{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:24:13Z","timestamp":1780669453258,"version":"3.54.1"},"reference-count":68,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-112-219"],"award-info":[{"award-number":["DMR-112-219"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-114-074"],"award-info":[{"award-number":["DMR-114-074"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technology Council","award":["114-2314-B-039-052"],"award-info":[{"award-number":["114-2314-B-039-052"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["CIMB"],"abstract":"<jats:p>Non-traumatic osteonecrosis of the femoral head (ONFH) is a multifactorial disorder in which genetic susceptibility is thought to play an important role, yet the contribution of many candidate genes remains unclear. The catenin beta-1 (CTNNB1) gene encodes \u03b2-catenin, a key regulator of the Wnt\/\u03b2-catenin signaling pathway involved in bone homeostasis and vascular regulation, and may therefore influence susceptibility to non-traumatic ONFH. In this case\u2013control study, genotype data from China Medical University Hospital were analyzed to evaluate the association between CTNNB1 polymorphisms and the risk of ONFH. A total of 609 patients with ONFH and 2436 age- and sex-matched controls were included. Fourteen CTNNB1 single-nucleotide polymorphisms (SNPs) with a minor allele frequency greater than 5% were selected and analyzed using logistic regression under multiple genetic models, with Hardy\u2013Weinberg equilibrium assessed in controls. Two SNPs, rs3774370 and rs11564478, showed significant differences in allele frequencies between cases and controls, with lower minor allele frequencies observed in the ONFH group. Both variants were associated with a reduced risk of ONFH, and these associations remained significant under dominant genetic models. These findings suggest that specific CTNNB1 polymorphisms may confer a protective effect against non-traumatic ONFH and provide further insight into the genetic architecture of this disease.<\/jats:p>","DOI":"10.3390\/cimb48020164","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:48:08Z","timestamp":1770025688000},"page":"164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Catenin Beta-1 (CTNNB1) Gene Polymorphisms and Non-Traumatic Osteonecrosis of the Femoral Head (ONFH)"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8335-1617","authenticated-orcid":false,"given":"I-Chang","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Education, China Medical University Hospital, Taichung 404327, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9920-712X","authenticated-orcid":false,"given":"De-Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Education, China Medical University Hospital, Taichung 404327, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1755-7634","authenticated-orcid":false,"given":"Shih-Chan","family":"Hsu","sequence":"additional","affiliation":[{"name":"School of Medicine, China Medical University, Taichung 404328, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2992-4608","authenticated-orcid":false,"given":"Shu-Jui","family":"Kuo","sequence":"additional","affiliation":[{"name":"School of Medicine, China Medical University, Taichung 404328, Taiwan"},{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung 404327, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1097\/JS9.0000000000001836","article-title":"Extracorporeal shock wave therapy with imaging examination for early osteonecrosis of the femoral head: A systematic review","volume":"111","author":"Tan","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1097\/JS9.0000000000002094","article-title":"Advances in mechanism and management of bone homeostasis in osteonecrosis: A review article from basic to clinical applications","volume":"111","author":"Xiang","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1097\/JS9.0000000000001625","article-title":"Core decompression combined with bone marrow mononuclear cells in the treatment of femoral head necrosis: A systematic review and meta-analysis","volume":"110","author":"Zhu","year":"2024","journal-title":"Int. J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1097\/JS9.0000000000001327","article-title":"Complex causal association between genetically predicted 731 immunocyte phenotype and osteonecrosis: A bidirectional two-sample Mendelian randomization analysis","volume":"110","author":"Li","year":"2024","journal-title":"Int. J. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1097\/JS9.0000000000001028","article-title":"Core decompression combined with platelet-rich plasma-augmented bone grafting for femur head necrosis: A systematic review and meta-analysis","volume":"110","author":"Zhu","year":"2024","journal-title":"Int. J. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s10020-024-00933-5","article-title":"SOST\/Sclerostin impairs the osteogenesis and angiogesis in glucocorticoid-associated osteonecrosis of femoral head","volume":"30","author":"Huang","year":"2024","journal-title":"Mol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s10020-024-00880-1","article-title":"Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head","volume":"30","author":"Yuan","year":"2024","journal-title":"Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Shao, W., Wang, P., Lv, X., Wang, B., Gong, S., and Feng, Y. (2024). Unraveling the Role of Endothelial Dysfunction in Osteonecrosis of the Femoral Head: A Pathway to New Therapies. Biomedicines, 12.","DOI":"10.3390\/biomedicines12030664"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2106\/JBJS.19.01271","article-title":"Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today? A 5-Year Update","volume":"102","author":"Mont","year":"2020","journal-title":"J. Bone Jt. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s43465-021-00583-3","article-title":"Association of Specific Genetic Polymorphisms with Atraumatic Osteonecrosis of the Femoral Head: A Narrative Review","volume":"56","author":"Kumar","year":"2022","journal-title":"Indian J. Orthop."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1097\/JS9.0000000000001557","article-title":"Epidemiological investigation of sex hormones and their metabolism-related gene single nucleotide polymorphisms in patients with benign prostatic hyperplasia complicated with late-onset hypogonadism: A retrospective cohort study","volume":"110","author":"Li","year":"2024","journal-title":"Int. J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s10020-025-01159-9","article-title":"Novel genetic determinants contribute to hearing loss in a central European cohort with enlarged vestibular aqueduct","volume":"31","author":"Bernardinelli","year":"2025","journal-title":"Mol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Saddeek, S. (2026). Exploration and Preliminary Investigation of Wiled Tinospora crispa: A Medicinal Plant with Promising Anti-Inflammatory and Antioxidant Properties. Curr. Issues Mol. Biol., 48.","DOI":"10.3390\/cimb48010070"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Szpecht, D., Abu-Amara, K., Kurzawinska, G., and Seremak-Mrozikiewicz, A. (2026). Analysis of the Role of Gene Variants in Matrix Metalloproteinases and Their Tissue Inhibitors in Bronchopulmonary Dysplasia (BPD): A Study in the Polish Population. Curr. Issues Mol. Biol., 48.","DOI":"10.3390\/cimb48010025"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sakuraba, S., Noguchi, A., Arai, H., Sasaki, A., Haga, M., Iwatani, A., Nishimura, E., Nagano, N., Suga, S., and Araki, S. (2026). Association of Bach1 Gene Polymorphisms with Susceptibility to Bronchopulmonary Dysplasia in Preterm Infants. Biomedicines, 14.","DOI":"10.3390\/biomedicines14010017"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Seipel, K., Mena, A., Horum, P., Hoffmann, M., Shaforostova, I., Bacher, U., and Pabst, T. (2026). Elevated Allele Frequency and Male-Predominance of a Common LAG3 Germline Variant in Multiple Myeloma. Curr. Issues Mol. Biol., 48.","DOI":"10.3390\/cimb48010005"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Varajti, K., Vereczkei, A., Kov\u00e1cs-Valasek, M., Zand, A., Varjas, T., and Kiss, I. (2025). An Exploratory Analysis of Tumor Site- and Sex-Specific Associations of SNPs of LncRNA CCAT1, CCAT2, H19, HOTAIR, and PTCSC3 in Colorectal Lesions: A Hungarian Case\u2013Control Study. Biomedicines, 13.","DOI":"10.3390\/biomedicines13123058"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lenort, M., Tomkowiak, A., Bocianowski, J., Bobrowska, R., Kurasiak-Popowska, D., Miko\u0142ajczyk, S., Kosiada, T., Weigt, D., and Gawrysiak, P. (2025). Using Genome-Wide Association Studies to Reveal DArTseq and SNP Loci Associated with Agronomic Traits and Yield in Maize. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47121008"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Yang, H.