{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T14:03:35Z","timestamp":1771423415473,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Technology R&D Project","doi-asserted-by":"publisher","award":["RS-2022-KH127452"],"award-info":[{"award-number":["RS-2022-KH127452"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Science Research Program","award":["RS-2023-00248483"],"award-info":[{"award-number":["RS-2023-00248483"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Cannabis seed (CS), also known as hemp seed, is a nutrient-dense plant-derived food material rich in polyunsaturated fatty acids and bioactive components with reported anti-inflammatory properties. However, potential nutritional effects of CS on acute pancreatitis (AP), an inflammation-driven disease with limited dietary management strategies, have not yet been investigated. In this study, we examined the effects of dietary CS extract in a cerulein-induced AP mouse model. CS extract (5, 10, or 50 mg\/kg) or vehicle (dimethyl sulfoxide) was orally administered 1 h prior to cerulein injection, and mice were euthanized 6 h after the final challenge. Oral supplementation with CS significantly attenuated AP severity, indicated by reducing pancreatic weight-to-body weight ratio, serum amylase and lipase activities, histopathological pancreatic injury, and pancreatic myeloperoxidase activity. CS administration alleviated AP-associated acute lung injury; markedly suppressing pancreatic mRNA expression of proinflammatory cytokines, including interleukin (IL)-1\u03b2, IL-6, and tumor necrosis factor-\u03b1. High-performance liquid chromatography analysis identified \u03b1-linolenic acid, an omega-3 polyunsaturated fatty acid, as a major nutritional component of CS extract. Collectively, these findings suggest that CS supplementation may contribute to nutritional modulation of inflammatory responses and systemic organ injury in experimental AP, supporting its potential as a functional food ingredient in inflammation-associated pancreatic disorders.<\/jats:p>","DOI":"10.3390\/cimb48020221","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T12:59:16Z","timestamp":1771419556000},"page":"221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Cannabis Seed Supplementation Attenuates Inflammation and Pancreatic Injury in a Cerulein-Induced Acute Pancreatitis Mouse Model"],"prefix":"10.3390","volume":"48","author":[{"given":"Dong-Uk","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, 460 Iksan-daero, Iksan 54538, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bitna","family":"Kweon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, 460 Iksan-daero, Iksan 54538, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jeonbuk National University, 567 Baekje-daero, Jeonbuk 54896, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Gu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Herbology, College of Korean Medicine, Dong-Eui University, 52\u201357 Yangjeong-ro, Busan 47227, Republic of Korea"},{"name":"Research Center of Korean Medicine for Diabetes and Obesity, Dong-Eui University, 52\u201357 Yangjeong-ro, Busan 47227, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi-Sang","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan 54538, Republic of Korea"},{"name":"Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, 460 Iksan-daero, Iksan 54538, Republic of Korea"},{"name":"Research Center of Traditional Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan 54538, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.3748\/wjg.v29.i18.2747","article-title":"Current trends in acute pancreatitis: Diagnostic and therapeutic challenges","volume":"29","author":"Zerem","year":"2023","journal-title":"World J. 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