{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T06:02:36Z","timestamp":1772517756946,"version":"3.50.1"},"reference-count":76,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["23K17413"],"award-info":[{"award-number":["23K17413"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The nuclear envelope (NE) functions as a barrier between the cytoplasm and nucleus. Over the past decade, NE has revealed unexpectedly divergent structural alterations. NE rupture triggers the uncontrollable exchange of macromolecules across the NE and potentially causes DNA damage. Conversely, a recent study demonstrated that DNA damage induces NE rupture and that one of the major kinases in the DNA damage response (DDR) pathway, ataxia telangiectasia and Rad3-related protein, ATR, is a key molecule in these events. Here, we review the role of the DDR pathway in NE regulation, with a focus mainly on ATR.<\/jats:p>","DOI":"10.3390\/cimb48030240","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:58:18Z","timestamp":1771952298000},"page":"240","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Roles of DNA Damage Response Pathway in the Regulation of the Nuclear Envelope"],"prefix":"10.3390","volume":"48","author":[{"given":"Yasunao","family":"Kamikawa","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9018-6504","authenticated-orcid":false,"given":"Kenshiro","family":"Fujise","sequence":"additional","affiliation":[{"name":"Department of Frontier Science and Interdisciplinary Research, Faculty of Medicine, Kanazawa University, 13-1 Takara-Machi, Kanazawa 920-8640, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"The Osaka Medical Research Foundation for Intractable Diseases, 3-7-11 Minamisumiyoshi, Sumiyoshi-ku, Osaka 558-0041, Osaka, Japan"},{"name":"Department of Child Development and Molecular Brain Science, United Graduate School of Child Development, Osaka University, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Frontier Science and Interdisciplinary Research, Faculty of Medicine, Kanazawa University, 13-1 Takara-Machi, Kanazawa 920-8640, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a000539","DOI":"10.1101\/cshperspect.a000539","article-title":"The nuclear envelope","volume":"2","author":"Hetzer","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"a000547","DOI":"10.1101\/cshperspect.a000547","article-title":"Nuclear Lamins","volume":"2","author":"Dechat","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-020-02003-5","article-title":"Lamina-associated domains: Peripheral matters and internal affairs","volume":"21","author":"Briand","year":"2020","journal-title":"Genome Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2352203","DOI":"10.1080\/19491034.2024.2352203","article-title":"Crosstalk between mitotic reassembly and repair of the nuclear envelope","volume":"15","author":"Kono","year":"2024","journal-title":"Nucleus"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2015.03.005","article-title":"Networking in the nucleus: A spotlight on LEM-domain proteins","volume":"34","author":"Barton","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2015.12.001","article-title":"The ESCRT machinery: New roles at new holes","volume":"38","author":"Olmos","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1016\/j.cub.2016.07.039","article-title":"Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation","volume":"26","author":"Olmos","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E2166","DOI":"10.1073\/pnas.1613916114","article-title":"LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells","volume":"114","author":"Gu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nrm.2016.153","article-title":"Mechanisms and functions of nuclear envelope remodeling","volume":"18","author":"Ungricht","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1091\/mbc.E18-10-0609","article-title":"Dissociation of membrane-chromatin contacts is required for proper chromosome segregation in mitosis","volume":"30","author":"Champion","year":"2019","journal-title":"Mol. Biol. Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1242\/jcs.033597","article-title":"Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly","volume":"121","author":"Haraguchi","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41586-020-2232-x","article-title":"LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation","volume":"582","author":"LaJoie","year":"2020","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4161\/nucl.18954","article-title":"Transient nuclear envelope rupturing during interphase in human cancer cells","volume":"3","author":"Vargas","year":"2012","journal-title":"Nucleus"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/jb\/mvac012","article-title":"Advances in understanding the mechanisms of repairing damaged nuclear envelope","volume":"171","author":"Kamikawa","year":"2022","journal-title":"J. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e2020997118","DOI":"10.1073\/pnas.2020997118","article-title":"Nuclear envelope budding is a response to cellular stress","volume":"118","author":"Panagaki","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.aad7297","article-title":"Nuclear envelope rupture and repair during cancer cell migration","volume":"352","author":"Denais","year":"2016","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.aad7611","article-title":"ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death","volume":"352","author":"Raab","year":"2016","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1016\/j.cell.2021.08.035","article-title":"Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion","volume":"184","author":"Nader","year":"2021","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1091\/mbc.E18-02-0079","article-title":"Constricted migration increases DNA damage and independently represses cell cycle","volume":"29","author":"Pfeifer","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e151515","DOI":"10.1172\/jci.insight.151515","article-title":"Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome","volume":"6","author":"Kim","year":"2021","journal-title":"JCI Insight"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41563-019-0563-5","article-title":"Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells","volume":"19","author":"Earle","year":"2020","journal-title":"Nat. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1083\/jcb.201901116","article-title":"Repair of nuclear ruptures requires barrier-to-autointegration factor","volume":"218","author":"Halfmann","year":"2019","journal-title":"J. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1091\/mbc.E20-01-0009","article-title":"BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins","volume":"31","author":"Young","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e202201024","DOI":"10.1083\/jcb.202201024","article-title":"Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS","volume":"221","author":"Kono","year":"2022","journal-title":"J. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaw6421","article-title":"BAF restricts cGAS on nuclear DNA to prevent innate immune activation","volume":"369","author":"Guey","year":"2020","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1158\/1541-7786.MCR-17-0084","article-title":"Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb","volume":"15","author":"Yang","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41420-023-01534-7","article-title":"Impact of cell cycle on repair of ruptured nuclear envelope and sensitivity to nuclear envelope stress in glioblastoma","volume":"9","author":"Kamikawa","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1016\/j.molcel.2023.09.023","article-title":"DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A\/C","volume":"83","author":"Kovacs","year":"2023","journal-title":"Mol. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1016\/j.molcel.2023.09.003","article-title":"ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei","volume":"83","author":"Joo","year":"2023","journal-title":"Mol. Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.1038\/s41467-025-63942-w","article-title":"Mitotic DNA repair by TMEJ suppresses replication stress-induced nuclear envelope reassembly defect","volume":"16","author":"Ye","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"eadr5683","DOI":"10.1126\/sciadv.adr5683","article-title":"ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders","volume":"11","author":"Chatzifrangkeskou","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.1038\/s44318-025-00566-2","article-title":"Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage","volume":"44","author":"Kamaras","year":"2025","journal-title":"EMBO J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrm.2017.67","article-title":"The essential kinase ATR: Ensuring faithful duplication of a challenging genome","volume":"18","author":"Saldivar","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1101\/gad.14.4.397","article-title":"ATR disruption leads to chromosomal fragmentation and early embryonic lethality","volume":"14","author":"Brown","year":"2000","journal-title":"Genes. Dev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/23969873241290680","article-title":"Risk factors for intracerebral hemorrhage by five specific bleeding sites: Japan Public Health Center-based Prospective Study","volume":"10","author":"Ariyada","year":"2024","journal-title":"Eur. Stroke J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/s41440-024-01653-3","article-title":"Blood pressure classification using the Japanese Society of Hypertension Guidelines for the Management of Hypertension and cardiovascular events among young to middle-aged working adults","volume":"47","author":"Kuwahara","year":"2024","journal-title":"Hypertens. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2014.05.046","article-title":"ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress","volume":"158","author":"Kumar","year":"2014","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1083\/jcb.201304181","article-title":"Chromatin insulator bodies are nuclear structures that form in response to osmotic stress and cell death","volume":"202","author":"Schoborg","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0092-8674(90)90470-Y","article-title":"Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis","volume":"61","author":"Heald","year":"1990","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/j.1460-2075.1991.tb07673.x","article-title":"Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase","volume":"10","author":"Peter","year":"1991","journal-title":"EMBO J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.cub.2014.07.001","article-title":"Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin","volume":"24","author":"Buxboim","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2013.06.007","article-title":"Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei","volume":"154","author":"Hatch","year":"2013","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1101\/gad.179515.111","article-title":"The role of nuclear lamin B1 in cell proliferation and senescence","volume":"25","author":"Shimi","year":"2011","journal-title":"Genes Dev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1091\/mbc.e11-10-0884","article-title":"Lamin B1 loss is a senescence-associated biomarker","volume":"23","author":"Freund","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e105819","DOI":"10.15252\/embj.2020105819","article-title":"Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis","volume":"40","author":"Bedrosian","year":"2021","journal-title":"EMBO J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.stem.2021.01.015","article-title":"Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity","volume":"28","author":"Jaeger","year":"2021","journal-title":"Cell Stem Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-genom-082908-150150","article-title":"The posttranslational processing of prelamin A and disease","volume":"10","author":"Davies","year":"2009","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ao, Y., Wu, Z., Liao, Z., Lan, J., Zhang, J., Sun, P., Liu, B., and Wang, Z. (2023). Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence. Cells, 12.","DOI":"10.3390\/cells12040639"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"eaav5078","DOI":"10.1126\/sciadv.aav5078","article-title":"Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model","volume":"5","author":"Ao","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/nar\/gkr697","article-title":"Safeguarding genome integrity: The checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication","volume":"40","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"gkaf852","DOI":"10.1093\/nar\/gkaf852","article-title":"Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation","volume":"53","author":"Roy","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1038\/s41467-020-18580-9","article-title":"ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration","volume":"11","author":"Kidiyoor","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"jcs261630","DOI":"10.1242\/jcs.261630","article-title":"Nuclear actin dynamics and functions at a glance","volume":"137","author":"Ulferts","year":"2024","journal-title":"J. Cell Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/jcs.189068","article-title":"Actin visualization at a glance","volume":"130","author":"Melak","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2320656","DOI":"10.1080\/19491034.2024.2320656","article-title":"Nuclear actin filaments\u2014A historical perspective","volume":"15","author":"Fernandez","year":"2024","journal-title":"Nucleus"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/bjc.2015.221","article-title":"Clinical utility of RASSF1A methylation in human malignancies","volume":"113","author":"Grawenda","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1242\/jcs.010389","article-title":"The RASSF1A tumor suppressor","volume":"120","author":"Donninger","year":"2007","journal-title":"J. Cell Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"EMBJ2018100532","DOI":"10.15252\/embj.2018100532","article-title":"RASSF1A controls tissue stiffness and cancer stem-like cells in lung adenocarcinoma","volume":"38","author":"Pankova","year":"2019","journal-title":"EMBO J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"EMBJ2018101168","DOI":"10.15252\/embj.2018101168","article-title":"RASSF1A is required for the maintenance of nuclear actin levels","volume":"38","author":"Chatzifrangkeskou","year":"2019","journal-title":"EMBO J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0167-4889(01)00072-6","article-title":"Structural and functional aspects of filamins","volume":"1538","author":"Sonnenberg","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1073\/pnas.0736237100","article-title":"Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions","volume":"100","author":"Loy","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1158\/0008-5472.CAN-07-5183","article-title":"RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1\/2 mutation carriers","volume":"68","author":"Gao","year":"2008","journal-title":"Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1158\/0008-5472.CAN-11-2906","article-title":"A RASSF1A Polymorphism Restricts p53\/p73 Activation and Associates with Poor Survival and Accelerated Age of Onset of Soft Tissue Sarcoma","volume":"72","author":"Yee","year":"2012","journal-title":"Cancer Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0014-5793(98)00294-4","article-title":"In vitro interaction of the carboxy-terminal domain of lamin A with actin","volume":"425","author":"Sasseville","year":"1998","journal-title":"FEBS Lett."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4161\/nucl.11799","article-title":"Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail","volume":"1","author":"Simon","year":"2010","journal-title":"Nucleus"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/19491034.2020.1815395","article-title":"Impairment of nuclear F-actin formation and its relevance to cellular phenotypes in Hutchinson-Gilford progeria syndrome","volume":"11","author":"Takahashi","year":"2020","journal-title":"Nucleus"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Shah, P., McGuigan, C.W., Cheng, S., Vanpouille-Box, C., Demaria, S., Weiss, R.S., and Lammerding, J. (2022). ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.875132"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"E423","DOI":"10.1073\/pnas.1111780109","article-title":"Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA","volume":"109","author":"Jung","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.molcel.2011.01.020","article-title":"The ATM kinase induces microRNA biogenesis in the DNA damage response","volume":"41","author":"Zhang","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"br6","DOI":"10.1091\/mbc.E24-05-0232","article-title":"DNA damage causes ATM-dependent heterochromatin loss leading to nuclear softening, blebbing, and rupture","volume":"36","author":"Eskndir","year":"2025","journal-title":"Mol. Biol. Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1128\/MCB.19.6.4366","article-title":"KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: A potential role for Kr\u00fcppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing","volume":"19","author":"Ryan","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1101\/gad.973302","article-title":"SETDB1: A novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins","volume":"16","author":"Schultz","year":"2002","journal-title":"Genes Dev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ncb1446","article-title":"Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway","volume":"8","author":"Ziv","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molcel.2008.05.017","article-title":"ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin","volume":"31","author":"Goodarzi","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1158\/0008-5472.CAN-18-2807","article-title":"Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related (ATR) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer","volume":"79","author":"Andrade","year":"2019","journal-title":"Cancer Res."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/3\/240\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:28:53Z","timestamp":1772515733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/3\/240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["cimb48030240"],"URL":"https:\/\/doi.org\/10.3390\/cimb48030240","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]}}}