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Issues Mol. Biol.","CIMB"],"abstract":"<jats:p>Balanced control of intracellular deoxyribonucleoside-triphosphate (dNTP) pools is crucial for accurate DNA replication and genome stability. Deoxycytidine triphosphate pyrophosphatase 1 (DCTPP1) is a cytosolic nucleotide-sanitizing enzyme that selectively hydrolyzes abnormal cytosine-derived triphosphates to maintain pyrimidine pool homeostasis. Dysregulated DCTPP1 expression disrupts this balance, leading to replication stress and genomic instability. Recent studies have revealed that DCTPP1 is frequently upregulated across various human cancers and contributes to tumor progression, stress tolerance, and chemoresistance. Particularly in hepatocellular carcinoma, an oncogenic DCTPP1\/MYC feedback loop has been reported to rewire pyrimidine metabolism. This review summarizes the current understanding of DCTPP1 biology, highlights its emerging role in hepatocellular carcinoma, and discusses its potential therapeutic implications.<\/jats:p>","DOI":"10.3390\/cimb48080770","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:45:14Z","timestamp":1785325514000},"page":"770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Understanding of DCTPP1 as an Emerging Therapeutic Target in Liver Cancer"],"prefix":"10.3390","volume":"48","author":[{"given":"Hye In","family":"Ka","sequence":"first","affiliation":[{"name":"Department of Molecular Science & Technology, Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Ha","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kosin University College of Medicine, Seo-gu, Busan 49267, Republic of Korea"},{"name":"Section of Hematology, Department of Internal Medicine and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Sun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2461-6702","authenticated-orcid":false,"given":"Jung Woo","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pai, C.-C., and Kearsey, S.E. 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