{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:15:20Z","timestamp":1785406520768,"version":"3.56.0"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404849"],"award-info":[{"award-number":["82404849"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304770"],"award-info":[{"award-number":["82304770"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82404849"],"award-info":[{"award-number":["82404849"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["82304770"],"award-info":[{"award-number":["82304770"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chongqing Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX1646"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX1646"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chongqing Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2024TIAD-KPX0062"],"award-info":[{"award-number":["CSTB2024TIAD-KPX0062"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chongqing Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX1214"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX1214"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing University of Chinese Medicine","award":["SQMS2024QNXM-001"],"award-info":[{"award-number":["SQMS2024QNXM-001"]}]},{"award":["SQMS2024QNXM-001"],"award-info":[{"award-number":["SQMS2024QNXM-001"]}],"id":[{"id":"https:\/\/ror.org\/023rhb549","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016834","name":"Key TCM Research Project of Chongqing Municipal Health Commission","doi-asserted-by":"publisher","award":["2025ZYZD001"],"award-info":[{"award-number":["2025ZYZD001"]}],"id":[{"id":"10.13039\/100016834","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2025ZYZD001"],"award-info":[{"award-number":["2025ZYZD001"]}],"id":[{"id":"https:\/\/ror.org\/04ce5fg13","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Chongqing University of Chinese Medicine","award":["JBGS2024-001"],"award-info":[{"award-number":["JBGS2024-001"]}]},{"award":["JBGS2024-001"],"award-info":[{"award-number":["JBGS2024-001"]}],"id":[{"id":"https:\/\/ror.org\/023rhb549","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Science and Technology Research Program of Chongqing Municipal Education Commission","award":["KJQN202215123"],"award-info":[{"award-number":["KJQN202215123"]}]},{"award":["KJQN202215123"],"award-info":[{"award-number":["KJQN202215123"]}],"id":[{"id":"https:\/\/ror.org\/031nm5713","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Cholestatic liver injury (CLI) is a complex condition for which current treatment options remain limited. Lysimachiae Herba (LH), a traditional Chinese medicine with hepatoprotective properties, has not yet been fully characterized in terms of its active constituents and underlying mechanisms in CLI. This study was designed to systematically determine the chemical composition of LH, characterize its absorbed constituents in vivo, and elucidate its therapeutic mechanisms against CLI. UPLC-Q-TOF-MS\/MS was employed to analyze the chemical composition of LH and its absorbed components in rat serum. Key targets and signaling pathways were predicted using network pharmacology and molecular docking, followed by experimental validation in an ANIT-induced CLI mouse model and LCA-treated HepG2 cells through biochemical assays, histological examination, transcriptomic analysis, qRT-PCR, Western blotting, and immunofluorescence analysis. A total of 129 compounds were tentatively identified in LH, among which 26 were detected in the bloodstream. Network analysis and molecular docking suggested that LH regulates bile acid homeostasis predominantly by the FXR signaling pathway. Both in vivo and in vitro experiments provided convergent evidence that LH modulates the FXR-related bile acid regulatory network, enhances bile acid efflux transporter expression, and alleviates CLI. In conclusion, this study systematically elucidates the chemical composition, absorbed constituents, and pharmacological mechanisms of LH in CLI, highlighting the involvement of FXR-related bile acid regulation as an important mechanism and providing a scientific basis for the potential development of LH for cholestatic liver injury.<\/jats:p>","DOI":"10.3390\/cimb48070682","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:52:24Z","timestamp":1783007544000},"page":"682","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lysimachiae Herba Modulates FXR to Alleviate Cholestatic Liver Injury: Insights from Serum Pharmacochemistry and Experimental Validation"],"prefix":"10.3390","volume":"48","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Chongqing University of Chinese Medicine, Chongqing 402760, China"},{"name":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Chongqing University of Chinese Medicine, Chongqing 402760, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengli","family":"Li","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Chongqing University of Chinese Medicine, Chongqing 402760, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Chongqing University of Chinese Medicine, Chongqing 402760, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Chongqing University of Chinese Medicine, Chongqing 402760, China"},{"name":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijbiomac.2022.02.056","article-title":"Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4\/NF-\u03baB signaling pathway","volume":"205","author":"Fang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Shi, Q., Yuan, X., Zeng, Y., Wang, J., Zhang, Y., Xue, C., and Li, L. (2023). Crosstalk between gut microbiota and bile acids in cholestatic liver disease. Nutrients, 15.","DOI":"10.3390\/nu15102411"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s40265-021-01545-7","article-title":"Cholestatic liver disease: Current treatment strategies and new therapeutic agents","volume":"81","author":"Hasegawa","year":"2021","journal-title":"Drugs"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"118108","DOI":"10.1016\/j.jep.2024.118108","article-title":"Mechanistic studies on the alleviation of ANIT-induced cholestatic liver injury by Polygala fallax Hemsl. polysaccharides","volume":"328","author":"Guan","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13578-023-01035-1","article-title":"Bile acid-mediated signaling in cholestatic liver diseases","volume":"13","author":"Zeng","year":"2023","journal-title":"Cell Biosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"737","DOI":"10.21037\/atm-20-5110","article-title":"The role of bile acids in cholestatic liver injury","volume":"9","author":"Cai","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/1751-2980.12378","article-title":"Role of farnesoid X receptor in cholestasis","volume":"17","author":"Yuan","year":"2016","journal-title":"J. Dig. Dis."