{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:40:50Z","timestamp":1790962850277,"version":"4.1.0"},"reference-count":202,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Cardiovascular diseases (CVDs) remain a leading cause of mortality worldwide. According to the WHO, every year, there is an increase in the rate of death globally due to CVDs, stroke, and myocardial infarction. Several risk factors contribute to the development of CVDs, one of which is hypoxia, defined as a reduction in oxygen levels. This major stressor affects aerobic species and plays a crucial role in the development of cardiovascular disease. Research has uncovered the \u201chypoxia-inducible factors (HIFs) switch\u201d and investigated the onset, progression, acute and chronic effects, and adaptations of hypoxia, particularly at high altitudes. The hypoxia signalling pathways are closely linked to natural rhythms such as the circadian rhythm and hibernation. In addition to genetic and evolutionary factors, epigenetics also plays an important role in postnatal cardiovascular responses to hypoxia. Oxidized LDL-C initiates atherosclerosis amidst oxidative stress, inflammation, endothelial dysfunction, and vascular remodelling in CVD pathogenesis. Anti-inflammatory and antioxidant biomarkers are needed to identify individuals at risk of cardiovascular events and enhance risk prediction. Among these, C-reactive protein (CRP) is a recognized marker of vascular inflammation in coronary arteries. Elevated pro-atherogenic oxidized LDL (oxLDL) expression serves as an antioxidant marker, predicting coronary heart disease in apparently healthy men. Natural antioxidants and anti-inflammatory molecules protect the heart by reducing oxidative stress, enhancing vasodilation, and improving endothelial function. For instance, the flavonoid quercetin exerts antioxidant and anti-inflammatory effects primarily by activating the Nrf2\/HO-1 signaling pathway, thereby enhancing cellular antioxidant defense and reducing reactive oxygen species. Carotenoids, such as astaxanthin, exhibit potent antioxidant activity by scavenging free radicals and preserving mitochondrial integrity. The alkaloid berberine mediates cardiovascular benefits through activation of AMO-activated protein kinase (AMPK) and inhibition of nuclear factor kappa B [NF-kB] signalling, improving lipid metabolism and suppressing inflammatory cytokines. Emerging evidence highlights microRNAs (miRNAs) as potential regulators of oxidative stress via endothelial nitric oxide synthase (eNOS) and silent mating-type information regulation 2 homolog (SIRT1). While the exact mechanisms remain unclear, their benefits are likely to include antioxidant and anti-inflammatory effects, notably reducing the susceptibility of low-density lipoproteins to oxidation. Additionally, the interactions between organs under hypoxia signalling underscore the need for a comprehensive regulatory framework that can support the identification of therapeutic targets, advance clinical research, and enhance treatments, including FDA-approved drugs and those in clinical trials. Promising natural products, including polysaccharides, alkaloids, saponins, flavonoids, and peptides, as well as traditional Indian medicines, have demonstrated anti-hypoxic properties. Their mechanisms of action include increasing haemoglobin, glycogen, and ATP levels, reducing oxidative stress and lipid peroxidation, preserving mitochondrial function, and regulating genes related to apoptosis. These findings emphasise the importance of anti-hypoxia research for the development of effective therapies to combat this critical health problem. A recent approach to controlling CVDs involves the use of antioxidant and anti-inflammatory therapeutics through low-dose dietary supplementation. Despite their effectiveness at low doses, further research on ROS, antioxidants, and nutrition, supported by large multicentre trials, is needed to optimize this strategy.<\/jats:p>","DOI":"10.3390\/cimb47110955","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:03:15Z","timestamp":1763564595000},"page":"955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of Anti-Inflammatory and Antioxidant Properties of Natural Products in Curing Cardiovascular Diseases"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0678-1265","authenticated-orcid":false,"given":"Amit","family":"Kulkarni","sequence":"first","affiliation":[{"name":"SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, Sattur, Dharwad 580009, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-6624","authenticated-orcid":false,"given":"Chaitra Chidambar","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Biotechnology & Crop Improvement, Kittur Rani Chennamma College of Horticulture (KRCCH), University of Horticultural Sciences, Arabhavi, Bagalkot 591218, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-2001","authenticated-orcid":false,"given":"Seetur Radhakrishna","family":"Pradeep","sequence":"additional","affiliation":[{"name":"Division of Yoga & Life Sciences, Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA), Swami Vivekananda Rd., Jigani, Bingipura, Bangalore 560105, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-6698","authenticated-orcid":false,"given":"Jagadeesha","family":"Poyya","sequence":"additional","affiliation":[{"name":"SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, Sattur, Dharwad 580009, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3619-4292","authenticated-orcid":false,"given":"Avinash Kundadka","family":"Kudva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4742-5650","authenticated-orcid":false,"given":"Vijay","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2018-9325","authenticated-orcid":false,"given":"Ajay Sathyanarayanrao","family":"Khandagale","sequence":"additional","affiliation":[{"name":"SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, Sattur, Dharwad 580009, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e7479357","DOI":"10.1155\/2016\/7479357","article-title":"Women in Saudi Arabia and the prevalence of cardiovascular risk factors: A systematic review","volume":"2016","author":"Alshaikh","year":"2016","journal-title":"J. Environ. Public Health"},{"key":"ref_2","first-page":"e48279","article-title":"The State of cardiac rehabilitation in Saudi Arabia: Barriers, facilitators, and policy implications","volume":"15","author":"Adam","year":"2023","journal-title":"Cureus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.31083\/j.rcm2405134","article-title":"Non-traditional risk factors as contributors to cardiovascular disease","volume":"24","author":"Wang","year":"2023","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17319","DOI":"10.3390\/ijms140917319","article-title":"Oxidative stress and microRNAs in vascular diseases","volume":"14","author":"Magenta","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1093\/jxb\/erv099","article-title":"ROS and RNS in plant physiology: An overview","volume":"66","year":"2015","journal-title":"J. Exp. Bot."