{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:46:46Z","timestamp":1782794806269,"version":"3.54.5"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Research Fund of Yunnan Characteristic Plant Extraction Laboratory","award":["YKKF2023003"],"award-info":[{"award-number":["YKKF2023003"]}]},{"name":"Yunnan Fundamental Research Projects","award":["202401BF070001-029"],"award-info":[{"award-number":["202401BF070001-029"]}]},{"name":"Independent Research Fund of the Yunnan Characteristic Plant Extraction Laboratory","award":["2025YKZY005"],"award-info":[{"award-number":["2025YKZY005"]}]},{"name":"Independent Research Fund of the Yunnan Characteristic Plant Extraction Laboratory","award":["2025YKZY006"],"award-info":[{"award-number":["2025YKZY006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Nicotinamide (NAM), a precursor of nicotinamide adenine dinucleotide (NAD+), and NAD+ are integral to a variety of cellular processes. NAM supplementation has been shown to have benefits for cellular senescence. However, the mechanism by which NAM improves skin photoaging remains unclear. In this study, the multi-omics analysis revealed that insufficient nicotinamide metabolism may be associated with a decrease in NAD+ synthesis during skin aging. Importantly, we found that NAM has an ameliorating effect on the skin photoaging in mice. Supplementation with NAM restored the expression of the salvage-pathway enzymes and NAD+ consumers. In addition, the supplementation with NAM was shown to restore the expression of skin barrier-related proteins (ZO1 and E-cadherin) and collagen I, while reducing the expression of senescence markers (\u03b3-H2AX, p53, and p21). Furthermore, we found that NAM effectively suppresses the senescence-associated secretory phenotype (SASP) factors\u2019 expression in skin photoaging. Our research reveals the dual role of NAM in attenuating skin photoaging, acting not only to delay cellular senescence but also to suppress the SASP.<\/jats:p>","DOI":"10.3390\/cimb48070661","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:11:57Z","timestamp":1782785517000},"page":"661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nicotinamide Improves Skin Photoaging in Mice by Delaying Cellular Senescence and Suppressing the Senescence-Associated Secretory Phenotype"],"prefix":"10.3390","volume":"48","author":[{"given":"Xin-Yue","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, School of Life Sciences, Southwest United Graduate School, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Jin","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, School of Life Sciences, Southwest United Graduate School, Yunnan University, Kunming 650500, China"},{"name":"Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, School of Life Sciences, Southwest United Graduate School, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yan","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, School of Life Sciences, Southwest United Graduate School, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, School of Life Sciences, Southwest United Graduate School, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Cheng","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, School of Life Sciences, Southwest United Graduate School, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-4402","authenticated-orcid":false,"given":"Cheng-Gang","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, School of Life Sciences, Southwest United Graduate School, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s40257-025-00933-z","article-title":"Photoaging: Current Concepts on Molecular Mechanisms, Prevention, and Treatment","volume":"26","author":"Kaltchenko","year":"2025","journal-title":"Am. 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