{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:21:01Z","timestamp":1785860461041,"version":"3.56.0"},"reference-count":122,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007686","name":"Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00ctdh943","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Endometriosis is a long-term gynecological condition marked by the growth of endometrial-like tissue outside the uterus, which undergoes proliferation, bleeding, and regeneration. This disease is associated with disrupted steroid hormone signaling, notably progesterone (P4) resistance and estradiol (E2) dominance. P4 resistance has been associated with impaired activation of the progesterone receptor (PR) and reduced transcription of P4 target genes, while elevated E2 levels induce estrogen receptor (ER)-mediated signaling, enhancing estrogen-dependent lesion growth. This hormonal imbalance contributes to a pro-inflammatory microenvironment, chronic pelvic pain, infertility, and enhanced neuroangiogenesis. Emerging evidence indicates that the coordinated regulation of neurotrophins and sex hormones promotes nerve fibers and blood vessel growth and invasion within endometriotic lesions. P4 and E2 have been shown to modulate the expression of key neurotrophins, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). This review presents current evidence on the interplay between neurotrophins and ovarian steroids in endometriosis, with a specific focus on their contribution to neuroangiogenesis and pain pathophysiology. The review includes articles in English containing the Medical Subject Headings (MeSH) terms: \u201cendometriosis\u201d, \u201cneurotrophins\u201d, \u201cnerve growth factor\u201d, \u201cbrain-derived neurotrophic factor\u201d, \u201cneuroangiogenesis\u201d, \u201cprogesterone\u201d, and \u201cestradiol\u201d, found in the PubMed database published between 2000 and 24 May 2026. This review included a range of original research articles, systematic reviews, meta-analyses, prospective observational studies, case\u2013control studies, and review papers, for a total of 122 articles.<\/jats:p>","DOI":"10.3390\/cimb48070649","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:57:24Z","timestamp":1782287844000},"page":"649","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interactions Between Neurotrophins and Ovarian Steroids in Endometriosis and Their Implications for Neuroangiogenesis: A Narrative Review"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3516-916X","authenticated-orcid":false,"given":"Olivia Tania","family":"Hern\u00e1ndez-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n-Unidad de Investigaci\u00f3n en Reproducci\u00f3n Humana, Instituto Nacional de Perinatolog\u00eda-Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora Mar\u00eda","family":"Vel\u00e1zquez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Reproducci\u00f3n Humana, Instituto Nacional de Perinatolog\u00eda-Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Camacho-Arroyo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Reproducci\u00f3n Humana, Instituto Nacional de Perinatolog\u00eda-Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12958-016-0178-5","article-title":"Localization of TrkB and P75 Receptors in Peritoneal and Deep Infiltrating Endometriosis: An Immunohistochemical Study","volume":"14","author":"Dewanto","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1093\/humrep\/dev147","article-title":"Pain Typology and Incident Endometriosis","volume":"30","author":"Schliep","year":"2015","journal-title":"Hum. Reprod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jama.2025.2975","article-title":"Endometriosis","volume":"334","author":"Mackenzie","year":"2025","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"179515","DOI":"10.1155\/2014\/179515","article-title":"Theories on the Pathogenesis of Endometriosis","volume":"2014","author":"Sourial","year":"2014","journal-title":"Int. J. Reprod. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ajpath.2023.04.007","article-title":"Neurotrophins and Their Receptors, Novel Therapeutic Targets for Pelvic Pain in Endometriosis, Are Coordinately Regulated by IL-1\u03b2 via the JNK Signaling Pathway","volume":"193","author":"Yu","year":"2023","journal-title":"Am. J. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1515\/HMBCI.2011.002","article-title":"A New Concept of Endometriosis and Adenomyosis: Tissue Injury and Repair (TIAR)","volume":"5","author":"Leyendecker","year":"2011","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.molmed.2018.07.004","article-title":"The Immunopathophysiology of Endometriosis","volume":"24","author":"Symons","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/GRF.0b013e3181db7ce8","article-title":"Invasive and Noninvasive Methods for the Diagnosis of Endometriosis","volume":"53","author":"Hsu","year":"2010","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis Is a Chronic Systemic Disease: Clinical Challenges and Novel Innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-physiol-012110-142158","article-title":"Endometriosis: The Role of Neuroangiogenesis","volume":"73","author":"Asante","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.gyobfe.2010.05.005","article-title":"Neurotrophines et Douleur: \u00c9tude d\u2019expression et de Corr\u00e9lation Dans l\u2019endom\u00e9triose","volume":"38","author":"Borghese","year":"2010","journal-title":"Gynecol. Obstet. Fertil."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Marquardt, R.M., Kim, T.H., Shin, J.-H., and Jeong, J.-W. (2019). Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153822"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1210\/en.2006-1692","article-title":"Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis","volume":"148","author":"Burney","year":"2007","journal-title":"Endocrinology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/aogs.13156","article-title":"Progesterone Resistance in Endometriosis: Origins, Consequences and Interventions","volume":"96","author":"Patel","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1080\/13543784.2022.2152325","article-title":"Advances in Targeting Estrogen Synthesis and Receptors in Patients with Endometriosis","volume":"31","author":"Clemenza","year":"2022","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.maturitas.2008.12.009","article-title":"The Dialectic Role of Progesterone","volume":"62","author":"Huber","year":"2009","journal-title":"Maturitas"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/humupd\/dmu056","article-title":"Role of Nuclear Progesterone Receptor Isoforms in Uterine Pathophysiology","volume":"21","author":"Patel","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/molehr\/gap013","article-title":"Overexpression of Progesterone Receptor A Isoform in Mice Leads to Endometrial Hyperproliferation, Hyperplasia and Atypia","volume":"15","author":"Fleisch","year":"2009","journal-title":"Mol. Hum. Reprod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.mce.2016.06.027","article-title":"Membrane Progesterone Receptors in Reproduction and Cancer","volume":"434","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2196024","DOI":"10.1155\/2020\/2196024","article-title":"Expression of Membrane Progesterone Receptors in Eutopic and Ectopic Endometrium of Women with Endometriosis","volume":"2020","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"109040","DOI":"10.1016\/j.steroids.2022.109040","article-title":"The Role of Progesterone Receptor Membrane Component (PGRMC) in the Endometrium","volume":"184","year":"2022","journal-title":"Steroids"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1210\/js.2018-00007","article-title":"Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis","volume":"2","author":"Brown","year":"2018","journal-title":"J. Endocr. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1177\/1933719115585145","article-title":"Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants","volume":"22","author":"Bedaiwy","year":"2015","journal-title":"Reprod. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.fertnstert.2003.11.048","article-title":"Reduction of Apoptosis and Proliferation in Endometriosis","volume":"82","author":"Foidart","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12672-010-0023-9","article-title":"Expression of Membrane Progesterone Receptors (MPR\/PAQR) in Ovarian Cancer Cells: Implications for Progesterone-Induced Signaling Events","volume":"1","author":"Charles","year":"2010","journal-title":"Horm. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.steroids.2006.10.006","article-title":"Identification of Membrane Progestin Receptors in Human Breast Cancer Cell Lines and Biopsies and Their Potential Involvement in Breast Cancer","volume":"72","author":"Dressing","year":"2007","journal-title":"Steroids"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1677\/joe.1.06242","article-title":"Regulated Expression of Putative Membrane Progestin Receptor Homologues in Human Endometrium and Gestational Tissues","volume":"187","author":"Fernandes","year":"2005","journal-title":"J. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Vel\u00e1zquez-Hern\u00e1ndez, D.M., V\u00e1zquez-Mart\u00ednez, E.R., Cruz-Orozco, O., Silvestri-Tomassoni, J.R., S\u00e1nchez-Ram\u00edrez, B., Olgu\u00edn-Ortega, A., Escobar-Ponce, L.F., Rodr\u00edguez-Dorantes, M., and Camacho-Arroyo, I. (2025). Membrane Progesterone Receptor Beta Regulates the Decidualization of Endometrial Stromal Cells in Women with Endometriosis. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26157297"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/humrep\/dew085","article-title":"A Prospective Cohort Study of Endometriosis and Subsequent Risk of Infertility","volume":"31","author":"Prescott","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"102311","DOI":"10.1016\/j.coph.2022.102311","article-title":"Hormonal Drugs for the Treatment of Endometriosis","volume":"67","author":"Capezzuoli","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1177\/1933719118779733","article-title":"Effectiveness of Dienogest for Treatment of Recurrent Endometriosis: Multicenter Data","volume":"25","author":"Lee","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11154-021-09666-w","article-title":"Hormonal Treatments for Endometriosis: The Endocrine Background","volume":"23","author":"Vannuccini","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/14728222.2016.1180368","article-title":"Selective Progesterone Receptor Modulators (SPRMs): Progesterone Receptor Action, Mode of Action on the Endometrium and Treatment Options in Gynecological Therapies","volume":"20","author":"Wagenfeld","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.gyobfe.2013.07.016","article-title":"Int\u00e9r\u00eat Actuel Des Selective Progesterone Receptor Modulators (SPRM) Dans l\u2019endom\u00e9triose","volume":"41","author":"Merviel","year":"2013","journal-title":"Gynecol. Obstet. Fertil."},{"key":"ref_35","unstructured":"Huang, W. (2012). Progesterone Receptor Antagonists and Progesterone Receptor Modulators for Endometriosis. Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yu, K., Huang, Z.-Y., Xu, X.-L., Li, J., Fu, X.-W., and Deng, S.-L. (2022). Estrogen Receptor Function: Impact on the Human Endometrium. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.827724"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-319-56895-9_6","article-title":"Estrogen Receptors in Cell Membranes: Regulation and Signaling","volume":"227","author":"Saczko","year":"2017","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1095\/biolreprod.107.061804","article-title":"Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1","volume":"77","author":"Xue","year":"2007","journal-title":"Biol. Reprod."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1210\/jc.2008-1466","article-title":"Estrogen Receptor (ER) \u03b2 Regulates ER\u03b1 Expression in Stromal Cells Derived from Ovarian Endometriosis","volume":"94","author":"Trukhacheva","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Chantalat, E., Valera, M.-C., Vaysse, C., Noirrit, E., Rusidze, M., Weyl, A., Vergriete, K., Buscail, E., Lluel, P., and Fontaine, C. (2020). Estrogen Receptors and Endometriosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082815"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1074\/jbc.M407879200","article-title":"Cell- and Ligand-Specific Regulation of Promoters Containing Activator Protein-1 and Sp1 Sites by Estrogen Receptors \u03b1 and \u03b2","volume":"280","author":"Schultz","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jsbmb.2003.11.008","article-title":"Differential Regulation of the Human Progesterone Receptor Gene through an Estrogen Response Element Half Site and Sp1 Sites","volume":"88","author":"Petz","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41574-023-00822-7","article-title":"The G Protein-Coupled Oestrogen Receptor GPER in Health and Disease: An Update","volume":"19","author":"Prossnitz","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/molehr\/gaq043","article-title":"G Protein-Coupled Estrogen Receptor 1 (GPER, GPR 30) in Normal Human Endometrium and Early Pregnancy Decidua","volume":"16","author":"Kolkova","year":"2010","journal-title":"Mol. Hum. Reprod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/07435800.2013.774011","article-title":"The Expression Status of G Protein-Coupled Receptor GPR30 Is Associated with the Clinical Characteristics of Endometriosis","volume":"38","author":"Yuguchi","year":"2013","journal-title":"Endocr. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1177\/1933719111431000","article-title":"G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal and Abnormal Endometrium","volume":"19","author":"Plante","year":"2012","journal-title":"Reprod. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cyto.2013.03.003","article-title":"Evidence of Neurotrophic Events Due to Peritoneal Endometriotic Lesions","volume":"62","author":"Arnold","year":"2013","journal-title":"Cytokine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0306-4522(01)00568-1","article-title":"Modulation of Nerve Growth Factor in Peripheral Organs by Estrogen and Progesterone","volume":"110","author":"Bjorling","year":"2002","journal-title":"Neuroscience"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI118815","article-title":"Vascular Endothelial Growth Factor Is Produced by Peritoneal Fluid Macrophages in Endometriosis and Is Regulated by Ovarian Steroids","volume":"98","author":"McLaren","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1111\/j.1460-9568.2003.03029.x","article-title":"Oestrogen Regulates Sympathetic Neurite Outgrowth by Modulating Brain Derived Neurotrophic Factor Synthesis and Release by the Rodent Uterus","volume":"18","author":"Pedchenko","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.fertnstert.2007.08.074","article-title":"Effects of Hormonal Treatment on Nerve Fibers in Endometrium and Myometrium in Women with Endometriosis","volume":"90","author":"Tokushige","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s13224-024-02097-y","article-title":"Recent Trends in Medical Management of Endometriosis","volume":"74","author":"Patel","year":"2024","journal-title":"J. Obstet. Gynecol. India"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/humupd\/dmy020","article-title":"Is It Time for a Paradigm Shift in Drug Research and Development in Endometriosis\/Adenomyosis?","volume":"24","author":"Guo","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1210\/en.2010-1010","article-title":"Treatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model","volume":"152","author":"Kulak","year":"2011","journal-title":"Endocrinology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/humupd\/dmy047","article-title":"Neurotrophins and Glial Cell Line-Derived Neurotrophic Factor in the Ovary: Physiological and Pathophysiological Implications","volume":"25","author":"Chang","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Skaper, S.D. (2018). Neurotrophic Factors: An Overview. Neurotrophic Factors, Humana Press.","DOI":"10.1007\/978-1-4939-7571-6"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101568","DOI":"10.1016\/j.jbc.2022.101568","article-title":"High-Affinity TrkA and P75 Neurotrophin Receptor Complexes: A Twisted Affair","volume":"298","author":"Conroy","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.mehy.2011.02.033","article-title":"DHEA Provides a Microenvironment for Endometrial Stem Cells Neurogenesis","volume":"76","author":"Sharif","year":"2011","journal-title":"Med. Hypotheses"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1210\/en.2014-1111","article-title":"Loss of Ntrk2\/Kiss1r Signaling in Oocytes Causes Premature Ovarian Failure","volume":"155","author":"Dorfman","year":"2014","journal-title":"Endocrinology"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Bao, W., Qiu, H., Yang, T., Luo, X., Zhang, H., and Wan, X. (2013). Upregulation of TrkB Promotes Epithelial-Mesenchymal Transition and Anoikis Resistance in Endometrial Carcinoma. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070616"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Maddern, J., Grundy, L., Castro, J., and Brierley, S.M. (2020). Pain in Endometriosis. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.590823"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Orita, S., Ishikawa, T., Miyagi, M., Ochiai, N., Inoue, G., Eguchi, Y., Kamoda, H., Arai, G., Toyone, T., and Aoki, Y. (2011). Pain-Related Sensory Innervation in Monoiodoacetate-Induced Osteoarthritis in Rat Knees That Gradually Develops Neuronal Injury in Addition to Inflammatory Pain. BMC Musculoskelet. Disord., 12.","DOI":"10.1186\/1471-2474-12-134"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.fertnstert.2012.05.027","article-title":"Proteomic Identification of Neurotrophins in the Eutopic Endometrium of Women with Endometriosis","volume":"98","author":"Browne","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"577406","DOI":"10.1016\/j.jneuroim.2020.577406","article-title":"The Emerging Role of the BDNF-TrkB Signaling Pathway in the Modulation of Pain Perception","volume":"349","author":"Cappoli","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/humupd\/dmaa008","article-title":"Brain-Derived Neurotrophic Factor (BDNF) Expression and Function in the Mammalian Reproductive Tract","volume":"26","author":"Chow","year":"2020","journal-title":"Hum. Reprod. Update"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/1933719117732161","article-title":"Role of Brain-Derived Neurotrophic Factor in Endometriosis Pain","volume":"25","author":"Ding","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Numakawa, T., and Kajihara, R. (2023). Involvement of Brain-Derived Neurotrophic Factor Signaling in the Pathogenesis of Stress-Related Brain Diseases. Front. Mol. Neurosci., 16.","DOI":"10.3389\/fnmol.2023.1247422"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00018-006-6010-1","article-title":"Neurotrophin Signaling: Many Exciting Surprises!","volume":"63","author":"Wu","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00296-013-2943-5","article-title":"Involvement of BDNF in Knee Osteoarthritis: The Relationship with Inflammation and Clinical Parameters","volume":"34","author":"Santos","year":"2014","journal-title":"Rheumatol. Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jpsychires.2006.02.007","article-title":"Increased BDNF Serum Concentration in Fibromyalgia with or without Depression or Antidepressants","volume":"41","author":"Laske","year":"2007","journal-title":"J. Psychiatr. Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Song, S.Y., Jung, Y.W., Shin, W., Park, M., Lee, G.W., Jeong, S., An, S., Kim, K., Ko, Y.B., and Lee, K.H. (2023). Endometriosis-Related Chronic Pelvic Pain. Biomedicines, 11.","DOI":"10.3390\/biomedicines11102868"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/00207454.2023.2285709","article-title":"Elucidating the Role of Brain-Derived Neurotrophic Factor (BDNF) and Its Receptor Tyrosine Receptor Kinase B (TrkB) in the Development and Symptoms of Endometriosis","volume":"135","author":"Bi","year":"2025","journal-title":"Int. J. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.freeradbiomed.2022.12.002","article-title":"TrkB Agonist N-Acetyl Serotonin Promotes Functional Recovery after Traumatic Brain Injury by Suppressing Ferroptosis via the PI3K\/Akt\/Nrf2\/Ferritin H Pathway","volume":"194","author":"Cheng","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_74","first-page":"2129","article-title":"MAPK\/ERK Signal Pathway Involved Expression of COX-2 and VEGF by IL-1\u03b2 Induced in Human Endometriosis Stromal Cells in Vitro","volume":"6","author":"Huang","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1093\/humrep\/del260","article-title":"Nerve Fibres in Peritoneal Endometriosis","volume":"21","author":"Tokushige","year":"2006","journal-title":"Hum. Reprod."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Garrido, M.P., Torres, I., Vega, M., and Romero, C. (2019). Angiogenesis in Gynecological Cancers: Role of Neurotrophins. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00913"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1477-7827-4-57","article-title":"Effects of Nerve Growth Factor (NGF) on Blood Vessels Area and Expression of the Angiogenic Factors VEGF and TGFbeta1 in the Rat Ovary","volume":"4","author":"Lara","year":"2006","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1210\/jc.2009-0542","article-title":"Nerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a TrkA Receptor\/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway","volume":"94","author":"Lozada","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3233\/CH-121647","article-title":"Angiogenesis: From Molecular Mechanisms to Translational Implications","volume":"54","author":"Li","year":"2013","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jri.2016.12.002","article-title":"Drospirenone Reduces Inflammatory Cytokines, Vascular Endothelial Growth Factor (VEGF) and Nerve Growth Factor (NGF) Expression in Human Endometriotic Stromal Cells","volume":"119","author":"Makabe","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/jnr.21370","article-title":"Progesterone Increases Brain-derived Neuroptrophic Factor Expression and Protects against Glutamate Toxicity in a Mitogen-activated Protein Kinase- and Phosphoinositide-3 Kinase-dependent Manner in Cerebral Cortical Explants","volume":"85","author":"Kaur","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroscience.2011.11.034","article-title":"Progesterone Effects on Neuronal Brain-Derived Neurotrophic Factor and Glial Cells during Progression of Wobbler Mouse Neurodegeneration","volume":"201","author":"Meyer","year":"2012","journal-title":"Neuroscience"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/humrep\/del479","article-title":"Influence of Endogenous and Exogenous Sex Hormones on Plasma Brain-Derived Neurotrophic Factor","volume":"22","author":"Begliuomini","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/humrep\/dev018","article-title":"Estrogen Induced Changes in Uterine Brain-Derived Neurotrophic Factor and Its Receptors","volume":"30","author":"Wessels","year":"2015","journal-title":"Hum. Reprod."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1210\/en.2014-1086","article-title":"Estrogen Receptor (ER) Agonists Differentially Regulate Neuroangiogenesis in Peritoneal Endometriosis via the Repellent Factor SLIT3","volume":"155","author":"Greaves","year":"2014","journal-title":"Endocrinology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cellsig.2017.08.006","article-title":"NGF Protects Endothelial Cells from Indomethacin-Induced Injury through Activation of Mitochondria and Upregulation of IGF-1","volume":"40","author":"Ahluwalia","year":"2017","journal-title":"Cell. Signal."