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of control in inflammation","volume":"420","author":"Nathan","year":"2002","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1159\/000477596","article-title":"PTPRO promotes oxidized low-density lipoprotein induced oxidative stress and cell apoptosis through toll-like receptor 4\/nuclear factor \u03baB pathway","volume":"42","author":"Liang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_8","first-page":"321","article-title":"Metabolomics and its application in the treatment of coronary heart disease with traditional Chinese medicine","volume":"17","author":"Wu","year":"2019","journal-title":"Chin. J. Nat. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1089\/ars.2012.4926","article-title":"The role of redox signaling in epigenetics and cardiovascular disease","volume":"18","author":"Kim","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/BF00857888","article-title":"Reactive oxygen molecules, oxidant injury and renal disease","volume":"5","author":"Andreoli","year":"1991","journal-title":"Pediatr. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev.bi.52.070183.003431","article-title":"Glutathione","volume":"52","author":"Meister","year":"1983","journal-title":"Annu. Rev. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s13105-010-0038-2","article-title":"Glutathione system in young spontaneously hypertensive rats","volume":"66","author":"Lee","year":"2010","journal-title":"J. Physiol. Biochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/ajh.2010.167","article-title":"Vascular structure and oxidative stress in salt-loaded spontaneously hypertensive rats: Effects of losartan and atenolol","volume":"23","author":"Ferder","year":"2010","journal-title":"Am. J. Hypertens."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.freeradbiomed.2006.07.019","article-title":"Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension","volume":"41","author":"Zhou","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11010-005-5424-7","article-title":"Different antioxidants status, total antioxidant power and free radicals in essential hypertension","volume":"277","author":"Kashyap","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"ref_16","first-page":"635","article-title":"The markers of oxidative stress and activity of the antioxidant system in the blood of elderly patients with essential arterial hypertension","volume":"9","author":"Czuczejko","year":"2004","journal-title":"Cell Mol. Biol. Lett."},{"key":"ref_17","first-page":"355","article-title":"Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential","volume":"16","author":"Kidd","year":"2011","journal-title":"Altern. Med. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00394-009-0056-4","article-title":"Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages","volume":"49","author":"Kishimoto","year":"2010","journal-title":"Eur. J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.biopha.2017.08.128","article-title":"Isoquercetin ameliorated hypoxia\/reoxygenation-induced H9C2 cardiomyocyte apo ptosis via a mitochondrial-dependent pathway","volume":"95","author":"Cao","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cbi.2017.09.015","article-title":"Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2\/ARE\/HO-1, PPAR\u03b3 and TGF-\u03b21\/Smad3 signalling, and amelioration of oxidative stress and inflammation","volume":"277","author":"Mahmoud","year":"2017","journal-title":"Chem. Interact."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1039\/C6FO01721E","article-title":"Astaxanthin in cardiovascular health and disease: Mechanisms of action, therapeutic merits, and knowledge gaps","volume":"8","author":"Visioli","year":"2017","journal-title":"Food Funct."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0002-9149(02)03143-0","article-title":"Vascular biology of atherosclerosis: Overview and state of art","volume":"91","author":"Libby","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jgr.2014.03.001","article-title":"A review on the medicinal potentials of ginseng and ginsenoids on cardiovascular diseases","volume":"38","author":"Chang","year":"2014","journal-title":"J. Ginseng Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jgr.2017.10.004","article-title":"Pharmacological and medical applications of Panax ginseng and ginsenosides: A review for use in cardiovascular diseases","volume":"42","author":"Kim","year":"2018","journal-title":"J. Ginseng Res."},{"key":"ref_25","first-page":"380","article-title":"Evaluation of anti-inflammatory activity of fatty acids of Ocimum sanctum fixed oil","volume":"35","author":"Singh","year":"1997","journal-title":"Indian J. Exp. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jep.2013.04.019","article-title":"Cardioprotective effects of the YiQi FuMai injection and isolated compounds on attenuating chronic heart failure via NF-\u03baB in activation and cytokine suppression","volume":"148","author":"Xing","year":"2013","journal-title":"J. Ethnopharmocol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/ars.2012.5116","article-title":"The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice","volume":"20","author":"Mo","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"E955","DOI":"10.1152\/ajpendo.90599.2008","article-title":"Berberine suppresses proinflammatory responses through AMPK activation in macrophages","volume":"296","author":"Jeong","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jep.2012.11.038","article-title":"Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor","volume":"145","author":"Lau","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhang, R., Han, D., Li, Z., Shen, C., Zhang, Y., Li, J., Yan, G., Li, S., Hu, B., and Li, J. (2018). Ginkgolide C alleviates myocardial ischemia\/reperfusion-induced inflammatory injury via inhibition of CD40-NF-\u03baB pathway. Front. Pharmacol., 9, Correction in Front. Pharmacol. 2025, 15, 1492520.","DOI":"10.3389\/fphar.2024.1492520"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.phymed.2017.09.022","article-title":"Ligustilide attenuates vascular inflammation and activates Nrf2\/HO-1 induction and, NO synthesis in HUVECs","volume":"38","author":"Choi","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jff.2017.01.007","article-title":"Apigenin protects myocardium by inhibiting the TGF-\u03b21-mediated Smad signaling transduction pathway in acute myocardial infarcted rats","volume":"30","author":"Wang","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12038-020-00047-0","article-title":"Apigenin attenuates myocardial infarction-induced cardiomyocyte injury by modulating Parkin-mediated mitochondrial autophagy","volume":"45","author":"Wang","year":"2020","journal-title":"J. Biosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"107133","DOI":"10.1016\/j.intimp.2020.107133","article-title":"The covalent NLRP3-inflammasome inhibitor oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice","volume":"90","author":"Gao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.7314\/APJCP.2015.16.15.6753","article-title":"Induction of apoptosis by Eugenol and Capsaicin in Human gastric cancer AGS Cells-Elucidating the Role of p53","volume":"16","author":"Arnab","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s11671-024-04100-x","article-title":"Therapeutic effect of targeted antioxidant natural products","volume":"19","author":"Mukherjee","year":"2024","journal-title":"Nanoscale Res. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-physiol-021113-170322","article-title":"Hypoxia-inducible factor 1 and cardiovascular disease","volume":"76","author":"Semenza","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.jacc.2007.01.084","article-title":"Central sleep apnea, right ventricular dysfunction, and low diastolic blood pressure are predictors of mortality in systolic heart failure","volume":"49","author":"Javaheri","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1056\/NEJM200003023420904","article-title":"Early expression of angiogenesis factors in acute myocardial ischemia and infarction","volume":"342","author":"Lee","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_42","first-page":"7","article-title":"Novel concepts in atherogenesis: Angiogenesis and hypoxia in atherosclerosis","volume":"218","author":"Sluimer","year":"2009","journal-title":"J. Pathol. J. Pathol. Soc. Great Br. Irel."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/01.mol.0000245261.71129.f0","article-title":"Angiogenesis in atherosclerosis: Gathering evidence beyond speculation","volume":"17","author":"Moulton","year":"2006","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1161\/CIRCRESAHA.119.315939","article-title":"Intracellular and intercellular aspects of macrophage immunometabolism in atherosclerosis","volume":"126","author":"Tabas","year":"2020","journal-title":"Circ. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrm1366","article-title":"Oxygen sensing by HIF hydroxylases","volume":"5","author":"Schofield","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.cell.2012.05.025","article-title":"SnapShot: Tumour angiogenesis","volume":"149","author":"Jain","year":"2012","journal-title":"Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"Epstein","year":"2001","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIF\u03b1 targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1089\/ars.2010.3769","article-title":"Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1\u2212\/\u2212) attenuates ex vivo myocardial ischemia\/reperfusion injury through hypoxia-inducible factor-1\u03b1 transcription factor and its target genes in mice","volume":"15","author":"Adluri","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.2174\/13816128113199990549","article-title":"Targeted gene deletion of prolyl hydroxylase domain protein 3 triggers angiogenesis and preserves cardiac function by stabilizing hypoxia inducible factor 1 alpha following myocardial infarction","volume":"20","author":"Oriowo","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Thirunavukkarasu, M., Pradeep, S.R., Oriowo, B., Lim, S.T., Maloney, M., Ahmed, S., Taylor, N., Russell, D.M., Socrates, P., and Batko, E. (2025). Stabilization of Transcription Factor, HIF-1\u03b1 by Prolyl hydroxylase 1 Knockout Reduces Cardiac Injury After Myocardial Infarction in Mice. Cells, 14.","DOI":"10.3390\/cells14060423"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/XCS.0000000000000241","article-title":"Protective effect of cardiomyocyte-specific prolyl-4-hydroxylase 2 inhibition on ischemic injury in a mouse MI model","volume":"235","author":"Pradeep","year":"2022","journal-title":"J. Am. Coll. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Zhou, H., and Toan, S. (2020). Pathological roles of mitochondrial oxidative stress and mitochondrial dynamics in cardiac microvascular ischemia\/reperfusion injury. Biomolecules, 10.","DOI":"10.3390\/biom10010085"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.redox.2014.05.006","article-title":"Mitochondrial reactive oxygen species: A double-edged sword in ischemia\/reperfusion vs preconditioning","volume":"2","author":"Kalogeris","year":"2014","journal-title":"Redox Biol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Hong, Y., Boiti, A., Vallone, D., and Foulkes, N.S. (2024). Reactive oxygen species signaling and oxidative stress: Transcriptional regulation and evolution. Antioxidants, 13.","DOI":"10.3390\/antiox13030312"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Averill-Bates, D. (2024). Reactive oxygen species and cell signaling. Review. Biochim. Biophys. Acta (BBA)-Mol. Cell Res., 1871.","DOI":"10.1016\/j.bbamcr.2023.119573"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Janaszak-Jasiecka, A., Siekierzycka, A., P\u0142oska, A., Dobrucki, I.T., and Kalinowski, L. (2021). Endothelial dysfunction driven by hypoxia\u2014The influence of oxygen deficiency on NO bioavailability. Biomolecules, 11.","DOI":"10.3390\/biom11070982"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/01.RES.86.5.541","article-title":"Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion","volume":"86","author":"Hoek","year":"2000","journal-title":"Circ. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"H216","DOI":"10.1152\/ajpheart.00060.2018","article-title":"Cardio protection by intermittent hypoxia conditioning: Evidence, mechanisms, and therapeutic potential","volume":"315","author":"Mallet","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Candia, A., Candia, A.A., Paz, A., Mobarec, F., Urbina-Varela, R., del Campo, A., Herrera, E.A., and Castillo, R.L. (2022). Cardioprotective antioxidant and anti-inflammatory mechanisms induced by intermittent hypobaric hypoxia. Antioxidants, 11.","DOI":"10.3390\/antiox11061043"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.yjmcc.2010.10.033","article-title":"Transforming growth factor (TGF)-\u03b2 signaling in cardiac remodeling","volume":"51","author":"Dobaczewski","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_65","first-page":"1458","article-title":"Hypoxia induces cardiac fibroblast proliferation and phenotypic switch: A role for caveolae and caveolin-1\/PTEN mediated pathway","volume":"6","author":"Gao","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Althurwi, H.N., Abdel-Rahman, R.F., Soliman, G.A., Ogaly, H.A., Alkholifi, F.K., Abd-Elsalam, R.M., Alqasoumi, S.I., and Abdel-Kader, M.S. (2022). Protective Effect of Beta-Carotene against Myeloperoxidase-Mediated Oxidative Stress and Inflammation in Rat Ischemic Brain Injury. Antioxidants, 11.","DOI":"10.3390\/antiox11122344"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Park, J.H., Lee, T.-K., Kim, D.W., Ahn, J.H., Lee, C.-H., Kim, J.-D., Shin, M.C., Cho, J.H., Lee, J.-C., and Won, M.