{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:30:39Z","timestamp":1788928239616,"version":"build-2803163510"},"reference-count":166,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Conventional hormonal and clinical models inadequately clarify the complex and diverse aspects of female infertility, resulting in poor reproductive outcomes and reduced egg viability. A growing body of research indicates that female reproductive failure is mostly due to disruptions in cellular homeostasis, especially concerning organelle quality control. Oxidative stress has emerged as a crucial mediator connecting metabolic, inflammatory, and ageing-related processes to ovarian failure, however its downstream impacts on intracellular organelle turnover remain insufficiently clarified. Our narrative review encapsulates the existing data for a unified pathogenic concept focused on the redox-regulated mitochondria\u2013lysosome axis. We examine the interaction of oxidative stress, mitochondrial malfunction, compromised mitophagy, and lysosomal deficiency in granulosa cells and oocytes. Prolonged oxidative stress may disrupt this equilibrium, leading to defective mitochondria accumulation and impaired mitophagy. This self-perpetuating cycle may ultimately jeopardises reproductive viability and oocyte integrity. The integrated axis offers a shared molecular foundation for various infertility-related diseases, such as inadequate ovarian response, obesity-associated infertility, polycystic ovary syndrome, and ovarian ageing. Ultimately, we analyse new findings suggesting that specific antioxidant chemicals modify mitophagy and lysosomal function while also neutralising reactive oxygen species, highlighting their potential use in precision fertility treatments. Our research redefines female infertility as a condition of redox-dependent organelle quality control, thereby introducing novel avenues for identifying biomarkers, categorising patients, and targeting treatments in assisted reproduction.<\/jats:p>","DOI":"10.3390\/cimb48040429","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:42:45Z","timestamp":1776771765000},"page":"429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Redox-Regulated Mitophagy and Lysosomal Dysfunction as a Convergent Mechanism in Female Infertility: Molecular Insights and Therapeutic Perspectives"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-7619","authenticated-orcid":false,"given":"Charalampos","family":"Voros","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios","family":"Chatzinikolaou","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, 54124 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Papadimas","sequence":"additional","affiliation":[{"name":"Athens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Karpouzos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-5054","authenticated-orcid":false,"given":"Ioannis","family":"Papapanagiotou","sequence":"additional","affiliation":[{"name":"Athens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotelis-Marios","family":"Koulakmanidis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diamantis","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, 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Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Anastasia","family":"Daskalaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8110-938X","authenticated-orcid":false,"given":"Christina","family":"Trakateli","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine, Aristotle University Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana Kojo","family":"Koranteng","sequence":"additional","affiliation":[{"name":"Athens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Thomakos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-5922","authenticated-orcid":false,"given":"Panagiotis","family":"Antsaklis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8686-594X","authenticated-orcid":false,"given":"Dimitrios","family":"Loutradis","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic Medicine and 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Reprod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"109193","DOI":"10.1016\/j.envint.2024.109193","article-title":"Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures","volume":"195","year":"2025","journal-title":"Environ. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1477-7827-3-28","article-title":"Role of oxidative stress in female reproduction","volume":"3","author":"Agarwal","year":"2005","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Song, J., Xiao, L., Zhang, Z., Wang, Y., Kouis, P., Rasmussen, L.J., and Dai, F. (2024). Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1347286"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13048-025-01764-6","article-title":"Mitochondrial dysfunction in oocytes: Implications for fertility and ageing","volume":"18","author":"Wang","year":"2025","journal-title":"J. Ovarian Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ju, W., Zhao, Y., Yu, Y., Zhao, S., Xiang, S., and Lian, F. (2024). Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1361289"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zhao, H., Wang, Y., Han, H., Jiang, Y., Ji, X., and Zhang, Y. (2025). The role of mitophagy in female reproductive system diseases: From molecular mechanisms to therapeutic strategies. