{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:29:30Z","timestamp":1771244970443,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Multiple Myeloma is a malignancy of the plasma cells of the bone marrow. This cancer rapidly becomes refractory to many of the currently available chemotherapeutic regimens used against it, requiring an alternative option or supplementary therapy. Pterostilbene is a naturally occurring compound in a variety of commonly consumed plants that exhibits strong antioxidant properties and, lately, has shown increasing activity as an anti-neoplastic compound. A review of the literature published since 2015 on Google Scholar and PubMed was conducted, with a focus on randomized controlled trials and an exclusion of review articles, unless pertinent to pathophysiology of Multiple Myeloma or background on Pterostilbene as a compound. Though data is limited in the use of Pterostilbene as an agent to combat Multiple Myeloma, studies have shown that it, along with synthetic derivatives, can induce apoptosis and limit proliferation of Multiple Myeloma cell lines. While safety has been evaluated in several settings with promising results, for Pterostilbene to be considered as a supplementary treatment in Multiple Myeloma, safe and effective doses of the compound in this patient population must be investigated and established via pre-clinical and clinical trials in the future.<\/jats:p>","DOI":"10.3390\/cimb48020216","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:11:28Z","timestamp":1771240288000},"page":"216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pterostilbene in the Management and Treatment of Multiple Myeloma"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4948-3181","authenticated-orcid":false,"given":"Benjamin S.","family":"Buehrer","sequence":"first","affiliation":[{"name":"College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1780-9877","authenticated-orcid":false,"given":"Adam R.","family":"Grden","sequence":"additional","affiliation":[{"name":"College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Johnson","sequence":"additional","affiliation":[{"name":"College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manav Y.","family":"Patel","sequence":"additional","affiliation":[{"name":"College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3892-8376","authenticated-orcid":false,"given":"Rupesh","family":"Raina","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Akron Children\u2019s Hospital, Akron, OH 44308, USA"},{"name":"Department of Nephrology, Akron Nephrology Associates\/Cleveland Clinic Akron General Medical Center, Akron, OH 44302, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1021\/jf040095e","article-title":"Resveratrol, Pterostilbene, and Piceatannol in Vaccinium Berries","volume":"52","author":"Rimando","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1016\/j.jss.2011.09.054","article-title":"Pterostilbene and Cancer: Current Review","volume":"173","author":"McCormack","year":"2012","journal-title":"J. Surg. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00280-010-1525-4","article-title":"Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats","volume":"68","author":"Kapetanovic","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.soncn.2017.05.012","article-title":"Pathobiology and Diagnosis of Multiple Myeloma","volume":"33","author":"Brigle","year":"2017","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jama.2022.0003","article-title":"Diagnosis and Management of Multiple Myeloma: A Review","volume":"327","author":"Cowan","year":"2022","journal-title":"JAMA"},{"key":"ref_6","first-page":"2676","article-title":"Pterostilbene inhibits nutrient metabolism and induces apoptosis through AMPK activation in multiple myeloma cells","volume":"42","author":"Mei","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Xie, B., Xu, Z., Hu, L., Chen, G., Wei, R., Yang, G., Li, B., Chang, G., Sun, X., and Wu, H. (2016). Pterostilbene Inhibits Human Multiple Myeloma Cells via ERK1\/2 and JNK Pathway In Vitro and In Vivo. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17111927"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/abbs\/gmz033","article-title":"DCZ0801, a novel compound, induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma","volume":"51","author":"Zhang","year":"2019","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.7150\/jca.45146","article-title":"Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt\/mTOR pathway in Multiple Myeloma","volume":"11","author":"Feng","year":"2020","journal-title":"J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111446","DOI":"10.1016\/j.intimp.2023.111446","article-title":"A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory","volume":"127","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12935-021-01973-1","article-title":"A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-\u03baB pathway","volume":"21","author":"Gao","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3177\/jnsv.71.70","article-title":"Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study","volume":"71","author":"Otsuka","year":"2025","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ejphar.2016.07.046","article-title":"Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence","volume":"789","author":"Kosuru","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Shin, H.J., Han, J.M., Choi, Y.S., and Jung, H.J. (2020). Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol. Molecules, 25.","DOI":"10.3390\/molecules25010228"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1158\/1940-6207.CAPR-08-0224","article-title":"Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells","volume":"2","author":"Paul","year":"2009","journal-title":"Cancer Prev. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Fan, F., and Podar, K. (2021). The Role of AP-1 Transcription Factors in Plasma Cell Biology and Multiple Myeloma Pathophysiology. Cancers, 13.","DOI":"10.3390\/cancers13102326"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.5694\/mja2.50129","article-title":"Biology and therapy of multiple myeloma","volume":"210","author":"Joshua","year":"2019","journal-title":"Med. J. Aust."