{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:18:23Z","timestamp":1787739503903,"version":"build-2784847793"},"reference-count":263,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr. Issues Mol. Biol.","CIMB"],"abstract":"<jats:p>Exosomes have emerged as key mediators of intercellular and inter-organ communication. Although substantial advances have expanded the understanding of the biology of extracellular vesicles, exosome biogenesis and their role in the disease progression of systemic diseases have not yet been fully elucidated. In this review, we present a comprehensive overview of the molecular pathways responsible for exosome biogenesis, emphasizing how the selective incorporation of proteins, lipids, metabolites, messenger RNAs, and microRNAs (miRs) determines the composition and biological activity of exosomes. We also discuss how exosome-mediated inter-organ communication functions as an integrated biological network that connects the kidney, the cardiovascular system, the brain, the liver, the immune system, and tumors, thereby coordinating the pathological responses underlying the progression of chronic diseases. Additionally, we demonstrate the recent advances in the potential of exosomes as minimally invasive biomarkers and clinical translational implantation. Finally, we discussed the methodological and biological challenges that limit the clinical application of exosomes. Overall, this review presents an integrated framework for understanding exosome biology and supports the concept that exosomes function as dynamic platforms for systemic signaling that link molecular mechanisms to disease pathogenesis and translational medicine.<\/jats:p>","DOI":"10.3390\/cimb48080845","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:31:59Z","timestamp":1787304719000},"page":"845","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exosome-Mediated Systemic Signaling: Mechanisms, Disease Integration, and Translational Potential"],"prefix":"10.3390","volume":"48","author":[{"given":"Adam","family":"Madore","sequence":"first","affiliation":[{"name":"Departments of Surgery, Internal Medicine and Biomedical Sciences, Joan C. 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Fibroblast Growth Factor-Derived Peptides: Sources, Functions, and Applications. Bioengineering, 12.","DOI":"10.3390\/bioengineering12101019"},{"key":"ref_4","first-page":"e47903","article-title":"Inter-organ communication: A gatekeeper for metabolic health","volume":"20","author":"Fajas","year":"2019","journal-title":"EMBO Rep."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Donniacuo, A., Mauro, A., Cardamone, C., Basile, A., Manzo, P., Dimitrov, J., Cammarota, A.L., Marzullo, L., Triggiani, M., and Turco, M.C. (2025). Comprehensive Profiling of Cytokines and Growth Factors: Pathogenic Roles and Clinical Applications in Autoimmune Diseases. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202508.0805.v1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"118186","DOI":"10.1016\/j.bcp.2026.118186","article-title":"Extracellular vesicles in molecular crosstalk and disease pathogenesis: A comprehensive review on mechanisms and therapeutic prospects","volume":"251","author":"Balachandran","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1161\/CIRCULATIONAHA.125.075579","article-title":"Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease","volume":"153","author":"Li","year":"2026","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e165172","DOI":"10.1172\/jci.insight.165172","article-title":"Circulating extracellular vesicles in human cardiorenal syndrome promote renal injury in a kidney-on-chip system","volume":"8","author":"Chatterjee","year":"2023","journal-title":"JCI Insight"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s42255-023-00971-z","article-title":"Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication","volume":"6","author":"Miotto","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"20677","DOI":"10.3402\/jev.v2i0.20677","article-title":"Distinct RNA profiles in subpopulations of extracellular vesicles: Apoptotic bodies, microvesicles and exosomes","volume":"2","author":"Crescitelli","year":"2013","journal-title":"J. Extracell. Vesicles"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-013-1084-8","article-title":"Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies","volume":"113","author":"Akers","year":"2013","journal-title":"J. Neuro-Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12964-021-00730-1","article-title":"The exosome journey: From biogenesis to uptake and intracellular signalling","volume":"19","author":"Gurung","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-1-0716-3287-1_17","article-title":"Live-Imaging Detection of Multivesicular Body-Plasma Membrane Fusion and Exosome Release in Cultured Primary Neurons","volume":"2683","author":"Pescosolido","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Krylova, S.V., and Feng, D. (2023). The Machinery of Exosomes: Biogenesis, Release, and Uptake. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021337"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s12276-024-01209-y","article-title":"Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer","volume":"56","author":"Lee","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e10250","DOI":"10.7554\/eLife.10250","article-title":"Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism","volume":"5","author":"Zhao","year":"2016","journal-title":"eLife"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.4049\/jimmunol.166.12.7309","article-title":"Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles","volume":"166","author":"Thery","year":"2001","journal-title":"J. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11649","DOI":"10.1074\/jbc.M112.445304","article-title":"The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes","volume":"288","author":"Jorge","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1126\/science.1153124","article-title":"Ceramide triggers budding of exosome vesicles into multivesicular endosomes","volume":"319","author":"Trajkovic","year":"2008","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ghadami, S., and Dellinger, K. (2023). The lipid composition of extracellular vesicles: Applications in diagnostics and therapeutic delivery. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1198044"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.jcis.2023.08.117","article-title":"Lipid bilayer fluidity and degree of order regulates small EVs adsorption on model cell membrane","volume":"652","author":"Paba","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1038\/s41467-024-49678-z","article-title":"Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions","volume":"15","author":"Peruzzi","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Xie, S., Zhang, Q., and Jiang, L. (2022). Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications. Membranes, 12.","DOI":"10.3390\/membranes12050498"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e202002160","DOI":"10.1083\/jcb.202002160","article-title":"Spatial regulation of clathrin-mediated endocytosis through position-dependent site maturation","volume":"219","author":"Pedersen","year":"2020","journal-title":"J. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e84850","DOI":"10.7554\/eLife.84850","article-title":"The yeast endocytic early\/sorting compartment exists as an independent sub-compartment within the trans-Golgi network","volume":"12","author":"Toshima","year":"2023","journal-title":"eLife"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"jcs260522","DOI":"10.1242\/jcs.260522","article-title":"Vps9d1 regulates tubular endosome formation through specific activation of Rab22A","volume":"136","author":"Nakashima","year":"2023","journal-title":"J. Cell Sci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Cai, Z., Li, Z., Li, N., He, X., Jin, Y., Lin, D., Fu, B., Ma, X., Hong, D., and Lin, K. (2026). Coro1a promotes the multivesicular body and plasma membrane fusion by facilitating PKM2-mediated SNAP-23 phosphorylation. Commun. Biol.","DOI":"10.1038\/s42003-026-10424-4"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1247\/csf.23067","article-title":"VAMP5 and distinct sets of cognate Q-SNAREs mediate exosome release","volume":"48","author":"Matsui","year":"2023","journal-title":"Cell Struct. Funct."