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1645711"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Lee, S., Son, J.-Y., Lee, J., and Cheong, H. (2023). Unraveling the Intricacies of Autophagy and Mitophagy: Implications in Cancer Biology. Cells, 12.","DOI":"10.3390\/cells12232742"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"16170","DOI":"10.18632\/oncotarget.14016","article-title":"Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway","volume":"8","author":"Leow","year":"2017","journal-title":"Oncotarget"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gao, Y., Zou, Y., Wu, G., and Zheng, L. (2023). Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1193749"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"De Gaetano, A., Gibellini, L., Zanini, G., Nasi, M., Cossarizza, A., and Pinti, M. (2021). Mitophagy and Oxidative Stress: The Role of Aging. Antioxidants, 10.","DOI":"10.3390\/antiox10050794"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Singh, S., Pal, N., Shubham, S., Sarma, D.K., Verma, V., Marotta, F., and Kumar, M. (2023). Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics. J. Clin. Med., 12.","DOI":"10.3390\/jcm12041454"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Jozkowiak, M., Hutchings, G., Jankowski, M., Kulcenty, K., Mozdziak, P., Kempisty, B., Spaczynski, R.Z., and Piotrowska-Kempisty, H. (2020). The Stemness of Human Ovarian Granulosa Cells and the Role of Resveratrol in the Differentiation of MSCs\u2014A Review Based on Cellular and Molecular Knowledge. Cells, 9.","DOI":"10.3390\/cells9061418"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Voros, C., Athanasiou, D., Papapanagiotou, I., Mavrogianni, D., Varthaliti, A., Bananis, K., Athanasiou, A., Athanasiou, A., Papadimas, G., and Gkirgkinoudis, A. (2025). Cracking the Code of Oocyte Quality: The Oxidative Stress Link to IVF Success. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136377"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Hong, Y., Boiti, A., Vallone, D., and Foulkes, N.S. (2024). Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution. Antioxidants, 13.","DOI":"10.3390\/antiox13030312"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"20535","DOI":"10.1074\/jbc.M201589200","article-title":"Redox Regulation of Cdc25C","volume":"277","author":"Savitsky","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chen, T.-H., Wang, H.-C., Chang, C.-J., and Lee, S.-Y. (2024). Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021314"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e240364","DOI":"10.1530\/REP-24-0364","article-title":"Nicotinic acid protects germinal vesicle oocyte meiosis against toxicity of benzo(a)pyrene in mice and humans","volume":"169","author":"Gao","year":"2025","journal-title":"Reproduction"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5698931","DOI":"10.1155\/2016\/5698931","article-title":"Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wang, Z.-H., Wang, Z.-J., Liu, H.-C., Wang, C.-Y., Wang, Y.-Q., Yue, Y., Zhao, C., Wang, G., and Wan, J.-P. (2024). Targeting mitochondria for ovarian aging: New insights into mechanisms and therapeutic potential. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1417007"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Deer, E., LaMarca, B., Reckelhoff, J.F., Shawky, N.M., and Edwards, K. (2025). The Role of Mitochondrial Dysfunction and Oxidative Stress in Women\u2019s Reproductive Disorders: Implications for Polycystic Ovary Syndrome and Preeclampsia. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136439"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mweene, B.C., Hatwiko, H., Povia, J.P., and Masenga, S.K. (2025). The Role of Mitochondrial Dysfunction and Dynamics in Hypertensive Heart Disease: Mechanisms and Recent Advances. Biology, 14.","DOI":"10.3390\/biology14091212"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1186\/s12967-025-06966-6","article-title":"Mitochondria-driven inflammation: A new frontier in ovarian ageing","volume":"23","author":"Ju","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Rong, Z., Tu, P., Xu, P., Sun, Y., Yu, F., Tu, N., Guo, L., and Yang, Y. (2021). The Mitochondrial Response to DNA Damage. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.669379"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1038\/s41598-019-41933-4","article-title":"Mitochondrial DNA mutations and respiratory chain dysfunction in idiopathic and connective tissue disease-related lung fibrosis","volume":"9","author":"Jaeger","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e70268","DOI":"10.1002\/mco2.70268","article-title":"Oxidative Stress: Signaling Pathways, Biological Functions, and Disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1080\/15548627.2019.1596486","article-title":"Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis","volume":"15","author":"Wang","year":"2019","journal-title":"Autophagy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13048-025-01639-w","article-title":"Overview of Nrf2 as a target in ovary and ovarian dysfunctions focusing on its antioxidant properties","volume":"18","author":"Ghantabpour","year":"2025","journal-title":"J. Ovarian Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Voros, C., Chatzinikolaou, F., Papadimas, G., Polykalas, S., Mavrogianni, D., Koulakmanidis, A.