{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T16:50:39Z","timestamp":1786812639325,"version":"build-2736575974"},"reference-count":64,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Oxidative stress plays a central role in the development of cardiovascular diseases (CVDs) and is strongly influenced by environmental toxicants such as heavy metals. Mercury (Hg) is a well-known pro-oxidant agent capable of disrupting cellular redox homeostasis, promoting reactive oxygen species (ROS) generation, and inducing structural and functional alterations in circulating blood cells. In particular, erythrocytes (RBC) are highly susceptible to oxidative damage due to their continuous exposure to oxygen and limited antioxidant repair mechanisms. In this study, we investigated the protective effects of polyphenolic extracts obtained from two tomato (Solanum lycopersicum) cultivars, Piccadilly and Piennolo, against HgCl2-induced oxidative stress in human RBC. Chemical characterization revealed that Piennolo extracts contained higher levels of total polyphenols, flavonoids, and ortho-diphenols compared with Piccadilly samples. Despite these differences, both extracts showed comparable antioxidant capacity. In RBC exposed to HgCl2, tomato extracts significantly reduced ROS production, lipid peroxidation (TBARS), methemoglobin formation, and sulfhydryl depletion, while restoring intracellular glutathione levels. Importantly, pretreatment with the extracts markedly decreased phosphatidylserine externalization, indicating preservation of membrane phospholipid asymmetry and a reduction in the procoagulant phenotype induced by oxidative stress. Overall, these findings suggest that bioactive compounds present in polyphenol-rich tomato extracts exert protective effects on RBC through antioxidant and membrane-stabilizing mechanisms.<\/jats:p>","DOI":"10.3390\/cimb48060567","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:37:26Z","timestamp":1780454246000},"page":"567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tomato Polyphenols Protect Human Red Blood Cells from Mercury-Induced Oxidative Stress and Phosphatidylserine Exposure"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9975-4918","authenticated-orcid":false,"given":"Claudia","family":"Moriello","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-2130","authenticated-orcid":false,"given":"Nicola","family":"Alessio","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Finamore","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"De Rosa","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, Department of Clinical Medicine, Surger University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1066-843X","authenticated-orcid":false,"given":"Chiara","family":"Schiraldi","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-0017","authenticated-orcid":false,"given":"Caterina","family":"Manna","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, School of Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7585-5052","authenticated-orcid":false,"given":"Stefania","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Department of Medical, Movement, and Wellbeing Sciences, Parthenope University of Naples, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5627-0267","authenticated-orcid":false,"given":"Pasquale","family":"Perrone","sequence":"additional","affiliation":[{"name":"Department of Psychology and Health Sciences, Pegaso Telematic University, 80143 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/CIRCRESAHA.123.322002","article-title":"Air Pollution, Built Environment, and Early Cardiovascular Disease","volume":"132","author":"Zhang","year":"2023","journal-title":"Circ. Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ahmed, Z., and Jun, G. (2025). Omics Approaches to Understand Cardiovascular Disease. BMC Cardiovasc. Disord., 25.","DOI":"10.1186\/s12872-025-05418-9"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.123.323617","article-title":"Heavy Metal Exposure and Cardiovascular Disease","volume":"134","author":"Pan","year":"2024","journal-title":"Circ. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Liccardo, M., Perrone, P., Perrella, S., Sirangelo, I., D\u2019Angelo, S., and Iannuzzi, C. (2026). Annurca Apple By-Products at Different Ripening Stages Inhibit AGE Formation and Protect Against AGE-Induced Cytotoxicity Through Antioxidant Activity. Antioxidants, 15.","DOI":"10.3390\/antiox15020200"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1007\/s11356-018-04062-5","article-title":"Mercury Chloride Toxicity in Human Erythrocytes: Enhanced Generation of ROS and RNS, Hemoglobin Oxidation, Impaired Antioxidant Power, and Inhibition of Plasma Membrane Redox System","volume":"26","author":"Ahmad","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1542\/peds.105.3.e34","article-title":"Mercury Intoxication and Arterial Hypertension: Report of Two Patients and Review of the Literature","volume":"105","author":"Ad","year":"2000","journal-title":"Pediatrics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/1573402117666210121102405","article-title":"Endothelial Dysfunction Induced by Cadmium and Mercury and Its Relationship to Hypertension","volume":"17","author":"Martins","year":"2021","journal-title":"Curr. Hypertens. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"125586","DOI":"10.1016\/j.chemosphere.2019.125586","article-title":"Toxicity of Mercury: Molecular Evidence","volume":"245","author":"Yang","year":"2020","journal-title":"Chemosphere"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cbi.2016.10.018","article-title":"Mercury and Protein Thiols: Stimulation of Mitochondrial F1FO-ATPase and Inhibition of Respiration","volume":"260","author":"Nesci","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Notariale, R., Perrone, P., Mele, L., Lettieri, G., Piscopo, M., and Manna, C. (2022). Olive Oil Phenols Prevent Mercury-Induced Phosphatidylserine Exposure and Morphological Changes in Human Erythrocytes Regardless of Their Different Scavenging Activity. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105693"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Daraghmeh, D.N., and Karaman, R. (2024). The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants. Antioxidants, 14.","DOI":"10.3390\/antiox14010036"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Perrone, P., Spinelli, S., Mantegna, G., Notariale, R., Straface, E., Caruso, D., Falliti, G., Marino, A., Manna, C., and Remigante, A. (2023). Mercury Chloride Affects Band 3 Protein-Mediated Anionic Transport in Red Blood Cells: Role of Oxidative Stress and Protective Effect of Olive Oil Polyphenols. Cells, 12.","DOI":"10.3390\/cells12030424"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/MOL.0000000000000298","article-title":"Phosphatidylserine in Atherosclerosis","volume":"27","author":"Darabi","year":"2016","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.coi.2019.11.009","article-title":"Flippase and Scramblase for Phosphatidylserine Exposure","volume":"62","author":"Nagata","year":"2020","journal-title":"Curr. Opin. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.freeradbiomed.2024.11.047","article-title":"Protective Effects of Olive Oil Antioxidant Phenols on Mercury-Induced Phosphatidylserine Externalization in Erythrocyte Membrane: Insights into Scramblase and Flippase Activity","volume":"227","author":"Perrone","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1046\/j.1365-2141.1999.01718.x","article-title":"Phosphatidylserine-Related Adhesion of Human Erythrocytes to Vascular Endothelium","volume":"107","author":"Closse","year":"1999","journal-title":"Br. J. Haematol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Perrone, P., Ortega-Luna, R., Manna, C., \u00c1lvarez-Ribelles, \u00c1., and Collado-Diaz, V. (2024). Increased Adhesiveness of Blood Cells Induced by Mercury Chloride: Protective Effect of Hydroxytyrosol. Antioxidants, 13.","DOI":"10.3390\/antiox13121576"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"106414","DOI":"10.1016\/j.phrs.2022.106414","article-title":"Polyphenols and Atherosclerosis: A Critical Review of Clinical Effects on LDL Oxidation","volume":"184","author":"Ahmadi","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103783","DOI":"10.1016\/j.redox.2025.103783","article-title":"Protective Effect of Hydroxytyrosol against Hyperglycemia-Induced Phosphatidylserine Exposure in Human Erythrocytes: Focus on Dysregulation of Calcium Homeostasis and Redox Balance","volume":"85","author":"Notariale","year":"2025","journal-title":"Redox Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bcp.2018.07.050","article-title":"Polyphenols, Food and Pharma. Current Knowledge and Directions for Future Research","volume":"156","author":"Moreno","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Moriello, C., Alessio, N., Perrone, P., Squillaro, T., D\u2019Angelo, S., Galderisi, U., and Bernardo, G.D. (2026). Polyphenol-Rich Extracts from Annurca Apple Differentially Modulate Oxidative Stress-Induced Senescence in Human Dermal Fibroblasts. Antioxidants, 15.","DOI":"10.3390\/antiox15030372"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mosca, L., Pagano, C., Tafuri, M.G., Maio, G.D., Rejano-Gordillo, C.M., Marca, R.D., D\u2019Angelo, S., Monda, M., Messina, G., and Polito, R. (2026). The Gut Microbiota\u2013Polyphenol\u2013NLRP3 Inflammasome Axis: A Key Regulatory Network Linking Diet to Chronic Inflammation. Nutrients, 18.","DOI":"10.3390\/nu18101483"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Przybylska, S., and Tokarczyk, G. (2022). Lycopene in the Prevention of Cardiovascular Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23041957"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Perrone, P., Moriello, C., Alessio, N., Manna, C., and D\u2019Angelo, S. (2025). Cytoprotective Potential of Annurca Apple Polyphenols on Mercury-Induced Oxidative Stress in Human Erythrocytes. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26188826"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Perrone, P., Palmieri, S., Piscopo, M., Lettieri, G., Eugelio, F., Fanti, F., and D\u2019Angelo, S. (2025). Antioxidant Activity of Annurca Apple By-Products at Different Ripening Stages: A Sustainable Valorization Approach. Antioxidants, 14.","DOI":"10.3390\/antiox14080941"},{"key":"ref_26","first-page":"19","article-title":"Spectrometric Measurement of Methemoglobin without Interference of Chemical or Enzymatic Reagents","volume":"26","author":"Naoum","year":"2004","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1590\/S0100-879X2012007500050","article-title":"Electron Paramagnetic Resonance Study of Lipid and Protein Membrane Components of Erythrocytes Oxidized with Hydrogen Peroxide","volume":"45","author":"Mendanha","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_28","first-page":"1","article-title":"Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay","volume":"159","author":"Borges","year":"2020","journal-title":"J. Vis. Exp."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1093\/jxb\/erv063","article-title":"Contribution of Glutathione to the Control of Cellular Redox Homeostasis under Toxic Metal and Metalloid Stress","volume":"66","author":"Escobar","year":"2015","journal-title":"J. Exp. Bot."},{"key":"ref_30","first-page":"287","article-title":"First Line Defence Antioxidants-Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPX): Their Fundamental Role in the Entire Antioxidant Defence Grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alex. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12933-023-01965-7","article-title":"The Role of Oxidative Stress in Diabetes Mellitus-Induced Vascular Endothelial Dysfunction","volume":"22","author":"An","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.2174\/1381612811319320005","article-title":"Hyperglycemia-Induced Oxidative Stress and Its Role in Diabetes Mellitus Related Cardiovascular Diseases","volume":"19","author":"Fiorentino","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"w13659","DOI":"10.4414\/smw.2012.13659","article-title":"Reactive Oxygen Species: From Health to Disease","volume":"142","author":"Brieger","year":"2012","journal-title":"Swiss Med. Wkly."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbrc.2022.08.098","article-title":"Reactive Oxygen Species (ROS), Oxygen Radicals and Antioxidants: Where Are We Now, Where Is the Field Going and Where Should We Go?","volume":"633","author":"Halliwell","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"He, F., Li, J., Liu, Z., Chuang, C.-C., Yang, W., and Zuo, L. (2016). Redox Mechanism of Reactive Oxygen Species in Exercise. Front. Physiol., 7.","DOI":"10.3389\/fphys.2016.00486"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/ars.2019.7955","article-title":"Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases","volume":"34","author":"Gianazza","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000073600","article-title":"Oxidative Stress in Endothelial Cell Dysfunction and Thrombosis","volume":"32","author":"Loscalzo","year":"2002","journal-title":"Pathophysiol. Haemost. Thromb."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3324\/haematol.2011.048694","article-title":"A Role for Activated Endothelial Cells in Red Blood Cell Clearance: Implications for Vasopathology","volume":"97","author":"Fens","year":"2012","journal-title":"Haematologica"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mohanty, J.G., Nagababu, E., and Rifkind, J.M. (2014). Red Blood Cell Oxidative Stress Impairs Oxygen Delivery and Induces Red Blood Cell Aging. Front. Physiol., 5.","DOI":"10.3389\/fphys.2014.00084"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Perrone, P., Moriello, C., Alessio, N., Contri, A., Manna, C., and D\u2019Angelo, S. (2026). Annurca Apple Polyphenols Prevent Mercury-Induced Phosphatidylserine Externalization in Human Erythrocytes via Calcium-Dependent PLSCR1 Regulation. Front. Nutr., 13.","DOI":"10.3389\/fnut.2026.1770188"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/ije\/dyw319","article-title":"Fruit and Vegetable Intake and the Risk of Cardiovascular Disease, Total Cancer and All-Cause Mortality-a Systematic Review and Dose-Response Meta-Analysis of Prospective Studies","volume":"46","author":"Aune","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"135319","DOI":"10.1016\/j.foodchem.2022.135319","article-title":"Integral Valorisation of Tomato By-Products towards Bioactive Compounds Recovery: Human Health Benefits","volume":"410","author":"Coelho","year":"2023","journal-title":"Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.foodchem.2017.11.055","article-title":"Can Lycopene Be Considered an Effective Protection against Cardiovascular Disease?","volume":"245","author":"Pinho","year":"2018","journal-title":"Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2713511","DOI":"10.1155\/2021\/2713511","article-title":"Lycopene: Food Sources, Biological Activities, and Human Health Benefits","volume":"2021","author":"Khan","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10546","DOI":"10.1080\/10408398.2023.2226211","article-title":"Tomato Wastes and