{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:48:13Z","timestamp":1783464493730,"version":"3.55.0"},"reference-count":58,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Key R&D Program: Vanguard and Leading Goose Initiative","award":["2025C01133"],"award-info":[{"award-number":["2025C01133"]}]},{"name":"The Funds of the Natural Science Foundation of Hangzhou","award":["2025SZRJJ1328"],"award-info":[{"award-number":["2025SZRJJ1328"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Rosa roxburghii Tratt., commonly known as Cili, is an emerging functional fruit native to southwestern China, characterized by extraordinarily high vitamin C content, robust superoxide dismutase activity, and a rich diversity of bioactive compounds. This review summarizes recent advances in its phytochemistry, molecular bioactivity, and omics-driven applications, with a focus on integrating evidence from genomic, transcriptomic, and metabolomic analyses. Multi-omics analyses reveal the coordinated regulation of ascorbate and secondary metabolite accumulation via key pathways and transcription factors. Mechanistically, bioactive compounds from Cili comprising ascorbate derivatives, polyphenols, flavonoids, polysaccharides, triterpenoids, and sterols, act synergistically. They also exhibit antioxidant, anti-inflammatory, gastrointestinal, hepatoprotective, cardiovascular protective, anti-obesity, anti-diabetic, metabolic regulatory, anti-cancer, and neuroprotective effects by modulating core metabolic and stress-response signaling pathways. Recent advances in functional food processing have further elevated its nutritional and industrial value, highlighting its potential as a sustainable nutraceutical resource.<\/jats:p>","DOI":"10.3390\/cimb48030249","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:33:02Z","timestamp":1772101982000},"page":"249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cili (Rosa roxburghii Tratt.) as a Functional Food and Medicinal Resource: Current Advances and Future Directions"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8790-7234","authenticated-orcid":false,"given":"Jiaqiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Zhejiang Institute of Landscape Plants and Flowers, Zhejiang Academy of Agricultural Sciences, Hangzhou 311251, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition and Feed Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-0723","authenticated-orcid":false,"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition and Feed Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-5668","authenticated-orcid":false,"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition and Feed Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Light Industry and Chemical Engineering, Guizhou Light Industry Polytechnic University, Guiyang 550005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbin","family":"Han","sequence":"additional","affiliation":[{"name":"College of Food Science & Technology, Nanjing Agricultural University, Nanjing 211816, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition and Feed Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-2015","authenticated-orcid":false,"given":"Rongchang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Agricultural Sciences, Murdoch University, Murdoch, WA 6150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103456","DOI":"10.1016\/j.jff.2019.103456","article-title":"Nutritional constituents, health benefits, and processing of Rosa roxburghii: A review","volume":"60","author":"Xu","year":"2019","journal-title":"J. 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