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12943-022-01671-0","article-title":"Exosome biogenesis: Machinery, regulation, and therapeutic implications in cancer","volume":"21","author":"Han","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ncb2000","article-title":"Rab27a and Rab27b control different steps of the exosome secretion pathway","volume":"12","author":"Ostrowski","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1083\/jcb.200911018","article-title":"Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C","volume":"189","author":"Hsu","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e202112032","DOI":"10.1083\/jcb.202112032","article-title":"ER membrane contact sites support endosomal small GTPase conversion for exosome secretion","volume":"221","author":"Verweij","year":"2022","journal-title":"J. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e0344622","DOI":"10.1128\/spectrum.03446-22","article-title":"Enterovirus A71 Promotes Exosome Secretion by the Nonstructural Protein 3A Interacting with Rab27a","volume":"11","author":"Wu","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.job.2023.11.007","article-title":"Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion","volume":"66","author":"Yoshida","year":"2024","journal-title":"J. Oral Biosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1242\/jcs.115.12.2505","article-title":"The exosome pathway in K562 cells is regulated by Rab11","volume":"115","author":"Savina","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1158\/2767-9764.CRC-22-0425","article-title":"RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion","volume":"3","author":"Meneses","year":"2023","journal-title":"Cancer Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41556-021-00693-y","article-title":"Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker","volume":"23","author":"Kugeratski","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tcb.2023.06.006","article-title":"The ins-and-outs of exosome biogenesis, secretion, and internalization","volume":"34","author":"Arya","year":"2024","journal-title":"Trends Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Liu, M., Wen, Z., Zhang, T., Zhang, L., Liu, X., and Wang, M. (2024). The role of exosomal molecular cargo in exosome biogenesis and disease diagnosis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1417758"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.devcel.2023.01.006","article-title":"GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis","volume":"58","author":"Lee","year":"2023","journal-title":"Dev. Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"103437","DOI":"10.1016\/j.isci.2021.103437","article-title":"Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production","volume":"24","author":"Wu","year":"2021","journal-title":"iScience"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10238-026-02092-9","article-title":"Exosomal bioactive molecules: Molecular regulation, functional heterogeneity, and translational implications in disease diagnostics and therapeutics","volume":"26","author":"Chigozie","year":"2026","journal-title":"Clin. Exp. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e2501349","DOI":"10.1002\/adhm.202501349","article-title":"Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs","volume":"14","author":"Pereira","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Lau, N.C.H., and Yam, J.W.P. (2023). From Exosome Biogenesis to Absorption: Key Takeaways for Cancer Research. Cancers, 15.","DOI":"10.3390\/cancers15071992"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"bqab133","DOI":"10.1210\/endocr\/bqab133","article-title":"Extracellular Vesicles-The Next Frontier in Endocrinology","volume":"162","author":"Krawczynska","year":"2021","journal-title":"Endocrinology"},{"key":"ref_48","first-page":"5553","article-title":"Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles","volume":"126","author":"Colombo","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1083\/jcb.201310114","article-title":"Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation","volume":"205","author":"Adell","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e31652","DOI":"10.7554\/eLife.31652","article-title":"Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding","volume":"6","author":"Adell","year":"2017","journal-title":"eLife"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"28614","DOI":"10.1073\/pnas.2014228117","article-title":"Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles","volume":"117","author":"Liese","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e201904113","DOI":"10.1083\/jcb.201904113","article-title":"ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes","volume":"219","author":"Larios","year":"2020","journal-title":"J. Cell Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/s41467-020-15205-z","article-title":"The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX\/syntenin\/syndecan-4 required for completion of cytokinesis","volume":"11","author":"Addi","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"117019","DOI":"10.1016\/j.bcp.2025.117019","article-title":"An updated review on the inhibition of exosome biogenesis, release, and uptake: A potential anticancer approach","volume":"239","author":"Gabaran","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"108255","DOI":"10.1016\/j.jbc.2025.108255","article-title":"Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles","volume":"301","author":"Duke","year":"2025","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12964-022-00900-9","article-title":"Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function","volume":"21","author":"Kong","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/aps.2017.118","article-title":"The ceramide pathway is involved in the survival, apoptosis and exosome functions of human multiple myeloma cells in vitro","volume":"39","author":"Cheng","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e01969-17","DOI":"10.1128\/JVI.01969-17","article-title":"Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1","volume":"92","author":"Hurwitz","year":"2018","journal-title":"J. Virol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e202006178","DOI":"10.1083\/jcb.202006178","article-title":"ECM deposition is driven by caveolin-1-dependent regulation of exosomal biogenesis and cargo sorting","volume":"219","author":"Lopez","year":"2020","journal-title":"J. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1038\/ncomms4477","article-title":"Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2","volume":"5","author":"Ghossoub","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"22362","DOI":"10.1074\/jbc.M110.156471","article-title":"Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference","volume":"286","author":"Wu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Bills, B.L., and Knowles, M.K. (2022). Phosphatidic Acid Accumulates at Areas of Curvature in Tubulated Lipid Bilayers and Liposomes. Biomolecules, 12.","DOI":"10.3390\/biom12111707"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ncb2502","article-title":"Syndecan-syntenin-ALIX regulates the biogenesis of exosomes","volume":"14","author":"Baietti","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1111\/j.1600-0854.2009.00948.x","article-title":"Sorting of MHC class II molecules into exosomes through a ubiquitin-independent pathway","volume":"10","author":"Gauvreau","year":"2009","journal-title":"Traffic"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1600-0854.2009.00920.x","article-title":"Multivesicular endosome biogenesis in the absence of ESCRTs","volume":"10","author":"Stuffers","year":"2009","journal-title":"Traffic"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12964-025-02630-0","article-title":"The interplay between the extracellular matrix and extracellular vesicle-associated microRNAs","volume":"24","author":"Wu","year":"2026","journal-title":"Cell Commun. Signal."