By-Products: Upcoming Sources of Polyphenols and Carotenoids for Food, Nutraceutical, and Pharma Applications","volume":"64","author":"Abuhabib","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Storniolo, C.E., Sacanella, I., Mitjavila, M.T., Lamuela-Raventos, R.M., and Moreno, J.J. (2019). Bioactive Compounds of Cooked Tomato Sauce Modulate Oxidative Stress and Arachidonic Acid Cascade Induced by Oxidized LDL in Macrophage Cultures. Nutrients, 11.","DOI":"10.3390\/nu11081880"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Fratianni, F., Cozzolino, A., d\u2019Acierno, A., Nazzaro, F., Riccardi, R., and Spigno, P. (2020). Qualitative Aspects of Some Traditional Landraces of the Tomato \u201cPiennolo\u201d (Solanum lycopersicum L.) of the Campania Region, Southern Italy. Antioxidants, 9.","DOI":"10.3390\/antiox9070565"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2022.06.004","article-title":"The Role of Glutathione Peroxidase-1 in Health and Disease","volume":"188","author":"Handy","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5028181","DOI":"10.1155\/2019\/5028181","article-title":"Glutathione \u201cRedox Homeostasis\u201d and Its Relation to Cardiovascular Disease","volume":"2019","author":"Bajic","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.abb.2014.05.017","article-title":"Polyphenols and Mitochondria: An Update on Their Increasingly Emerging ROS-Scavenging Independent Actions","volume":"559","author":"Ferreira","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0076-6879(01)35243-6","article-title":"Metal Chelation of Polyphenols","volume":"335","author":"Hider","year":"2001","journal-title":"Methods Enzymol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S335","DOI":"10.3233\/JAD-200185","article-title":"Polyphenols as Potential Metal Chelation Compounds Against Alzheimer\u2019s Disease","volume":"82","author":"Burillo","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Bucciantini, M., Leri, M., Nardiello, P., Casamenti, F., and Stefani, M. (2021). Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants, 10.","DOI":"10.3390\/antiox10071044"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.foodchem.2013.09.012","article-title":"Polyphenols in Barringtonia Racemosa and Their Protection against Oxidation of LDL, Serum and Haemoglobin","volume":"146","author":"Kong","year":"2014","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3233\/CH-131716","article-title":"Lipid Peroxidation Affects Red Blood Cells Membrane Properties in Patients with Systemic Lupus Erythematosus","volume":"58","author":"Spengler","year":"2014","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12340","DOI":"10.1021\/acs.jafc.4c00523","article-title":"Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2\/GPx4 Pathway","volume":"72","author":"Zhang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0955-2863(02)00208-5","article-title":"Flavonoid Antioxidants: Chemistry, Metabolism and Structure-Activity Relationships","volume":"13","author":"Heim","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.nut.2004.03.025","article-title":"Plant Genotype Affects Total Antioxidant Capacity and Phenolic Contents in Fruit","volume":"21","author":"Scalzo","year":"2005","journal-title":"Nutrition"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jsps.2016.04.025","article-title":"The Pharmacological Potential of Rutin","volume":"25","author":"Ganeshpurkar","year":"2017","journal-title":"Saudi Pharm. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.foodchem.2014.10.057","article-title":"Bioactivity of Phenolic Acids: Metabolites versus Parent Compounds: A Review","volume":"173","author":"Heleno","year":"2015","journal-title":"Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.saa.2013.06.110","article-title":"Spectroscopic Studies on the Antioxidant Activity of p-Coumaric Acid","volume":"115","year":"2013","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/febs.14606","article-title":"Oxidative Stress, Eryptosis and Anemia: A Pivotal Mechanistic Nexus in Systemic Diseases","volume":"286","author":"Bissinger","year":"2019","journal-title":"FEBS J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.taap.2005.07.022","article-title":"Stimulation of Erythrocyte Phosphatidylserine Exposure by Mercury Ions","volume":"210","author":"Eisele","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/ijerph2006030005","article-title":"Mercury-Induced Externalization of Phosphatidylserine and Caspase 3 Activation in Human Liver Carcinoma (HepG2) Cells","volume":"3","author":"Sutton","year":"2006","journal-title":"Int. J. Environ. Res. Public Health"}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/6\/567\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:18:20Z","timestamp":1780546700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/6\/567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":64,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["cimb48060567"],"URL":"https:\/\/doi.org\/10.3390\/cimb48060567","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]}}}