},{"key":"ref_8","first-page":"467","article-title":"Lysimachia christinae Hance aqueous extract ameliorates renal injury in kidney stone rats and calcium oxalate crystal-induced oxidative stress in HK-2 cells via inhibiting the PI3K\/Akt\/mTOR pathway","volume":"41","author":"Zheng","year":"2026","journal-title":"Histol. Histopathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jep.2011.04.029","article-title":"Evaluation of Lysimachia christinae Hance extracts as anticholecystitis and cholagogic agents in animals","volume":"137","author":"Yang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"141158","DOI":"10.1016\/j.ijbiomac.2025.141158","article-title":"Lysimachia christinae polysaccharides dampen pseudorabies viral infection by downregulating adsorption and exert antioxidant activity","volume":"306","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"131700","DOI":"10.1016\/j.seppur.2025.131700","article-title":"Extraction, isolation and cytotoxic activities of triterpene saponins from ornamental and medicinal plant Lysimachia christinae","volume":"362","author":"Deng","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"117840","DOI":"10.1016\/j.jep.2024.117840","article-title":"A study for quality evaluation of Lysimachiae herba from different origins based on fingerprint-activity relationship modeling and multi-component content determination","volume":"325","author":"Zhou","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1039\/D0FO02567D","article-title":"An integrated strategy for evaluation of sulfur-fumigated edible herb Astragali radix based on UPLC-MS\/MS platforms and pharmacological analysis","volume":"12","author":"Ma","year":"2021","journal-title":"Food Funct."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"156531","DOI":"10.1016\/j.phymed.2025.156531","article-title":"Integrating serum pharmacochemistry, network pharmacology, metabolomics and 16S rRNA sequencing to explore the mechanism of total flavonoids from Flemingia philippinensis in treating collagen induced arthritis rats","volume":"139","author":"Qiu","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/pca.70038","article-title":"Unraveling the Therapeutic Mechanisms of Shanzhen Mingmu Pill in Diabetic Retinopathy: An Integration of Serum Pharmacochemistry, Network Pharmacology, and Experimental Validation","volume":"37","author":"Yang","year":"2026","journal-title":"Phytochem. Anal."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13020-024-01056-z","article-title":"Network pharmacology: A crucial approach in traditional Chinese medicine research","volume":"20","author":"Zhai","year":"2025","journal-title":"Chin. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"108326","DOI":"10.1016\/j.bioorg.2025.108326","article-title":"Discovery of ASGR1 and HMGCR dual-target inhibitors based on supervised learning, molecular docking, molecular dynamics simulations, and biological evaluation","volume":"158","author":"Liu","year":"2025","journal-title":"Bioorganic Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhang, X., Wang, K., Dai, H., Cai, J., Liu, Y., Yin, C., Wu, J., Li, X., Wu, G., and Lu, A. (2022). Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1018273"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"118540","DOI":"10.1016\/j.microc.2026.118540","article-title":"Ultrasound-assisted deep eutectic solvent extraction of total flavonoids from Lysimachia christinae Hance: Optimization using ANN-GA, characterization, and evaluation of antihyperlipidemic activity in vitro and in vivo","volume":"226","author":"Yu","year":"2026","journal-title":"Microchem. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1002\/jssc.202100390","article-title":"The active ingredients analysis of Herba Lysimachiae treating osteoarthritis based on the LC\u2013MS\/MS technology and public bioinformatics platforms","volume":"44","author":"Li","year":"2021","journal-title":"J. Sep. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.foodchem.2012.09.096","article-title":"Simultaneous detection of flavonoids and phenolic acids in Herba Lysimachiae and Herba Desmodii Styracifolii using liquid chromatography tandem mass spectrometry","volume":"138","author":"Sun","year":"2013","journal-title":"Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e5385","DOI":"10.1002\/bmc.5385","article-title":"Biolabel-led research pattern reveals serum profile in rats after treatment with Herba Lysimachiae: Combined analysis of metabonomics and proteomics","volume":"36","author":"Li","year":"2022","journal-title":"Biomed. Chromatogr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"119072","DOI":"10.1016\/j.jep.2024.119072","article-title":"Investigating the possible mechanism of Cornus officinalis in the therapy of ischemic stroke by UHPLC-Q-TOF-MS, network pharmacology, molecular docking, and experimental verification","volume":"338","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"124272","DOI":"10.1016\/j.jchromb.2024.124272","article-title":"An innovative UPLC-MS\/MS method for the quantitation and pharmacokinetics of eupafolin in rat plasma","volume":"1245","author":"Xia","year":"2024","journal-title":"J. Chromatogr. B"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2238959","DOI":"10.1080\/19490976.2023.2238959","article-title":"Protection against metabolic associated fatty liver disease by protocatechuic acid","volume":"15","author":"Tan","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.toxrep.2021.01.001","article-title":"Hepatoprotective, antioxidant and, anti-inflammatory potentials of gallic acid in carbon tetrachloride-induced hepatic damage in Wistar rats","volume":"8","author":"Ojeaburu","year":"2021","journal-title":"Toxicol. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101117","DOI":"10.1016\/j.redox.2019.101117","article-title":"(-)-Epicatechin attenuates hepatic sinusoidal obstruction syndrome by inhibiting liver oxidative and inflammatory injury","volume":"22","author":"Huang","year":"2019","journal-title":"Redox Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"20240994","DOI":"10.1515\/med-2024-0994","article-title":"New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study","volume":"19","author":"Zhou","year":"2024","journal-title":"Open Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"154529","DOI":"10.1016\/j.phymed.2022.154529","article-title":"NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury","volume":"108","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"119400","DOI":"10.1016\/j.jep.2025.119400","article-title":"Ribes diacanthum Pall modulates bile acid homeostasis and oxidative stress in cholestatic mice by activating the SIRT1\/FXR and Keap1\/Nrf2 signaling pathways","volume":"342","author":"Bayoude","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/bs.pmch.2021.01.004","article-title":"Use of molecular docking computational tools in drug discovery","volume":"60","author":"Stanzione","year":"2021","journal-title":"Prog. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"103672","DOI":"10.1016\/j.etap.2021.103672","article-title":"Intrahepatic cholestasis induced by \u03b1-naphthylisothiocyanate can cause gut-liver axis disorders","volume":"86","author":"Chen","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbadis.2017.06.027","article-title":"Animal models of biliary injury and altered bile acid metabolism","volume":"1864","author":"Mariotti","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.7861\/clinmed.2020-0697","article-title":"An update on the management of cholestatic liver diseases","volume":"20","author":"Appanna","year":"2020","journal-title":"Clin. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/aps.2014.119","article-title":"Resveratrol effectively attenuates \u03b1-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms","volume":"35","author":"Wang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"115164","DOI":"10.1016\/j.jep.2022.115164","article-title":"Swertiamarin, an active iridoid glycoside from Swertia pseudochinensis H. Hara, protects against alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway","volume":"291","author":"Shi","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"117308","DOI":"10.1016\/j.taap.2025.117308","article-title":"\u03b2-Sitosterol protects against lithocholic acid-induced hepatotoxicity and cholestasis via farnesoid X receptor-mediated regulation of transporters and enzymes in vitro and in vivo","volume":"498","author":"Wang","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1369\/0022155418804507","article-title":"Prevention of cell growth by suppression of villin expression in lithocholic acid-stimulated HepG2 cells","volume":"67","author":"Ozeki","year":"2019","journal-title":"J. Histochem. Cytochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejphar.2015.08.029","article-title":"Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism","volume":"765","author":"Chen","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"G774","DOI":"10.1152\/ajpgi.00387.2024","article-title":"Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice","volume":"328","author":"Jiang","year":"2025","journal-title":"Am. J. Physiol.\u2014Gastrointest. Liver Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2024.08.006","article-title":"ROS-responsive nanoparticle delivery of obeticholic acid mitigate primary sclerosing cholangitis","volume":"374","author":"Yao","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1007\/s00018-018-2892-y","article-title":"The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses","volume":"75","author":"Eller","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/HEP.0000000000001438","article-title":"Benefits and challenges to therapeutic targeting of bile acid circulation in cholestatic liver disease","volume":"82","author":"Trauner","year":"2025","journal-title":"Hepatology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"112672","DOI":"10.1016\/j.jep.2020.112672","article-title":"Yinchenzhufu decoction protects against alpha-naphthylisothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses","volume":"254","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"154173","DOI":"10.1016\/j.phymed.2022.154173","article-title":"Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis","volume":"102","author":"Liu","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: Regulation of synthesis: Thematic Review Series: Bile Acids","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jhep.2009.05.012","article-title":"New molecular insights into the mechanisms of cholestasis","volume":"51","author":"Wagner","year":"2009","journal-title":"J. Hepatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1053\/jhep.2003.50317","article-title":"Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis","volume":"38","author":"Geier","year":"2003","journal-title":"Hepatology"}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/7\/682\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:43:24Z","timestamp":1783014204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/7\/682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["cimb48070682"],"URL":"https:\/\/doi.org\/10.3390\/cimb48070682","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]}}}