{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:11:11Z","timestamp":1789049471478,"version":"build-2803163510"},"reference-count":44,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001352","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["25-13-20056"],"award-info":[{"award-number":["25-13-20056"]}],"id":[{"id":"10.13039\/100001352","id-type":"DOI","asserted-by":"publisher"}]},{"award":["25-13-20056"],"award-info":[{"award-number":["25-13-20056"]}],"id":[{"id":"https:\/\/ror.org\/03y2gwe85","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr. Issues Mol. Biol.","CIMB"],"abstract":"<jats:p>Depression and stress-related disorders remain important targets for the development of new neuroactive compounds. We evaluated three imidazo[1,2-a]pyridine\u2013[1,2,5]oxadiazolo[3,4-b]pyrazine derivatives, selected by a SERT-oriented computational screen, using chemical characterization, zebrafish embryo toxicity, larval and adult zebrafish behavioural assays, mouse behavioural HPLC, and qPCR experiments. AD19\/UtIA-0167 had the highest computational consensus but showed greater embryo toxicity and no consistent advantage in adult zebrafish. AD20\/UtIA-0108 showed a distinct larval locomotor profile, increased middle-zone occupancy after chronic exposure in stressed adult zebrafish, and was therefore examined in mice. Chronic AD20 increased latency to enter the dark compartment; whereas, time in the light compartment, open-field measures and forced-swim immobility were unchanged. HPLC and qPCR changes were region-specific and did not demonstrate direct SERT engagement. AD20 should therefore be regarded as an early neuroactive candidate from a SERT-oriented screen, not as a confirmed SERT inhibitor or antidepressant. Interpretation across species is limited by the duplicated zebrafish serotonin-transporter system, waterborne exposure and the limited scope of the mouse behavioural effect. Direct transporter assays, pharmacokinetic studies and independent behavioural replication are required.<\/jats:p>","DOI":"10.3390\/cimb48090922","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:02:48Z","timestamp":1788962568000},"page":"922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross-Species Triage of SERT-Oriented Polyheteroaryl Candidates Prioritizes AD20\/UtIA-0108 as an Early Neuroactive Candidate"],"prefix":"10.3390","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-8358","authenticated-orcid":false,"given":"Maria V.","family":"Komelkova","sequence":"first","affiliation":[{"name":"Russian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-2677","authenticated-orcid":false,"given":"Stanislav A.","family":"Fedorov","sequence":"additional","affiliation":[{"name":"Russian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika A.","family":"Isaeva","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathophysiology, Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 106 Pervomaiskaya Street, 620049 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4692-9176","authenticated-orcid":false,"given":"Irina A.","family":"Utepova","sequence":"additional","affiliation":[{"name":"Russian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia D.","family":"Grygoreva","sequence":"additional","affiliation":[{"name":"Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent\u2019yeva, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inessa Yu","family":"Bahareva","sequence":"additional","affiliation":[{"name":"Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent\u2019yeva, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitalii S.","family":"Moskaliuk","sequence":"additional","affiliation":[{"name":"Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent\u2019yeva, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M.","family":"Kondaurova","sequence":"additional","affiliation":[{"name":"Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent\u2019yeva, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-8976","authenticated-orcid":false,"given":"Alexandr V.","family":"Zhdanov","sequence":"additional","affiliation":[{"name":"Russian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel O.","family":"Platkovskii","sequence":"additional","affiliation":[{"name":"Russian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Trestsova","sequence":"additional","affiliation":[{"name":"Russian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia"},{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 28 Mira Street, 620002 Ekaterinburg, Russia"},{"name":"Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoy Street, 620066 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria A.","family":"Andreeva","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 28 Mira Street, 620002 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-3299","authenticated-orcid":false,"given":"Maxim A.","family":"Perfilev","sequence":"additional","affiliation":[{"name":"Scientific Center for Innovative Medicines, Volgograd State Medical University, 1 Pavshikh Bortsov Sq., 400066 Volgograd, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey N.","family":"Kochetkov","sequence":"additional","affiliation":[{"name":"Scientific Center for Innovative Medicines, Volgograd State Medical University, 1 Pavshikh Bortsov Sq., 400066 Volgograd, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-5052","authenticated-orcid":false,"given":"Pavel M.","family":"Vassiliev","sequence":"additional","affiliation":[{"name":"Russian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia"},{"name":"Scientific Center for Innovative Medicines, Volgograd State Medical University, 1 Pavshikh Bortsov Sq., 400066 Volgograd, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7196-4729","authenticated-orcid":false,"given":"Vladimir S.","family":"Naumenko","sequence":"additional","affiliation":[{"name":"Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent\u2019yeva, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-9655","authenticated-orcid":false,"given":"Alexey P.","family":"Sarapultsev","sequence":"additional","affiliation":[{"name":"Russian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, June 20). Depressive Disorder (Depression). Fact Sheet, 29 August 2025. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression."},{"key":"ref_2","unstructured":"World Health Organization (2026, June 20). Over a Billion People Living with Mental Health Conditions\u2014Services Require Urgent Scale-Up. News Release, 2 September 2025. Available online: https:\/\/www.who.int\/news\/item\/02-09-2025-over-a-billion-people-living-with-mental-health-conditions-services-require-urgent-scale-up."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/wps.21120","article-title":"Treatment-resistant depression: Definition, prevalence, detection, management, and investigational interventions","volume":"22","author":"McIntyre","year":"2023","journal-title":"World Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s43556-024-00205-y","article-title":"Treatment-resistant depression: Molecular mechanisms and management","volume":"5","author":"Kajumba","year":"2024","journal-title":"Mol. Biomed."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kositsyn, Y.M., de Abreu, M.S., Kolesnikova, T.O., Lagunin, A.A., Poroikov, V.V., Harutyunyan, H.S., Yenkoyan, K.B., and Kalueff, A.V. (2023). Towards novel potential molecular targets for antidepressant and antipsychotic drugs. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119482"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"23889","DOI":"10.1021\/acsomega.5c00549","article-title":"AI-driven drug discovery: A comprehensive review","volume":"10","author":"Ferreira","year":"2025","journal-title":"ACS Omega"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s43094-025-00862-y","article-title":"Assessing molecular docking tools: Understanding drug discovery and design","volume":"11","author":"Nivatya","year":"2025","journal-title":"Future J. Pharm. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17374","DOI":"10.1039\/D5SC05395A","article-title":"Decoding the limits of deep learning in molecular docking for drug discovery","volume":"16","author":"Li","year":"2025","journal-title":"Chem. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9955","DOI":"10.1038\/s41467-024-54375-y","article-title":"Deep phenotypic profiling of neuroactive drugs in larval zebrafish","volume":"15","author":"Gendelev","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chaoul, V., Dib, E.-Y., Bedran, J., Khoury, C., Shmoury, O., Harb, F., and Soueid, J. (2023). Assessing drug administration techniques in zebrafish models of neurological disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914898"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chauhan, A., Raviraj, T., Sobti, R.C., Dutta, A., Shukla, M.K., and Korinek, M. (2026). Zebrafish models for neurological disorders: A platform for natural product-based drug discovery. Front. Nat. Prod., 4.","DOI":"10.3389\/fntpr.2025.1679580"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1620\/tjem.208.267","article-title":"Characterization and expression of serotonin transporter genes in zebrafish","volume":"208","author":"Wang","year":"2006","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/cne.21831","article-title":"Comparative analysis of serotonin receptor HTR1A\/HTR1B families and transporter slc6a4a\/b gene expression in the zebrafish brain","volume":"511","author":"Norton","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1111\/j.1471-4159.2008.05285.x","article-title":"Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site","volume":"105","author":"Severinsen","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100405","DOI":"10.1016\/j.ynstr.2021.100405","article-title":"Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals","volume":"15","author":"Giacomini","year":"2021","journal-title":"Neurobiol. Stress"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Xie, Y., Meijer, A.H., and Schaaf, M.J.M. (2021). Modeling inflammation in zebrafish for the development of anti-inflammatory drugs. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.620984"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W.J., Clark, A., Cuthill, I.C., and Dirnagl, U. (2020). The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000410"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.22138\/2500-0918-2025-22-1-73-91","article-title":"Neural Network Modeling of the Multitarget Serotonergic Mechanism of Cellular Stress","volume":"22","author":"Vassiliev","year":"2025","journal-title":"J. Ural Med. Acad. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Vassiliev, P.M., Maltsev, D.V., Spasov, A.A., Perfilev, M.A., Skripka, M.O., and Kochetkov, A.N. (2023). Consensus Ensemble Multitarget Neural Network Model of Anxiolytic Activity of Chemical Compounds and Its Use for Multitarget Pharmacophore Design. Pharmaceuticals, 16.","DOI":"10.3390\/ph16050731"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1039\/C5GC00753D","article-title":"Aerobic oxidative C\u2013H\/C\u2013H coupling of azaaromatics with indoles and pyrroles in the presence of TiO2 as a photocatalyst","volume":"17","author":"Utepova","year":"2015","journal-title":"Green Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11172-016-1319-x","article-title":"Direct functionalization of the C\u2013H bond in (hetero)arenes: Aerobic photoinduced oxidative coupling of azines with aromatic nucleophiles in the presence of a CdS\/TiO2 photocatalyst","volume":"65","author":"Utepova","year":"2016","journal-title":"Russ. Chem. Bull."