{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:25:58Z","timestamp":1792027558601,"version":"4.4.0"},"reference-count":50,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405522"],"award-info":[{"award-number":["82405522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Shaanxi Provincial Department of Science and Technology","award":["2023-JC-QN-0963"],"award-info":[{"award-number":["2023-JC-QN-0963"]}]},{"name":"Natural Science Foundation of Shaanxi Provincial Department of Science and Technology","award":["2025JC-YBQN-1124"],"award-info":[{"award-number":["2025JC-YBQN-1124"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["202410716019"],"award-info":[{"award-number":["202410716019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Cellular senescence, characterized by permanent cell cycle arrest, significantly influences cancer development, immune regulation, and progression. However, the precise mechanisms by which senescence contributes to colorectal cancer prognosis remain to be fully elucidated. By integrating expression profiles of senescence-related and prognostic genes in colon adenocarcinoma (COAD) patients, we formulated and confirmed a nine-gene cellular senescence-related signature (CSRS) that integrates senescence-associated and prognosis-predictive genes using data from the CellAge, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). A cell senescence-related prognostic formula was developed as follows: CSRS = (CASP2 \u00d7 0.2098) + (CDKN2A \u00d7 0.1196) + (FOXD1 \u00d7 0.1472) + (ING5 \u00d7 0.3723) + (OXTR \u00d7 0.0786) + (PHGDH \u00d7 0.1408) + (SERPINE1 \u00d7 0.1127) + (SNAI1 \u00d7 0.1034) + (LIMK1 \u00d7 0.0747). In a multivariate Cox proportional hazards model, the CSRS score, age and TNM stage were all identified as significant independent indicators for overall survival, affirming their prognostic value in colorectal cancer. The CSRS-high group exhibited significantly up-regulated senescence-associated secretory phenotype (SASP) and immune cell infiltration, whereas the CSRS-low group showed an apparent better response to immune-checkpoint inhibitor therapy. Our findings suggest CSRS score and its constituent genes represent potential biomarkers for prognosis and immunotherapeutic benefit in COAD patients. Extending this nine-gene set into a broader senescence-associated panel should be a next step toward delivering truly individualized treatment plans.<\/jats:p>","DOI":"10.3390\/cimb48010114","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:11:17Z","timestamp":1768993877000},"page":"114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Senescence-SASP Landscape in Colon Adenocarcinoma: Prognostic and Therapeutic Implications"],"prefix":"10.3390","volume":"48","author":[{"given":"Tianyu","family":"Ren","sequence":"first","affiliation":[{"name":"Faulty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyouwei","family":"Gao","sequence":"additional","affiliation":[{"name":"Faulty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangrong","family":"Feng","sequence":"additional","affiliation":[{"name":"Faulty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Xu","sequence":"additional","affiliation":[{"name":"Faulty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Mi","sequence":"additional","affiliation":[{"name":"Faulty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jite","family":"Shi","sequence":"additional","affiliation":[{"name":"Faulty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-7550","authenticated-orcid":false,"given":"Man","family":"Chu","sequence":"additional","affiliation":[{"name":"Faulty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0140-6736(25)01635-6","article-title":"The global, regional, and national burden of cancer, 1990\u20132023, with forecasts to 2050: A systematic analysis for the Global Burden of Disease Study 2023","volume":"406","author":"Force","year":"2025","journal-title":"Lancet"},{"key":"ref_2","unstructured":"National Cancer Institute. 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