{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:23:23Z","timestamp":1790295803978,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>The thyroid gland plays a significant role in the metabolism and proliferation of blood cells; hematological disorders are frequently observed in patients with thyroid disorders, and the most frequent problem is anemia. The main objective of this research work is to evaluate the prevalence and types of thyroid dysfunction and their association with anemia in different gender stratified by age in the Asir region of Saudi Arabia. Four years of data from July 2016 to July 2020 for 9992 study subjects were collected. Statistical analysis was performed based on thyroid disorder and anemia stratified by gender and age subgroup. The mean age of the study subject was 43.4 \u00b1 15.8 years, and females constituted 61.7% of cases. Thyroid dysfunction was observed in 49.76% (4973), and subclinical hypothyroidism was the most prevalent type (3922\/9992), followed by primary hypothyroidism (530\/9992). Females have a significantly higher overall prevalence of thyroid dysfunction than males (p &lt; 0.05). Anemia was detected in 1344 females and 465 males with a thyroid disorder, and also, the prevalence was significantly higher (p &lt; 0.05), compared to the normal thyroid group. Thyroid disorders are a common problem in our population, more prevalent in females than males, with the peak age of above 30 years, and are associated with an increased prevalence of anemia.<\/jats:p>","DOI":"10.3390\/clinpract11030065","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T05:22:01Z","timestamp":1628227321000},"page":"494-504","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Prevalence and Characteristics of Thyroid Abnormalities and Its Association with Anemia in ASIR Region of Saudi Arabia: A Cross-Sectional Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-6562","authenticated-orcid":false,"given":"Saif Aboud M.","family":"Alqahtani","sequence":"first","affiliation":[{"name":"Internal Medicine Department, College of Medicine, King Khalid University, P.O. Box 641, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrendo.2018.18","article-title":"Global epidemiology of hyperthyroidism and hypothyroidism","volume":"14","author":"Taylor","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/jc.2013-2409","article-title":"The incidence and prevalence of thyroid dysfunction in Europe: A meta-analysis","volume":"99","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/EJE-14-0898","article-title":"Shift of the TSH reference range with improved iodine supply in Northeast Germany","volume":"172","author":"Ittermann","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1530\/EJE-12-0111","article-title":"Geographic variations in the frequency of thyroid disorders and thyroid peroxidase antibodies in persons without former thyroid disease within Germany","volume":"167","author":"Meisinger","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13156","DOI":"10.1038\/s41598-019-49540-z","article-title":"Prevalence and Risk Factors of Thyroid Dysfunction in Older Adults in the Community","volume":"9","author":"Diab","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1089\/thy.2020.0715","article-title":"Abnormal Liver Blood Tests in Patients with Hyperthyroidism: Systematic Review and Meta-Analysis","volume":"31","author":"Scappaticcio","year":"2021","journal-title":"Thyroid"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1001\/archinte.168.14.1514","article-title":"Thyroid function and the risk of Alzheimer disease: The Framingham Study","volume":"168","author":"Tan","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1210\/jcem-40-2-211","article-title":"Erythropoiesis and erythropoietin in hypo- and hyperthyroidism","volume":"40","author":"Das","year":"1975","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_9","first-page":"73","article-title":"Effect of thyroid dysfunctions on blood cell count and red blood cell indice","volume":"3","author":"Dorgalaleh","year":"2013","journal-title":"Iran. J. Ped. Hematol. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2141.1977.tb06833.x","article-title":"Thyroid hormones stimulate erythropoiesis in vitro","volume":"37","author":"Golde","year":"1977","journal-title":"Br. J. Haematol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1530\/EJE-09-0875","article-title":"Clinical relevance of thyroid dysfunction in human haematopoiesis: Biochemical and molecular studies","volume":"162","author":"Kawa","year":"2010","journal-title":"Eur. J. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.amsu.2020.07.008","article-title":"Effects of thyroid dysfunction on hematological parameters: Case controlled study","volume":"57","author":"Ahmed","year":"2020","journal-title":"Ann. Med. Surg. (Lond.)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.15537\/smj.2018.3.21621","article-title":"Prevalence of subclinical hypothyroidism in pregnancy in Saudi Arabia","volume":"39","author":"Alkhudairy","year":"2018","journal-title":"Saudi. Med. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1507\/endocrj.EJ11-0096","article-title":"Characteristics of anemia in subclinical and overt hypothyroid patients","volume":"59","author":"Erdogan","year":"2012","journal-title":"Endocr. J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Fatima, Q., Dotasara, P., and Gauri, L.A. (2020). Hematological profile in primary hypothyroidism. Int. J. Med. Biomed. Stud., 4.","DOI":"10.32553\/ijmbs.v4i1.840"},{"key":"ref_16","first-page":"101","article-title":"The haematology of hypothyroidism","volume":"45","author":"Horton","year":"1976","journal-title":"Q. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0025-7125(16)31963-0","article-title":"Anemia in thyroid diseases","volume":"59","author":"Fein","year":"1975","journal-title":"Med. Clin. N. Am."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bmb\/ldr030","article-title":"The epidemiology of thyroid disease","volume":"99","author":"Vanderpump","year":"2011","journal-title":"Br. Med. Bull."