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/BF00673330","article-title":"Synthesis of furazano [3,4-b]pyrazine derivatives","volume":"14","author":"Eremeev","year":"1978","journal-title":"Chem. Heterocycl. Compd."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/jhet.5570190636","article-title":"On the reaction of 2-aminopyridines with \u03b1-halocarbonyl compounds","volume":"19","author":"Elliott","year":"1982","journal-title":"J. Heterocycl. Chem."},{"key":"ref_25","unstructured":"OECD (2025). Test No. 236: Fish Embryo Acute Toxicity (FET) Test, OECD Publishing. OECD Guidelines for the Testing of Chemicals, Section 2."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.scitotenv.2018.05.402","article-title":"Comparative behavioral toxicology with two common larval fish models: Exploring relationships among modes of action and locomotor responses","volume":"640\u2013641","author":"Steele","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"104812","DOI":"10.1016\/j.dib.2019.104812","article-title":"Zebrafish (Danio rerio) embryo-larvae locomotor activity data analysis: Evaluating anxiolytic effects of the antidepressant compound citalopram","volume":"27","author":"Pohl","year":"2019","journal-title":"Data Brief"},{"key":"ref_28","first-page":"1054","article-title":"Lack of gas bladder inflation by the larvae of zebrafish in the absence of an air\u2013water interface","volume":"55","author":"Goolish","year":"1999","journal-title":"J. Fish Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuro.2008.09.011","article-title":"Locomotion in larval zebrafish: Influence of time of day, lighting and ethanol","volume":"30","author":"MacPhail","year":"2009","journal-title":"Neurotoxicology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1038\/s41467-019-11936-w","article-title":"Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation","volume":"10","author":"McCarroll","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e70048","DOI":"10.1002\/jnr.70048","article-title":"Modeling stress-related disorders in zebrafish using prolonged predator exposure and prolonged unpredictable stress","volume":"103","author":"Zhdanov","year":"2025","journal-title":"J. Neurosci. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2014.07.045","article-title":"Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains","volume":"274","author":"Naumenko","year":"2014","journal-title":"Behav. Brain Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s10517-006-0090-7","article-title":"Effect of imipramine on the behavior and cerebral 5-HT1A serotonin receptors in mice genetically predisposed to catalepsy","volume":"141","author":"Tikhonova","year":"2006","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jneumeth.2004.06.005","article-title":"Quantitative RT-PCR assay of 5-HT1A and 5-HT2A serotonin receptor mRNAs using genomic DNA as an external standard","volume":"141","author":"Kulikov","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1134\/S0026893306010067","article-title":"Quantitative assay of 5-HT1A receptor gene expression in the brain","volume":"40","author":"Naumenko","year":"2006","journal-title":"Mol. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jneumeth.2008.01.008","article-title":"Utilization of a two-standard system in real-time PCR for quantification of gene expression in the brain","volume":"170","author":"Naumenko","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.2174\/1568026616666160506145539","article-title":"Medicinal attributes of imidazo [1,2-a]pyridine derivatives: An update","volume":"16","author":"Devi","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_38","unstructured":"Xiong, Y., Feichtinger, K., Ren, A.S., and Ulmann, B. (2013). Imidazo [1,2-a]pyridine Derivatives as Modulators of the 5-HT2A Serotonin Receptor Useful for the Treatment of Disorders Related Thereto. (EP2190844B1)."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00359-024-01693-7","article-title":"Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio)","volume":"210","author":"Tea","year":"2024","journal-title":"J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aquatox.2013.12.005","article-title":"Similar anxiolytic effects of agonists targeting serotonin 5-HT1A or cannabinoid CB receptors on zebrafish behaviour in novel environments","volume":"151","author":"Connors","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1074\/jbc.M109.045401","article-title":"Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter","volume":"285","author":"Sinning","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1124\/mol.110.067538","article-title":"The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter","volume":"78","author":"Sarker","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10276","DOI":"10.1074\/jbc.M806907200","article-title":"Location of the antidepressant binding site in the serotonin transporter: Importance of Ser-438 in recognition of citalopram and tricyclic antidepressants","volume":"284","author":"Andersen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nsmb.1602","article-title":"Antidepressant specificity of serotonin transporter suggested by three LeuT\u2013SSRI structures","volume":"16","author":"Zhou","year":"2009","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/9\/922\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:26:12Z","timestamp":1789046772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/48\/9\/922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["cimb48090922"],"URL":"https:\/\/doi.org\/10.3390\/cimb48090922","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]}}}