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"18396","DOI":"10.3402\/jev.v1i0.18396","article-title":"Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes","volume":"1","author":"Verhaar","year":"2012","journal-title":"J. Extracell. Vesicles"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e71982","DOI":"10.7554\/eLife.71982","article-title":"Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates","volume":"10","author":"Liu","year":"2021","journal-title":"eLife"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41586-021-04234-3","article-title":"MicroRNA sequence codes for small extracellular vesicle release and cellular retention","volume":"601","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e19276","DOI":"10.7554\/eLife.19276","article-title":"Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction","volume":"5","author":"Shurtleff","year":"2016","journal-title":"eLife"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.celrep.2016.09.031","article-title":"The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting","volume":"17","author":"Santangelo","year":"2016","journal-title":"Cell Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-021-00881-9","article-title":"Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice","volume":"116","author":"Gregorius","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biocel.2019.01.017","article-title":"Exosomes from hypoxia-treated human adipose-derived mesenchymal stem cells enhance angiogenesis through VEGF\/VEGF-R","volume":"109","author":"Han","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s12951-023-02110-y","article-title":"Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1\/STAT3 signaling pathway","volume":"21","author":"Gao","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/cbin.11664","article-title":"Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure","volume":"45","author":"Wang","year":"2021","journal-title":"Cell Biol. Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12957-022-02706-y","article-title":"Hypoxic lung cancer cell-derived exosomal miR-21 mediates macrophage M2 polarization and promotes cancer cell proliferation through targeting IRF1","volume":"20","author":"Jin","year":"2022","journal-title":"World J. Surg. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Chiaradia, E., Tancini, B., Emiliani, C., Delo, F., Pellegrino, R.M., Tognoloni, A., Urbanelli, L., and Buratta, S. (2021). Extracellular Vesicles under Oxidative Stress Conditions: Biological Properties and Physiological Roles. Cells, 10.","DOI":"10.3390\/cells10071763"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Haque, S., Kodidela, S., Sinha, N., Kumar, P., Cory, T.J., and Kumar, S. (2020). Differential packaging of inflammatory cytokines\/chemokines and oxidative stress modulators in U937 and U1 macrophages-derived extracellular vesicles upon exposure to tobacco constituents. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0233054"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"236","DOI":"10.62347\/UWCR7720","article-title":"A panel of serum-derived exosomal miRNAs as markers of cardiovascular risk assessed by carotid intima-media thickness in patients with type 2 diabetes","volume":"18","author":"Lu","year":"2026","journal-title":"Am. J. Transl. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1038\/s41467-023-40680-5","article-title":"Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired","volume":"14","author":"Liang","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"123658","DOI":"10.1016\/j.lfs.2025.123658","article-title":"Excessive mitochondrial fission and associated extracellular mitochondria mediate cardiac dysfunction in obesity cardiomyopathy","volume":"373","author":"Li","year":"2025","journal-title":"Life Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jare.2024.09.021","article-title":"DeSUMOylation of RBMX regulates exosomal sorting of cargo to promote renal tubulointerstitial fibrosis in diabetic kidney disease","volume":"74","author":"Yang","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Chen, Y., Qi, W., Wang, Z., and Niu, F. (2025). Exosome Source Matters: A Comprehensive Review from the Perspective of Diverse Cellular Origins. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17020147"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.2147\/IJN.S449388","article-title":"Macrophage-Derived Exosomes as Advanced Therapeutics for Inflammation: Current Progress and Future Perspectives","volume":"19","author":"Song","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"106551","DOI":"10.1016\/j.intimp.2020.106551","article-title":"Exosomes from high glucose-treated macrophages activate macrophages andinduce inflammatory responses via NF-kappaB signaling pathway in vitro and in vivo","volume":"84","author":"Zhu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_86","first-page":"764","article-title":"Senescent HUVECs-secreted exosomes trigger endothelial barrier dysfunction in young endothelial cells","volume":"18","author":"Wong","year":"2019","journal-title":"EXCLI J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"110756","DOI":"10.1016\/j.biopha.2020.110756","article-title":"Endothelial progenitor cell-derived exosomes ameliorate endothelial dysfunction in a mouse model of diabetes","volume":"131","author":"Bai","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1038\/s41598-024-55100-x","article-title":"Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2\/Bax\/Caspase-3 pathway","volume":"14","author":"Tan","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1038\/s41467-018-05858-2","article-title":"Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1038\/s41467-019-11534-w","article-title":"Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS","volume":"10","author":"Men","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00401-018-1868-1","article-title":"Alzheimer\u2019s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers","volume":"136","author":"Civitelli","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3233\/JAD-180776","article-title":"Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo","volume":"67","author":"Winston","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41419-021-04037-4","article-title":"Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP\/KLF2 in non-small cell lung cancer","volume":"12","author":"Ma","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1038\/s41467-018-07810-w","article-title":"Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis","volume":"9","author":"Zeng","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1158\/1078-0432.CCR-16-2819","article-title":"Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck Cancer","volume":"23","author":"Ludwig","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Chen, Y.X., Wu, Y.S., Yu, R.D., Dong, Y.Y., Zhao, J.X., and Zhang, Y.F. (2026). Exosome-mediated cell-cell communication: A new perspective on the mechanisms and therapeutic potential of diabetic microvascular complications. Front. Pharmacol., 17.","DOI":"10.3389\/fphar.2026.1839895"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jnr.24113","article-title":"A novel cell-cell communication mechanism in the nervous system: Exosomes","volume":"96","author":"Zhang","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3759339","DOI":"10.1155\/2024\/3759339","article-title":"Exosomes as Emerging Regulators of Immune Responses in Type 2 Diabetes Mellitus","volume":"2024","author":"Zheng","year":"2024","journal-title":"J. Diabetes Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e12356","DOI":"10.1002\/jev2.12356","article-title":"Identification of the SNARE complex that mediates the fusion of multivesicular bodies with the plasma membrane in exosome secretion","volume":"12","author":"Liu","year":"2023","journal-title":"J. Extracell. Vesicles"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"115130","DOI":"10.1016\/j.ab.2023.115130","article-title":"An in vitro lipid-mixing assay to investigate the fusion between small extracellular vesicles and endosome","volume":"669","author":"Takeda","year":"2023","journal-title":"Anal. Biochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"22258","DOI":"10.1074\/jbc.M114.588046","article-title":"Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery","volume":"289","author":"Tian","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/SHK.0000000000001928","article-title":"Exosomal Transfer of DNA Methyl-Transferase mRNA Induces an Immunosuppressive Phenotype in Human Monocytes","volume":"57","author":"Wisler","year":"2022","journal-title":"Shock"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molimm.2021.05.006","article-title":"M2 macrophage-derived exosomes carry miR-1271-5p to alleviate cardiac injury in acute myocardial infarction through down-regulating SOX6","volume":"136","author":"Long","year":"2021","journal-title":"Mol. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.7150\/ijbs.79784","article-title":"M1 Microglia-derived Exosomes Promote Activation of Resting Microglia and Amplifies Proangiogenic Effects through Irf1\/miR-155-5p\/Socs1 Axis in the Retina","volume":"19","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41417-023-00617-y","article-title":"Recent progress in exosome research: Isolation, characterization and clinical applications","volume":"30","author":"Wang","year":"2023","journal-title":"Cancer Gene Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/stmcls\/sxac087","article-title":"Inflammatory Periodontal Ligament Stem Cells Drive M1 Macrophage Polarization via Exosomal miR-143-3p-Mediated Regulation of PI3K\/AKT\/NF-kappaB Signaling","volume":"41","author":"Wang","year":"2023","journal-title":"Stem Cells"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.thromres.2019.02.002","article-title":"Exosomes of bone-marrow stromal cells inhibit cardiomyocyte apoptosis under ischemic and hypoxic conditions via miR-486-5p targeting the PTEN\/PI3K\/AKT signaling pathway","volume":"177","author":"Sun","year":"2019","journal-title":"Thromb. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e71050","DOI":"10.1111\/jcmm.71050","article-title":"Exosomal HMGB1 Orchestrates NSCLC Progression and Immunosuppressive Macrophage Polarisation Through the TLR4\/NF-kappaB\/IL-6\/STAT3 Signalling Cascade","volume":"30","author":"Huang","year":"2026","journal-title":"J. Cell. Mol. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e14428","DOI":"10.1111\/cns.14428","article-title":"Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the miR-21\/JAK2\/STAT3 pathway","volume":"30","author":"Yang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e01610","DOI":"10.1002\/smll.202501610","article-title":"Lung-Derived Small Extracellular Vesicles Containing miR-15a-5p\/miR-96-5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7","volume":"21","author":"Long","year":"2025","journal-title":"Small"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41420-025-02739-8","article-title":"Exosomal miR-122-5p from tubular cells ameliorates renal interstitial fibrosis by regulating fibroblasts via HIF-1alpha","volume":"11","author":"Yang","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_113","first-page":"225re221","article-title":"Targeting miR-21 to treat psoriasis","volume":"6","author":"Jimenez","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1158\/0008-5472.CAN-12-0639","article-title":"MicroRNA-21 modulates the levels of reactive oxygen species by targeting SOD3 and TNFalpha","volume":"72","author":"Zhang","year":"2012","journal-title":"Cancer Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e1800149","DOI":"10.1002\/pmic.201800149","article-title":"Exosomes in Inflammation and Inflammatory Disease","volume":"19","author":"Chan","year":"2019","journal-title":"Proteomics"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Gao, K., Jin, J., Huang, C., Li, J., Luo, H., Li, L., Huang, Y., and Jiang, Y. (2019). Exosomes Derived From Septic Mouse Serum Modulate Immune Responses via Exosome-Associated Cytokines. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01560"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Xiao, Y., Liang, J., Witwer, K.W., Zhang, Y., Wang, Q., and Yin, H. (2022). Extracellular vesicle-associated microRNA-30b-5p activates macrophages through the SIRT1\/ NF-kappaB pathway in cell senescence. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.955175"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"109771","DOI":"10.1016\/j.cellsig.2020.109771","article-title":"Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process","volume":"75","author":"Salminen","year":"2020","journal-title":"Cell Signal."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1159\/000492252","article-title":"Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways","volume":"48","author":"Song","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.2337\/db09-0216","article-title":"Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance","volume":"58","author":"Deng","year":"2009","journal-title":"Diabetes"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2017.08.035","article-title":"Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity","volume":"171","author":"Ying","year":"2017","journal-title":"Cell"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI123069","article-title":"Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation","volume":"129","author":"Pan","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"12158","DOI":"10.1073\/pnas.1808855115","article-title":"Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice","volume":"115","author":"Castano","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2457687","DOI":"10.1155\/2022\/2457687","article-title":"T Lymphocyte-Derived Exosomes Transport MEK1\/2 and ERK1\/2 and Induce NOX4-Dependent Oxidative Stress in Cardiac Microvascular Endothelial Cells","volume":"2022","author":"Rolski","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"100756","DOI":"10.1016\/j.jhepr.2023.100756","article-title":"Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance","volume":"5","author":"Alen","year":"2023","journal-title":"JHEP Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1038\/s41467-022-32487-7","article-title":"mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1","volume":"13","author":"Vionnet","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.ymthe.2019.07.003","article-title":"Peripheral Circulating Exosome-Mediated Delivery of miR-155 as a Novel Mechanism for Acute Lung Inflammation","volume":"27","author":"Jiang","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e71453","DOI":"10.1096\/fj.202503753R","article-title":"GMSCs-Derived Exosome ZHX2 Improves Diabetes Nephropathy by Blocking AGEs\/RAGE\/NLRP3 Pathway to Inhibit Podocyte Pyroptosis and Inflammatory Response","volume":"40","author":"Wang","year":"2026","journal-title":"FASEB J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.cmet.2025.03.006","article-title":"O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles","volume":"37","author":"Ding","year":"2025","journal-title":"Cell Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.RES.81.3.363","article-title":"High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alpha","volume":"81","author":"Hempel","year":"1997","journal-title":"Circ. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"BSR20192554","DOI":"10.1042\/BSR20192554","article-title":"High glucose provokes microvesicles generation from glomerular podocytes via NOX4\/ROS pathway","volume":"39","author":"Li","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"102013","DOI":"10.1016\/j.redox.2021.102013","article-title":"Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes","volume":"43","author":"Li","year":"2021","journal-title":"Redox Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12933-025-02715-7","article-title":"AGE induced macrophage-derived exosomes induce endothelial dysfunction in diabetes via miR-22-5p\/FOXP1","volume":"24","author":"Ji","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"106713","DOI":"10.1016\/j.biocel.2024.106713","article-title":"Adipose tissue macrophages-derived exosomal MiR-500a-5p under high glucose promotes adipocytes inflammation by suppressing Nrf2 expression","volume":"178","author":"Li","year":"2025","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"101117","DOI":"10.1016\/j.gendis.2023.101117","article-title":"Exosome-mediated renal protection: Halting the progression of fibrosis","volume":"11","author":"Liu","year":"2024","journal-title":"Genes Dis."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Cao, H., Li, Z., Ye, J., Lv, Y., Zhang, C., Liang, T., and Wang, Y. (2025). Emerging roles of exosomes in the diagnosis and treatment of kidney diseases. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1525314"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41419-019-1605-2","article-title":"The role of extracellular vesicles in renal fibrosis","volume":"10","author":"Jing","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Freise, C., Zappe, A., Lowa, N., Schnorr, J., Pagel, K., Wiekhorst, F., and Taupitz, M. (2023). Uremic Toxin-Induced Exosome-like Extracellular Vesicles Contain Enhanced Levels of Sulfated Glycosaminoglycans which Facilitate the Interaction with Very Small Superparamagnetic Iron Oxide Particles. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241814253"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"122810","DOI":"10.1016\/j.lfs.2024.122810","article-title":"Proteomic analysis of endothelial cells and extracellular vesicles in response to indoxyl sulfate: Mechanisms of endothelial dysfunction in chronic kidney disease","volume":"351","author":"Figuer","year":"2024","journal-title":"Life Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/cvr\/cvaa322","article-title":"MicroRNA-mediated vascular intercellular communication is altered in chronic kidney disease","volume":"118","author":"Zietzer","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e70062","DOI":"10.1002\/jev2.70062","article-title":"Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease","volume":"14","author":"Behrens","year":"2025","journal-title":"J. Extracell. Vesicles"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000449290","article-title":"Early Changes in Monocyte Adhesion Molecule Expression and Tumor Necrosis Factor-alpha Levels in Chronic Kidney Disease\u2014A 5-Year Prospective Study","volume":"44","author":"Wallquist","year":"2016","journal-title":"Am. J. Nephrol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1038\/s41598-021-87710-0","article-title":"Detection of pro angiogenic and inflammatory biomarkers in patients with CKD","volume":"11","author":"Jalal","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1038\/s41467-025-59997-4","article-title":"Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype","volume":"16","author":"Reck","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"8660","DOI":"10.7150\/thno.62820","article-title":"Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Glowacki, F., Savary, G., Gnemmi, V., Buob, D., Van der Hauwaert, C., Lo-Guidice, J.M., Bouye, S., Hazzan, M., Pottier, N., and Perrais, M. (2013). Increased circulating miR-21 levels are associated with kidney fibrosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058014"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"jcs202317","DOI":"10.1242\/jcs.202317","article-title":"The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis","volume":"131","author":"Sun","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.kint.2019.11.026","article-title":"Tubule-derived exosomes play a central role in fibroblast activation and kidney fibrosis","volume":"97","author":"Liu","year":"2020","journal-title":"Kidney Int."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e12203","DOI":"10.1002\/jev2.12203","article-title":"beta-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis","volume":"11","author":"Chen","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/ATVBAHA.117.310578","article-title":"Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein)","volume":"38","author":"Viegas","year":"2018","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1161\/CIRCRESAHA.116.305012","article-title":"Vascular smooth muscle cell calcification is mediated by regulated exosome secretion","volume":"116","author":"Kapustin","year":"2015","journal-title":"Circ. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/CIRCRESAHA.122.321939","article-title":"Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease","volume":"132","author":"Koide","year":"2023","journal-title":"Circ. Res."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Reiss, A.B., Ahmed, S., Johnson, M., Saeedullah, U., and De Leon, J. (2023). Exosomes in Cardiovascular Disease: From Mechanism to Therapeutic Target. Metabolites, 13.","DOI":"10.3390\/metabo13040479"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e70000","DOI":"10.1002\/jev2.70000","article-title":"Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes","volume":"13","author":"Viola","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"152191","DOI":"10.1016\/j.bbrc.2025.152191","article-title":"NHE9 regulates exosomal stress response to hypoxia in cardiomyocytes","volume":"776","author":"Hafezi","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_156","first-page":"4873","article-title":"HSP20-mediated cardiomyocyte exosomes improve cardiac function in mice with myocardial infarction by activating Akt signaling pathway","volume":"23","author":"Yu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/cvr\/cvt047","article-title":"Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes","volume":"98","author":"Tian","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e00611-16","DOI":"10.1128\/MCB.00611-16","article-title":"Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy","volume":"37","author":"Datta","year":"2017","journal-title":"Mol. Cell. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s00018-022-04464-2","article-title":"Extracellular vesicles carrying proinflammatory factors may spread atherosclerosis to remote locations","volume":"79","author":"Peng","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"5047954","DOI":"10.1155\/2016\/5047954","article-title":"Endothelial Microparticle-Derived Reactive Oxygen Species: Role in Endothelial Signaling and Vascular Function","volume":"2016","author":"Burger","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"R509","DOI":"10.1152\/ajpregu.00146.2025","article-title":"Circulating endothelial extracellular vesicles progressively increase with age and are associated with endothelial vasodilator dysfunction","volume":"329","author":"DeSouza","year":"2025","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1161\/hc5001.100631","article-title":"Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL","volume":"104","author":"Xu","year":"2001","journal-title":"Circulation"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/cvr\/cvp036","article-title":"RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice","volume":"82","author":"Sun","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.omtn.2018.05.013","article-title":"miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN","volume":"12","author":"Nie","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e39332","DOI":"10.1016\/j.heliyon.2024.e39332","article-title":"Impaired cardiomyocytes accelerate cardiac hypertrophy and fibrosis by delivering exosomes containing Shh\/N-Shh\/Gli1 in angiotensin II infused mice","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1172\/JCI94753","article-title":"Fibroblast-specific TGF-beta-Smad2\/3 signaling underlies cardiac fibrosis","volume":"127","author":"Khalil","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Eldh, M., Ekstrom, K., Valadi, H., Sjostrand, M., Olsson, B., Jernas, M., and Lotvall, J. (2010). Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015353"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41467-017-02583-0","article-title":"Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer","volume":"9","author":"Fang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1096\/fj.201902307RRR","article-title":"Exosomal miR-103-3p from LPS-activated THP-1 macrophage contributes to the activation of hepatic stellate cells","volume":"34","author":"Chen","year":"2020","journal-title":"FASEB J."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41392-025-02329-1","article-title":"Organ cross-talk: Molecular mechanisms, biological functions, and therapeutic interventions for diseases","volume":"11","author":"Che","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.cmet.2021.08.006","article-title":"Exosomes as mediators of intercellular crosstalk in metabolism","volume":"33","author":"Isaac","year":"2021","journal-title":"Cell Metab."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Aljohani, M.A. (2025). Exosomes in Clinical Laboratory: From Biomarker Discovery to Diagnostic Implementation. Medicina, 61.","DOI":"10.3390\/medicina61111930"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Zhao, H., Liu, H., Liu, Y., Jin, J., He, Q., and Lin, B. (2022). The role of extracellular vesicles in vascular calcification in chronic kidney disease. Front. Med., 9.","DOI":"10.3389\/fmed.2022.997554"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1681\/ASN.2009060640","article-title":"Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification","volume":"21","author":"Shroff","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.110.238808","article-title":"Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization","volume":"109","author":"Kapustin","year":"2011","journal-title":"Circ. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"H553","DOI":"10.1152\/ajpheart.00280.2022","article-title":"Epidermal growth factor receptor inhibition prevents vascular calcifying extracellular vesicle biogenesis","volume":"324","author":"Ng","year":"2023","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e174977","DOI":"10.1172\/jci.insight.174977","article-title":"Activation of the IKK2\/NF-kappaB pathway in VSMCs inhibits calcified vascular stiffness in CKD","volume":"9","author":"Masuda","year":"2024","journal-title":"JCI Insight"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.atherosclerosis.2022.01.015","article-title":"PCSK9 promotes arterial medial calcification","volume":"346","author":"Lupo","year":"2022","journal-title":"Atherosclerosis"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s41419-022-05064-5","article-title":"The crosstalk between endothelial cells and vascular smooth muscle cells aggravates high phosphorus-induced arterial calcification","volume":"13","author":"Lin","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"351","DOI":"10.34067\/KID.0000000678","article-title":"Exosomes Derived from Dialysis Patients\u2019 Serum Enhance Endothelial-Mesenchymal Transition and Calcification in Endothelial Cells","volume":"6","author":"Kuchuk","year":"2025","journal-title":"Kidney360"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"101937","DOI":"10.1016\/j.isci.2020.101937","article-title":"Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease","volume":"24","author":"Scullion","year":"2021","journal-title":"iScience"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"e045148","DOI":"10.1161\/JAHA.125.045148","article-title":"Circulating Extracellular Vesicle MicroRNAs as Predictive Biomarkers for Kidney and Cardiovascular Events","volume":"15","author":"Inaba","year":"2026","journal-title":"J. Am. Heart Assoc."},{"key":"ref_183","first-page":"100301","article-title":"Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives","volume":"7","author":"Wu","year":"2024","journal-title":"Curr. Res. Microb. Sci."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Sultan, S., Mottawea, W., Yeo, J., and Hammami, R. (2021). Gut Microbiota Extracellular Vesicles as Signaling Molecules Mediating Host-Microbiota Communications. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222313166"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"e0136824","DOI":"10.1128\/spectrum.01368-24","article-title":"Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling","volume":"13","author":"Mottawea","year":"2025","journal-title":"Microbiol. Spectr."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/gutjnl-2018-317726","article-title":"Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction","volume":"69","author":"Tulkens","year":"2020","journal-title":"Gut"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2541036","DOI":"10.1080\/19490976.2025.2541036","article-title":"Diarrheal microbiota-derived extracellular vesicles drive intestinal homeostasis dysfunction via miR-125b\/NF-kappaB-mediated macrophage polarization","volume":"17","author":"Song","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"3710372","DOI":"10.1155\/2021\/3710372","article-title":"The Immunomodulation Potential of Exosomes in Tumor Microenvironment","volume":"2021","author":"Wang","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41392-020-00359-5","article-title":"Exosome-mediated metabolic reprogramming: The emerging role in tumor microenvironment remodeling and its influence on cancer progression","volume":"5","author":"Yang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1186\/s12967-025-06814-7","article-title":"Tumor-derived exosomes and their application in cancer treatment","volume":"23","author":"Mowla","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.omtn.2021.04.015","article-title":"Cancer-derived exosome miRNAs induce skeletal muscle wasting by Bcl-2-mediated apoptosis in colon cancer cachexia","volume":"24","author":"Miao","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41420-022-00972-z","article-title":"GDF-15 in tumor-derived exosomes promotes muscle atrophy via Bcl-2\/caspase-3 pathway","volume":"8","author":"Zhang","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/jcsm.12851","article-title":"Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole","volume":"13","author":"Liu","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41556-022-00919-7","article-title":"Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth","volume":"24","author":"Cao","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/ncb3094","article-title":"Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis","volume":"17","author":"Fong","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Tomida, R., Ozaki, K., Tanaka, Y., Komatsu, R., Hirata, S., Uchida, T., Furukawa, J., Nikawa, T., and Fukawa, T. (2026). Regulatory mechanisms of mitochondrial function by cancer-derived exosomes in cachexia. Front. Oncol., 16.","DOI":"10.3389\/fonc.2026.1715589"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13395-021-00274-5","article-title":"Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release","volume":"11","author":"Zhou","year":"2021","journal-title":"Skelet. Muscle"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Gan, D.X., Wang, Y.B., He, M.Y., Chen, Z.Y., Qin, X.X., Miao, Z.W., Chen, Y.H., and Li, B. (2020). Lung Cancer Cells-Controlled Dkk-1 Production in Brain Metastatic Cascade Drive Microglia to Acquire a Pro-tumorigenic Phenotype. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.591405"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"112582","DOI":"10.1016\/j.celrep.2023.112582","article-title":"Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung","volume":"42","author":"Kersten","year":"2023","journal-title":"Cell Rep."