{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:03:49Z","timestamp":1792008229068,"version":"4.4.0"},"reference-count":116,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Cutaneous T-cell lymphoma (CTCL) is a heterogeneous malignancy characterized by the proliferation of skin-homing CD4+ T cells and profound immune dysregulation within the tumor microenvironment (TME). This review synthesizes evidence on chemokine\u2013receptor networks that govern malignant T-cell trafficking among blood, skin, and lymph nodes, the formation of immunosuppressive niches, and clinically actionable biomarker candidates. Among the best-supported axes, CCL17\/CCL22\u2013CCR4 and CCL27\/CCL28\u2013CCR10 mediate skin tropism, CCL19\/CCL21\u2013CCR7 contributes to lymph node homing, and CXCL12\u2013CXCR4 supports skin trafficking and is associated with disease progression. In contrast, CCR2\/CCR5\/CCR6\/CCR8-centered circuits and CXCR3\/CXCR5 pathways are emerging regulators of myeloid recruitment, regulatory T-cell accumulation, and context-dependent immune activation. Therapeutically, agents targeting chemokine pathways, most notably the CCR4 monoclonal antibody Mogamulizumab, have demonstrated clinical efficacy, while emerging inhibitors of CCR6, CCR5, and CXCR4 offer promising avenues for intervention. We further highlight how recent single-cell and other high-dimensional omics studies refine cell-type\u2013specific chemokine sources and receptor expression, enabling more precise mapping of chemokine-driven intercellular communication programs in CTCL TME remodeling and better prioritization of therapeutic targets and biomarkers.<\/jats:p>","DOI":"10.3390\/cimb48010079","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:17:32Z","timestamp":1768292252000},"page":"79","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chemokine Networks in Cutaneous T Cell Lymphoma: Tumor Microenvironment Remodeling and Therapeutic Targets"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7467-0483","authenticated-orcid":false,"given":"Zihao","family":"Yu","sequence":"first","affiliation":[{"name":"College of Life Sciences, Northwest University, Xi\u2019an 710127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Air Force Medical University, Air Force Medical Center, PLA, Beijing 100142, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Quan","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Northwest University, Xi\u2019an 710127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8844-3392","authenticated-orcid":false,"given":"Weijian","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Northwest University, Xi\u2019an 710127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Air Force Medical University, Air Force Medical Center, PLA, Beijing 100142, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-5609","authenticated-orcid":false,"given":"Xin","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Northwest University, Xi\u2019an 710127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ajh.26760","article-title":"Cutaneous T-Cell Lymphomas: 2023 Update on Diagnosis, Risk-Stratification, and Management","volume":"98","author":"Hristov","year":"2023","journal-title":"Am. 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