{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:41:09Z","timestamp":1781264469497,"version":"3.54.1"},"reference-count":24,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Recurrent aphthous stomatitis (RAS) is an oral condition characterized by painful oral ulcerations. While the clinical features of this disease are easily defined, the etiology remains unclear. Thus, existing treatments are still unsatisfactory in reducing the severity, healing, and recurrence rate; however, there is no permanent and definitive treatment. Effective treatment for aphthous stomatitis is not available, and those treatments available mainly focus on suppressing its symptoms. We are reporting a case of a 17-year-old boy who presented with a 3-year history of multiple recurrent major ulcers in the oral cavity. Levamisole with steroids has been used in many clinical trials to treat aphthous ulcers, showing an improvement in pain, discomfort, healing time, and reduction in the number of ulcers. The same method was used to treat our patient, who showed promising results, with no recurrence for one year. Levamisole is a safe, easily tolerable and promising drug for the treatment of RAS.<\/jats:p>","DOI":"10.3390\/clinpract11020038","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T11:10:27Z","timestamp":1620299427000},"page":"250-256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Combination of Levamisole with Prednisone in Treating Recurrent Major Aphthous Ulcer in a Young Boy: A Case Report"],"prefix":"10.3390","volume":"11","author":[{"given":"Jyoti","family":"Prajapat","sequence":"first","affiliation":[{"name":"Private Dental Practitioner, Oral Medicine and Radiology, Gurugram 122001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Prajapat","sequence":"additional","affiliation":[{"name":"Private Practitioner, Prosthodontics Crown and Bridge, Al Jazeera Medical Complex, Al Naseem, Riyadh 14236, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-7773","authenticated-orcid":false,"given":"Sanjeev B.","family":"Khanagar","sequence":"additional","affiliation":[{"name":"Preventive Dental Science Department, College of Dentistry, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11426, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh 11426, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Vishwanathaiah","sequence":"additional","affiliation":[{"name":"Division of Pedodontics, Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan 44512, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Naik","sequence":"additional","affiliation":[{"name":"Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, P. O. Box 10219, Riyadh 11433, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Jhugroo","sequence":"additional","affiliation":[{"name":"Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, P. O. Box 10219, Riyadh 11433, Saudi Arabia"},{"name":"Nano Dental Clinic, Vacoas 74101, Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan","family":"Devang Divakar","sequence":"additional","affiliation":[{"name":"Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, P. O. Box 10219, Riyadh 11433, Saudi Arabia"},{"name":"Nano Dental Clinic, Vacoas 74101, Mauritius"},{"name":"Department of Oral Medicine and Radiology, Faculty of Dentistry, Levy Mwanawasa Medical University (LMMU), Ministry of Health, Lusaka 10101, Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"ref_1","first-page":"74","article-title":"Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners","volume":"7","author":"Tarakji","year":"2015","journal-title":"JIOH"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1600-0714.2012.01134.x","article-title":"Recurrent aphthous stomatitis: A review","volume":"41","author":"Chavan","year":"2012","journal-title":"J. Oral Pathol. 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