-H., Baldauf, C., Pickering, T.A., Gjessing, H.K., Ingles, S.A., and Wilson, M.L. (2025). Maternal and Fetal SERPINA3 Polymorphisms and Risk of Preeclampsia: A Dyad and Triad Based Case-Control Study. Curr. Issues Mol. Biol., 47.","DOI":"10.20944\/preprints202509.1485.v1"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Manzoor, S., Majeed, A., Waheed, P., and Rashid, A. (2025). Identification and Association of CYP2R1, CYP27B1, and GC Gene Polymorphisms with Vitamin D Deficiency in Apparently Healthy Population and in Silico Analysis of the Binding Pocket of Vitamin D3. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47100849"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tsedendorj, Y., Daramjav, D., Enkhbat, Y., Dondov, G., Dashjamts, G., Khayankhyarvaa, E., Ganzorig, A.-E., Ulziitsogt, B., Badamjav, T., and Batsaikhan, B. (2025). Genetic Risk of MASLD in Mongolians: Role of PNPLA3 and FTO SNPs. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47080605"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ayaz, I., Choudhry, N., Ihsan, A., Zubair, T., Gondal, A.J., and Yasmin, N. (2025). Association of Nrf2 Single Nucleotide Polymorphism rs35652124 and FABP4 Levels with Peripheral Artery Disease Among Type 2 Diabetes Mellitus Pakistani Population. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47070530"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"\u017bebrowska-Nawrocka, M., \u015awiechowski, R., Szmajda-Krygier, D., Lenda, B., Mirowski, M., Czaplij, M., Balcerczak, M., and Balcerczak, E. (2025). In Silico and Wet Analysis of BAX Gene G-248A Polymorphism and mRNA Expression in Peptic Ulcer Disease and Gastric Cancer. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47121005"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Radouani, F., Deligny, C., Cesaire, R., Dueymes, M., and Dos Santos, G. (2025). FCGR2A-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean Population. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47070490"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"12772","DOI":"10.3390\/cimb46110760","article-title":"The Pre-\/Post-Transplant Hepatitis C Antibody Associated with the IL-28B RS8099917 TT Genotype and miRNA-122 Expression May Protect Acute Cellular Rejection After LDLT","volume":"46","author":"Chiu","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12694","DOI":"10.3390\/cimb46110753","article-title":"Correlation of Eight (8) Polymorphisms and Their Genotypes with the Risk Factors of Cardiovascular Disease in a Black Elderly Population","volume":"46","author":"Chalwe","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.3390\/cimb46070414","article-title":"ADRB2 and ADCY9 Sequence Variations in Brazilian Asthmatic Patients","volume":"46","author":"Silva","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.3390\/cimb46040217","article-title":"Frequency of Gene Polymorphisms in Admixed Venezuelan Women with Recurrent Pregnancy Loss: Microsomal Epoxy Hydroxylase (rs1051740) and Enos (rs1799983)","volume":"46","author":"Garmendia","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.3390\/cimb46040176","article-title":"Genetic Variant of DNAM-1 rs763361 C>T Is Associated with Ankylosing Spondylitis in a Mexican Population","volume":"46","author":"Haramati","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Li, Q., Long, Y., Qin, Y., Zhang, L., Zeng, R., Luo, D., Li, Y., Chen, J., Zhu, Y., and Feng, J. (2025). Early-life tobacco exposure, genetic susceptibility and multiple digestive diseases: Evidence from two large cohorts and genetic analyses. Int. J. Surg.","DOI":"10.1097\/JS9.0000000000003967"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9250","DOI":"10.1097\/JS9.0000000000003087","article-title":"Lifestyle, genetic susceptibility, and risk of diverticular disease: A prospective cohort study","volume":"111","author":"Guo","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Xiao, J., Liu, M., Zhou, M., Deng, G., Yang, Q., and Li, Q. (2026). The causal effects of dementia on systemic sclerosis: A two-sample bidirectional Mendelian randomization study. Int. J. Surg.","DOI":"10.1097\/JS9.0000000000004881"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Shi, H., Ma, H., Li, Q., Ma, J., Peng, X., Yang, D., Song, Z., and Gu, Y. (2026). Genetic correlations among diaphragmatic, femoral, inguinal, ventral, and umbilical hernias and identification of their candidate genes. Int. J. Surg.","DOI":"10.1097\/JS9.0000000000004699"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9012","DOI":"10.1097\/JS9.0000000000003283","article-title":"Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma","volume":"111","author":"Zhang","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1097\/JS9.0000000000002869","article-title":"Genetic insights into lipid traits and atherosclerosis risk: A Mendelian randomization and polygenic risk score analysis","volume":"111","author":"Zhang","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhang, W., Zhong, M.