reprod. Med. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Colaco, S., and Modi, D. (2018). Genetics of the human Y chromosome and its association with male infertility. Reprod. Biol. Endocrinol. RBE, 16.","DOI":"10.1186\/s12958-018-0330-5"},{"key":"ref_53","first-page":"132","article-title":"Underestimated Aspects in Male Infertility: Epigenetics is A New Approach in Men with Obesity or Diabetes: A Review","volume":"16","author":"Jazayeri","year":"2022","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40246-024-00626-4","article-title":"Sperm epigenetics and male infertility: Unraveling the molecular puzzle","volume":"18","author":"Hosseini","year":"2024","journal-title":"Hum. Genom."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13148-018-0568-y","article-title":"Idiopathic male infertility is strongly associated with aberrant DNA methylation of imprinted loci in sperm: A case-control study","volume":"10","author":"Tang","year":"2018","journal-title":"Clin. Epigenet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2217\/epi.09.33","article-title":"DNA hypomethylation in cancer cells","volume":"1","author":"Ehrlich","year":"2009","journal-title":"Epigenomics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/modpathol.2008.127","article-title":"Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors","volume":"21","author":"Netto","year":"2008","journal-title":"Mod. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.rbmo.2011.08.010","article-title":"Relationships between human sperm protamines, DNA damage and assisted reproduction outcomes","volume":"23","author":"Simon","year":"2011","journal-title":"Reprod. BioMed. Online"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Punjabi, U., Goovaerts, I., Peeters, K., Van Mulders, H., and De Neubourg, D. (2022). Sperm as a Carrier of Genome Instability in Relation to Paternal Lifestyle and Nutritional Conditions. Nutrients, 14.","DOI":"10.3390\/nu14153155"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00018-024-05399-6","article-title":"The functions and mechanisms of piRNAs in mediating mammalian spermatogenesis and their applications in reproductive medicine","volume":"81","author":"Du","year":"2024","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e33767","DOI":"10.1016\/j.heliyon.2024.e33767","article-title":"PIWI-interacting RNAs (PiRNAs) as emerging biomarkers and therapeutic targets in biliary tract cancers: A comprehensive review","volume":"10","author":"Aghadavood","year":"2024","journal-title":"Heliyon"},{"key":"ref_62","unstructured":"Feingold, K.R., Ahmed, S.F., Anawalt, B., Blackman, M.R., Boyce, A., and Chrousos, G. (2025, October 03). Primary Testicular Failure, Endotext [Internet], Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279076\/."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.21037\/tau.2019.08.08","article-title":"Fertility considerations in men with testicular cancer","volume":"9","author":"Parekh","year":"2020","journal-title":"Transl. Androl. Urol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4103\/jhrs.JHRS_150_18","article-title":"Role of Oxidative Stress in Male Infertility: An Updated Review","volume":"12","author":"Alahmar","year":"2019","journal-title":"J. Hum. Reprod. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Harding, A.T., and Heaton, N.S. (2022). The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection. Cancers, 14.","DOI":"10.3390\/cancers14040909"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"531","DOI":"10.14310\/horm.2002.1622","article-title":"Klinefelter Syndrome and medical treatment: Hypogonadism and beyond","volume":"14","author":"Chang","year":"2015","journal-title":"Hormones"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.21037\/tau-20-685","article-title":"Impact of environmental toxin exposure on male fertility potential","volume":"9","author":"Krzastek","year":"2020","journal-title":"Transl. Androl. Urol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Tesarik, J. (2025). Lifestyle and Environmental Factors Affecting Male Fertility, Individual Predisposition, Prevention, and Intervention. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202503.1302.v1"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","article-title":"Oxidative stress and male infertility: Current knowledge of pathophysiology and role of antioxidant therapy in disease management","volume":"77","author":"Barati","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Moustakli, E., Zikopoulos, A., Katopodis, P., Dafopoulos, S., Paraschos, V.S., Zachariou, A., and Dafopoulos, K. (2025). Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management-A Narrative Review. Metabolites, 15.","DOI":"10.3390\/metabo15060379"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Puzuka, A., Alksere, B., Gailite, L., and Erenpreiss, J. (2021). Idiopathic Infertility as a Feature of Genome Instability. Life, 11.","DOI":"10.3390\/life11070628"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/MOU.0b013e32833f1c21","article-title":"DNA mismatch repair and infertility","volume":"20","author":"Mukherjee","year":"2010","journal-title":"Curr. Opin. Urol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s43032-024-01714-5","article-title":"Perspective in the Mechanisms for Repairing Sperm DNA Damage","volume":"32","author":"Li","year":"2025","journal-title":"Reprod. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"100030","DOI":"10.1016\/j.pharmr.2024.100030","article-title":"Cell cycle dysregulation in cancer","volume":"77","author":"Glaviano","year":"2025","journal-title":"Pharmacol. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Dutta, S., Sengupta, P., Slama, P., and Roychoudhury, S. (2021). Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221810043"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e70268","DOI":"10.1002\/mco2.70268","article-title":"Oxidative Stress: Signaling Pathways, Biological Functions, and Disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Baumann, A.A., Buribayev, Z., Wolkenhauer, O., Salybekov, A.A., and Wolfien, M. (2025). Epigenomic Echoes-Decoding Genomic and Epigenetic Instability to Distinguish Lung Cancer Types and Predict Relapse. Epigenomes, 9.","DOI":"10.3390\/epigenomes9010005"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Guede, \u00c1., Vera, O., and Ib\u00e1\u00f1ez-de-Caceres, I. (2020). When Oxidative Stress Meets Epigenetics: Implications in Cancer Development. Antioxidants, 9.","DOI":"10.3390\/antiox9060468"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Vega, A., Baptissart, M., Caira, F., Brugnon, F., Lobaccaro, J.M.A., and Volle, D.H. (2012). Epigenetic: A molecular link between testicular cancer and environmental exposures. Front. Endocrinol., 3.","DOI":"10.3389\/fendo.2012.00150"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"119670","DOI":"10.1016\/j.cca.2024.119670","article-title":"Cancer risk and male Infertility: Unravelling predictive biomarkers and prognostic indicators","volume":"558","author":"Tiwari","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Assidi, M. (2022). Infertility in Men: Advances towards a Comprehensive and Integrative Strategy for Precision Theranostics. Cells, 11.","DOI":"10.3390\/cells11101711"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.taap.2005.01.058","article-title":"Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders","volume":"207","author":"Virtanen","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S2352-4642(18)30254-2","article-title":"Association between male genital anomalies and adult male reproductive disorders: A population-based data linkage study spanning more than 40 years","volume":"2","author":"Schneuer","year":"2018","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Sengupta, P., Dutta, S., Karkada, I.R., and Chinni, S.V. (2021). Endocrinopathies and Male Infertility. Life, 12.","DOI":"10.3389\/fphys.2021.746049"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Adamczewska, D., S\u0142owikowska-Hilczer, J., and Walczak-J\u0119drzejowska, R. (2022). The Fate of Leydig Cells in Men with Spermatogenic Failure. Life, 12.","DOI":"10.3390\/life12040570"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Zhao, C.C., Scott, M., and Eisenberg, M.L. (2024). Male Fertility as a Proxy for Health. J. Clin. Med., 13.","DOI":"10.3390\/jcm13185559"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3329\/jcmcta.v31i1.65495","article-title":"The Study of Semen Quality for Evaluation of Male Factor Infertility","volume":"31","author":"Khanam","year":"2020","journal-title":"J. Chittagong Med. Coll. Teach. Assoc."},{"key":"ref_88","unstructured":"PDQ Cancer Genetics Editorial Board (2025, October 03). Genetics of Prostate Cancer (PDQ\u00ae): Health Professional Version, PDQ Cancer Information Summaries [Internet], Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK65784\/."