-H. (2022). Astaxanthin Confers a Significant Attenuation of Hippocampal Neuronal Loss Induced by Severe Ischemia-Reperfusion Injury in Gerbils by Reducing Oxidative Stress. Mar. Drugs, 20.","DOI":"10.3390\/md20040267"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/ejcts\/ezs549","article-title":"Hypoxia-preconditioned mesenchymal stromal cells improve cardiac function in a swine model of chronic myocardial ischaemia","volume":"43","author":"Jaussaud","year":"2013","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Yan, F., Yao, Y., Chen, L., Li, Y., Sheng, Z., and Ma, G. (2012). Hypoxic preconditioning improves survival of cardiac progenitor cells: Role of stromal cell derived factor-1\u03b1\u2013CXCR4 axis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037948"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13287-017-0543-0","article-title":"Autophagy mediates the beneficial effect of hypoxic preconditioning on bone marrow mesenchymal stem cells for the therapy of myocardial infarction","volume":"8","author":"Zhang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Paw, M., Kusiak, A.A., Nit, K., Litewka, J.J., Piejko, M., Wnuk, D., Sarna, M., Fic, K., Stopa, K.B., and Hammad, R. (2023). Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p\/TGF\u03b2\/SMAD2 axis. BMC Med., 21.","DOI":"10.1186\/s12916-023-03117-w"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.7150\/ijms.99359","article-title":"Mitochondrial stress as a central player in the pathogenesis of hypoxia-related myocardial dysfunction: New insights","volume":"21","author":"Guo","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: The evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3390\/compounds4030029","article-title":"Plant Antioxidants: Therapeutic Potential in Cardiovascular Diseases","volume":"4","author":"Poblano","year":"2024","journal-title":"Compounds"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e32563","DOI":"10.1016\/j.heliyon.2024.e32563","article-title":"Flavonoids: Potential therapeutic agents for cardiovascular disease","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.2147\/DDDT.S194753","article-title":"Lycopene Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Permeability Transition Pore Opening","volume":"13","author":"Li","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.lfs.2016.04.028","article-title":"The Antioxidant and Antiapoptotic Effects of Crocin Pretreatment on Global Cerebral Ischemia Reperfusion Injury Induced by Four Vessels Occlusion in Rats","volume":"154","author":"Oruc","year":"2016","journal-title":"Life Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2220\/biomedres.45.197","article-title":"Quercetin protects human coronary artery endothelial cells against hypoxia\/reoxygenation-induced mitochondrial apoptosis via the Nrf2\/HO-1 axis","volume":"45","author":"Song","year":"2024","journal-title":"Biomed. Res."},{"key":"ref_79","first-page":"184","article-title":"Cardioprotective effect of quercetin against ischemia\/reperfusion injury is mediated through NO system and mitochondrial K-ATP channels","volume":"23","author":"Liu","year":"2021","journal-title":"Cell J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5529913","DOI":"10.1155\/2021\/5529913","article-title":"Quercetin improves cardiomyocyte vulnerability to hypoxia by regulating SIRT1\/TMBIM6-related mitophagy and endoplasmic reticulum stress","volume":"2021","author":"Chang","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e39031","DOI":"10.1016\/j.heliyon.2024.e39031","article-title":"Quercetin inhibits cardiomyocyte apoptosis via Sirt3\/SOD2\/mitochondrial reactive oxygen species during myocardial ischemia\u2013reperfusion injury","volume":"10","author":"Xiong","year":"2024","journal-title":"Heliyon"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.biopha.2017.05.033","article-title":"The protective effect of Luteolin on myocardial ischemia\/reperfusion (I\/R) injury through TLR4\/NF-\u03baB\/NLRP3 inflammasome pathway","volume":"91","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s10753-021-01530-y","article-title":"SHP-1\/STAT3 interaction is related to luteolin-induced myocardial ischemia protection","volume":"45","author":"Liu","year":"2022","journal-title":"Inflammation"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"E782","DOI":"10.1210\/jc.2010-2879","article-title":"Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome","volume":"96","author":"Rizza","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/10715760903071656","article-title":"Protection against in vivo focal myocardial ischemia\/reperfusion injury-induced arrhythmias and apoptosis by hesperidin","volume":"43","author":"Gandhi","year":"2009","journal-title":"Free Radic. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1159\/000447884","article-title":"Short-term hesperidin pretreatment attenuates rat myocardial ischemia\/reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K\/Akt pathway","volume":"39","author":"Li","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Thawabteh, A., Juma, S., Bader, M., Karaman, D., Scrano, L., Bufo, S.A., and Karaman, R. (2009). The biological activity of natural alkaloids against herbivores, cancerous cells and pathogens. Toxins, 11.","DOI":"10.3390\/toxins11110656"},{"key":"ref_88","first-page":"14513","article-title":"Cardioprotective effect of berberine against myocardial ischemia\/reperfusion injury via attenuating mitochondrial dysfunction and apoptosis","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2015.05.028","article-title":"Berberine alleviates cardiac ischemia\/reperfusion injury by inhibiting excessive autophagy in cardiomyocytes","volume":"762","author":"Huang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e18407","DOI":"10.1111\/jcmm.18407","article-title":"Berberine ameliorates chronic intermittent hypoxia-induced cardiac remodelling by preserving mitochondrial function, role of SIRT6 signalling","volume":"28","author":"Zhou","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"ref_91","first-page":"1225","article-title":"Berberine inhibits the ischemia-reperfusion injury induced inflammatory response and apoptosis of myocardial cells through the phosphoinositide 3-kinase\/RAC-\u03b1 serine\/threonine-protein kinase and nuclear factor-\u03baB signaling pathways","volume":"15","author":"Wang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3892\/ijmm.2024.5373","article-title":"Berberine inhibits excessive autophagy and protects myocardium against ischemia\/reperfusion injury via the RhoE\/AMPK pathway","volume":"53","author":"Hu","year":"2024","journal-title":"Int. J. Mol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Han, Y., Zhang, W., Tang, Y., Bai, W., Yang, F., Xie, L., Li, X., Zhou, S., Pan, S., and Chen, Q. (2012). l-Tetrahydropalmatine, an active component of Corydalis yanhusuo WT Wang, protects against myocardial ischaemia-reperfusion injury in rats. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038627"},{"key":"ref_94","first-page":"1286","article-title":"Tetrahydropalmatine inhibiting mitophagy through ULK1\/FUNDC1 pathway to alleviate hypoxia\/reoxygenation injury in H9c2 cells","volume":"49","author":"Xin","year":"2024","journal-title":"Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China J. Chin. Mater. Medica"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1142\/S0192415X2250080X","article-title":"Cardioprotective effects of tetrahydropalmatine on acute myocardial infarction in rats","volume":"50","author":"Han","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.imr.2018.01.003","article-title":"Structural characteristics, bioavailability and cardioprotective potential of saponins","volume":"7","author":"Singh","year":"2018","journal-title":"Integr. Med. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jgr.2024.07.003","article-title":"Ginsenoside Rg1 reduces cardiac inflammation against myocardial ischemia\/reperfusion injury by inhibiting macrophage polarization","volume":"48","author":"Xu","year":"2024","journal-title":"J. Ginseng Res."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Chen, P., Gao, Z., Guo, M., Pan, D., Zhang, H., Du, J., and Shi, D. (2024). Efficacy and safety of Panax notoginseng saponin injection in the treatment of acute myocardial infarction: A systematic review and meta-analysis of randomized controlled trials. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1353662"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000484578","article-title":"Ginsenoside Rg1 protects cardiomyocytes against hypoxia\/reoxygenation injury via activation of Nrf2\/HO-1 signaling and inhibition of JNK","volume":"44","author":"Li","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Shen, T., Lyu, D., Zhang, M., Shang, H., and Lu, Q. (2022). Dioscin alleviates cardiac dysfunction in acute myocardial infarction via rescuing mitochondrial malfunction. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.783426"},{"key":"ref_101","first-page":"246","article-title":"Diosgenin protects rats from myocardial inflammatory injury induced by ischemia-reperfusion","volume":"24","author":"Wang","year":"2018","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e37019","DOI":"10.1016\/j.heliyon.2024.e37019","article-title":"Astragaloside IV ameliorates pressure overload-induced heart failure by enhancing angiogenesis through HSF1\/VEGF pathway","volume":"10","author":"Du","year":"2024","journal-title":"Heliyon"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1124\/jpet.111.180992","article-title":"Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1\u03b1 accumulation via phosphatidylinositol 3-kinase\/Akt pathway","volume":"338","author":"Zhang","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3892\/mmr.2021.11883","article-title":"Astragaloside IV improves angiogenesis under hypoxic conditions by enhancing hypoxia-inducible factor-1\u03b1 SUMOylation","volume":"23","author":"Wang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Si, J., Wang, N., Wang, H., Xie, J., Yang, J., Yi, H., Shi, Z., Ma, J., Wang, W., and Yang, L. (2014). HIF-1\u03b1 signaling activation by post-ischemia treatment with astragaloside IV attenuates myocardial ischemia-reperfusion injury. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107832"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/ptr.5297","article-title":"Astragaloside IV attenuates injury caused by myocardial ischemia\/reperfusion in rats via regulation of toll-like receptor 4\/nuclear factor-\u03baB signaling pathway","volume":"29","author":"Lu","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3892\/mmr.2016.5296","article-title":"Astragalus polysaccharide protects human cardiac microvascular endothelial cells from hypoxia\/reoxygenation injury: The role of PI3K\/AKT, Bax\/Bcl-2 and caspase-3","volume":"14","author":"Xie","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Wang, H., Jiang, M., Li, X., Zhao, Y., Shao, J., Liu, Z., Lin, L., Xu, Q., Wang, L., and Lu, X. (2021). Anti-inflammatory Therapies for Coronary Heart Disease: A Systematic Review and Meta-Analysis. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.726341"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1079\/BJN2002725","article-title":"The biological action of saponins in animal systems: A review","volume":"88","author":"Francis","year":"2002","journal-title":"Br. J. Nutr."},{"key":"ref_110","first-page":"67","article-title":"Saponins from edible legumes: Chemistry, processing, and health benefits","volume":"7","author":"Shi","year":"2004","journal-title":"J. Nutr. Food Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.lfs.2009.09.001","article-title":"the protective effect of Ganoderma atrum polysaccharide against anoxia\/reoxygenation injury in neonatal rat cardiomyocytes","volume":"85","author":"Li","year":"2009","journal-title":"Life Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jcb.22526","article-title":"Ganoderma atrum polysaccharide protects cardiomyocytes against anoxia\/reoxygenation-induced oxidative stress by mitochondrial pathway","volume":"110","author":"Li","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Liuand, C., and Huang, Y. (2016). Chinese herbal medicine on cardio vascular diseases and the mechanisms of action. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00469"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3231424","DOI":"10.1155\/2019\/3231424","article-title":"The role of traditional Chinese medicine in the regulation of oxidative stress in treating coronary heart disease","volume":"2019","author":"Yang","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/ptr.5087","article-title":"\u03b2-sitosterol enhances cellular glutathione redox cycling by reactive oxygen species generated from mitochondrial respiration: Protection against oxidant injury in H9c2 cells and rat hearts","volume":"28","author":"Wong","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-nutr-011215-025104","article-title":"Mediterranean dietary patterns and cardiovascular health","volume":"35","author":"Shen","year":"2015","journal-title":"Annu. Rev. Nutr."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhang, M., Qin, C., Wang, Z., Chen, J., Wang, R., Hu, J., Zou, Q., and Niu, X. (2022). Niu Resveratrol attenuates myocardial injury by inhibiting ferroptosis via inducing KAT5\/GPX4 in myocardial infarction. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.906073"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"5430407","DOI":"10.1155\/2020\/5430407","article-title":"Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress","volume":"2020","author":"Chang","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_119","first-page":"58","article-title":"Reconsideration of Eating Time of Citrus and Fibrous Fruits to Assure Maximum Health Benefits by Proper Nutrition: Empirical vs. Theoretical","volume":"1","author":"Banerjee","year":"2020","journal-title":"Food Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1080\/10286020.2014.939584","article-title":"Treatment with Lutein Provides Neuroprotection in Mice Subjected to Transient Cerebral Ischemia","volume":"16","author":"Sun","year":"2014","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s11064-018-2545-4","article-title":"All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia\u2013Reperfusion Injury in Rats by Inhibiting the Loss of the Blood\u2013Brain Barrier via the JNK\/P38MAPK Signaling Pathway","volume":"43","author":"Li","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11010-006-9182-y","article-title":"Effect of Ascorbic Acid Supplementation on Certain Oxidative Stress Parameters in the Post Reperfusion Patients of Myocardial Infarction","volume":"290","author":"Bhakuni","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/bab.1797","article-title":"Vitamin