{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:25:45Z","timestamp":1787149545043,"version":"build-2736575974"},"reference-count":88,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005187","name":"National and Kapodistrian University of Athens Special Account for Research Grants","doi-asserted-by":"publisher","award":["19214"],"award-info":[{"award-number":["19214"]}],"id":[{"id":"10.13039\/501100005187","id-type":"DOI","asserted-by":"publisher"}]},{"award":["19214"],"award-info":[{"award-number":["19214"]}],"id":[{"id":"https:\/\/ror.org\/04gnjpq42","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr. Issues Mol. Biol.","CIMB"],"abstract":"<jats:p>The Breast Cancer (BRCA) genes play an important role in repairing double-strand deoxyribonucleic acid (DNA) breaks. Mutations in these genes are associated with the development of malignancies, most notably breast and ovarian cancer. Carriers of these mutations are often faced with issues that have serious implications for their reproductive choices, including the occurrence and treatment of breast or ovarian cancer, recommendations for preventive mastectomy and salpingo-oophorectomy, and the risk of transmitting the BRCA gene mutation to an offspring. These issues often lead to the search for methods of fertility preservation or assisted reproduction. This review aims to highlight and explain all the ways in which BRCA gene mutations affect fertility in women. Specifically, the effect of BRCA carriage is assessed at the molecular, histological, clinical, and laboratory levels. Next, fertility preservation methods in carriers are analyzed and evaluated in terms of their safety and effectiveness. In addition, the effect of systemic therapies for breast cancer on ovarian reserves is explained. Finally, the possibility of preimplantation diagnosis of BRCA gene carriage is also examined.<\/jats:p>","DOI":"10.3390\/cimb48080843","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:14:01Z","timestamp":1787145241000},"page":"843","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reproductive Challenges in Mutated BRCA Gene Carriers: A Narrative Review"],"prefix":"10.3390","volume":"48","author":[{"given":"Maria","family":"Vouza","sequence":"first","affiliation":[{"name":"6th Department of Obstetrics & Gynaecology, General and Maternity Hospital Elena Venizelou, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Papadoliopoulou","sequence":"additional","affiliation":[{"name":"4th Department of Surgery, Attikon University Hospital, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Dimitrakakis","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynaecology, Alexandra Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Zografos","sequence":"additional","affiliation":[{"name":"1st Propaedeutic Department of Surgery, Hippocration General Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos V.","family":"Michalopoulos","sequence":"additional","affiliation":[{"name":"1st Propaedeutic Department of Surgery, Hippocration General Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Arkadopoulos","sequence":"additional","affiliation":[{"name":"4th Department of Surgery, Attikon University Hospital, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s13193-011-0049-7","article-title":"BRCA1 and BRCA1 genes and inherited breast and\/or ovarian cancer: Benefits of genetic testing","volume":"1","author":"Somasundaram","year":"2010","journal-title":"Indian J. Surg. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0168-9525(99)01930-7","article-title":"Insights into the functions of BRCA1 and BRCA2","volume":"16","author":"Welcsh","year":"2000","journal-title":"Trends Genet."},{"key":"ref_3","first-page":"862","article-title":"BRCA genes: BRCA 1 and BRCA 2","volume":"23","author":"Varol","year":"2018","journal-title":"J. Balk. Union Oncol."},{"key":"ref_4","unstructured":"National Cancer Institute (2026, January 10). BRCAgene Changes: Cancer Risk Genetic Testing, Available online: https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/genetics\/brca-fact-sheet."},{"key":"ref_5","unstructured":"Dixon, M.J., Barber, M.D., Paterson-Brown, S., and Garden, O.J. (2024). Breast Surgery, Elsevier. [7th ed.]."},{"key":"ref_6","unstructured":"National Cancer Institute (2026, January 10). Cancer Stat Facts: Ovarian Cancer, Available online: https:\/\/seer.cancer.gov\/statfacts\/html\/ovary.html."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12609-019-00350-2","article-title":"Risk management for BRCA1\/BRCA2 mutation carriers without and with breast cancer","volume":"12","author":"Mainor","year":"2020","journal-title":"Curr. Breast Cancer Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1001\/jamaoncol.2022.0476","article-title":"Expansion of cancer risk profile for BRCA1 and BRCA2 pathogenic variants","volume":"8","author":"Momozawa","year":"2022","journal-title":"JAMA Oncol."},{"key":"ref_9","unstructured":"National Comprehensive Cancer Network (2025). NCCN Clinical Practice Guidelines in Oncology: Genetic\/Familial High-Risk Assessment\u2014Breast, Ovarian, Pancreatic, and Prostate, NCCN. Available online: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_bopp.pdf."