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41698-022-00282-8","article-title":"An appraisal of genetic testing for prostate cancer susceptibility","volume":"6","author":"Finch","year":"2022","journal-title":"NPJ Precis. Oncol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"300060519896712","DOI":"10.1177\/0300060519896712","article-title":"Chromosomal abnormalities and Y chromosome microdeletions in infertile men with azoospermia and oligozoospermia in Eastern China","volume":"48","author":"Sha","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Black, K., \u00d8lgaard, S., Khoei, A.A., Glazer, C., Ohl, D.A., and Jensen, C.F.S. (2025). The Genetic Landscape of Male Factor Infertility and Implications for Men\u2019s Health and Future Generations. Uro, 5.","DOI":"10.3390\/uro5010002"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Cescon, M., Chianese, R., and Tavares, R.S. (2020). Environmental Impact on Male (In)Fertility via Epigenetic Route. J. Clin. Med., 9.","DOI":"10.3390\/jcm9082520"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.toxrep.2024.05.001","article-title":"A critical review of the recent concept of regulatory performance of DNA Methylations, and DNA methyltransferase enzymes alongside the induction of immune microenvironment elements in recurrent pregnancy loss","volume":"12","author":"Babaei","year":"2024","journal-title":"Toxicol. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/ijc.35518","article-title":"Plasma proteomic profiles for early detection and risk stratification of non-small cell lung carcinoma: A prospective cohort study with 52,913 participants","volume":"157","author":"Zhao","year":"2025","journal-title":"Int. J. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Al-Daffaie, F.M., Al-Mudhafar, S.F., Alhomsi, A., Tarazi, H., Almehdi, A.M., El-Huneidi, W., Abu-Gharbieh, E., Bustanji, Y., Alqudah, M.A.Y., and Abuhelwa, A.Y. (2024). Metabolomics and Proteomics in Prostate Cancer Research: Overview, Analytical Techniques, Data Analysis, and Recent Clinical Applications. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105071"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jconrel.2024.05.029","article-title":"Prostate cancer-derived extracellular vesicles metabolic biomarkers: Emerging roles for diagnosis and prognosis","volume":"371","author":"Hamed","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5534\/wjmh.240069","article-title":"Contemporary Diagnostic Work-Up for Male Infertility: Emphasizing Comprehensive Baseline Assessment","volume":"43","author":"Pozzi","year":"2025","journal-title":"World J. Men\u2019s Health"},{"key":"ref_98","unstructured":"Leslie, S.W., Soon-Sutton, T.L., and Skelton, W.P. (2025, October 03). Prostate Cancer, StatPearls [Internet], Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470550\/."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S1470-2045(21)00522-2","article-title":"A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): Initial results from an international prospective study","volume":"22","author":"Bancroft","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/humrep\/del500","article-title":"High prevalence of testicular cancer in azoospermic men without spermatogenesis","volume":"22","author":"Mancini","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.juro.2008.10.074","article-title":"Cryptorchidism and testicular cancer: Separating fact from fiction","volume":"181","author":"Wood","year":"2009","journal-title":"J. Urol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/archdischild-2012-302051","article-title":"A meta-analysis of the risk of boys with isolated cryptorchidism developing testicular cancer in later life","volume":"98","author":"Lip","year":"2013","journal-title":"Arch. Dis. Child."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4103\/aja202493","article-title":"Association of higher serum follicle-stimulating hormone levels with successful microdissection testicular sperm extraction outcomes in nonobstructive azoospermic men with reduced testicular volumes","volume":"27","author":"Song","year":"2025","journal-title":"Asian J. Androl."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/sj.bjc.6602677","article-title":"Fertility, gonadal and sexual function in survivors of testicular cancer","volume":"93","author":"Huddart","year":"2005","journal-title":"Br. J. Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4111\/icu.20210459","article-title":"Low serum total testosterone level as a predictor of upgrading in low-risk prostate cancer patients after radical prostatectomy: A systematic review and meta-analysis","volume":"63","author":"Gan","year":"2022","journal-title":"Investig. Clin. Urol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3892\/ol.2017.5616","article-title":"Low serum testosterone is associated with tumor aggressiveness and poor prognosis in prostate cancer","volume":"13","author":"Tu","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_107","first-page":"1121","article-title":"Serum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: A nested case-control study","volume":"22","author":"Yao","year":"2011","journal-title":"Cancer Causes Control CCC"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1158\/1055-9965.EPI-14-0700","article-title":"Sex steroid hormone metabolism in relation to risk of aggressive prostate cancer","volume":"23","author":"Black","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1093\/humrep\/12.12.2830","article-title":"Semen parameters and testicular pathology in men with testicular cancer and contralateral carcinoma in situ or bilateral testicular malignancies","volume":"12","author":"Kliesch","year":"1997","journal-title":"Hum. Reprod."