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"385940","DOI":"10.1155\/2013\/385940","article-title":"Thryroid hormones and hematological indices levels in thyroid disorders patients at moi teaching and referral hospital, Western kenya","volume":"2013","author":"Iddah","year":"2013","journal-title":"ISRN Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/cen.14313","article-title":"Neutropenia in patients with hyperthyroidism: Systematic review and meta-analysis","volume":"94","author":"Scappaticcio","year":"2021","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1089\/thy.2006.16.403","article-title":"Pancytopenia in untreated patients with Graves\u2019 disease","volume":"16","author":"Lima","year":"2006","journal-title":"Thyroid"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1001\/archinte.160.4.526","article-title":"The Colorado thyroid disease prevalence study","volume":"160","author":"Canaris","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"ref_23","first-page":"1517","article-title":"Subclinical thyroid disease","volume":"72","author":"Wilson","year":"2005","journal-title":"Am. Fam. Phys."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"l2006","DOI":"10.1136\/bmj.l2006","article-title":"Thyroid hormones treatment for subclinical hypothyroidism: A clinical practice guideline","volume":"365","author":"Bekkering","year":"2019","journal-title":"BMJ"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/2319-4170.151032","article-title":"Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study","volume":"38","author":"Refaat","year":"2015","journal-title":"Biomed. J."},{"key":"ref_26","unstructured":"Thyroidfriends (2021, July 28). ATA Professional Guidelines. Available online: https:\/\/www.thyroid.org\/professionals\/ata-professional-guidelines\/."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15226\/2374-6890\/3\/4\/00159","article-title":"Prevalence of thyroids dysfunction among Saudi adult males and females from (June\u2013September 2016)","volume":"3","author":"Ali","year":"2016","journal-title":"Endocrinol. Diab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15761\/TDM.1000107","article-title":"The frequency of hypothyroidism in saudi community-based hospital: A retrospective single centre study","volume":"2","author":"Aljabri","year":"2019","journal-title":"Trends. Diabetes. Metab."},{"key":"ref_29","first-page":"56","article-title":"Hypothyroidism in Saudi Arabia; Prevalence, risk factors, and its relation with Diabetes Mellitus","volume":"11","author":"Alqahtiani","year":"2020","journal-title":"Arch. Pharm. Pract."},{"key":"ref_30","unstructured":"(2021, July 28). Iodine Deficiency. Available online: https:\/\/www.thyroid.org\/iodine-deficiency\/."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.5144\/0256-4947.1997.293","article-title":"Iodine deficiency in Saudi Arabia","volume":"17","author":"Kamel","year":"1997","journal-title":"Ann. Saudi. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1017\/S1368980014003073","article-title":"Iodine-deficiency disorders in the Aseer region, south-western Saudi Arabia: 20 years after the national survey and universal salt iodization","volume":"18","author":"Abbag","year":"2015","journal-title":"Public Health Nutr."},{"key":"ref_33","first-page":"163","article-title":"The role of changing diet and altitude on goitre prevalence in five regional states in Ethiopia","volume":"5","author":"Abuye","year":"2008","journal-title":"East Afr. J. Public Health"},{"key":"ref_34","first-page":"146","article-title":"Endemic goitre in schoolchildren in high and low altitude areas of Asir region, Saudi Arabia","volume":"22","author":"Abolfotouh","year":"2001","journal-title":"Saudi. Med. J."},{"key":"ref_35","first-page":"276","article-title":"Pattern of Thyroid Disease in Hail Region, Saudi Arabia","volume":"5","author":"Moussa","year":"2013","journal-title":"Int. J. Sci. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.12816\/0044365","article-title":"The Patterns of Surgically Treated Thyroid Disease in Central Rural Region of Saudi Arabia","volume":"70","author":"Aljarbou","year":"2018","journal-title":"Egypt. J. Hosp. Med."},{"key":"ref_37","first-page":"286","article-title":"Incidence of thyroid diseases in female Saudi adults visiting a tertiary care hospital in Riyadh","volume":"7","author":"Rana","year":"2017","journal-title":"Epidemiol. Open Access"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.12816\/0045841","article-title":"Prevalence of Hypothyroidism and Its Associated Risk Factors in Arar City, Saudi Arabia","volume":"71","author":"Alrowaili","year":"2018","journal-title":"Egypt. J. Hosp. Med."},{"key":"ref_39","first-page":"172","article-title":"Comparison of hematological parameters in untreated and treated subclinical hypothyroidism and primary hypothyroidism patients","volume":"26","author":"Bashir","year":"2012","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1365-2265.2011.04228.x","article-title":"Significant association between thyroid hormones and erythrocyte indices in euthyroid subjects","volume":"76","author":"Bremner","year":"2012","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"ref_41","first-page":"98","article-title":"Effect of hypothyroidism on haematological parameters: A gender-based comparison","volume":"74","author":"Karkoutly","year":"2020","journal-title":"N. Z. J. Med. Lab. Sci."},{"key":"ref_42","first-page":"783","article-title":"Erythrocyte abnormalities in thyroid dysfunction","volume":"88","author":"Omar","year":"2010","journal-title":"Tunis. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"E271","DOI":"10.25011\/cim.v33i5.14352","article-title":"Immunological and hematological changes in patients with hyperthyroidism or hypothyroidism","volume":"33","author":"Jafarzadeh","year":"2010","journal-title":"Clin. Investig. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1210\/jc.2018-00481","article-title":"The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data","volume":"103","author":"Wopereis","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/11\/3\/65\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:41:29Z","timestamp":1760164889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/11\/3\/65"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["clinpract11030065"],"URL":"https:\/\/doi.org\/10.3390\/clinpract11030065","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,6]]}}}