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"860","DOI":"10.3892\/ijo.2014.2774","article-title":"Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E","volume":"46","author":"Zismanov","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8091","DOI":"10.1038\/s41598-017-08547-0","article-title":"Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress","volume":"7","author":"Ma","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tamura, H., Ishibashi, M., Sunakawa-Kii, M., and Inokuchi, K. (2020). PD-L1\u2013PD-1 Pathway in the Pathophysiology of Multiple Myeloma. Cancers, 12.","DOI":"10.3390\/cancers12040924"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1159\/000443071","article-title":"Pterostilbene Inhibits the Growth of Human Esophageal Cancer Cells by Regulating Endoplasmic Reticulum Stress","volume":"38","author":"Feng","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wen, W., Lowe, G., Roberts, C.M., Finlay, J., Han, E.S., Glackin, C.A., and Dellinger, T.H. (2018). Pterostilbene Suppresses Ovarian Cancer Growth via Induction of Apoptosis and Blockade of Cell Cycle Progression Involving Inhibition of the STAT3 Pathway. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071983"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Hsu, Y.H., Chen, S.Y., Wang, S.Y., Lin, J.A., and Yen, G.C. (2020). Pterostilbene Enhances Cytotoxicity and Chemosensitivity in Human Pancreatic Cancer Cells. Biomolecules, 10.","DOI":"10.3390\/biom10050709"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1080\/01635581.2020.1817513","article-title":"Pterostilbene as a Phytochemical Compound Induces Signaling Pathways Involved in the Apoptosis and Death of Mutant P53-Breast Cancer Cell Lines","volume":"73","author":"Elsherbini","year":"2021","journal-title":"Nutr. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wawszczyk, J., Jesse, K., Smolik, S., and Kapral, M. (2022). Mechanism of Pterostilbene-Induced Cell Death in HT-29 Colon Cancer Cells. Molecules, 27.","DOI":"10.3390\/molecules27020369"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Senguttuvan, R.N., Cho, H., Wu, X., Frankel, P.H., Ruel, N., Yost, S.E., Kebria, M., Han, E., Song, M., and de Leon, M. (2025). The Anti-Cancer Role of Pterostilbene in Endometrial Cancer: A Phase II Prospective, Randomized, Window-of-Opportunity Clinical Trial with Megestrol Acetate. Antioxidants, 14.","DOI":"10.3390\/antiox14030345"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lee, H., Kim, Y., Jeong, J.H., Ryu, J.H., and Kim, W.Y. (2016). ATM\/CHK\/p53 Pathway Dependent Chemopreventive and Therapeutic Activity on Lung Cancer by Pterostilbene. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162335"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"37417","DOI":"10.1038\/srep37417","article-title":"Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells","volume":"6","author":"Kong","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Frezzato, F., Visentin, A., Severin, F., Pizzo, S., Ruggeri, E., Mouawad, N., Martinello, L., Pagnin, E., Trimarco, V., and Tonini, A. (2021). Targeting of HSP70\/HSF1 Axis Abrogates In Vitro Ibrutinib-Resistance in Chronic Lymphocytic Leukemia. Cancers, 13.","DOI":"10.3390\/cancers13215453"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/1735-5362.251853","article-title":"Pterostilbene increases Fas expression in T-lymphoblastic leukemia cell lines","volume":"14","author":"Ramezani","year":"2019","journal-title":"Res. Pharm. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41598-021-04654-1","article-title":"Pterostilbene downregulates BCR\/ABL and induces apoptosis of T315I-mutated BCR\/ABL-positive leukemic cells","volume":"12","author":"Kawakami","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9872073","DOI":"10.1155\/2017\/9872073","article-title":"Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia\/Lymphoma by Suppressing the ERK1\/2 Pathway","volume":"2017","author":"Chang","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3892\/or.2017.5675","article-title":"The blueberry component pterostilbene has potent anti-myeloma activity in bortezomib-resistant cells","volume":"38","author":"Chen","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15239","DOI":"10.1038\/srep15239","article-title":"Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity","volume":"5","author":"Tolba","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1056\/NEJMoa1606038","article-title":"Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma","volume":"375","author":"Palumbo","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1056\/NEJMoa2203478","article-title":"Teclistamab in Relapsed or Refractory Multiple Myeloma","volume":"387","author":"Moreau","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/biof.1410","article-title":"Metabolism and pharmacokinetics of resveratrol and pterostilbene","volume":"44","author":"Wang","year":"2018","journal-title":"BioFactors"},{"key":"ref_38","first-page":"406","article-title":"Effect of pterostilbene on in vitro drug metabolizing enzyme activity","volume":"27","author":"Albassam","year":"2019","journal-title":"Saudi Pharm. J. Off. Publ. Saudi Pharm. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1080\/01480545.2022.2042014","article-title":"Subacute oral toxicology and toxicokinetics of pterostilbene, a novel Top1\/Tdp1 inhibiting anti-tumor reagent","volume":"46","author":"Sun","year":"2023","journal-title":"Drug Chem. Toxicol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.canlet.2021.05.001","article-title":"Resveratrol for cancer therapy: Challenges and future perspectives","volume":"515","author":"Ren","year":"2021","journal-title":"Cancer Lett."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/2\/216\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:56:42Z","timestamp":1771243002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/2\/216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["cimb48020216"],"URL":"https:\/\/doi.org\/10.3390\/cimb48020216","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]}}}