-M., Athanasiou, D., Kanaka, V., Bananis, K., and Athanasiou, A. (2026). Oxidative Stress and SIRT1-Nrf2 Anti-Ferroptotic Pathways in Granulosa Cells: A Molecular Key to Follicular Atresia and Ovarian Aging. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27020950"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41392-024-02044-3","article-title":"Mitochondrial diseases: From molecular mechanisms to therapeutic advances","volume":"10","author":"Wen","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/GCO.0000000000000164","article-title":"Oocyte mitochondrial function and reproduction","volume":"27","author":"Babayev","year":"2015","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ga\u0142\u0119ska, E., Kowalczyk, A., Wrzeci\u0144ska, M., Garc\u00eda, M.C., Czerniawska-Pi\u0105tkowska, E., Gwo\u017adziewicz, S., Witkiewicz, W., and Dobrza\u0144ski, Z. (2025). The Importance of Mitochondrial Processes in the Maturation and Acquisition of Competences of Oocytes and Embryo Culture. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26094098"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"108854","DOI":"10.1016\/j.abb.2021.108854","article-title":"Ultrastructure of mitochondria of human oocytes in different clinical conditions during assisted reproduction","volume":"703","author":"Belli","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Almansa-Ordonez, A., Bellido, R., Vassena, R., Barragan, M., and Zambelli, F. (2020). Oxidative Stress in Reproduction: A Mitochondrial Perspective. Biology, 9.","DOI":"10.3390\/biology9090269"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41586-023-06441-6","article-title":"Structural mechanism of mitochondrial membrane remodelling by human OPA1","volume":"620","author":"Sapp","year":"2023","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: Overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e12672","DOI":"10.1002\/rmb2.12672","article-title":"Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies","volume":"24","author":"Morimoto","year":"2025","journal-title":"Reprod. Med. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.21037\/tau-24-262","article-title":"A narrative review of mitochondrial dysfunction and male infertility","volume":"13","author":"Mai","year":"2024","journal-title":"Transl. Androl. Urol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4162\/nrp.2022.16.3.314","article-title":"Reduction of oocyte lipid droplets and meiotic failure due to biotin deficiency was not rescued by restoring the biotin nutritional status","volume":"16","author":"Tsuji","year":"2022","journal-title":"Nutr. Res. Pract."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sreerangaraja Urs, D.B., Wu, W.-H., Komrskova, K., Postlerova, P., Lin, Y.-F., Tzeng, C.-R., and Kao, S.-H. (2020). Mitochondrial Function in Modulating Human Granulosa Cell Steroidogenesis and Female Fertility. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103592"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/lifemedi\/lnac014","article-title":"Aging-associated accumulation of mitochondrial DNA mutations in tumor origin","volume":"1","author":"Kong","year":"2022","journal-title":"Life Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wu, S., and Zou, M.-H. (2020). AMPK, Mitochondrial Function, and Cardiovascular Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144987"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: The good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Zhang, T., Lin, M., Wang, C., and Zhou, J. (2025). Mechanisms of follicular atresia: Focus on apoptosis, autophagy, and ferroptosis. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1603467"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s11658-024-00669-4","article-title":"Inter- and intracellular mitochondrial communication: Signaling hubs in aging and age-related diseases","volume":"29","author":"Zhang","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Chen, C., Huang, Z., Dong, S., Ding, M., Li, J., Wang, M., Zeng, X., Zhang, X., and Sun, X. (2024). Calcium signaling in oocyte quality and functionality and its application. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1411000"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kobayashi, H., and Imanaka, S. (2024). Mitochondrial DNA Damage and Its Repair Mechanisms in Aging Oocytes. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252313144"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1089\/ars.2009.2598","article-title":"Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial\u2013Lysosomal Axis Theory of Aging","volume":"12","author":"Terman","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/biolre\/ioaa194","article-title":"Effect of mitophagy in oocytes and granulosa cells on oocyte quality","volume":"104","author":"Shen","year":"2021","journal-title":"Biol. Reprod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.devcel.2011.12.014","article-title":"Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin","volume":"22","author":"Lazarou","year":"2012","journal-title":"Dev. Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1007\/s00018-019-03203-4","article-title":"Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond","volume":"76","author":"Bayne","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Narendra, D.P., Jin, S.M., Tanaka, A., Suen, D.-F., Gautier, C.A., Shen, J., Cookson, M.R., and Youle, R.J. (2010). PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin. PLoS Biol., 8.","DOI":"10.1371\/journal.pbio.1000298"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Iorio, R., Celenza, G., and Petricca, S. (2021). Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK\/ULK1 Axis. Cells, 11.","DOI":"10.3390\/cells11010030"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Lee, I.-W., Adhikari, D., and Carroll, J. (2022). Miro1 depletion disrupts spatial distribution of mitochondria and leads to oocyte maturation defects. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.986454"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"100889","DOI":"10.1016\/j.repbio.2024.100889","article-title":"Mitophagy in mammalian follicle development and health","volume":"24","author":"Zhou","year":"2024","journal-title":"Reprod. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"20988","DOI":"10.18632\/oncotarget.15470","article-title":"Drp1-dependent mitophagy protects against cisplatin-induced apoptosis of renal tubular epithelial cells by improving mitochondrial function","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1161\/RES.0000000000000104","article-title":"Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement from the American Heart Association","volume":"118","author":"Murphy","year":"2016","journal-title":"Circ. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1080\/15384101.2023.2167949","article-title":"Emerging role of mitophagy in heart failure: From molecular mechanism to targeted therapy","volume":"22","author":"Liu","year":"2023","journal-title":"Cell Cycle"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2174\/1570159X18666200522202319","article-title":"The Dawn of Mitophagy: What Do We Know by Now?","volume":"19","author":"Belousov","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"107283","DOI":"10.1016\/j.nbd.2026.107283","article-title":"New perspective on neurodegenerative diseases: Focusing on the interaction between autophagy and oxidative stress and targeted strategies","volume":"220","author":"Jin","year":"2026","journal-title":"Neurobiol. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Khandia, R., Dadar, M., Munjal, A., Dhama, K., Karthik, K., Tiwari, R., Yatoo, M.I., Iqbal, H.M.N., Singh, K.P., and Joshi, S.K. (2019). A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy. Cells, 8.","DOI":"10.3390\/cells8070674"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"De La Mata, M., Cot\u00e1n, D., Villanueva-Paz, M., De Lavera, I., \u00c1lvarez-C\u00f3rdoba, M., Luz\u00f3n-Hidalgo, R., Su\u00e1rez-Rivero, J., Tiscornia, G., and Oropesa-\u00c1vila, M. (2016). Mitochondrial Dysfunction in Lysosomal Storage Disorders. Diseases, 4.","DOI":"10.3390\/diseases4040031"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.05.010","article-title":"Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3","volume":"187","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/10985549.2025.2494762","article-title":"Key Mechanisms in Lysosome Stability, Degradation and Repair","volume":"45","author":"Zhang","year":"2025","journal-title":"Mol. Cell. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1038\/s44318-025-00493-2","article-title":"The proteostatic landscape of healthy human oocytes","volume":"44","author":"Zaffagnini","year":"2025","journal-title":"EMBO J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.mcb.2014.11.011","article-title":"TFEB and the CLEAR network","volume":"Volume 126","author":"Settembre","year":"2015","journal-title":"Methods in Cell Biology"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Franco-Ju\u00e1rez, B., Coronel-Cruz, C., Hern\u00e1ndez-Ochoa, B., G\u00f3mez-Manzo, S., C\u00e1rdenas-Rodr\u00edguez, N., Arreguin-Espinosa, R., Bandala, C., Canseco-\u00c1vila, L.M., and Ortega-Cuellar, D. (2022). TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator. Cells, 11.","DOI":"10.3390\/cells11193153"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"133634","DOI":"10.1016\/j.jhazmat.2024.133634","article-title":"The role of mTORC1\/TFEB axis mediated lysosomal biogenesis and autophagy impairment in fluoride neurotoxicity and the intervention effects of resveratrol","volume":"467","author":"Tang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/ddp483","article-title":"Tsc\/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles","volume":"19","author":"Adhikari","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/s41422-018-0080-0","article-title":"STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/s12276-025-01579-x","article-title":"Failure of lysosomal acidification and endomembrane network in neurodegeneration","volume":"57","author":"Kim","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/ars.2008.2263","article-title":"Oxidative Stress and Autophagy in the Regulation of Lysosome-Dependent Neuron Death","volume":"11","author":"Pivtoraiko","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Liu, X., Li, Z., Hu, Y., Li, T., and Wang, H. (2026). Pathogen-Induced Lysosomal Membrane Permeabilization: A Critical Interface Between Host Defense and Cell Death. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27031515"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Ke, P.-Y. (2024). Molecular Mechanism of Autophagosome\u2013Lysosome Fusion in Mammalian Cells. Cells, 13.","DOI":"10.3390\/cells13060500"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"109011","DOI":"10.1016\/j.reprotox.2025.109011","article-title":"Oxidative stress: Oocyte quality and infertility","volume":"137","author":"Begum","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tibs.2020.09.004","article-title":"How Lysosomes Sense, Integrate, and Cope with Stress","volume":"46","author":"Saftig","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s11658-024-00633-2","article-title":"Lysosome quality control in health and neurodegenerative diseases","volume":"29","author":"Ferrari","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/2096-2924.288025","article-title":"Functions of Lysosomes in Mammalian Female Reproductive System","volume":"4","author":"Li","year":"2020","journal-title":"Reprod. Dev. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1242\/jcs.196287","article-title":"Mechanisms and functions of lysosome positioning","volume":"129","author":"Pu","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Hu, Y., Yang, Z., Wang, X., Li, X., and Wei, M. (2026). Oxidative Stress and Lysosomal Dysfunction in Neurodegenerative Diseases: Underlying Mechanisms and Nanotherapeutic Targeting Strategies. Antioxidants, 15.","DOI":"10.3390\/antiox15010073"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Xie, Y., Sun, W., Han, A., Zhou, X., Zhang, S., Shen, C., Xie, Y., Wang, C., and Xie, N. (2025). Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases. Front. Mol. Neurosci., 17.","DOI":"10.3389\/fnmol.2024.1527013"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Kim, J., and Bai, H. (2022). Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging. Antioxidants, 11.","DOI":"10.3390\/antiox11020192"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Bordoni, M., Pansarasa, O., Scarian, E., Cristofani, R., Leone, R., Fantini, V., Garofalo, M., Diamanti, L., Bernuzzi, S., and Gagliardi, S. (2022). Lysosomes Dysfunction Causes Mitophagy Impairment in PBMCs of Sporadic ALS Patients. Cells, 11.","DOI":"10.3390\/cells11081272"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41556-025-01634-9","article-title":"Harnessing lysohormesis for healthy ageing","volume":"27","author":"Tan","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zhong, R., and Richardson, C.E. (2025). Maintenance and Decline of Neuronal Lysosomal Function in Aging. Cells, 14.","DOI":"10.3390\/cells14241976"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Kiraly, S., Stanley, J., and Eden, E.R. (2025). Lysosome-Mitochondrial Crosstalk in Cellular Stress and Disease. Antioxidants, 14.","DOI":"10.3390\/antiox14020125"},{"key":"ref_90","first-page":"1","article-title":"Organelle Communication at Membrane Contact Sites (MCS): From Curiosity to Center Stage in Cell Biology and Biomedical Research","volume":"Volume 997","author":"Tagaya","year":"2017","journal-title":"Organelle Contact Sites"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5483\/BMBRep.2011.44.3.147","article-title":"Post-transcriptional and post-translational regulation during mouse oocyte maturation","volume":"44","author":"Kang","year":"2011","journal-title":"BMB Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.3390\/ijms10041911","article-title":"Heterogeneity of Mitochondria and Mitochondrial Function within Cells as Another Level of Mitochondrial Complexity","volume":"10","author":"Kuznetsov","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1089\/ars.2018.7681","article-title":"Mitochondrial Reactive Oxygen Species Generated at the Complex-II Matrix or Intermembrane Space Microdomain Have Distinct Effects on Redox Signaling and Stress Sensitivity in Caenorhabditis elegans","volume":"31","author":"Trewin","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0968-0004(03)00174-9","article-title":"Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction","volume":"28","author":"Chiarugi","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41392-024-01888-z","article-title":"Cell\u2013cell communication: New insights and clinical implications","volume":"9","author":"Su","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Inpanathan, S., and Botelho, R.J. (2019). The Lysosome Signaling Platform: Adapting With the Times. Front. Cell Dev. Biol., 7.","DOI":"10.3389\/fcell.2019.00113"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"103887","DOI":"10.1016\/j.mcn.2023.103887","article-title":"Glutamine metabolism in diseases associated with mitochondrial dysfunction","volume":"126","author":"Bornstein","year":"2023","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"32651","DOI":"10.1074\/jbc.M111.238014","article-title":"Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1\/TSC2-Rheb GTPase Pathway","volume":"286","author":"Yoshida","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e00441-17","DOI":"10.1128\/MCB.00441-17","article-title":"MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling","volume":"37","author":"Asahara","year":"2017","journal-title":"Mol. Cell. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tcb.2024.04.008","article-title":"Role of lipids in interorganelle communication","volume":"35","author":"Domingues","year":"2025","journal-title":"Trends Cell Biol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Casares, D., Escrib\u00e1, P.V., and Rossell\u00f3, C.A. (2019). Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092167"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Picca, A., Calvani, R., Coelho-Junior, H.J., Landi, F., Bernabei, R., and Marzetti, E. (2020). Inter-Organelle Membrane Contact Sites and Mitochondrial Quality Control during Aging: A Geroscience View. Cells, 9.","DOI":"10.3390\/cells9030598"},{"key":"ref_103","unstructured":"Sun, Y., Wei, J., Ma, S., He, C., Sui, L., Pan, X., and Zhu, X. (2025). Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy. Aging Dis."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Ichimiya, T., Yamakawa, T., Hirano, T., Yokoyama, Y., Hayashi, Y., Hirayama, D., Wagatsuma, K., Itoi, T., and Nakase, H. (2020). Autophagy and Autophagy-Related Diseases: A Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21238974"},{"key":"ref_105","unstructured":"Wetherall, B., and Madgwick, S. (2025). Peculiarities of the mammalian oocyte cell cycle. Physiology, physiol.00027.2025."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41392-024-01953-7","article-title":"Signaling pathways involved in colorectal cancer: Pathogenesis and targeted therapy","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/jnc.14471","article-title":"Mitochondria, lysosomes, and dysfunction: Their meaning in neurodegeneration","volume":"147","author":"Audano","year":"2018","journal-title":"J. Neurochem."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Signorini, C., Saso, L., Ghareghomi, S., Telkoparan-Akillilar, P., Collodel, G., and Moretti, E. (2024). Redox Homeostasis and Nrf2-Regulated Mechanisms Are Relevant to Male Infertility. Antioxidants, 13.","DOI":"10.3390\/antiox13020193"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: Mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/JCMA.0000000000001281","article-title":"Unraveling mitochondrial dysfunction in polycystic ovary syndrome: Pathophysiological insights","volume":"88","author":"Li","year":"2025","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Liao, B., Qi, X., Yun, C., Qiao, J., and Pang, Y. (2022). Effects of Androgen Excess-Related Metabolic Disturbances on Granulosa Cell Function and Follicular Development. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.815968"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Uo, T., Sprenger, C.C., and Plymate, S.R. (2020). Androgen Receptor Signaling and Metabolic and Cellular Plasticity During Progression to Castration Resistant Prostate Cancer. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.580617"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1073\/pnas.95.20.11715","article-title":"Mitochondrial reactive oxygen species trigger hypoxia-induced transcription","volume":"95","author":"Chandel","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/AGINGADV.AGINGADV-D-25-00018","article-title":"Narrative review of mitochondrial dysfunction in aging-related salt-sensitive hypertension: Outcomes, mechanisms, and therapeutic implications","volume":"3","author":"Masenga","year":"2026","journal-title":"Aging Adv."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Voros, C., Papadimas, G., Mavrogianni, D., Koulakmanidis, A.-M., Athanasiou, D., Bananis, K., Athanasiou, A., Athanasiou, A., Papapanagiotou, I., and Vaitsis, D. (2025). Molecular Signatures of Obesity-Associated Infertility in Polycystic Ovary Syndrome: The Emerging Role of Exosomal microRNAs and Non-Coding RNAs. Genes, 16.","DOI":"10.3390\/genes16091101"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Siemers, K.M., Klein, A.K., and Baack, M.L. (2023). Mitochondrial Dysfunction in PCOS: Insights into Reproductive Organ Pathophysiology. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202307.1807.v2"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/ijpvm.IJPVM_576_17","article-title":"Oxidative Stress and Polycystic Ovary Syndrome: A Brief Review","volume":"10","author":"Mohammadi","year":"2019","journal-title":"Int. J. Prev. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1186\/s12967-025-06976-4","article-title":"Targeting mitochondrial transporters and metabolic reprogramming for disease treatment","volume":"23","author":"Anselme","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Huo, M., Zhang, J., Huang, W., and Wang, Y. (2021). Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.793428"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"124117","DOI":"10.1016\/j.lfs.2025.124117","article-title":"Impaired metabolic cooperation between oocyte and granulosa cells may contribute to the disrupted folliculogenesis and poor oocyte quality in PCOS","volume":"384","author":"Naigaonkar","year":"2026","journal-title":"Life Sci."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Liao, B., Qiao, J., and Pang, Y. (2021). Central Regulation of PCOS: Abnormal Neuronal-Reproductive-Metabolic Circuits in PCOS Pathophysiology. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.667422"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1007\/s00018-011-0883-3","article-title":"Androgens and skeletal muscle: Cellular and molecular action mechanisms underlying the anabolic actions","volume":"69","author":"Dubois","year":"2012","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/aro2.82","article-title":"Obesity and oxidative stress: Implications for female fertility","volume":"2","author":"Heng","year":"2024","journal-title":"Anim. Res. One Health"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.yjmcc.2009.02.019","article-title":"Prolonged exposure to high dietary lipids is not associated with lipotoxicity in heart failure","volume":"46","author":"Rennison","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1074\/jbc.M112.425876","article-title":"Cardiolipin-dependent Reconstitution of Respiratory Supercomplexes from Purified Saccharomyces cerevisiae Complexes III and IV","volume":"288","author":"Mileykovskaya","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"a007559","DOI":"10.1101\/cshperspect.a007559","article-title":"Quality Control of Mitochondrial Proteostasis","volume":"3","author":"Baker","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Kim, Y., Kim, E.-K., Chey, Y., Song, M.-J., and Jang, H.H. (2023). Targeted Protein Degradation: Principles and Applications of the Proteasome. Cells, 12.","DOI":"10.3390\/cells12141846"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4093\/dmj.2023.0213","article-title":"Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases","volume":"48","author":"Tang","year":"2024","journal-title":"Diabetes Metab. J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.arr.2016.05.004","article-title":"Disorders of lysosomal acidification\u2014The emerging role of v-ATPase in aging and neurodegenerative disease","volume":"32","author":"Colacurcio","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"116179","DOI":"10.1016\/j.celrep.2025.116179","article-title":"Lysosomal polyamine storage upon ATP13A2 loss impairs \u03b2-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions","volume":"44","author":"Samaddar","year":"2025","journal-title":"Cell Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1194\/jlr.R046896","article-title":"Lysosomal exocytosis and lipid storage disorders","volume":"55","author":"Samie","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Arcaro, A., Lepore, A., Cetrangolo, G.P., Paventi, G., Ames, P.R.J., and Gentile, F. (2025). A Reassessment of Sarcopenia from a Redox Perspective as a Basis for Preventive and Therapeutic Interventions. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26167787"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The Hallmarks of Aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10522-014-9515-2","article-title":"Mitochondrial function and mitochondrial DNA maintenance with advancing age","volume":"15","author":"Gaziev","year":"2014","journal-title":"Biogerontology"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Sasaki, H., Hamatani, T., Kamijo, S., Iwai, M., Kobanawa, M., Ogawa, S., Miyado, K., and Tanaka, M. (2019). Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00811"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Figge, M.T., Reichert, A.S., Meyer-Hermann, M., and Osiewacz, H.D. (2012). Deceleration of Fusion\u2013Fission Cycles Improves Mitochondrial Quality Control during Aging. PLoS Comput. Biol., 8.","DOI":"10.1371\/journal.pcbi.1002576"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"R113","DOI":"10.1530\/RAF-21-0060","article-title":"The role of mitophagy during oocyte aging in human, mouse, and Drosophila: Implications for oocyte quality and mitochondrial disease","volume":"2","author":"Cox","year":"2021","journal-title":"Reprod. Fertil."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/157340308784245801","article-title":"The Involvement of Lysosomes in Myocardial Aging and Disease","volume":"4","author":"Terman","year":"2008","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.freeradbiomed.2024.10.311","article-title":"The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death","volume":"225","author":"Baldensperger","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1089\/ars.2017.7111","article-title":"Redox Signaling in Neurotransmission and Cognition During Aging","volume":"28","author":"Kumar","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41392-024-02095-6","article-title":"Redox regulation: Mechanisms, biology and therapeutic targets in diseases","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41418-024-01384-5","article-title":"ARHGAP26 deficiency drives the oocyte aneuploidy and early embryonic development failure","volume":"32","author":"Li","year":"2025","journal-title":"Cell Death Differ."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1046\/j.1432-1033.2002.02869.x","article-title":"The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis","volume":"269","author":"Brunk","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ymgme.2022.07.003","article-title":"Mitochondrial DNA maintenance defects: Potential therapeutic strategies","volume":"137","author":"Almannai","year":"2022","journal-title":"Mol. Genet. Metab."