-E., Li, C., Ren, Y., Zhang, Y., Kuang, Y., Du, Z., He, X., Wang, Y., and Jiang, J. (2025). Ganglion cell-inner plexiform layer thinning and colorectal cancer risk: Phenotypic and genetic evidence for shared pathways. Int. J. Surg.","DOI":"10.1097\/JS9.0000000000003913"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1097\/JS9.0000000000002491","article-title":"Sleep patterns, genetic susceptibility, and osteoarthritis risk: Insights from the UK Biobank and external validation in the Xiangya Osteoarthritis Study","volume":"111","author":"Sha","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/JS9.0000000000002039","article-title":"Unraveling the genetic susceptibility of irritable bowel syndrome: Integrative genome-wide analyses in 845,492 individuals: A diagnostic study","volume":"111","author":"Huang","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9219","DOI":"10.1097\/JS9.0000000000002898","article-title":"Combination of biological aging and genetic risk helps identify at-risk population of thoracic aortic aneurysms: Insight from a prospective cohort study of UK Biobank","volume":"111","author":"Xu","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/JS9.0000000000001966","article-title":"Associations of biological age accelerations and genetic risk with incident endometrial cancer: A prospective analysis in UK Biobank","volume":"111","author":"Yang","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1097\/JS9.0000000000002552","article-title":"Association of cross-life-cycle body size and genetic risk with cardio-renal-metabolic conditions in adulthood: Evidence from a prospective cohort study","volume":"111","author":"Yu","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1097\/JS9.0000000000001795","article-title":"Association of triglyceride glucose index with stroke: From two large cohort studies and Mendelian randomization analysis","volume":"110","author":"Jiang","year":"2024","journal-title":"Int. J. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1097\/JS9.0000000000002457","article-title":"The causal effects of primary biliary cholangitis on irritable bowel syndrome: A mendelian randomization study","volume":"111","author":"Niu","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1097\/JS9.0000000000001514","article-title":"Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials","volume":"110","author":"Sun","year":"2024","journal-title":"Int. J. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/JS9.0000000000003523","article-title":"Potential regulators and metabolic networks of muscle fatty infiltration: Genomic and radiomics investigation based on 33 300 participants","volume":"112","author":"Tan","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.2147\/IJGM.S316481","article-title":"RAB40C Gene Polymorphisms Were Associated with Alcohol-Induced Osteonecrosis of the Femoral Head","volume":"14","author":"Liu","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1080\/21691401.2019.1593995","article-title":"Association between NOS3 polymorphisms and osteonecrosis of the femoral head","volume":"47","author":"Zhao","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_48","first-page":"797","article-title":"PFKP and GPC6 Variants Were Correlated with Alcohol-Induced Femoral Head Necrosis Risk in the Chinese Han Population","volume":"15","author":"Liu","year":"2022","journal-title":"Pharmacogenomics Pers. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00264-018-4172-8","article-title":"Osteonecrosis of the femoral head: Genetic basis","volume":"43","author":"Wang","year":"2019","journal-title":"Int. Orthop."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Wang, R., Li, R., and Liu, R. (2022). An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development. BMC Med. Genom., 15.","DOI":"10.1186\/s12920-021-01142-3"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00439-019-02034-4","article-title":"Missing heritability of complex diseases: Case solved?","volume":"139","author":"Genin","year":"2020","journal-title":"Hum. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Li, Z., Li, H., Qiao, W., Yu, S., Fan, B., Yang, M., Zhou, L., Qiu, F., Wu, Z., and Wang, J. (2025). Multi-omics dissection of high TWAS-active endothelial pathogenesis in pulmonary arterial hypertension: Bridging single-cell heterogeneity, machine learning-driven biomarkers, and developmental reprogramming. Int. J. Surg.","DOI":"10.1097\/JS9.0000000000003601"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zhao, D., Jiao, Y., Li, R.-H., Xu, H.-Y., Wang, L., Liu, Y.-H., and Liu, B. (2025). The causal effects of COVID-19 on chronic pancreatitis: A mendelian randomization study-quality improvement study. Int. J. Surg.","DOI":"10.1097\/JS9.0000000000003866"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chen, Q., Zhang, L., Shou, W., Sun, S., Fang, J., and Guo, Y. (2025). Potential neutrophil activation-related pathogenic genes in venous thromboembolism: A multi-omics mendelian randomization study. Int. J. Surg.","DOI":"10.1097\/JS9.0000000000004473"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"15035","DOI":"10.1038\/s41598-017-14778-y","article-title":"Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head","volume":"7","author":"Sakamoto","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"bbac019","DOI":"10.1093\/bib\/bbac019","article-title":"Evaluation of phenotype-driven gene prioritization methods for Mendelian diseases","volume":"23","author":"Yuan","year":"2022","journal-title":"Brief. Bioinform."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/GIM.0b013e31819995ca","article-title":"Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes","volume":"11","author":"Sookoian","year":"2009","journal-title":"Genet. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1534\/g3.118.200082","article-title":"Functional Validation of Candidate Genes Detected by Genomic Feature Models","volume":"8","author":"Rohde","year":"2018","journal-title":"G3"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1038\/s41598-017-12196-8","article-title":"Excessive Activation of TLR4\/NF-kappaB Interactively Suppresses the Canonical Wnt\/beta-catenin Pathway and Induces SANFH in SD Rats","volume":"7","author":"Pei","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Huang, J., Zhou, Y., Xiao, W., Deng, P., Wei, Q., and Lu, W. (2022). Serum beta-catenin changes vary among different stages of osteonecrosis of the femoral head: An exploratory biomarker study. BMC Musculoskelet. Disord., 23.","DOI":"10.1186\/s12891-022-05399-2"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"108746","DOI":"10.1016\/j.biopha.2019.108746","article-title":"Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt\/beta-catenin signaling pathway","volume":"112","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"BSR20171121","DOI":"10.1042\/BSR20171121","article-title":"Comprehensive assessment and meta-analysis of the association between CTNNB1 polymorphisms and cancer risk","volume":"37","author":"Li","year":"2017","journal-title":"Biosci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41525-021-00178-9","article-title":"Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese","volume":"6","author":"Wei","year":"2021","journal-title":"npj Genom. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"100197","DOI":"10.1016\/j.xgen.2022.100197","article-title":"Taiwan Biobank: A rich biomedical research database of the Taiwanese population","volume":"2","author":"Feng","year":"2022","journal-title":"Cell Genom."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrg3051","article-title":"Understanding the contribution of synonymous mutations to human disease","volume":"12","author":"Sauna","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1111\/jcmm.15103","article-title":"Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol-induced osteonecrosis of the femoral head","volume":"24","author":"Yu","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s12020-015-0747-y","article-title":"Lithium prevents rat steroid-related osteonecrosis of the femoral head by beta-catenin activation","volume":"52","author":"Yu","year":"2016","journal-title":"Endocrine"}],"updated-by":[{"DOI":"10.3390\/cimb48050504","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000}}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/2\/164\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:49:36Z","timestamp":1778748576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/2\/164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":68,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["cimb48020164"],"URL":"https:\/\/doi.org\/10.3390\/cimb48020164","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]}}}