{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:02:27Z","timestamp":1785301347620,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr. Issues Mol. Biol.","CIMB"],"abstract":"<jats:p>Ultraviolet B (UVB) radiation is a major environmental factor contributing to skin photoaging through excessive reactive oxygen species (ROS) generation, activation of stress-responsive signaling pathways, DNA damage, cellular senescence, and extracellular matrix (ECM) degradation. Mangiferin, a naturally occurring xanthone glucoside with potent antioxidant and anti-inflammatory properties, has attracted considerable interest as a potential photoprotective agent. The present study investigated the protective effects of mangiferin against UVB-induced photoaging in human dermal fibroblasts (HDFs). The effects of mangiferin on oxidative stress, RAGE\/NF-\u03baB\/MAPK signaling, DNA damage, cellular senescence, and ECM degradation were evaluated. Mangiferin significantly suppressed UVB-induced ROS accumulation and attenuated activation of the RAGE\/NF-\u03baB\/MAPK signaling cascade. Furthermore, mangiferin reduced \u03b3-H2AX expression, indicating protection against UVB-mediated DNA damage, while decreasing p16, p21, and p53 expression and restoring LMNB1 levels. Mangiferin also inhibited MMP-2 and MMP-9 activities as well as collagenase, elastase, and hyaluronidase activities, suggesting preservation of ECM homeostasis. These findings demonstrate that mangiferin protects dermal fibroblasts against UVB-induced photoaging through suppression of oxidative stress, inhibition of RAGE\/NF-\u03baB\/MAPK signaling, attenuation of DNA damage and cellular senescence, and preservation of ECM integrity, supporting its potential application in photoprotective and anti-photoaging dermocosmetic formulations.<\/jats:p>","DOI":"10.3390\/cimb48080757","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:54:26Z","timestamp":1785153266000},"page":"757","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mangiferin Protects Human Dermal Fibroblasts Against UVB-Induced Photoaging by Regulating RAGE\/NF-\u03baB\/p38 MAPK Signaling, Cellular Senescence, and ECM Homeostasis"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2459-2058","authenticated-orcid":false,"given":"\u0130nci","family":"Kurt-Celep","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Faculty of Pharmacy, Istanbul Okan University, Tuzla, Istanbul 34959, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e16688","DOI":"10.1111\/jocd.16688","article-title":"Influences on skin and intrinsic aging: Biological, environmental, and therapeutic insights","volume":"24","author":"Hussein","year":"2025","journal-title":"J. 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