{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:48:36Z","timestamp":1781279316665,"version":"3.54.1"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Idiopathic scoliosis is a condition characterized by a three-dimensional curvature of the spine. However, in addition to the spinal curvature, it has also been reported that patients with idiopathic scoliosis can display other abnormal physiologic parameters, such as hormone imbalances, genetic variants, and micronutrient deficiencies. The present study evaluates the salivary progesterone levels from a historical cohort of patients seeking treatment at a single integrative medicine clinic. A group of female patients with a history of idiopathic scoliosis is compared to a group of non-scoliosis female patients. Salivary progesterone levels were 49% higher in non-scoliosis patients compared to the scoliosis group (p &lt; 0.05). When compared by the menstrual cycling status, non-scoliosis females had a 60% higher average progesterone level, while the progesterone level among non-cycling, non-scoliosis females was 39% higher than non-cycling scoliosis females. These results suggest a potential relationship between salivary progesterone and idiopathic scoliosis among female patients.<\/jats:p>","DOI":"10.3390\/clinpract12030038","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T03:28:43Z","timestamp":1652326123000},"page":"326-332","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Salivary Progesterone Levels in Female Patients with a History of Idiopathic Scoliosis: A Retrospective Cross-Sectional Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-8889","authenticated-orcid":false,"given":"Mark W.","family":"Morningstar","sequence":"first","affiliation":[{"name":"Natural Wellness & Pain Relief Center, Grand Blanc, MI 48423, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan N.","family":"Strauchman","sequence":"additional","affiliation":[{"name":"Natural Wellness & Pain Relief Center, Grand Blanc, MI 48423, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/13638490310001636808","article-title":"The effect of a modified Boston Brace with antirotatory blades on the progression of curves in idiopathic scoliosis: Aetiologic implications","volume":"6","author":"Grivas","year":"2003","journal-title":"Pediatr. Rehabil."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11832-012-0457-4","article-title":"Epidemiology of adolescent idiopathic scoliosis","volume":"7","author":"Konieczny","year":"2013","journal-title":"J. Child Orthop."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13013-017-0145-8","article-title":"2016 SOSORT guidelines: Orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth","volume":"13","author":"Negrini","year":"2018","journal-title":"Scoliosis Spinal Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1001\/jama.289.5.559","article-title":"Health and function of patients with untreated idiopathic scoliosis: A 50-year natural history study","volume":"289","author":"Weinstein","year":"2003","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00586-005-1053-9","article-title":"The adult scoliosis","volume":"14","author":"Aebi","year":"2005","journal-title":"Eur. Spine J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.5606\/tftrd.2020.6225","article-title":"Rehabilitation in adult spinal deformity","volume":"66","year":"2020","journal-title":"Turk. J. Phys. Med. Rehabil."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.31616\/asj.2018.12.6.1127","article-title":"The Role of Vitamin D in the Pathogenesis of Adolescent Idiopathic Scoliosis","volume":"12","author":"Ng","year":"2018","journal-title":"Asian Spine J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.2174\/1874325001711011466","article-title":"Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present","volume":"11","author":"Fadzan","year":"2017","journal-title":"Open Orthop. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4055\/cios.2014.6.2.180","article-title":"Evaluation of bone mineral status in adolescent idiopathic scoliosis","volume":"6","author":"Erfani","year":"2014","journal-title":"Clin. Orthop. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.31616\/asj.2018.0096","article-title":"Etiology of Adolescent Idiopathic Scoliosis: A Literature Review","volume":"13","author":"Kikanloo","year":"2019","journal-title":"Asian Spine J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1590\/1413-785220172501168600","article-title":"Role of different hormones in the pathogenesis and severity of adolescent idiopathic scoliosis","volume":"25","author":"Silva","year":"2017","journal-title":"Acta Ortop. Bras."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s13018-020-01988-w","article-title":"Disordered leptin and ghrelin bioactivity in adolescent idiopathic scoliosis (AIS): A systematic review and meta-analysis","volume":"15","author":"Wang","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1748-7161-4-24","article-title":"Pathogenesis of adolescent idiopathic scoliosis in girls\u2014A double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: Possible dependency on sympathetic nervous system and hormones with implications for medical therapy","volume":"4","author":"Burwell","year":"2009","journal-title":"Scoliosis"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00264-015-2742-6","article-title":"Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis","volume":"39","author":"Kulis","year":"2015","journal-title":"Int. Orthop."},{"key":"ref_15","first-page":"71","article-title":"Variability of serum prolactin and progesterone levels in normal women: The relevance of single hormone measurements in the clinical setting","volume":"76","author":"Fujimoto","year":"1990","journal-title":"Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1196\/annals.1384.022","article-title":"Patterns of salivary estradiol and progesterone across the menstrual cycle","volume":"1098","author":"Gandara","year":"2007","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1210\/jc.2010-0125","article-title":"Salivary progesterone levels before menarche: A prospective study of adolescent girls","volume":"95","author":"Gray","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1749-6632.1993.tb18349.x","article-title":"Status report on measurement of salivary estrogens and androgens","volume":"694","author":"Read","year":"1993","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1749-6632.1993.tb18350.x","article-title":"Measurements of salivary progesterone","volume":"694","author":"Ellison","year":"1993","journal-title":"Ann. NY Acad. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0015-0282(01)01960-4","article-title":"Relationship between salivary progesterone, 17-hydroxyprogesterone, and cortisol levels throughout the normal menstrual cycle of healthy postmenarcheal girls","volume":"76","author":"Rauh","year":"2001","journal-title":"Fertil. Steril."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/09513599309152488","article-title":"Assessment of bioavailability of oral micronized progesterone using a salivary progesterone enzymeimmunoassay","volume":"7","author":"Bolaji","year":"1993","journal-title":"Gynecol. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2106\/00004623-196951030-00001","article-title":"Long-term follow-up of patients with idiopathic scoliosis not treated surgically","volume":"51","author":"Collis","year":"1969","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1097\/01.brs.0000263328.89135.a6","article-title":"Natural history of progressive adult scoliosis","volume":"32","author":"Scattin","year":"2007","journal-title":"Spine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1097\/00007632-199912150-00006","article-title":"Natural history","volume":"24","author":"Weinstein","year":"1999","journal-title":"Spine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroscience.2012.10.051","article-title":"Progesterone-estrogen interactions in synaptic plasticity and neuroprotection","volume":"239","author":"Baudry","year":"2013","journal-title":"Neuroscience"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1016\/j.neuropsychologia.2010.06.039","article-title":"Parietal cortex coding of limb posture: In search of the body-schema","volume":"48","author":"Parkinson","year":"2010","journal-title":"Neuropsychologia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/09593980701884832","article-title":"The role of the cerebellum in procedural learning\u2014Are there implications for physiotherapists\u2019 clinical practice?","volume":"24","author":"Saywell","year":"2008","journal-title":"Physiother. Theory Pract."}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/12\/3\/38\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:09:33Z","timestamp":1760137773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/12\/3\/38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,11]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["clinpract12030038"],"URL":"https:\/\/doi.org\/10.3390\/clinpract12030038","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,11]]}}}