{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:06:19Z","timestamp":1783940779075,"version":"3.55.0"},"reference-count":44,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mexico State Council for Science and Technology","award":["CIKAS-FICDTEM25-019"],"award-info":[{"award-number":["CIKAS-FICDTEM25-019"]}]},{"name":"Programa Acad\u00e9mico de Investigaci\u00f3n e Innovaci\u00f3n Tecnol\u00f3gica (PAPIIT)-UNAM","award":["IN208126"],"award-info":[{"award-number":["IN208126"]}]},{"name":"Programa Acad\u00e9mico de Investigaci\u00f3n e Innovaci\u00f3n Tecnol\u00f3gica (PAPIIT)-UNAM","award":["IV200425"],"award-info":[{"award-number":["IV200425"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Intestinal dysbiosis is a hallmark of both inflammatory bowel conditions and colorectal cancer, yet the mechanisms by which inflammatory mediators alter microbial communities and may contribute to tumor development remain poorly understood. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in innate immunity and the progression of inflammatory and neoplastic disorders. In this study, sequencing of the microbial 16S rRNA gene was performed to characterize the fecal microbiota profiles of wild-type (WT) and MIF-knockout (MIF-KO) BALB\/c mice subjected to AOM\/DSS-induced colitis-associated colorectal cancer (CAC). CAC induction resulted in marked microbial shifts, including increases in Muribaculaceae and Bacteroidota, in both WT and MIF-KO mice. Notably, MIF-KO CAC mice developed more severe disease compared with WT CAC mice. Furthermore, FMT experiments revealed that the fecal microbiota from MIF-KO donors was associated with increased tumor burden in WT recipients under CAC-inducing conditions compared with that in recipients colonized with WT-derived microbiota. Together, these findings suggest that MIF deficiency is associated with gut microbiota remodeling during CAC and support a potential relationship between the MIF-dependent host context, microbial composition and colorectal cancer severity.<\/jats:p>","DOI":"10.3390\/cimb48070712","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:51:09Z","timestamp":1783936269000},"page":"712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MIF Deficiency Modulates Gut Microbiota Composition and Promotes Colitis-Associated Colorectal Cancer in a Murine Model"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-9996","authenticated-orcid":false,"given":"Sonia","family":"H. Navia","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunidad Innata, Unidad de Investigaci\u00f3n en Biomedicina (UBIMED), Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Av. de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-5486","authenticated-orcid":false,"given":"Oscar","family":"Illescas","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology and Pharmacogenomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6702-4578","authenticated-orcid":false,"given":"Miguel Atl","family":"Silva-Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Ciencias Bioqu\u00edmicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"},{"name":"Divisi\u00f3n de Gen\u00f3mica Computacional, Instituto Nacional de Medicina Gen\u00f3mica, Perif\u00e9rico Sur, 14610 Ciudad de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imelda","family":"Ju\u00e1rez-Avelar","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunidad Innata, Unidad de Investigaci\u00f3n en Biomedicina (UBIMED), Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Av. de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"},{"name":"Programa de Doctorado en Ciencias Biol\u00f3gicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Terrazas-Rodriguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunidad Innata, Unidad de Investigaci\u00f3n en Biomedicina (UBIMED), Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Av. de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-9706","authenticated-orcid":false,"given":"Felipe","family":"Vaca-Paniagua","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunidad Innata, Unidad de Investigaci\u00f3n en Biomedicina (UBIMED), Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Av. de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"},{"name":"Laboratorio Nacional en Salud, Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Av. de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Estela","family":"D\u00edaz Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunidad Innata, Unidad de Investigaci\u00f3n en Biomedicina (UBIMED), Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Av. de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"},{"name":"Laboratorio Nacional en Salud, Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Av. de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-5267","authenticated-orcid":false,"given":"Libia","family":"Vega","sequence":"additional","affiliation":[{"name":"Departamento de Toxicolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Av. 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