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00024382-200302000-00007","article-title":"Human Dermal Microvascular Endothelial Cells Produce Nerve Growth Factor: Implications for Wound Repair","volume":"19","author":"Gibran","year":"2003","journal-title":"Shock"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"11094","DOI":"10.1073\/pnas.0403663101","article-title":"Innervation of Ectopic Endometrium in a Rat Model of Endometriosis","volume":"101","author":"Berkley","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1749-6632.2002.tb02792.x","article-title":"Using Rats as a Research Model for the Study of Endometriosis","volume":"955","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/humrep\/del339","article-title":"Association between Endometriosis Stage, Lesion Type, Patient Characteristics and Severity of Pelvic Pain Symptoms: A Multivariate Analysis of over 1000 Patients","volume":"22","author":"Vercellini","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1097\/AOG.0b013e3181758ec6","article-title":"Surgical Treatment of Endometriosis","volume":"111","author":"Shakiba","year":"2008","journal-title":"Obstet. Gynecol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/humrep\/den464","article-title":"Rich Innervation of Deep Infiltrating Endometriosis","volume":"24","author":"Wang","year":"2008","journal-title":"Hum. Reprod."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1016\/j.fertnstert.2009.12.074","article-title":"Nerve Fibers in Ovarian Endometriomas","volume":"94","author":"Tokushige","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.fertnstert.2008.09.006","article-title":"A Pilot Study to Evaluate the Clinical Relevance of Endometriosis-Associated Nerve Fibers in Peritoneal Endometriotic Lesions","volume":"92","author":"Mechsner","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1093\/humrep\/dep275","article-title":"Diagnosis of Endometriosis by Detection of Nerve Fibres in an Endometrial Biopsy: A Double Blind Study","volume":"24","author":"Dezarnaulds","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1007\/s12035-018-1348-6","article-title":"The Expression and Cellular Localisation of Neurotrophin and Neural Guidance Molecules in Peritoneal Ectopic Lesions","volume":"56","author":"Asally","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.tjog.2023.07.003","article-title":"Brain-Derived Neurotrophic Factor and Nerve Growth Factor Expression in Endometriosis: A Systematic Review and Meta-Analysis","volume":"62","author":"Liu","year":"2023","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00737-020-01094-0","article-title":"Addictive Behaviors across the Menstrual Cycle: A Systematic Review","volume":"24","author":"Joyce","year":"2021","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Kuan, K.K.W., Gibson, D.A., Whitaker, L.H.R., and Horne, A.W. (2021). Menstruation Dysregulation and Endometriosis Development. Front. Reprod. Health, 3.","DOI":"10.3389\/frph.2021.756704"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.fertnstert.2011.11.011","article-title":"Endometriosis-Associated Nerve Fibers, Peritoneal Fluid Cytokine Concentrations, and Pain in Endometriotic Lesions from Different Locations","volume":"97","author":"McKinnon","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1507\/endocrj.EJ13-0027","article-title":"Possible Involvement of Nerve Growth Factor in Dysmenorrhea and Dyspareunia Associated with Endometriosis","volume":"60","author":"Kajitani","year":"2013","journal-title":"Endocr. J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jmig.2009.06.017","article-title":"Endometriosis and Mechanisms of Pelvic Pain","volume":"16","author":"Howard","year":"2009","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.neuro.29.051605.112929","article-title":"Neurotrophins: Mediators and Modulators of Pain","volume":"29","author":"Pezet","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.fertnstert.2006.03.057","article-title":"Pain, Mast Cells, and Nerves in Peritoneal, Ovarian, and Deep Infiltrating Endometriosis","volume":"86","author":"Anaf","year":"2006","journal-title":"Fertil. Steril."