{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:45:23Z","timestamp":1760233523875,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>There is an increasing consensus that the treatment of Hidradenitis suppurativa (HS) significantly varies with the degree of inflammation and that treatment according to guidelines is not always successful. Here, we report the case of a 31-year-old male with widespread, highly inflammatory Hurley Stage II HS in multiple locations who failed to respond to any kind of established medical treatment, including biologics. As an alternative approach, Ustekinumab was maintained, and additionally the patient was treated with LAight therapy, a combination of intense pulsed light and radiofrequency. After 10 sessions, deroofing of multiple lesions was performed in a two-step process. After a few weeks of healing time accompanied by specialized wound experts, the patient continued with LAight therapy to control and prevent recurrence. This case shows that the combination of LAight therapy and deroofing is a promising treatment plan for the long-term symptom control of mild and moderate HS.<\/jats:p>","DOI":"10.3390\/clinpract11010005","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T12:20:26Z","timestamp":1611750026000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combining Deroofing with LAight\u00ae Therapy for Long-Term Disease Control of Hurley Stage II Hidradenitis Suppurativa: Case Report"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2957-074X","authenticated-orcid":false,"given":"Michael","family":"Schultheis","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Scheuern","sequence":"additional","affiliation":[{"name":"WZ\u00ae-WundZentren GmbH, 40217 Dusseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Radkov","sequence":"additional","affiliation":[{"name":"MVZ Mgef\u00e4ss und wundVersorgungsZentrum GmbH, 47119 Duisburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.12703\/P6-112","article-title":"Update on hidradenitis suppurativa: Connecting the tracts","volume":"6","author":"Gill","year":"2014","journal-title":"F1000Prime Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1468-3083.2009.03356.x","article-title":"Hidradenitis suppurativa","volume":"23","author":"Revuz","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s15006-016-8662-6","article-title":"St\u00e4ndig entz\u00fcndliche Knoten und Abszesse in Achsel und Leiste","volume":"158","author":"Bechara","year":"2016","journal-title":"MMW Fortschr. Med."},{"doi-asserted-by":"crossref","unstructured":"Del Duca, E., Morelli, P., Bennardo, L., Di Raimondo, C., and Nistic\u00f2, S.P. (2020). Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa. Int. J. Mol. Sci., 21.","key":"ref_4","DOI":"10.3390\/ijms21228436"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1365-2133.2006.07155.x","article-title":"Clindamycin and rifampicin combination therapy for hidradenitis suppurativa","volume":"154","author":"Mendonca","year":"2006","journal-title":"Br. J. 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Treat., 1\u20138.","key":"ref_11","DOI":"10.1080\/09546634.2019.1677842"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1038\/s41598-019-41322-x","article-title":"Effects of intradermal radiofrequency treatment and intense pulsed light therapy in an acne-induced rabbit ear model","volume":"9","author":"Seok","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1524-4725.2009.01380.x","article-title":"Effect of smooth pulsed light at 400 to 700 and 870 to 1200 nm for acne vulgaris in Asian skin","volume":"36","author":"Kawana","year":"2010","journal-title":"Dermatol. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00042728-200801000-00025","article-title":"Treatment of hidradenitis suppurativa with a nonablative radiofrequency device","volume":"34","author":"Iwasaki","year":"2008","journal-title":"Dermatol. Surg."}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/11\/1\/5\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:16:02Z","timestamp":1760159762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/11\/1\/5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["clinpract11010005"],"URL":"https:\/\/doi.org\/10.3390\/clinpract11010005","relation":{},"ISSN":["2039-7283"],"issn-type":[{"type":"electronic","value":"2039-7283"}],"subject":[],"published":{"date-parts":[[2021,1,27]]}}}