D Attenuates Myocardial Ischemia\u2013Reperfusion Injury by Inhibiting Inflammation via Suppressing the RhoA\/ROCK\/NF-\u0138B Pathway","volume":"66","author":"Qian","year":"2019","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00210-020-02007-9","article-title":"Pretreatment with Bisoprolol and Vitamin E Alone or in Combination Provides Neuroprotection against Cerebral Ischemia\/Reperfusion Injury in Rats","volume":"394","author":"Salehi","year":"2021","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Liang, X., Shi, L., Wang, M., Zhang, L., Gong, Z., Luo, S., Wang, X., Zhang, Q., and Zhang, X. (2023). Folic Acid Ameliorates Synaptic Impairment Following Cerebral Ischemia\/Reperfusion Injury via Inhibiting Excessive Activation of NMDA Receptors. J. Nutr. Biochem., 112.","DOI":"10.1016\/j.jnutbio.2022.109209"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/1440-1681.13691","article-title":"Epigallocatechin gallate for Parkinson\u2019s disease","volume":"49","author":"Sergi","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"H7","DOI":"10.1111\/j.1750-3841.2010.01907.x","article-title":"Effect of oryzanol and ferulic acid on the glucose metabolism of mice fed with a high-fat diet","volume":"76","author":"Son","year":"2011","journal-title":"J. Food Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"109470","DOI":"10.1016\/j.fsi.2024.109470","article-title":"In vitro immune-depression and anti-inflammatory activities of cantharidin on gilthead seabream (Sparus aurata) leucocytes activated by \u03bb-carrageenan","volume":"148","author":"Guardiola","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"113113","DOI":"10.1016\/j.intimp.2024.113113","article-title":"Bufalin alleviates inflammatory response and oxidative stress in experimental severe acute pancreatitis through activating Keap1-Nrf2\/HO-1 and inhibiting NF-\u03baB pathways","volume":"142","author":"Niu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An overview","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"114226","DOI":"10.1016\/j.phytochem.2024.114226","article-title":"Ganospirones A\u2212G, Seven undescribed spiro-meroterpenoids from Ganoderma lucidum and their biological activities","volume":"227","author":"Li","year":"2024","journal-title":"Phytochemistry"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1021\/ol503610b","article-title":"ChemInform Abstract: Applanatumin A, A new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity","volume":"17","author":"Luo","year":"2015","journal-title":"Org. Lett."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/acs.orglett.5b00448","article-title":"(\u00b1)-Sinensilactam A, a pair of rare hybrid metabolites with Smad3 phosphorylation inhibition from Ganoderma sinensis","volume":"17","author":"Luo","year":"2015","journal-title":"Org. Lett."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.metabol.2009.11.010","article-title":"Protective effect of caffeic acid on cardiac markers and lipid peroxide metabolism in cardiotoxic rats: An in vivo and in vitro study","volume":"59","author":"Kumaran","year":"2010","journal-title":"Metabolism"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Tsai, C.-F., Su, H.-H., Chen, K., Liao, J.-M., Yao, Y.-T., Chen, Y.-H., Wang, M., Chu, Y.-C., Wang, Y.-H., and Huang, S.-S. (2021). Paeonol protects against myocardial ischemia\/reperfusion-induced injury by mediating apoptosis and autophagy crosstalk. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.586498"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1055\/s-2007-993775","article-title":"Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia\/reperfusion injury in rats","volume":"74","author":"Nizamutdinova","year":"2008","journal-title":"Planta Medica"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s11030-023-10607-9","article-title":"Clarifying the mechanism of apigenin against blood-brain barrier disruption in ischemic stroke using systems pharmacology","volume":"28","author":"Wang","year":"2024","journal-title":"Mol. Divers."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jgr.2021.06.011","article-title":"Cardioprotective effect of ginsenoside Rb1 via regulating metabolomics profiling and AMP-activated protein kinase-dependent mitophagy","volume":"46","author":"Hu","year":"2022","journal-title":"J. Ginseng Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jare.2023.12.012","article-title":"Ginsenoside Rb2 inhibits p300-mediated SF3A2 acetylation at lysine 10 to promote Fscn1 alternative splicing against myocardial ischemic\/reperfusion injury","volume":"65","author":"Huang","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13020-022-00616-5","article-title":"Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia\/reperfusion injury","volume":"17","author":"Li","year":"2022","journal-title":"Chin. Med."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Shen, Y., Wang, X., Shen, X., Wang, Y., Wang, S., Zhang, Y., Yao, X., Xu, Y., Sang, M., and Pan, J. (2022). Geniposide possesses the protective effect on myocardial injury by inhibiting oxidative stress and ferroptosis via activation of the Grsf1\/GPx4 Axis. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.879870"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"155362","DOI":"10.1016\/j.phymed.2024.155362","article-title":"Catalpol attenuates ischemic stroke by promoting neurogenesis and angiogenesis via the SDF\u20131\u03b1\/CXCR4 pathway","volume":"128","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Bai, X., Wang, W.-X., Fu, R.-J., Yue, S.-J., Gao, H., Chen, Y.-Y., and Tang, Y.-P. (2020). Therapeutic potential of hydroxysafflor yellow A on cardio-cerebrovascular diseases. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.01265"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1007\/s10753-020-01405-8","article-title":"Betulin alleviates myocardial ischemiareperfusion injury in rats via regulating the Siti1\/NLRP3\/NF-\u03baB signaling pathway","volume":"44","author":"Yu","year":"2021","journal-title":"Inflammation"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11010-020-03842-3","article-title":"Artemisinin suppresses myocardial ischemia-reperfusion injury via NLRP3 inflammasome mechanism","volume":"474","author":"Wang","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/s41401-018-0160-1","article-title":"Berberine attenuates ischemia-reperfusion injury through inhibiting HMGB1 release and NF-\u03baB nuclear translocation","volume":"39","author":"Zhu","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/eurheartj\/ehab724.1273","article-title":"Colchicine in patients with acute myocardial infarction: An updated meta-analysis of randomized controlled trials","volume":"42","author":"Mendoza","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.apsb.2022.07.006","article-title":"Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS","volume":"13","author":"Wu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zhou, G., Zhu, J., Jin, L., Chen, J., Xu, R., Zhao, Y., Yan, T., and Wan, H. (2023). Salvianolic-acid-Bloaded HA self-healing hydrogel