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/1933719117716778","article-title":"Nerve Growth Factor Is Associated With Sexual Pain in Women With Endometriosis","volume":"25","author":"Peng","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13048-022-00963-9","article-title":"BDNF and TrKB Expression Levels in Patients with Endometriosis and Their Associations with Dysmenorrhoea","volume":"15","author":"Wang","year":"2022","journal-title":"J. Ovarian Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.ajpath.2018.06.011","article-title":"IL-1\u03b2 Stimulates Brain-Derived Neurotrophic Factor Production in Eutopic Endometriosis Stromal Cell Cultures","volume":"188","author":"Yu","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/(SICI)1097-4695(199609)31:1<77::AID-NEU7>3.0.CO;2-C","article-title":"Nerve Growth Factor (NGF) Regulation of Estrogen Receptors in Explant Cultures of the Developing Forebrain","volume":"31","author":"Miranda","year":"1996","journal-title":"J. Neurobiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1073\/pnas.92.24.11110","article-title":"Identification of a Putative Estrogen Response Element in the Gene Encoding Brain-Derived Neurotrophic Factor","volume":"92","author":"Sohrabji","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.fertnstert.2006.12.078","article-title":"Different Types of Small Nerve Fibers in Eutopic Endometrium and Myometrium in Women with Endometriosis","volume":"88","author":"Tokushige","year":"2007","journal-title":"Fertil. Steril."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/humupd\/dmz018","article-title":"The Endometrial Immune Environment of Women with Endometriosis","volume":"25","author":"Houshdaran","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1523-1747.2003.12487.x","article-title":"17\u03b2-Estradiol Enhances the Production of Nerve Growth Factor in THP-1-Derived Macrophages or Peripheral Blood Monocyte-Derived Macrophages","volume":"121","author":"Kanda","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12958-018-0441-z","article-title":"Villainous Role of Estrogen in Macrophage-Nerve Interaction in Endometriosis","volume":"16","author":"Liang","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/humupd\/dmaa009","article-title":"Progesterone Receptor Ligands for the Treatment of Endometriosis: The Mechanisms behind Therapeutic Success and Failure","volume":"26","author":"Reis","year":"2020","journal-title":"Hum. Reprod. Update"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Li, Y., Adur, M.K., Kannan, A., Davila, J., Zhao, Y., Nowak, R.A., Bagchi, M.K., Bagchi, I.C., and Li, Q. (2016). Progesterone Alleviates Endometriosis via Inhibition of Uterine Cell Proliferation, Inflammation and Angiogenesis in an Immunocompetent Mouse Model. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165347"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.2165\/11206320-000000000-00000","article-title":"Dienogest: A Review of Its Use in the Treatment of Endometriosis","volume":"70","author":"McCormack","year":"2010","journal-title":"Drugs"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.fertnstert.2011.06.048","article-title":"Progestins Inhibit Estradiol-Induced Vascular Endothelial Growth Factor and Stromal Cell\u2013Derived Factor 1 in Human Endometrial Stromal Cells","volume":"96","author":"Okada","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.fertnstert.2013.10.038","article-title":"Dienogest Inhibits Nerve Growth Factor Expression Induced by Tumor Necrosis Factor-\u03b1 or Interleukin-1\u03b2","volume":"101","author":"Mita","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/GCO.0000000000000983","article-title":"Medical Management of Endometriosis","volume":"36","author":"Alonso","year":"2024","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Jafarabady, K., Shafiee, A., Bahri, R.A., Mohammadi, I., Amini, M.j., Rajai, S., Akbarzadeh, D., Abhari, F.S., Movahed, E., and Parvari, S. (2024). Brain-Derived Neurotrophic Factor (BDNF) as a Potential Marker of Endometriosis: A Systematic Review and Meta-Analysis. BMC Women\u2019s Health, 24.","DOI":"10.1186\/s12905-023-02877-0"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2217\/bmm-2016-0327","article-title":"Plasma Brain-Derived Neurotrophic Factor in Women With Pelvic Pain: A Potential Biomarker for Endometriosis?","volume":"11","author":"Rocha","year":"2017","journal-title":"Biomark. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.fertnstert.2017.01.009","article-title":"Biomarkers in Endometriosis: Challenges and Opportunities","volume":"107","author":"Ahn","year":"2017","journal-title":"Fertil. Steril."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/7\/649\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:31:31Z","timestamp":1782534691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/7\/649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":122,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["cimb48070649"],"URL":"https:\/\/doi.org\/10.3390\/cimb48070649","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]}}}