{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:05:42Z","timestamp":1788231942871,"version":"build-2803163510"},"reference-count":72,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Coordination Unit of Karadeniz Technical University","award":["THD-2024-15929"],"award-info":[{"award-number":["THD-2024-15929"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Cisplatin-induced ovarian damage is a significant concern for young women receiving chemotherapy. Although propolis, a polyphenol- and flavonoid-rich natural product, has been proposed as a protective agent, its effects on cisplatin-related ovarian injury remain insufficiently defined. This study aimed to investigate whether propolis mitigates cisplatin-induced ovarian toxicity. In this study, 36 adult female Wistar rats were randomly allocated into six groups: Control, Propolis (50 mg\/kg), Propolis (100 mg\/kg), Cisplatin (7 mg\/kg), Cisplatin + Propolis (50 mg\/kg), and Cisplatin + Propolis (100 mg\/kg). Cisplatin was administered as a single intraperitoneal dose on day 1, while propolis was given orally by gavage once daily for 14 days. Biochemical, histopathological, and endoplasmic reticulum (ER)-stress-related parameters were evaluated. Histopathologically, cisplatin caused significant vascular congestion, hemorrhage, edema, and follicular degeneration (p &lt; 0.01), accompanied by marked reductions in primordial, primary, secondary, and tertiary follicle counts and a significant increase in atretic follicles. Propolis co-administration significantly ameliorated these lesions and partially preserved follicular counts, particularly at the 100 mg\/kg dose (p &lt; 0.01). Cisplatin markedly increased malondialdehyde (MDA) levels and ER stress markers (GRP78, ATF6, and CHOP), while reducing glutathione (GSH). Propolis treatment ameliorated these changes, decreased TNF-\u03b1 and caspase-3 levels, and attenuated oxidative, inflammatory, and apoptotic responses. Propolis exerts strong antioxidant, anti-inflammatory, anti-apoptotic, and ER-stress-modulating effects that collectively counteract cisplatin-induced ovarian injury.<\/jats:p>","DOI":"10.3390\/cimb48020212","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:11:28Z","timestamp":1771240288000},"page":"212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Propolis Attenuates Cisplatin-Induced Ovarian Injury by Modulating Oxidative Stress, Inflammation, Apoptosis, and GRP78\/ATF6\/CHOP Pathway"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2480-1374","authenticated-orcid":false,"given":"Bakiye","family":"Akba\u015f","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7261-7067","authenticated-orcid":false,"given":"\u015eeyda","family":"Kanbolat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-5616","authenticated-orcid":false,"given":"Merve","family":"Badem","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0436-682X","authenticated-orcid":false,"given":"Oktay","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa \u00d6zg\u00fcr","family":"Yalman","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-4394","authenticated-orcid":false,"given":"Engin","family":"Yenilmez","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0143-8795","authenticated-orcid":false,"given":"Rezzan","family":"Aliyaz\u0131c\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"ref_2","first-page":"443","article-title":"Cancer statistics for adolescents and young adults, 2020","volume":"70","author":"Miller","year":"2020","journal-title":"CA A Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e000049","DOI":"10.1136\/bmjonc-2023-000049","article-title":"Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019","volume":"2","author":"Zhao","year":"2023","journal-title":"BMJ Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: Molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mariconda, A., Ceramella, J., Catalano, A., Saturnino, C., Sinicropi, M.S., and Longo, P. (2025). Cisplatin, the Timeless Molecule. Inorganics, 13.","DOI":"10.3390\/inorganics13070246"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chang, E.M., Lim, E., Yoon, S., Jeong, K., Bae, S., Lee, D.R., Yoon, T.K., Choi, Y., and Lee, W.S. (2015). Cisplatin induces overactivation of the dormant primordial follicle through PTEN\/AKT\/FOXO3a pathway which leads to loss of ovarian reserve in mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144245"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Li, Z., Qi, H., Li, Z., Bao, Y., Yang, K., and Min, Q. (2023). Research progress on the premature ovarian failure caused by cisplatin therapy. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1276310"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1200\/JCO.22.01885","article-title":"Cancer treatment-related ovarian dysfunction in women of childbearing potential: Management and fertility preservation options","volume":"41","author":"Reynolds","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Aksu, E., and Erbas, O. (2025). Krill Oil Mitigates Cisplatin-Induced Ovarian Toxicity via Attenuation of Oxidative Stress and Inflammatory Pathways. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47090708"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12958-018-0404-4","article-title":"Alleviation of endoplasmic reticulum stress protects against cisplatin-induced ovarian damage","volume":"16","author":"Wu","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"127356","DOI":"10.1016\/j.jtemb.2023.127356","article-title":"Syringic acid alleviates cisplatin-induced ovarian injury through modulating endoplasmic reticulum stress, inflammation and Nrf2 pathway","volume":"82","author":"Demir","year":"2024","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. (GMS)"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Al-Shahat, A., Hulail, M.A.E., Soliman, N.M.M., Khamis, T., Fericean, L.M., Arisha, A.H., and Moawad, R.S. (2022). Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN\/PI3K\/Akt\/mTOR\/AMPK Signaling Pathway in Female Rats. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14122769"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"109402","DOI":"10.1016\/j.cbi.2021.109402","article-title":"Resveratrol protects against cisplatin-induced ovarian and uterine toxicity in female rats by attenuating oxidative stress, inflammation and apoptosis","volume":"338","author":"Ibrahim","year":"2021","journal-title":"Chem.-Biol. Interact."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"113995","DOI":"10.1016\/j.fct.2023.113995","article-title":"Fertility-enhancing effects of inositol & vitamin C on cisplatin induced ovarian and uterine toxicity in rats via suppressing oxidative stress and apoptosis","volume":"179","author":"Moslehi","year":"2023","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zulhendri, F., Lesmana, R., Tandean, S., Christoper, A., Chandrasekaran, K., Irsyam, I., Suwantika, A.A., Abdulah, R., and Wathoni, N. (2022). Recent update on the anti-inflammatory activities of propolis. Molecules, 27.","DOI":"10.3390\/molecules27238473"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Martinotti, S., Bonsignore, G., and Ranzato, E. (2025). Propolis: A natural substance with multifaceted properties and activities. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26041519"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1016\/j.fct.2010.06.049","article-title":"Propolis prevents aluminium-induced genetic and hepatic damages in rat liver","volume":"48","author":"Yousef","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.etp.2014.06.003","article-title":"The ameliorative effect of propolis against methoxychlor induced ovarian toxicity in rat","volume":"66","author":"Kames","year":"2014","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3233\/JAD-170630","article-title":"Brazilian Green Propolis Prevents Cognitive Decline into Mild Cognitive Impairment in Elderly People Living at High Altitude","volume":"63","author":"Zhu","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.biopha.2018.12.113","article-title":"The protective effect of propolis on rat ovary against ischemia-reperfusion injury: Immunohistochemical, biochemical and histopathological evaluations","volume":"111","author":"Koc","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12032-025-02888-x","article-title":"Anatolian propolis extracts enhance cisplatin efficacy in ovarian cancer through AKT\/mTOR pathway modulation and demonstrate antibacterial and antibiofilm activities","volume":"42","author":"Tekedereli","year":"2025","journal-title":"Med. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.redox.2017.11.023","article-title":"Cardioprotection of CAPE-oNO2 against myocardial ischemia\/reperfusion induced ROS generation via regulating the SIRT1\/eNOS\/NF-\u03baB pathway in vivo and in vitro","volume":"15","author":"Li","year":"2018","journal-title":"Redox Biol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"P\u00e9rez, R., Burgos, V., Mar\u00edn, V., Camins, A., Olloquequi, J., Gonz\u00e1lez-Chavarr\u00eda, I., Ulrich, H., Wyneken, U., Luarte, A., and Ortiz, L. (2023). Caffeic acid phenethyl ester (CAPE): Biosynthesis, derivatives and formulations with neuroprotective activities. Antioxidants, 12.","DOI":"10.3390\/antiox12081500"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cbi.2018.07.010","article-title":"Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4\/NF-\u03baB signaling in A549 cells","volume":"292","author":"Wu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Hamed, A.M., Ali, F.A.Z., Mohammed, A.E.M., Alrasheedi, M., Ragab, I., Aldoghaim, M., and Soliman, S.S. (2024). The ameliorative effect of chrysin on ovarian toxicity caused by methidathion in female rats. Front. Mol. Biosci., 11.","DOI":"10.3389\/fmolb.2024.1470711"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2008.03.049","article-title":"Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro","volume":"1216","author":"Liu","year":"2008","journal-title":"Brain Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2011.03.010","article-title":"Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats","volume":"1391","author":"Meng","year":"2011","journal-title":"Brain Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Aladaileh, S.H., Abukhalil, M.H., Saghir, S.A., Hanieh, H., Alfwuaires, M.A., Almaiman, A.A., Bin-Jumah, M., and Mahmoud, A.M. (2019). Galangin activates Nrf2 signaling and attenuates oxidative damage, inflammation, and apoptosis in a rat model of cyclophosphamide-induced hepatotoxicity. Biomolecules, 9.","DOI":"10.3390\/biom9080346"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"111410","DOI":"10.1016\/j.biopha.2021.111410","article-title":"Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats","volume":"138","author":"Abukhalil","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Al-Amarat, W., Abukhalil, M.H., Althunibat, O.Y., Alfwuaires, M.A., Alnamshan, M.M., Alqosaibi, A.I., Ahmeda, A.F., Kamel, E.M., Arab, H.H., and Mahmoud, A.M. (2021). Galangin