promotes diabetic wound healing through promotion of anti-inflammation and angiogenesis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076844"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.phymed.2018.09.187","article-title":"Fisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE\/NF-B mediated oxidative stress, apoptosis and inflammation","volume":"56","author":"Garg","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"8194690","DOI":"10.1155\/2016\/8194690","article-title":"Cardioprotective Effects of Astragalin against Myocardial Ischemia\/Reperfusion Injury in Isolated Rat Heart","volume":"2016","author":"Qu","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_152","first-page":"518","article-title":"The effect and mechanism of hyperoside on high glucose-induced oxidative stress injury of myocardial cells","volume":"49","author":"Wang","year":"2018","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s13105-014-0318-3","article-title":"Naringenin confers protection against oxidative stress through upregulation of Nrf2 target genes in cardiomyoblast cells","volume":"70","author":"Ramprasath","year":"2014","journal-title":"J. Physiol. Biochem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.febslet.2008.12.037","article-title":"Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia\/reperfusion induced injury","volume":"583","author":"Scarabelli","year":"2009","journal-title":"FEBS Lett."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4077\/CJP.2016.BAE393","article-title":"Suppression of isoproterenol-induced apoptosis in H9c2 cardiomyoblast cells by daidzein through activation of Akt","volume":"59","author":"Hu","year":"2016","journal-title":"Chin. J. Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"173414","DOI":"10.1016\/j.ejphar.2020.173414","article-title":"Targeting NOX 4 by petunidin improves anoxia\/reoxygenation-induced myocardium injury","volume":"888","author":"Cai","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejphar.2016.02.055","article-title":"Mangiferin protect myocardial insults through modulation of MAPK\/TGF-pathways","volume":"776","author":"Suchal","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_158","first-page":"2007","article-title":"Cardioprotective effects of Malvidin against isoproterenol-induced myocardial infarction in rats: A mechanistic study","volume":"23","author":"Wei","year":"2017","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13020-023-00726-8","article-title":"The alkaloids of Corydalis hendersonii Hemsl. contribute to the cardioprotective effect against ischemic injury in mice by attenuating cardiomyocyte apoptosis via p38 MAPK signaling pathway","volume":"18","author":"Ge","year":"2023","journal-title":"Chin. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41420-024-02278-8","article-title":"Free radicals and their impact on health and antioxidant defenses: A review","volume":"11","author":"Chandimali","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Ooi, B.K., Chan, K.-G., Goh, B.H., and Yap, W.H. (2018). The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01308"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.intimp.2015.09.016","article-title":"Fucosterol protects cobalt chloride induced inflammation by the inhibition of hypoxia-inducible factor through PI3K\/Akt pathway","volume":"29","author":"Sun","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_163","first-page":"989","article-title":"Cardioprotective and antilipidemic potential of Cyperus rotundus in chemically induced cardiotoxicity","volume":"14","author":"Jahan","year":"2012","journal-title":"Int. J. Agric. Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1248\/bpb.29.684","article-title":"Antihypertensive potential and mechanism of action of astaxanthin: III. Antioxidant and histopathological effects in spontaneously hypertensive rats","volume":"29","author":"Hussein","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4629189","DOI":"10.1155\/2020\/4629189","article-title":"Astaxanthin attenuates hypertensive vascular remodeling by protecting vascular smooth muscle cells from oxidative stress-induced mitochondrial dysfunction","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.phrs.2010.09.003","article-title":"Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats","volume":"63","author":"Sevilla","year":"2011","journal-title":"Pharmacol. Res."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Gloria, J.L., Arellano-Buend\u00eda, A.S., Ju\u00e1rez-Rojas, J.G., Garc\u00eda-Arroyo, F.E., Arg\u00fcello-Garc\u00eda, R., S\u00e1nchez-Mu\u00f1oz, F., S\u00e1nchez-Lozada, L.G., and Osorio-Alonso, H. (2022). Cellular mechanisms underlying the cardioprotective role of allicin on cardiovascular dis eases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169082"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"S1119","DOI":"10.1016\/j.arabjc.2013.02.004","article-title":"Evaluation of antioxidant activity of crocin, podophyllotoxin and kaempferol by chemical, biochemical and electrochemical assays","volume":"10","author":"Dar","year":"2017","journal-title":"Arab. J. Chem."},{"key":"ref_169","first-page":"553","article-title":"Crocin prevents sub- cellular organelle damage, proteolysis and apoptosis in rat hepatocytes: A justification for its hepatoprotection","volume":"17","author":"Yousefsani","year":"2018","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.numecd.2018.06.005","article-title":"Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathy","volume":"28","author":"Feidantsis","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"H212","DOI":"10.1111\/j.1750-3841.2010.01755.x","article-title":"Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis","volume":"75","author":"Lee","year":"2010","journal-title":"J. Food Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/biof.1557","article-title":"Therapeutic effects of Crocin in autoimmune diseases: A review","volume":"45","author":"Korani","year":"2019","journal-title":"BioFactors"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.transproceed.2019.04.039","article-title":"Allicin attenuates myocardial ischemia reperfusion injury in rats by inhibition of inflammation and oxidative stress","volume":"51","author":"Liu","year":"2019","journal-title":"Transpl. Proc."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"111521","DOI":"10.1016\/j.fct.2020.111521","article-title":"Crocin: A fighter against inflammation and pain","volume":"143","author":"Hashemzaei","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_175","first-page":"20","article-title":"The Essence of Indian Indigenous Knowledge in the Perspective of Ayurveda, Nutrition, and Yoga","volume":"7","author":"Banerjee","year":"2020","journal-title":"Res. Rev. Biotechnol. Bioscis. (RRBB)"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/B978-0-12-819489-8.00013-2","article-title":"Chapter 6\u2014The structure-activity relationship of marine products for neuroinflammatory disorders","volume":"Volume 70","author":"Attaur","year":"2021","journal-title":"Studies in Natural Products Chemistry"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1016\/j.ijcard.2013.07.073","article-title":"Docosahexaenoic acid inhibits development of hypoxic pulmonary hypertension: In vitro and in vivo studies","volume":"168","author":"Yan","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/an.111.000893","article-title":"Omega-3 fatty acids EPA and DHA: Health benefits throughout life","volume":"3","author":"Swanson","year":"2012","journal-title":"Adv. Nutr."