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"E886","DOI":"10.1503\/cmaj.190281","article-title":"Management of ovarian cancer risk in women with BRCA1\/2 pathogenic variants","volume":"191","author":"Walker","year":"2019","journal-title":"Can. Med. Assoc. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1001\/jama.286.18.2251","article-title":"Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: NSABP-P1 Breast Cancer Prevention Trial","volume":"286","author":"King","year":"2001","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/j.ejca.2010.04.018","article-title":"Oral contraceptive use and breast or ovarian cancer risk in BRCA1\/2 carriers: A meta-analysis","volume":"46","author":"Iodice","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1095\/biolreprod.115.132290","article-title":"BRCA mutations, DNA repair deficiency, and ovarian aging","volume":"93","author":"Oktay","year":"2015","journal-title":"Biol. Reprod."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"172ra21","DOI":"10.1126\/scitranslmed.3004925","article-title":"Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans","volume":"5","author":"Titus","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105262","DOI":"10.1016\/j.ebiom.2024.105262","article-title":"Conditional loss of Brca1 in oocytes causes reduced litter size, ovarian reserve depletion and impaired oocyte in vitro maturation with advanced reproductive age in mice","volume":"106","author":"Winship","year":"2024","journal-title":"eBioMedicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1242\/dev.00888","article-title":"BRCA2 deficiency in mice leads to meiotic impairment and infertility","volume":"131","author":"Sharan","year":"2004","journal-title":"Development"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.fertnstert.2005.02.037","article-title":"Upregulation of the BRCA1 gene in human germ cells and in preimplantation embryos","volume":"84","author":"Perrin","year":"2005","journal-title":"Fertil. Steril."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0047-6374(00)00151-2","article-title":"Repair of telomeric DNA prior to replicative senescence","volume":"118","author":"Lansdorp","year":"2000","journal-title":"Mech. Ageing Dev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/01.gco.0000193019.05686.49","article-title":"The telomere theory of reproductive senescence in women","volume":"18","author":"Keefe","year":"2006","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/hmg\/ddl002","article-title":"A role for Brca1 in chromosome end maintenance","volume":"15","author":"McPherson","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1210\/jc.2017-00765","article-title":"Ovarian aging in women with BRCA germline mutations","volume":"102","author":"Lin","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/annonc\/mdx639","article-title":"Reproductive potential and performance of fertility preservation strategies in BRCA-mutated breast cancer patients","volume":"29","author":"Lambertini","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.fertnstert.2008.12.052","article-title":"Hereditary Breast Cancer Clinical Study Group. Fertility in women with BRCA mutations: A case-control study","volume":"93","author":"Pal","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/ajhb.20978","article-title":"Impact of BRCA mutations on female fertility and offspring sex ratio","volume":"22","author":"Moslehi","year":"2010","journal-title":"Am. J. Hum. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.fertnstert.2013.01.109","article-title":"Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation","volume":"99","author":"Finch","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/ijgc-2019-000626","article-title":"Assessment of ovarian reserve and reproductive outcomes in BRCA1 or BRCA2 mutation carriers","volume":"30","author":"Ponce","year":"2020","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.maturitas.2020.04.011","article-title":"Effects of BRCA gene mutation on female reproductive potential: A systematic review","volume":"137","author":"Hu","year":"2020","journal-title":"Maturitas"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"20249999","DOI":"10.1515\/med-2024-9999","article-title":"Reproductive outcomes in women with BRCA1\/2 germline mutations: A retrospective observational study and literature review","volume":"19","author":"Dellino","year":"2024","journal-title":"Open Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/jayao.2016.0009","article-title":"Association of BRCA1 mutations with impaired ovarian reserve: Connection between infertility and breast\/ovarian cancer risk","volume":"5","author":"Giordano","year":"2016","journal-title":"J. Adolesc. Young Adult Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1098\/rspb.2011.1697","article-title":"Effects of BRCA1 and BRCA2 mutations on female fertility","volume":"279","author":"Smith","year":"2012","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kwiatkowski, F., Arbre, M., Bidet, Y., Laquet, C., Uhrhammer, N., and Bignon, Y.J. (2015). BRCA mutations increase fertility in families at hereditary breast\/ovarian cancer risk. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127363"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/bcr1387","article-title":"Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers","volume":"8","author":"Friedman","year":"2006","journal-title":"Breast Cancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/IGC.0000000000000058","article-title":"BRCA mutation carriers do not have compromised ovarian reserve","volume":"24","author":"Mor","year":"2014","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.fertnstert.2018.10.014","article-title":"BRCA carriers have similar reproductive potential at baseline to noncarriers: Comparisons in cancer and cancer-free cohorts undergoing fertility preservation","volume":"111","author":"Gunnala","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s43032-022-00997-w","article-title":"The impact of BRCA1- and BRCA2 mutations on ovarian reserve status","volume":"30","author":"Drechsel","year":"2023","journal-title":"Reprod. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.fertnstert.2014.08.014","article-title":"BRCA1 germline mutations may be associated with reduced ovarian reserve","volume":"102","author":"Wang","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/humrep\/dew044","article-title":"Anti-M\u00fcllerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations","volume":"31","author":"Phillips","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1200\/JCO.20.02880","article-title":"Association of germline BRCA pathogenic variants with diminished ovarian reserve: A meta-analysis of individual patient-level data","volume":"39","author":"Turan","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1016\/j.fertnstert.2014.07.536","article-title":"AMH values in reproductive aged women with and without the BRCA1 mutation","volume":"102","author":"Pavone","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.fertnstert.2017.03.018","article-title":"Antim\u00fcllerian hormone levels are lower in BRCA2 mutation carriers","volume":"107","author":"Johnson","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.breast.2021.09.006","article-title":"Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis","volume":"60","author":"Gasparri","year":"2021","journal-title":"Breast"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/cncr.27952","article-title":"Comparison of age at natural menopause in BRCA1\/2 mutation carriers with a non-clinic-based sample of women in northern California","volume":"119","author":"Lin","year":"2013","journal-title":"Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1200\/JCO.2013.49.3007","article-title":"Do BRCA1 and BRCA2 mutation carriers have earlier natural menopause than their noncarrier relatives? Results from the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer","volume":"31","author":"Collins","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/GME.0000000000000633","article-title":"Do BRCA1\/2 mutation carriers have an earlier onset of natural menopause?","volume":"23","author":"Broekmans","year":"2016","journal-title":"Menopause"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1200\/JCO.2009.24.2057","article-title":"Association of BRCA1 mutations with occult primary ovarian insufficiency: A possible explanation for the link between infertility and breast\/ovarian cancer risks","volume":"28","author":"Oktay","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10815-019-01658-9","article-title":"Impact of BRCA1 and BRCA2 mutations on ovarian reserve and fertility preservation outcomes in young women with breast cancer","volume":"37","author":"Porcu","year":"2020","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/09513590.2021.2002294","article-title":"Impact of BRCA mutations and hormone receptor status on reproductive potential in breast cancer patients undergoing fertility preservation","volume":"38","author":"Kim","year":"2022","journal-title":"Gynecol. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"El Moujahed, L., Philis, R., Grynberg, M., Laot, L., Mur, P., Amsellem, N., Mayeur, A., Benoit, A., Rakrouki, S., and Sifer, C. (2023). Response to ovarian stimulation for urgent fertility preservation before gonadotoxic treatment in BRCA-pathogenic-variant-positive breast cancer patients. Cancer, 15.","DOI":"10.3390\/cancers15030895"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s10815-017-1014-3","article-title":"BRCA1 mutation carriers have a lower number of mature oocytes after ovarian stimulation for IVF\/PGD","volume":"34","author":"Smits","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.fertnstert.2015.07.1162","article-title":"BRCA mutation carriers show normal ovarian response in in vitro fertilization cycles","volume":"104","author":"Shapira","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Prokurotaite, E., Condorelli, M., Dechene, J., Bouziotis, J., Lambertini, M., and