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"eabf8631","DOI":"10.1126\/sciadv.abf8631","article-title":"The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication","volume":"7","author":"Jiang","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/ncomms2001","article-title":"Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A","volume":"3","author":"Farge","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1083\/jcb.201708044","article-title":"Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences","volume":"217","author":"Backes","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"539","DOI":"10.5483\/BMBRep.2017.50.11.157","article-title":"Two distinct nodes of translational inhibition in the Integrated Stress Response","volume":"50","author":"Ryoo","year":"2017","journal-title":"BMB Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41467-020-20597-z","article-title":"LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding","volume":"12","author":"Shin","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Torres, A.K., Fleischhart, V., and Inestrosa, N.C. (2024). Mitochondrial unfolded protein response (UPRmt): What we know thus far. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1405393"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tibs.2010.09.003","article-title":"Regulation of intermediary metabolism by protein acetylation","volume":"36","author":"Guan","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"103300","DOI":"10.1016\/j.redox.2024.103300","article-title":"Loss of NAMPT and SIRT2 but not SIRT1 attenuate GLO1 expression and activity in human skeletal muscle","volume":"75","author":"Miranda","year":"2024","journal-title":"Redox Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s44324-025-00067-0","article-title":"The role of NAD+ metabolism and its modulation of mitochondria in aging and disease","volume":"3","author":"Yusri","year":"2025","journal-title":"Npj Metab. Health Dis."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ncb2757","article-title":"ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase","volume":"15","author":"Russell","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/art.39025","article-title":"Autophagy Activation and Protection From Mitochondrial Dysfunction in Human Chondrocytes","volume":"67","author":"Lotz","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Liu, Q., Wang, W., Xu, L., Zhang, Q., and Wang, H. (2024). The host mannose-6-phosphate pathway and viral infection. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1349221"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.devcel.2020.08.008","article-title":"Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation","volume":"55","author":"Lee","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e47928","DOI":"10.15252\/embr.201947928","article-title":"Metabolic implications of organelle\u2013mitochondria communication","volume":"20","author":"Zorzano","year":"2019","journal-title":"EMBO Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e13127","DOI":"10.1111\/cpr.13127","article-title":"Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling Ca2+ entry","volume":"54","author":"Zhang","year":"2021","journal-title":"Cell Prolif."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Harrath, A.H., Rahman, M.A., Bhajan, S.K., Bishwas, A.K., Rahman, M.H., Alwasel, S., Jalouli, M., Kang, S., Park, M.N., and Kim, B. (2024). Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies. Cells, 13.","DOI":"10.3390\/cells13161354"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Nakashima, A., Furuta, A., Yamada, K., Yoshida-Kawaguchi, M., Yamaki-Ushijima, A., Yasuda, I., Ito, M., Yamashita, S., Tsuda, S., and Yoneda, S. (2023). The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field. Biology, 12.","DOI":"10.3390\/biology12030373"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1097\/CM9.0000000000003801","article-title":"Mitochondrial dysfunction in ovarian aging","volume":"138","author":"Ma","year":"2025","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Cota, V., Sohrabi, S., Kaletsky, R., and Murphy, C.T. (2022). Oocyte mitophagy is critical for extended reproductive longevity. PLoS Genet., 18.","DOI":"10.1371\/journal.pgen.1010400"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Yamada, K., Ito, M., Nunomura, H., Nishigori, T., Furuta, A., Yoshida, M., Yamaki, A., Shozu, K., Yasuda, I., and Tsuda, S. (2025). Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian Aging. Antioxidants, 14.","DOI":"10.20944\/preprints202507.0406.v1"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s42003-025-08576-w","article-title":"HEP14 treatment improves ovarian function in aged mice through mitophagy enhancement and oxidative stress reduction","volume":"8","author":"Gui","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s43556-025-00338-8","article-title":"ROS homeostasis in cell fate, pathophysiology, and therapeutic interventions","volume":"6","author":"Chen","year":"2025","journal-title":"Mol. Biomed."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/4\/429\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:55:50Z","timestamp":1776776150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/4\/429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":166,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["cimb48040429"],"URL":"https:\/\/doi.org\/10.3390\/cimb48040429","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}