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.2147\/DMSO.S430443","article-title":"Pancreatic Cancer-Derived Exosomal miR-Let-7b-5p Stimulates Insulin Resistance in Skeletal Muscle Cells Through RNF20\/STAT3\/FOXO1 Axis Regulation","volume":"16","author":"Wang","year":"2023","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06114-4","article-title":"Tumour extracellular vesicles and particles induce liver metabolic dysfunction","volume":"618","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Zhao, C., Cheng, L., Li, A., Wang, H., Li, X., and Xu, J. (2025). EGFR-Mutant Lung Adenocarcinoma Cell-Derived Exosomal miR-651-5p Induces CD8+ T Cell Apoptosis via Downregulating BCL2 Expression. Biomedicines, 13.","DOI":"10.3390\/biomedicines13020482"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Huyan, T., Gao, L., Gao, N., Wang, C., Guo, W., Zhou, X., and Li, Q. (2022). miR-221-5p and miR-186-5p Are the Critical Bladder Cancer Derived Exosomal miRNAs in Natural Killer Cell Dysfunction. Int. J. Mol. Sci., 23.","DOI":"10.21203\/rs.3.rs-1851016\/v1"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"e21784","DOI":"10.1002\/advs.202521784","article-title":"Tumor-Derived Exosomes Deliver Membrane-Bound Fgl2 to Activate FcgammaRIIB-Mediated Immunosuppression in Myeloid-Derived Suppressor Cells","volume":"13","author":"Lin","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e478","DOI":"10.1002\/ctm2.478","article-title":"Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway","volume":"11","author":"Chen","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41392-020-0129-7","article-title":"Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+gammadelta1 Treg cells","volume":"5","author":"Ni","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3892\/ijmm.2022.5195","article-title":"Exosomal STAT1 derived from high phosphorus-stimulated vascular endothelial cells induces vascular smooth muscle cell calcification via the Wnt\/beta-catenin signaling pathway","volume":"50","author":"Qin","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"3753485","DOI":"10.1155\/2019\/3753485","article-title":"Exosomes Mediate Hippocampal and Cortical Neuronal Injury Induced by Hepatic Ischemia-Reperfusion Injury through Activating Pyroptosis in Rats","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12974-021-02364-z","article-title":"Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury","volume":"18","author":"Chavez","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Chen, E., Zhu, X., Chang, H., Li, Q., Zhao, Z., Zhang, C., Cao, Y., Wang, Y., Ma, X., and Zhu, T. (2026). Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia-reperfusion. BMC Med., 24.","DOI":"10.1186\/s12916-026-04792-1"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s43556-025-00280-9","article-title":"Exosomes in inflammation and cancer: From bench to bedside applications","volume":"6","author":"Huang","year":"2025","journal-title":"Mol. Biomed."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12012-021-09700-y","article-title":"Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease","volume":"22","author":"Nikdoust","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"11267","DOI":"10.2147\/IJN.S529311","article-title":"Exosomes and Renal Fibrosis: Diagnostic Value, Therapeutic Potential and Challenges","volume":"20","author":"Li","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Appiah, M.G., Park, E.J., Akama, Y., Nakamori, Y., Kawamoto, E., Gaowa, A., and Shimaoka, M. (2021). Cellular and Exosomal Regulations of Sepsis-Induced Metabolic Alterations. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158295"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jim.2014.06.007","article-title":"Isolation of biologically-active exosomes from human plasma","volume":"411","author":"Muller","year":"2014","journal-title":"J. Immunol. Methods"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/1873-3468.13487","article-title":"Urinary exosomal proteins as (pan-)cancer biomarkers: Insights from the proteome","volume":"593","author":"Erozenci","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s12017-023-08744-3","article-title":"Multiplex Analysis of Cerebrospinal Fluid and Serum Exosomes MicroRNAs of Untreated Relapsing Remitting Multiple Sclerosis (RRMS) and Proposing Noninvasive Diagnostic Biomarkers","volume":"25","author":"Mohammadinasr","year":"2023","journal-title":"Neuromol. Med."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"31233","DOI":"10.1038\/s41598-024-82488-3","article-title":"Salivary extracellular vesicles isolation methods impact the robustness of downstream biomarkers detection","volume":"14","author":"Boulestreau","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"e2403199","DOI":"10.1002\/adma.202403199","article-title":"Immunogenicity of Extracellular Vesicles","volume":"36","author":"Xia","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.immuni.2024.07.009","article-title":"The biology and function of extracellular vesicles in immune response and immunity","volume":"57","author":"Kalluri","year":"2024","journal-title":"Immunity"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"aaf8759","DOI":"10.1126\/sciimmunol.aaf8759","article-title":"Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation","volume":"1","author":"Marino","year":"2016","journal-title":"Sci. Immunol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1111\/ajt.16591","article-title":"T cell antigenicity and immunogenicity of allogeneic exosomes","volume":"21","author":"Prunevieille","year":"2021","journal-title":"Am. J. Transpl."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s11095-024-03757-4","article-title":"Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles","volume":"41","author":"Takakura","year":"2024","journal-title":"Pharm. Res."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"825","DOI":"10.4049\/jimmunol.1801628","article-title":"Allogenicity Boosts Extracellular Vesicle-Induced Antigen-Specific Immunity and Mediates Tumor Protection and Long-Term Memory In Vivo","volume":"203","author":"Larssen","year":"2019","journal-title":"J. Immunol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"e12458","DOI":"10.1002\/jev2.12458","article-title":"A systematic review and meta-analysis of clinical trials assessing safety and efficacy of human extracellular vesicle-based therapy","volume":"13","author":"Derdelinckx","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/jcmm.14778","article-title":"Knockout of beta-2 microglobulin reduces stem cell-induced immune rejection and enhances ischaemic hindlimb repair via exosome\/miR-24\/Bim pathway","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-022-00410-w","article-title":"Therapeutically harnessing extracellular vesicles","volume":"21","author":"Cheng","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biopsych.2021.12.015","article-title":"Exosomal MicroRNA-Based Predictive Model for Preclinical Alzheimer\u2019s Disease: A Multicenter Study","volume":"92","author":"Jia","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Qadeer, A., Ullah, A., Khan, M.Z., Alsharif, K.F., Alzahrani, F.M., Alzahrani, K.J., and Abuderman, A.A. (2026). Extracellular Vesicles Associated Metabolites as Intercellular Signalling Mediators in Disease and Therapy. Metabolites, 16.","DOI":"10.3390\/metabo16030207"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1001\/jamasurg.2025.2493","article-title":"Exosomal Liquid Biopsy for the Early Detection of Gastric Cancer: The DESTINEX Multicenter Study","volume":"160","author":"Sui","year":"2025","journal-title":"JAMA Surg."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Shen, A., Guo, F., Song, Y., Jing, N., Ding, X., Pan, M., Zhang, H., Wang, J., and Wu, L. (2020). Urinary Exosomal MiRNA-4534 as a Novel Diagnostic Biomarker for Diabetic Kidney Disease. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00590"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"e001403","DOI":"10.1136\/bmjdrc-2020-001403","article-title":"Effect of diabetes on exosomal miRNA profile in patients with obesity","volume":"8","author":"Kim","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/HYPERTENSIONAHA.120.16598","article-title":"Urinary- and Plasma-Derived Exosomes Reveal a Distinct MicroRNA Signature Associated with Albuminuria in Hypertension","volume":"77","author":"Ortega","year":"2021","journal-title":"Hypertension"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"23897","DOI":"10.1038\/s41598-025-06810-3","article-title":"Expression of urinary exosomal miR-136-5p in diabetic kidney disease and evaluation of its clinical diagnostic value","volume":"15","author":"Zheng","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1158\/1078-0432.CCR-24-1934","article-title":"An Exosome-Based Liquid Biopsy Predicts Depth of Response and Survival Outcomes to Cetuximab and Panitumumab in Metastatic Colorectal Cancer: The EXONERATE Study","volume":"31","author":"Xu","year":"2025","journal-title":"Clin. Cancer Res."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"13048","DOI":"10.18632\/oncotarget.14369","article-title":"Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"32945","DOI":"10.3402\/jev.v5.32945","article-title":"Techniques used for the isolation and characterization of extracellular vesicles: Results of a worldwide survey","volume":"5","author":"Gardiner","year":"2016","journal-title":"J. Extracell. Vesicles"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1038\/s41416-021-01567-8","article-title":"Changes in circulating exosome molecular profiles following surgery\/(chemo)radiotherapy: Early detection of response in head and neck cancer patients","volume":"125","author":"Theodoraki","year":"2021","journal-title":"BR J. Cancer"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12974-025-03567-4","article-title":"Exosomal pHERV-W ENV as a dynamic biomarker for relapse prediction and prognosis in multiple sclerosis","volume":"22","author":"Saba","year":"2025","journal-title":"J. Neuroinflamm."},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Prendergast, E.N., de Souza Fonseca, M.A., Dezem, F.S., Lester, J., Karlan, B.Y., Noushmehr, H., Lin, X., and Lawrenson, K. (2018). Optimizing exosomal RNA isolation for RNA-Seq analyses of archival sera specimens. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196913"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/j.tibtech.2025.12.032","article-title":"Clinical-scale bioreactor production of hiPSC-derived extracellular vesicles modulates miRNA and protein cargo to enhance angiogenic function","volume":"44","author":"Meliciano","year":"2026","journal-title":"Trends Biotechnol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.jacc.2015.02.026","article-title":"Plasma exosomes protect the myocardium from ischemia-reperfusion injury","volume":"65","author":"Vicencio","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.116.310557","article-title":"Angiogenic Mechanisms of Human CD34(+) Stem Cell Exosomes in the Repair of Ischemic Hindlimb","volume":"120","author":"Mathiyalagan","year":"2017","journal-title":"Circ. Res."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"167890","DOI":"10.1016\/j.bbadis.2025.167890","article-title":"Exosomes generated from bone marrow mesenchymal stem cells limit the damage caused by myocardial ischemia-reperfusion via controlling the AMPK\/PGC-1alpha signaling pathway","volume":"1871","author":"Zhuang","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1186\/s13287-025-04665-z","article-title":"Extracellular vesicle bioactivity and potential for clinical development are determined by mesenchymal stromal cell clonal subtype","volume":"16","author":"Ioannou","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"8166","DOI":"10.1074\/jbc.M114.621383","article-title":"Stabilization of exosome-targeting peptides via engineered glycosylation","volume":"290","author":"Hung","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bbrc.2018.03.227","article-title":"Cardiac-specific delivery by cardiac tissue-targeting peptide-expressing exosomes","volume":"499","author":"Kim","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"10555","DOI":"10.1021\/acsnano.9b04651","article-title":"Rapid On-Demand Extracellular Vesicle Augmentation with Versatile Oligonucleotide Tethers","volume":"13","author":"Yerneni","year":"2019","journal-title":"ACS Nano"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"21933","DOI":"10.1038\/srep21933","article-title":"Engineering hybrid exosomes by membrane fusion with liposomes","volume":"6","author":"Sato","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00216-022-04248-4","article-title":"Single-particle assessment of six different drug-loading strategies for incorporating doxorubicin into small extracellular vesicles","volume":"415","author":"Chen","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1208\/s12249-023-02624-6","article-title":"Impact of the Drug Loading Method on the Drug Distribution and Biological Efficacy of Exosomes","volume":"24","author":"Kumar","year":"2023","journal-title":"AAPS PharmSciTech"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1021\/acs.nanolett.8b02689","article-title":"In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR\/dCas9","volume":"19","author":"Li","year":"2019","journal-title":"Nano Lett."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Seow","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"101266","DOI":"10.1016\/j.jbc.2021.101266","article-title":"Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity","volume":"297","author":"Tsai","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Shtam, T., Evtushenko, V., Samsonov, R., Zabrodskaya, Y., Kamyshinsky, R., Zabegina, L., Verlov, N., Burdakov, V., Garaeva, L., and Slyusarenko, M. (2020). Evaluation of immune and chemical precipitation methods for plasma exosome isolation. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0242732"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"e12376","DOI":"10.1002\/jev2.12376","article-title":"Physical association of low density lipoprotein particles and extracellular vesicles unveiled by single particle analysis","volume":"12","author":"Gijsbers","year":"2023","journal-title":"J. Extracell. Vesicles"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s00018-018-2773-4","article-title":"Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins","volume":"75","author":"Karimi","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1021\/acs.analchem.5c05327","article-title":"Orthogonal Investigation at Single-Particle and Ensemble Levels Uncovers Lipoprotein-Extracellular Vesicle Binding","volume":"98","author":"Musico","year":"2026","journal-title":"Anal. Chem."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jim.2016.08.007","article-title":"The impact of various preanalytical treatments on the phenotype of small extracellular vesicles in blood analyzed by protein microarray","volume":"438","author":"Baek","year":"2016","journal-title":"J. Immunol. Methods"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"26913","DOI":"10.3402\/jev.v3.26913","article-title":"Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles","volume":"3","author":"Lotvall","year":"2014","journal-title":"J. Extracell. Vesicles"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"669","DOI":"10.20517\/evcna.2025.68","article-title":"MISEV and MIQE: Integrating domain-specific and general standards to strengthen extracellular vesicle biomarker research","volume":"6","author":"Pfaffl","year":"2025","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"14293","DOI":"10.1038\/s41598-017-14301-3","article-title":"Exosomal microRNA signatures in multiple sclerosis reflect disease status","volume":"7","author":"Ebrahimkhani","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Avasthi, K.K., Manley, B.J., Pellini, B., Zhang, J., Bloomer, A.M., Jean-Baptiste, E., Marchion, D.C., Fang, B., Koomen, J.M., and Siegel, E.M. (2025). Different plasma exosome isolation methods generated distinct microRNA and protein profiles in healthy controls and patients with advanced prostate and lung cancer. 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