Demeestere, I. (2023). Impact of breast cancer and germline BRCA pathogenic variants on fertility preservation in young women. Life, 13.","DOI":"10.3390\/life13040930"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s10815-020-01745-2","article-title":"Navigating the body of literature assessing BRCA1\/2 mutations and markers of ovarian function: A systematic review and meta-analysis","volume":"37","author":"McGuinness","year":"2020","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/humrep\/dey358","article-title":"BRCA1\/2 gene mutations do not affect the capacity of oocytes from breast cancer candidates for fertility preservation to mature in vitro","volume":"34","author":"Grynberg","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1200\/JCO.2005.05.037","article-title":"Fertility preservation in breast cancer patients: A prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation","volume":"23","author":"Oktay","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1200\/JCO.2014.59.3723","article-title":"Fertility preservation success subsequent to concurrent aromatase inhibitor treatment and ovarian stimulation in women with breast cancer","volume":"33","author":"Oktay","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1002\/cncr.33601","article-title":"The impact of fertility preservation on the timing of breast cancer treatment, recurrence, and survival","volume":"127","author":"Greer","year":"2021","journal-title":"Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.rbmo.2010.03.004","article-title":"GnRH agonist trigger for women with breast cancer undergoing fertility preservation by aromatase inhibitor\/FSH stimulation","volume":"20","author":"Oktay","year":"2010","journal-title":"Reprod. Biomed. Online"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/1933719117728800","article-title":"Ovarian stimulation in patients with cancer: Impact of letrozole and BRCA mutations on fertility preservation cycle outcomes","volume":"25","author":"Turan","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Bonardi, B., Massarotti, C., Bruzzone, M., Goldrat, O., Mangili, G., Anserini, P., Spinaci, S., Arecco, L., Del Mastro, L., and Ceppi, M. (2020). Efficacy and safety of controlled ovarian stimulation with or without letrozole co-administration for fertility preservation: A systematic review and meta-analysis. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.574669"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1210\/jc.2015-3878","article-title":"Long-term safety of letrozole and gonadotropin stimulation for fertility preservation in women with breast cancer","volume":"101","author":"Kim","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_61","first-page":"1111","article-title":"Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: A case-control study","volume":"19","author":"Kotsopoulos","year":"2008","journal-title":"Cancer Causes Control"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41416-018-0139-1","article-title":"Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1\/2 mutation carriers","volume":"119","author":"Schrijver","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.fertnstert.2021.02.030","article-title":"Fertility treatments and breast cancer risk in Jewish Israeli BRCA mutation carriers","volume":"116","author":"Perri","year":"2021","journal-title":"Fertil. Steril."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1177\/1933719117702251","article-title":"Current success and efficiency of autologous ovarian transplantation: A meta-analysis","volume":"24","author":"Pacheco","year":"2017","journal-title":"Reprod. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10815-016-0843-9","article-title":"86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: Focus on birth and perinatal outcome in 40 of these children","volume":"34","author":"Jensen","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1001\/jama.286.12.1490","article-title":"Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm","volume":"286","author":"Oktay","year":"2001","journal-title":"JAMA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/humrep\/dev325","article-title":"Similar in vitro maturation rates of oocytes retrieved during the follicular or luteal phase offer flexible options for urgent fertility preservation in breast cancer patients","volume":"31","author":"Grynberg","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s10815-021-02263-5","article-title":"Perspectives on the development and future of oocyte IVM in clinical practice","volume":"38","author":"Grynberg","year":"2021","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12958-023-01162-x","article-title":"In vitro maturation (IVM) of human immature oocytes: Is it still relevant?","volume":"21","author":"Das","year":"2023","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1093\/humrep\/deaa175","article-title":"Live births following fertility preservation using in vitro maturation of ovarian tissue oocytes","volume":"35","author":"Segers","year":"2020","journal-title":"Hum. Reprod."