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"S587","DOI":"10.3945\/jn.111.148080","article-title":"The Omega-3 Fatty Acid Nutritional Landscape: Health Benefits and Sources","volume":"142","author":"Deckelbaum","year":"2012","journal-title":"J. Nutr."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.3390\/md10112535","article-title":"Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids","volume":"10","author":"Russell","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.plefa.2010.02.020","article-title":"N-3 vs. saturated fatty acids: Effects on the arterial wall","volume":"82","author":"Sudheendran","year":"2010","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_182","first-page":"S22","article-title":"Abstract 15404: Eicosapentaenoic Acid Ameliorates Pulmonary Hypertension via G Protein-Coupled Receptor 120 Pathway in Rats","volume":"128","author":"Ishii","year":"2013","journal-title":"Circulation"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/13880200490893483","article-title":"Flavonoids and cardiovascular disease","volume":"42","author":"Gross","year":"2004","journal-title":"Pharm. Biol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/21551197.2012.698219","article-title":"Flavonoid basics: Chemistry, sources, mechanisms of action, and safety","volume":"31","author":"Corcoran","year":"2012","journal-title":"J. Nutr. Gerontol. Geriatr."},{"key":"ref_185","first-page":"25","article-title":"Flavonoid properties of five families newly incorporated into the order Caryophyllales","volume":"39","author":"Iwashina","year":"2013","journal-title":"Bull. Natl. Mus. Nat. Sci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"6713194","DOI":"10.1155\/2019\/6713194","article-title":"The bioprotective effects of polyphenols on metabolic syndrome against oxidative stress: Evidences and perspectives","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.yclnex.2015.09.001","article-title":"The value of flavonoids for the human nutrition: Short review and perspectives","volume":"3","author":"Hoensch","year":"2015","journal-title":"Clin. Nutr. Exp."},{"key":"ref_188","first-page":"344","article-title":"Antioxidant Effects of Combined Vitamins C and E in Acute Myocardial Infarction. The Randomized, Double-Blind, Placebo Controlled, Multicenter Pilot Myocardial Infarction and Vitamins (MIVIT) Trial","volume":"62","author":"Bednarz","year":"2005","journal-title":"Kardiol. Pol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1179\/1351000215Y.0000000018","article-title":"Amelioration of Persistent Left Ventricular Function Impairment through Increased Plasma Ascorbate Levels Following Myocardial Infarction","volume":"21","author":"Valls","year":"2016","journal-title":"Redox Rep."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/039463200501800308","article-title":"Antioxidant Vitamins Reduce Oxidative Stress and Ventricular Remodeling in Patients with Acute Myocardial Infarction","volume":"18","author":"Gasparetto","year":"2005","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/annonc\/mdp286","article-title":"Effects of antioxidant supplements on cancer prevention: Meta-analysis of randomized controlled trials","volume":"21","author":"Myung","year":"2010","journal-title":"Ann. Oncol."},{"key":"ref_192","first-page":"1318","article-title":"Trime tazidine combined with berberine on endothelial function of patients with coronary heart disease combined with primary hypertension","volume":"16","author":"Zhang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Shaito, A., Phu, D.T.B.T.H.T., Nguyen, T.H.D., Hasan, H., Halabi, S., Abdelhady, S., Nasrallah, G.K., Eid, A.H., and Pintus, G. (2020). Herbal medicine for Cardiovascular Diseases: Efficacy, Mechanisms and safety. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00422"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Trindade, L.R., da Silva, D.V.T., Bai\u00e3o, D.d.S., and Paschoalin, V.M.F. (2021). Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases. Molecules, 26.","DOI":"10.3390\/molecules26154621"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Chen, L., Dai, L., Xu, J., Duan, L., Hou, X., Zhang, L., Song, L., Zhao, F., and Jiang, Y. (2024). Chinese herbal compound preparation Qing-Xin-Jie-Yu granules for intermediate coronary lesions in patients with stable coronary artery disease: Study protocol for a multicenter, randomized, double-blind, placebo-controlled trial. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0307074"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1038\/s41401-021-00835-w","article-title":"Therapeutic potential of colchicine in cardiovascular medicine: A pharmacological review","volume":"43","author":"Zhang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Ghani, M.A.A., Ugusman, A., Latip, J., and Zainalabidin, S. (2023). Role of Terpenophenolics in Modulating Inflammation and Apoptosis in Cardiovascular Diseases: A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065339"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1021\/acs.analchem.7b04833","article-title":"Microfluidic coculture device for monitoring of inflammation-induced myocardial injury dynamics Anal. Chem","volume":"90","author":"Ai","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12980\/APJTB.4.2014C980","article-title":"Nanotechnology: An effective tool for enhancing bioavailability and bioactivity of phytomedicine","volume":"4","author":"Gunasekaran","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/eurheartj\/ehu203","article-title":"Anti-inflammatory therapies for cardiovascular disease","volume":"35","author":"Ridker","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Quek, J., Lim, G., Lim, W.H., Ng, C.H., So, W.Z., Toh, J., Pan, X.H., Chin, Y.H., Muthiah, M.D., and Chan, S.P. (2021). The Association of Plant-Based Diet with Cardiovascular Disease and Mortality: A Meta-Analysis and Systematic Review of Prospect Cohort Studies. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.756810"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"152474","DOI":"10.1155\/2011\/152474","article-title":"Liposomal Antioxidants for Protection against Oxidant-Induced Damage","volume":"2011","author":"Suntres","year":"2011","journal-title":"J. Toxicol."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/11\/955\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:11:15Z","timestamp":1763701875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/11\/955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":202,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["cimb47110955"],"URL":"https:\/\/doi.org\/10.3390\/cimb47110955","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]}}}