{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:05:05Z","timestamp":1787763905513,"version":"build-2784847793"},"reference-count":56,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at Misr University for Science and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and Huntington\u2019s disease (HD) are major neurodegenerative disorders that share certain pathological features but differ in their genetic etiology and clinical presentation. Their potential molecular intersections remain incompletely understood. In this research, we conducted a comparative transcriptomic analysis using postmortem brain RNA-seq datasets from AD (GSE53697), PD (GSE68719), and HD (GSE64810) to identify shared and disease-specific transcriptional signatures. Differentially expressed genes (DEGs) were determined and functionally characterized through Gene Ontology (GO) enrichment. Protein\u2013protein interaction (PPI) networks were generated using STRING and visualized in Cytoscape to identify central hub genes, followed by gene\u2013disease and drug-interaction analyses to assess functional and therapeutic relevance. Ten DEGs were found to overlap among the three disorders, exhibiting variable directions of regulation across diseases. Enrichment analysis indicated convergence on immune- and inflammation-related biological processes. Key hub genes, including MMP9, LCN2, CXCL2, CCL2, S100A8, and S100A9, were identified as central nodes within the PPI network. Although the overlap in DEGs was limited, the findings suggest that neuroinflammatory signaling represents a shared molecular theme across AD, PD, and HD, warranting further validation in independent cohorts.<\/jats:p>","DOI":"10.3390\/cimb47120976","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:31:34Z","timestamp":1764091894000},"page":"976","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Multi-Omics Analysis Identifies Shared Transcriptomic Signatures and Therapeutic Targets in Alzheimer\u2019s, Parkinson\u2019s, and Huntington\u2019s Diseases"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1256-1614","authenticated-orcid":false,"given":"Luai Ibrahim","family":"Alharbi","sequence":"first","affiliation":[{"name":"Department of Science and Artificial Intelligence, Faculty of Information Technology, Monash University, Clayton, VIC 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-1169","authenticated-orcid":false,"given":"Elsayed","family":"Badr","sequence":"additional","affiliation":[{"name":"Department of Information Systems, College of Information Technology, Misr University for Science and Technology (MUST), Giza P.O. Box 77, Egypt"},{"name":"Department of Scientific Computing, Faculty of Computer and Artificial Intelligence, Benha University, Benha 13518, Egypt"},{"name":"The Egyptian School of Data Science (ESDS), Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7245-6260","authenticated-orcid":false,"given":"Abdallah","family":"Donia","sequence":"additional","affiliation":[{"name":"Department of Scientific Computing, Faculty of Computer and Artificial Intelligence, Benha University, Benha 13518, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3729-2778","authenticated-orcid":false,"given":"Eman","family":"Monir","sequence":"additional","affiliation":[{"name":"Department of Scientific Computing, Faculty of Computer and Artificial Intelligence, Benha University, Benha 13518, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association (2019). 2019 Alzheimer\u2019s disease facts and figures. 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