{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:50:20Z","timestamp":1770814220561,"version":"3.50.1"},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Although rare, acute myelogenous leukemia (AML) can include extramedullary manifestations, sometimes presenting as a solid tumor called a myeloid sarcoma. Myeloid sarcoma can be the cause of the initial presenting complaint before AML diagnosis, or may be detected as a sign of disease-relapse after treatment. Here, we report a case in which the initial presentation included abdominal discomfort and signs of kidney failure. Further investigation revealed signs of unilateral hydronephrosis. Due to a diagnostic delay, the patient was diagnosed with AML with extramedullary manifestation only after the development of full-blown leukemia. Biopsy of the compressive tumor confirmed an extramedullary myeloid sarcoma, and [18F]-FDG-PET\/CT proved useful for patient diagnosis and follow-up. This case report illustrates the importance of thorough examination and diagnosis, as a serious underlying disease with a rare cause can debut with an unusual presentation.<\/jats:p>","DOI":"10.3390\/clinpract11030061","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T22:06:48Z","timestamp":1626991608000},"page":"459-466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Kidney Failure and Abdominal Discomfort as Initial Signs of Extramedullary Acute Myelogenous Leukemia"],"prefix":"10.3390","volume":"11","author":[{"given":"Peter Ferkis","family":"Steinfeld","sequence":"first","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Knoop","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway"},{"name":"Institute of Medical Science, University of Bergen, N-5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linn Hereide","family":"Trovik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde Kollsete","family":"Gjelberg","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haukeland University Hospital, N-5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torjan Magne","family":"Haslerud","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Haukeland University Hospital, N-5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-8411","authenticated-orcid":false,"given":"H\u00e5kon","family":"Reikvam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway"},{"name":"Institute of Clinical Science, University of Bergen, N-5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1681\/ASN.2004100843","article-title":"Renal failure associated with cancer and its treatment: An update","volume":"16","author":"Humphreys","year":"2005","journal-title":"J. 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