{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:18:30Z","timestamp":1792653510658,"version":"4.5.0"},"reference-count":14,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Cardiac contractility modulation (CCM) is a novel device-based therapy used in patients with HFrEF. CCM therapy is associated with an improvement in exercise tolerance, increased quality of life, reduced HF hospitalizations, and reverse remodelling of the left ventricle in patients with HFrEF. In this case, we report the clinical benefit of CCM in an older patient with advanced HFrEF due to ischemic dilated cardiomyopathy with frequent heart failure-related hospitalizations and poor quality of life despite optimal medical therapy.<\/jats:p>","DOI":"10.3390\/clinpract11040098","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T17:59:38Z","timestamp":1635962378000},"page":"835-840","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Use of Cardiac Contractility Modulation in an Older Patient with Non-Ischemic Dilated Cardiomyopathy: A Case Report"],"prefix":"10.3390","volume":"11","author":[{"given":"Gianvito","family":"Manganelli","sequence":"first","affiliation":[{"name":"Cardiology Department, ASL Avellino\u2013Sant\u2019Ottone Frangipane Hospital, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-1514","authenticated-orcid":false,"given":"Antonio","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Impulse Dynamics Germany, 60487 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Ceravolo","sequence":"additional","affiliation":[{"name":"Impulse Dynamics Germany, 60487 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefana","family":"Minichiello","sequence":"additional","affiliation":[{"name":"Cardiology Department, ASL Avellino\u2013Sant\u2019Ottone Frangipane Hospital, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bianchino","sequence":"additional","affiliation":[{"name":"Cardiology Department, ASL Avellino\u2013Sant\u2019Ottone Frangipane Hospital, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Bellizzi","sequence":"additional","affiliation":[{"name":"Cardiology Department, ASL Avellino\u2013Sant\u2019Ottone Frangipane Hospital, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pacileo","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Department of Cardiology, A. 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Med., 7.","DOI":"10.3390\/jcm7110436"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11886-019-1236-3","article-title":"Risk Stratification for Sudden Cardiac Death in Non-Ischaemic Dilated Cardiomyopathy","volume":"21","author":"Akhtar","year":"2019","journal-title":"Curr. Cardiol. 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