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"489","DOI":"10.4111\/icu.20220402","article-title":"Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation","volume":"64","author":"Song","year":"2023","journal-title":"Investig. Clin. Urol."},{"key":"ref_111","first-page":"306","article-title":"Sperm DNA Fragmentation: Causes, evaluation and management in male infertility","volume":"28","author":"Andrabi","year":"2024","journal-title":"JBRA Assist. Reprod."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1001\/jamaoncol.2024.2185","article-title":"BRCA1, BRCA2, and Associated Cancer Risks and Management for Male Patients: A Review","volume":"10","author":"Cheng","year":"2024","journal-title":"JAMA Oncol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1631\/jzus.B1500162","article-title":"Impact of DNA mismatch repair system alterations on human fertility and related treatments","volume":"17","author":"Hu","year":"2016","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1200\/JCO.1987.5.8.1290","article-title":"Klinefelter\u2019s syndrome associated with mediastinal germ cell neoplasms","volume":"5","author":"Nichols","year":"1987","journal-title":"J. Clin. Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13633-020-00088-0","article-title":"Klinefelter syndrome and germ cell tumors: Review of the literature","volume":"2020","author":"Bonouvrie","year":"2020","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e21099","DOI":"10.1016\/j.heliyon.2023.e21099","article-title":"Impact of DNA methylation of the human mesoderm-specific transcript (MEST) on male infertility","volume":"9","author":"Amjadian","year":"2023","journal-title":"Heliyon"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Cannarella, R., Crafa, A., Barbagallo, F., Lundy, S.D., La Vignera, S., Condorelli, R.A., and Calogero, A.E. (2023). H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087224"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.3892\/etm.2016.3569","article-title":"DNA methylation in spermatogenesis and male infertility","volume":"12","author":"Cui","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1074\/mcp.RA119.001612","article-title":"Multi-omics Biomarker Pipeline Reveals Elevated Levels of Protein-glutamine Gamma-glutamyltransferase 4 in Seminal Plasma of Prostate Cancer Patients","volume":"18","author":"Drabovich","year":"2019","journal-title":"Mol. Cell. Proteom. MCP"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Fietz, D., Sgaier, R., O\u2019Donnell, L., Stanton, P.G., Dagley, L.F., Webb, A.I., Schuppe, H.C., Diemer, T., and Pilatz, A. (2024). Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1327800"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"101308","DOI":"10.1016\/j.mam.2024.101308","article-title":"Impacts of cancer therapy on male fertility: Past and present","volume":"100","author":"Duffin","year":"2024","journal-title":"Mol. Asp. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.21037\/tau-19-725","article-title":"Genetic testing for men with infertility: Techniques and indications","volume":"10","author":"Pelzman","year":"2021","journal-title":"Transl. Androl. Urol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Esteves, S.C., Humaidan, P., Ubaldi, F.M., Alviggi, C., Antonio, L., Barratt, C.L.R., Behre, H.M., J\u00f8rgensen, N., Pacey, A.A., and Simoni, M. (2024). APHRODITE criteria: Addressing male patients with hypogonadism and\/or infertility owing to altered idiopathic testicular function. Reprod. Biomed. Online, 48.","DOI":"10.1016\/j.rbmo.2023.103647"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Ethics Committee of the American Society for Reproductive Medicine (2005). Fertility preservation and reproduction in cancer patients. Fertil. Steril., 83, 1622\u20131628.","DOI":"10.1016\/j.fertnstert.2005.03.013"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"100138","DOI":"10.1016\/j.pecinn.2023.100138","article-title":"Do people with hereditary cancer syndromes inform their at-risk relatives? A systematic review and meta-analysis","volume":"2","author":"Ahsan","year":"2023","journal-title":"PEC Innov."