{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:59:55Z","timestamp":1760237995090,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Adenocarcinoma of the small bowel is rather uncommon and several etio-pathogenic factors have been proposed. We report a case of multiple synchronous adenocarcinomas arising in the non-ampullary duodenum and first tract of the jejunum in a background of Brunner\u2019s glands agenesia, chronic duodenitis, and extensive dysplasia in a 64 year-old woman. To the best of our knowledge such association has not been reported so far.<\/jats:p>","DOI":"10.3390\/clinpract12050069","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T21:28:12Z","timestamp":1661462892000},"page":"672-676","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple Adenocarcinomas of the Small Bowel in a Patient with Brunner\u2019s Glands Agenesia: A Previously Unreported Association"],"prefix":"10.3390","volume":"12","author":[{"given":"Sergio","family":"Coverlizza","sequence":"first","affiliation":[{"name":"Department of Pathology, San Giovanni Bosco Hospital, 10154 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"Masu","sequence":"additional","affiliation":[{"name":"Department of Pathology, S. Andrea Hospital, ASLVC, 13100 Vercelli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5823-7137","authenticated-orcid":false,"given":"Claudia","family":"Manini","sequence":"additional","affiliation":[{"name":"Department of Pathology, San Giovanni Bosco Hospital, 10154 Turin, Italy"},{"name":"Department of Sciences of Public Health and Pediatrics, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00004836-200110000-00004","article-title":"Small intestinal neoplasms","volume":"33","author":"Gill","year":"2001","journal-title":"J. Clin. 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Epidemiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1158\/1541-7786.MCR-05-0261","article-title":"Inflammation, a key event in cancer development","volume":"4","author":"Lu","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.suc.2007.03.011","article-title":"Operative management of small bowel Crohn\u2019s disease","volume":"87","author":"Gardiner","year":"2007","journal-title":"Surg. Clin. N. Am."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1203\/01.PDR.0000179408.74781.C9","article-title":"Lineage development in a patient without goblet, Paneth, and enteroendocrine cells: A clue for intestinal epithelial differentiation","volume":"58","author":"Shaoul","year":"2005","journal-title":"Pediatr. Res."},{"key":"ref_16","first-page":"689","article-title":"Histogenesis and histomorphometric study of human fetal small intestine","volume":"29","author":"Salva","year":"2019","journal-title":"Ethiop. J. Health Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ar.1092360206","article-title":"Dynamics of epithelial cells in the corpus of the mouse stomach. V. Behavior of entero-endocrine and caveolated cells: General conclusions on the kinetics in the oxyntic epithelium","volume":"236","author":"Karam","year":"1993","journal-title":"Anat. Rec."},{"key":"ref_18","first-page":"121","article-title":"Management of adenocarcinoma of the small intestine","volume":"3","author":"Dasari","year":"2009","journal-title":"Gastrointest. Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2169\/internalmedicine.51.6999","article-title":"Primary segmental and multiple adenocarcinomas of the small bowel","volume":"51","author":"Ren","year":"2012","journal-title":"Intern. 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