{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:53:19Z","timestamp":1785433999340,"version":"3.56.0"},"reference-count":67,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002476","name":"Eulji University","doi-asserted-by":"crossref","award":["2024-0119"],"award-info":[{"award-number":["2024-0119"]}],"id":[{"id":"10.13039\/501100002476","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2024-0119"],"award-info":[{"award-number":["2024-0119"]}],"id":[{"id":"https:\/\/ror.org\/005bty106","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Durae Corporation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>This study evaluated olive leaf extract (OLE) as a multifunctional dermocosmetic candidate for sebum-related and inflammatory responses relevant to oily and acne-prone skin using an axis-aligned in vitro panel: (i) sebocyte lipogenesis, (ii) inflammatory mediator production in keratinocytes, and (iii) fibroblast-mediated collagen gel contraction. In addition, supportive mechanistic evidence for the sebum-related effects of OLE was obtained by examining signaling proteins associated with sebocyte lipogenesis, including PPAR-\u03b3 and SREBP-1. As a result, OLE significantly inhibited linoleic acid-induced lipid accumulation in SEB-1 sebocytes without cytotoxicity. In HaCaT keratinocytes, OLE significantly reduced the production of pro-inflammatory cytokines, including IL-8, TNF-\u03b1, and PGE2, induced by Cutibacterium acnes or UVB. In dermal fibroblast-containing collagen gels, OLE enhanced fibroblast-mediated gel contraction. Additionally, analysis of the main mechanisms of lipid inhibition using SEB-1 sebocytes revealed that OLE exerts a dual regulatory role in lipid synthesis and inflammation by downregulating AKT and ERK phosphorylation and inhibiting PPAR-\u03b3 and SREBP-1 expression. Furthermore, among the tested extracts, the 70% ethanol extract (OLE70) exhibited the strongest antioxidant activity, the greatest gel contraction response, and the highest content of oleuropein, a major bioactive phenolic compound derived from olive. Like OLE, oleuropein also showed sebum-regulatory activity by reducing lipid accumulation in SEB-1 sebocytes, an inhibitory effect on IL-8 expression in HaCaT keratinocytes, and an inhibitory effect on the expression of PPAR-\u03b3 and SREBP-1, which are involved in sebum secretion. Taken together, these findings suggest that OLE and its major phenolic constituent, oleuropein, may modulate sebum-related, inflammatory, oxidative, and dermal remodeling-associated responses in skin cell models. These results should be interpreted as exploratory and provide a basis for further mechanistic and translational investigation.<\/jats:p>","DOI":"10.3390\/cimb48060549","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T02:32:28Z","timestamp":1779676348000},"page":"549","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Olive Leaf Extract Suppresses Sebogenesis and Inflammation via AKT\/ERK and SREBP-1\/PPAR-\u03b3 Signaling in Human Sebocytes"],"prefix":"10.3390","volume":"48","author":[{"given":"Jeeyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang 14048, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Won","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Senior Healthcare, Eulji University, Sujeong-gu, Seongnam 13135, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weon Jeong","family":"Bang","sequence":"additional","affiliation":[{"name":"Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang 14048, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang 14048, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Hyup","family":"Joo","sequence":"additional","affiliation":[{"name":"Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang 14048, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang 14048, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4814-5685","authenticated-orcid":false,"given":"Chang-Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Senior Healthcare, Eulji University, Sujeong-gu, Seongnam 13135, Gyeonggi-do, Republic of Korea"},{"name":"Cosmetic Science Major, Eulji University, Sujeong-gu, Seongnam 13135, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4161\/derm.3.1.13900","article-title":"An update on the role of the sebaceous gland","volume":"3","author":"Makrantonaki","year":"2011","journal-title":"Derm.-Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/jdv.12298","article-title":"Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions","volume":"28","author":"Zouboulis","year":"2014","journal-title":"J. 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