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s10897-016-9957-6","article-title":"The Genetic Counselor\u2019s Role in Managing Ethical Dilemmas Arising in the Laboratory Setting","volume":"25","author":"Balcom","year":"2016","journal-title":"J. Genet. Couns."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Jansen, S.N.G., Kamphorst, B.A., Mulder, B.C., van Kamp, I., Boekhold, S., van den Hazel, P., and Verweij, M.F. (2024). Ethics of early detection of disease risk factors: A scoping review. BMC Med. Ethics, 25.","DOI":"10.1186\/s12910-024-01012-4"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"105534","DOI":"10.1016\/j.isci.2022.105534","article-title":"Guideline for software life cycle in health informatics","volume":"25","author":"Hauschild","year":"2022","journal-title":"iScience"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.eururo.2019.08.019","article-title":"Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers","volume":"76","author":"Page","year":"2019","journal-title":"Eur. Urol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.fertnstert.2018.05.006","article-title":"Personalized medicine: Motivation, challenges, and progress","volume":"109","author":"Goetz","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.tibtech.2019.12.021","article-title":"Enabling Technologies for Personalized and Precision Medicine","volume":"38","author":"Ho","year":"2020","journal-title":"Trends Biotechnol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"532","DOI":"10.5694\/mja2.51734","article-title":"Long term all-cause and cardiovascular disease mortality among women who undergo fertility treatment","volume":"217","author":"Yiallourou","year":"2022","journal-title":"Med. J. Aust."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/dom.16263","article-title":"An overview of obesity-related complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes","volume":"27","year":"2025","journal-title":"Diabetes Obes. Metab."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10689-025-00474-8","article-title":"A coordinated multidisciplinary model of care is needed for child and family centered care in pediatric genetic cancer risk services: A scoping review","volume":"24","author":"Grant","year":"2025","journal-title":"Fam. Cancer"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/jgc4.1374","article-title":"Risk assessment and genetic counseling for hereditary breast and ovarian cancer syndromes-Practice resource of the National Society of Genetic Counselors","volume":"30","author":"Berliner","year":"2021","journal-title":"J. Genet. Couns."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"hoac047","DOI":"10.1093\/hropen\/hoac047","article-title":"Indicators of infertility and fertility care: A systematic scoping review","volume":"2022","author":"Nabhan","year":"2022","journal-title":"Hum. Reprod. Open"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/women2010008","article-title":"Emotional Support for Infertility Patients: Integrating Mental Health Professionals in the Fertility Care Team","volume":"2","author":"Sax","year":"2022","journal-title":"Women"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Gale\u0219, L.N., P\u0103un, M.A., Anghel, R.M., and Trif\u0103nescu, O.G. (2024). Cancer Screening: Present Recommendations, the Development of Multi-Cancer Early Development Tests, and the Prospect of Universal Cancer Screening. Cancers, 16.","DOI":"10.3390\/cancers16061191"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13690-024-01248-x","article-title":"\u201cFor and against\u201d factors influencing participation in personalized breast cancer screening programs: A qualitative systematic review until March 2022","volume":"82","author":"Laza","year":"2024","journal-title":"Arch. Public Health"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"715","DOI":"10.17749\/2313-7347\/ob.gyn.rep.2021.228","article-title":"Characteristic of spermogram parameters in men with reproductive pathology in age-related aspect","volume":"15","author":"Pichugova","year":"2022","journal-title":"Obstet. Gynecol. Reprod."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/humupd\/dmx021","article-title":"The diagnosis of male infertility: An analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities","volume":"23","author":"Barratt","year":"2017","journal-title":"Hum. Reprod. Update"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.fertnstert.2023.02.028","article-title":"A prospective cohort study of infertility and cancer incidence","volume":"120","author":"Wang","year":"2023","journal-title":"Fertil. Steril."