{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:45:20Z","timestamp":1760233520180,"version":"build-2065373602"},"reference-count":67,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Pregnancy is a period of continuous change in the maternal cardiovascular system, partly mediated by the autonomic nervous system. Insufficient autonomic adaptation to increasing gestation is associated with pregnancy complications, such as hypertensive disorders of pregnancy and preterm birth (both major causes of perinatal morbidity and mortality). Consequently, maternal heart rate variability (mHRV), which is a proxy measure for autonomic activity, is increasingly assessed in these cohorts to investigate the pathophysiology of their complications. A better pathophysiological understanding could facilitate the early detection of these complications, which remains challenging. However, such studies (typically performed in pregnancies leading to hospitalization) have generated conflicting findings. A probable reason for these conflicting findings is that these study cohorts were likely administered routine obstetric medications during the study period of which the effects on mHRV are largely unknown. Subsequently, we design a longitudinal, observational study to quantifying the effect of these medications\u2014particularly corticosteroids, which are known to affect fetal HRV\u2014on mHRV to improve the interpretation of past and future studies. We will enroll 61 women admitted to a tertiary obstetric unit with an indication to receive corticosteroids antenatally. Participants\u2019 mHRV will be continuously acquired throughout their hospitalization with wrist-worn photoplethysmography to facilitate a within-patient comparison of the effect of corticosteroids on mHRV.<\/jats:p>","DOI":"10.3390\/clinpract11010004","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T09:49:21Z","timestamp":1611222561000},"page":"13-25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in Maternal Heart Rate Variability in Response to the Administration of Routine Obstetric Medication in Hospitalized Patients: Study Protocol for a Cohort Study (MAMA-Heart Study)"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8730-6365","authenticated-orcid":false,"given":"Maretha","family":"Bester","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands"},{"name":"Department of Family Care Solutions, Philips Research, 5656 AE Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Moors","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands"},{"name":"Department of Obstetrics and Gynecology, M\u00e1xima MC, 5504 DB Veldhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6504-9399","authenticated-orcid":false,"given":"Rohan","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Family Care Solutions, Philips Research, 5656 AE Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Nichting","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands"},{"name":"Department of Obstetrics and Gynecology, M\u00e1xima MC, 5504 DB Veldhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5805-5333","authenticated-orcid":false,"given":"M. Beatrijs","family":"van der Hout-van der Jagt","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands"},{"name":"Department of Obstetrics and Gynecology, M\u00e1xima MC, 5504 DB Veldhoven, The Netherlands"},{"name":"Department of Biomedical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Guid","family":"Oei","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands"},{"name":"Department of Obstetrics and Gynecology, M\u00e1xima MC, 5504 DB Veldhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-5385","authenticated-orcid":false,"given":"Massimo","family":"Mischi","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-6098","authenticated-orcid":false,"given":"Rik","family":"Vullings","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith O. E. H.","family":"van Laar","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Eindhoven University of Technology, 5612 AP Eindhoven, The Netherlands"},{"name":"Department of Obstetrics and Gynecology, M\u00e1xima MC, 5504 DB Veldhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.bpobgyn.2013.08.001","article-title":"Alterations in physiology and anatomy during pregnancy","volume":"27","author":"Tan","year":"2013","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/978-3-319-77932-4_26","article-title":"Hemodynamic and electrocardiographic aspects of uncomplicated singleton pregnancy","volume":"1065","author":"Fu","year":"2018","journal-title":"Adv. Exp. Med. 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