},{"key":"ref_71","first-page":"65255","article-title":"Ovarian tissue oocyte in vitro maturation for fertility preservation","volume":"207","author":"Segers","year":"2024","journal-title":"J. Vis. Exp."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/GRF.0b013e3181f96b54","article-title":"Toxicity of chemotherapy and radiation on female reproduction","volume":"53","author":"Meirow","year":"2010","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Lambertini, M., Olympios, N., Lequesne, J., Calbrix, C., Fontanilles, M., Loeb, A., Leheurteur, M., Demeestere, I., Di Fiore, F., and Perdrix, A. (2019). Impact of taxanes, endocrine therapy, and deleterious germline BRCA mutations on anti-M\u00fcllerian hormone levels in early breast cancer patients treated with anthracycline- and cyclophosphamide-based chemotherapy. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00575"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/jncimonographs\/lgi025","article-title":"Appraisal of chemotherapy effects on reproductive outcome according to animal studies and clinical data","volume":"2005","author":"Meirow","year":"2005","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1002\/cncr.31732","article-title":"Pregnancy after cancer: Does timing of conception affect infant health?","volume":"124","author":"Hartnett","year":"2018","journal-title":"Cancer"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1200\/JCO.2006.06.5888","article-title":"American Society of Clinical Oncology recommendations on fertility preservation in cancer patients","volume":"24","author":"Lee","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1200\/JCO.2012.47.7893","article-title":"Chemotherapy-induced amenorrhea in patients with breast cancer with a BRCA1 or BRCA2 mutation","volume":"31","author":"Valentini","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.fertnstert.2020.01.033","article-title":"Increased chemotherapy-induced ovarian reserve loss in women with germline BRCA mutations due to oocyte deoxyribonucleic acid double strand break repair deficiency","volume":"113","author":"Oktay","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1093\/annonc\/mdv374","article-title":"Ovarian suppression using luteinizing hormone-releasing hormone agonists during chemotherapy to preserve ovarian function and fertility of breast cancer patients: A meta-analysis of randomized studies","volume":"26","author":"Lambertini","year":"2015","journal-title":"Ann. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1200\/JCO.2018.78.0858","article-title":"Gonadotropin-releasing hormone agonists during chemotherapy for preservation of ovarian function and fertility in premenopausal patients with early breast cancer: A systematic review and meta-analysis of individual patient-level data","volume":"36","author":"Lambertini","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Buonomo, B., Massarotti, C., Dellino, M., Anserini, P., Ferrari, A., Campanella, M., Magnotti, M., De Stefano, C., Peccatori, F.A., and Lambertini, M. (2021). Reproductive issues in carriers of germline pathogenic variants in the BRCA1\/2 genes: An expert meeting. BMC Med., 19.","DOI":"10.1186\/s12916-021-02081-7"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.fertnstert.2016.10.020","article-title":"Impact of tamoxifen therapy on fertility in breast cancer survivors","volume":"107","author":"Shandley","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10549-020-05933-7","article-title":"Impact of adjuvant chemotherapy or tamoxifen alone on the ovarian reserve of young women with breast cancer","volume":"185","author":"Goldfarb","year":"2021","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1056\/NEJMoa2212856","article-title":"Interrupting endocrine therapy to attempt pregnancy after breast cancer","volume":"388","author":"Partridge","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1093\/humrep\/deu132","article-title":"ESHRE Task Force on Ethics and Law22: Preimplantation Genetic Diagnosis","volume":"29","author":"Dondorp","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"ESHRE PGT-M Working Group, Carvalho, F., Moutou, C., Dimitriadou, E., Dreesen, J., Gim\u00e9nez, C., Goossens, V., Kakourou, G., Vermeulen, N., and Zuccarello, D. (2020). ESHRE PGT Consortium good practice recommendations for the detection of monogenic disorders. Hum. Reprod. Open, 2020, hoaa018.","DOI":"10.1093\/hropen\/hoaa018"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s10549-014-2951-5","article-title":"Hereditary breast and ovarian cancer and reproduction: An observational study on the suitability of preimplantation genetic diagnosis for both asymptomatic carriers and breast cancer survivors","volume":"145","author":"Mackens","year":"2014","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fertnstert.2017.12.004","article-title":"BRCA mutations and reproduction","volume":"109","author":"Daum","year":"2018","journal-title":"Fertil. 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