attenuates liver injury, oxidative stress and inflammation, and upregulates Nrf2\/HO-1 signaling in streptozotocin-induced diabetic rats. Processes, 9.","DOI":"10.3390\/pr9091562"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5344\/ajev.1977.28.1.49","article-title":"Total phenol analysis: Automation and comparison with manual methods","volume":"28","author":"Slinkard","year":"1977","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.foodchem.2006.09.014","article-title":"Antioxidant power of Iranian propolis extract","volume":"103","author":"Mohammadzadeh","year":"2007","journal-title":"Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0076-6879(99)99005-5","article-title":"Ferric reducing\/antioxidant power assay: Direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration","volume":"299","author":"Benzie","year":"1999","journal-title":"Methods Enzymol."},{"key":"ref_34","first-page":"211","article-title":"The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity","volume":"26","author":"Molyneux","year":"2004","journal-title":"Songklanakarin J. Sci. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0074-7696(08)61524-7","article-title":"Development of follicles in the mammalian ovary","volume":"124","author":"Hirshfield","year":"1991","journal-title":"Int. Rev. Cytol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1530\/rep.1.00095","article-title":"Methods for quantifying follicular numbers within the mouse ovary","volume":"127","author":"Myers","year":"2004","journal-title":"Reproduction"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Klopfleisch, R. (2013). Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology\u2014A systematic review. BMC Vet. Res., 9.","DOI":"10.1186\/1746-6148-9-123"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.fertnstert.2008.10.053","article-title":"The effects of carbon dioxide pneumoperitoneum on ovarian blood flow, oxidative stress markers, and morphology during laparoscopy: A rabbit model","volume":"93","author":"Guven","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/107155769900600502","article-title":"Preservation of fertility and ovarian function and minimizing chemotherapy-induced gonadotoxicity in young women","volume":"6","author":"Blumenfeld","year":"1999","journal-title":"J. Soc. Gynecol. Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1038\/s44321-024-00124-z","article-title":"Can we manipulate the ovary\u2019s own metabolism to protect it from chemotherapy-induced damage?","volume":"16","author":"Liugaila","year":"2024","journal-title":"EMBO Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.biopha.2018.03.119","article-title":"Zingerone ameliorates cisplatin-induced ovarian and uterine toxicity via suppression of sex hormone imbalances, oxidative stress, inflammation and apoptosis in female wistar rats","volume":"102","author":"Kaygusuzoglu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00210-019-01662-x","article-title":"Mechanistic perspective of protective effects of resveratrol against cisplatin-induced ovarian injury in rats: Emphasis on anti-inflammatory and anti-apoptotic effects","volume":"392","author":"Said","year":"2019","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1038\/s41598-023-31712-7","article-title":"Mechanism of ferroptosis in a rat model of premature ovarian insufficiency induced by cisplatin","volume":"13","author":"Du","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"448","DOI":"10.5114\/aoms.2019.87540","article-title":"Evaluation of protective effects of GnRH agonist or antagonist on ovarian reserve with anti-M\u00fcllerian hormone and histological analysis in a rat model using cisplatin","volume":"19","author":"Tas","year":"2019","journal-title":"Arch. Med. Sci. AMS"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00404-019-05303-9","article-title":"The propolis and boric acid can be highly suitable, alone\/or as a combinatory approach on ovary ischemia-reperfusion injury","volume":"300","author":"Geyikoglu","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_48","first-page":"3083","article-title":"Using of Propolis on the treated rats induced with Polysystic ovarian syndrome by Litrozol drug","volume":"140","author":"Ahmed","year":"2022","journal-title":"Bull. Natl. Inst. Health Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3802\/jgo.2013.24.2.177","article-title":"The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats","volume":"24","author":"Li","year":"2013","journal-title":"J. Gynecol. Oncol."},{"key":"ref_50","first-page":"3789351","article-title":"Determination of Total phenolics, flavonoids, and antioxidant activity and GC-MS analysis of Malaysian stingless bee propolis water extracts","volume":"2021","author":"Ahmad","year":"2021","journal-title":"Scientifica"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1007\/s00217-025-04756-4","article-title":"Phenolic content, volatile compounds and antioxidant activity in pooled propolis samples from Turkey and Poland","volume":"251","author":"Kara","year":"2025","journal-title":"Eur. Food Res. Technol."},{"key":"ref_52","first-page":"10","article-title":"Investigation of phenolic compounds and antioxidant properties in honey, pollen and propolis according to regional and Apis mellifera genotypes","volume":"69","year":"2025","journal-title":"Food Nutr. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Ayad, A.S., Benchaabane, S., Daas, T., Smagghe, G., and Loucif-Ayad, W. (2025). Propolis Stands out as a Multifaceted Natural Product: Meta-Analysis on Its Sources, Bioactivities, Applications, and Future Perspectives. Life, 15.","DOI":"10.3390\/life15050764"},{"key":"ref_54","first-page":"7195","article-title":"Fertility protective effect of taxifolin in cisplatin-induced ovarian damage","volume":"26","author":"Ozyurt","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_55","first-page":"1","article-title":"Propolis extract attenuates cisplatin-induced nephrotoxicity in female rats and their offspring","volume":"12","author":"Mohamed","year":"2025","journal-title":"Egypt. J. Basic Appl. Sci."},{"key":"ref_56","first-page":"293","article-title":"Honeybee Propolis Phenol, Caffeic Acid Phenethyl Ester, Attenuates Cisplatin-Induced Kidney Damage-a Multitarget Approach","volume":"16","year":"2022","journal-title":"Rec. Nat. Prod."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"579","DOI":"10.32598\/ijvm.19.3.1005667","article-title":"Effect of Propolis Supplementation on Structural Histomorphology of the Pituitary-ovarian-uterine Axis in Rats","volume":"19","author":"Albishtue","year":"2025","journal-title":"Iran. J. Vet. Med."},{"key":"ref_58","first-page":"509","article-title":"The effects of propolis extract on ovarian tissue and oxidative stress in rats with maternal separation stress","volume":"15","author":"Arabameri","year":"2017","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"103191","DOI":"10.1016\/j.arabjc.2021.103191","article-title":"Quercetin attenuates cisplatin-induced ovarian toxicity in rats: Emphasis on anti-oxidant, anti-inflammatory and anti-apoptotic activities","volume":"14","author":"Algandaby","year":"2021","journal-title":"Arab. J. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/01480545.2021.2011312","article-title":"Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats","volume":"46","author":"Demir","year":"2023","journal-title":"Drug Chem. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"108514","DOI":"10.1016\/j.reprotox.2023.108514","article-title":"The effects of propolis-loaded chitosan nanoparticles and menstrual blood stem cells on LPS-induced ovarian inflammation in the murine ovary in vivo: An in vitro and in vivo study","volume":"123","author":"Ding","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4067\/S0717-95022017000100023","article-title":"Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Ischemia-Reperfusion Injury in Rat Ovary","volume":"35","author":"Togrul","year":"2017","journal-title":"Int. J. Morphol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"920178","DOI":"10.4061\/2011\/920178","article-title":"IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging","volume":"2011","author":"Decuypere","year":"2011","journal-title":"J. Aging Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s12276-021-00560-8","article-title":"The Aftermath of the Interplay between the Endoplasmic Reticulum Stress Response and Redox Signaling","volume":"53","author":"Bhattarai","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"100665","DOI":"10.1016\/j.jbc.2021.100665","article-title":"Oxidation of Peroxiredoxin-4 Induces Oligomerization and Promotes Interaction with Proteins Governing Protein Folding and Endoplasmic Reticulum Stress","volume":"296","author":"Elko","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1101\/gad.1250704","article-title":"CHOP Induces Death by Promoting Protein Synthesis and Oxidation in the Stressed Endoplasmic Reticulum","volume":"18","author":"Marciniak","year":"2004","journal-title":"Genes Dev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"9100","DOI":"10.1074\/jbc.M210284200","article-title":"Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling","volume":"278","author":"Mandic","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.7150\/ijbs.66630","article-title":"Icariside II enhances cisplatin-induced apoptosis by promoting endoplasmic reticulum stress signalling in non-small cell lung cancer cells","volume":"18","author":"Tang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"14004","DOI":"10.1038\/s41598-024-64619-y","article-title":"Protective roles of thrombomodulin in cisplatin-induced nephrotoxicity through the inhibition of oxidative and endoplasmic reticulum stress","volume":"14","author":"Yamamoto","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12958-022-00956-9","article-title":"Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells","volume":"20","author":"Tang","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Huang, C.-M., Huang, H.-M., Li, Y.-H., Liang, X.-W., Kim, N.-H., and Xu, Y.-N. (2024). Effects of Caffeic Acid Phenethyl Ester on Embryonic Development Through Regulation of Mitochondria and Endoplasmic Reticulum. Vet. Sci., 11.","DOI":"10.3390\/vetsci11120625"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Lin, M., Guo, X., Xu, X., Chang, C., Le, T.N., Cai, H., and Zhao, M. (2025). Caffeic Acid Phenethyl Ester Alleviates Alcohol-Induced Inflammation Associated with Pancreatic Secretion and Gut Microbiota in Zebrafish. Biomolecules, 15.","DOI":"10.3390\/biom15070918"}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/2\/212\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:56:21Z","timestamp":1771242981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/2\/212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,14]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["cimb48020212"],"URL":"https:\/\/doi.org\/10.3390\/cimb48020212","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,14]]}}}