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Ghantasala, G.S.P., Dilip, K., Vidyullatha, P., Allabun, S., Alqahtani, M.S., Othman, M., Abbas, M., and Soufiene, B.O. (2024). Enhanced ovarian cancer survival prediction using temporal analysis and graph neural networks. BMC Med. Inform. Decis. Mak., 24.","DOI":"10.1186\/s12911-024-02665-2"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/14789450.2024.2327553","article-title":"Bringing proteomics to bear on male fertility: Key lessons","volume":"21","author":"Parkes","year":"2024","journal-title":"Expert Rev. Proteom."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/19396368.2024.2317804","article-title":"Insight into the complexity of male infertility: A multi-omics review","volume":"70","author":"Podgrajsek","year":"2024","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Serrano-G\u00f3mez, G., Ya\u00f1ez, F., Soler, Z., Pons-Tarin, M., Mayorga, L., Herrera-deGuise, C., Borruel, N., Rodriguez-Sinovas, A., Consegal, M., and Manj\u00f3n, I. (2025). Microbiome multi-omics analysis reveals novel biomarkers and mechanisms linked with CD etiopathology. Biomark. Res., 13.","DOI":"10.1186\/s40364-025-00802-1"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Hachem, S., Yehya, A., El Masri, J., Mavingire, N., Johnson, J.R., Dwead, A.M., Kattour, N., Bouchi, Y., Kobeissy, F., and Rais-Bahrami, S. (2024). Contemporary Update on Clinical and Experimental Prostate Cancer Biomarkers: A Multi-Omics-Focused Approach to Detection and Risk Stratification. Biology, 13.","DOI":"10.3390\/biology13100762"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Fernandez-Encinas, A., Garc\u00eda-Peir\u00f3, A., Del Rey, J., Ribas-Maynou, J., Abad, C., Amengual, M.J., Prada, E., Navarro, J., and Benet, J. (2020). Proteomic Analysis in Seminal Plasma of Fertile Donors and Infertile Patients with Sperm DNA Fragmentation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145046"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"472","DOI":"10.5534\/wjmh.190018","article-title":"Sperm and Seminal Plasma Proteomics: Molecular Changes Associated with Varicocele-Mediated Male Infertility","volume":"38","author":"Agarwal","year":"2020","journal-title":"World J. Men\u2019s Health."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e006013","DOI":"10.1136\/jitc-2022-006013","article-title":"Cell-free DNA approaches for cancer early detection and interception","volume":"11","author":"Medina","year":"2023","journal-title":"J. ImmunoTher. Cancer"},{"key":"ref_151","first-page":"100259","article-title":"Circulating cell-free DNA for cancer early detection","volume":"3","author":"Gao","year":"2022","journal-title":"Innovation"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Larriba, S., Vigu\u00e9s, F., and Bassas, L. (2023). Using Small Non-Coding RNAs in Extracellular Vesicles of Semen as Biomarkers of Male Reproductive System Health: Opportunities and Challenges. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065447"},{"key":"ref_153","first-page":"338","article-title":"Emerging technologies towards extracellular vesicles large-scale production","volume":"52","author":"Huang","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41431-024-01782-w","article-title":"Artificial intelligence in clinical genetics","volume":"33","author":"Duong","year":"2025","journal-title":"Eur. J. Hum. Genet. EJHG"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"S229","DOI":"10.4103\/jpbs.jpbs_1765_24","article-title":"Applications, Challenges, and Future Perspectives of Artificial Intelligence in Psychopharmacology, Psychological Disorders and Physiological Psychology: A Comprehensive Review","volume":"17","author":"Salemi","year":"2025","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s40001-025-02479-6","article-title":"Artificial intelligence (AI) approaches to male infertility in IVF: A mapping review","volume":"30","author":"Qaderi","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_157","first-page":"302","article-title":"A Framework to Ethically Approach Incidental Findings in Genetic Research","volume":"31","author":"Beshir","year":"2020","journal-title":"EJIFCC"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Piessens, V., Van den Bruel, A., Piessens, A., Van Hecke, A., Brodersen, J.B., Lauwerier, E., Stul, F., De Sutter, A., and Heytens, S. (2025). Do health professionals know about overdiagnosis in screening, and how are they dealing with it? A mixed-methods systematic scoping review. 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