{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:27Z","timestamp":1792787727622,"version":"4.5.0"},"reference-count":65,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Background: Low back pain (LBP) is an emerging disease. This review aims to investigate the role of gender-related factors in the diagnosis, clinical, and surgical management of LBP. Methods: From January 2002 to March 2023, EMBASE, SCOPUS, OVID-MEDLINE, Google Scholar, PubMed, and Web of Science were searched to identify relevant papers for further analysis. Results: Fifteen papers were included in this review. Sex- and gender-related differences were analyzed regarding the following points: (1) LBP epidemiology; (2) LBP physiopathology; (3) conservative management of LBP; (4) major vertebral surgery for LBP. The conservative treatment of LBP highlights that women claim services later in terms of poorer health status than men. In the postoperative phase, female patients show worse LBP, quality of life, and disability, but equal or greater interval change, compared with male patients complaining of lumbar degenerative disease. Conclusions: LBP epidemiology and clinical outcomes, following conservative and surgical management of patients complaining of back pain, might depend on both sex- and gender-related factors. It is mandatory to assess gender-related indicators in patients referred to LBP and address them to improve their clinical outcomes and quality of life.<\/jats:p>","DOI":"10.3390\/clinpract13060122","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T13:26:55Z","timestamp":1698672415000},"page":"1360-1368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Gender-Related Issues in the Management of Low-Back Pain: A Current Concepts Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Davide","family":"Bizzoca","sequence":"first","affiliation":[{"name":"UOSD Vertebral Surgery, AOU Consorziale Policlinico di Bari, 70124 Bari, Italy"},{"name":"Ph.D. Course in Public Health, Clinical Medicine and Oncology, Department DiMePre-J, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Solarino","sequence":"additional","affiliation":[{"name":"Orthopedics Unit, Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, School of Medicine and Surgery, University of Bari, General Hospital, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1414-5692","authenticated-orcid":false,"given":"Alessandro","family":"Pulcrano","sequence":"additional","affiliation":[{"name":"Orthopedics Unit, Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, School of Medicine and Surgery, University of Bari, General Hospital, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Orthopedics Unit, Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, School of Medicine and Surgery, University of Bari, General Hospital, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Moretti","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Santa Maria Hospital, Via De Ferrariis 18\/D, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4215-7615","authenticated-orcid":false,"given":"Lorenzo","family":"Moretti","sequence":"additional","affiliation":[{"name":"Orthopedics Unit, Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, School of Medicine and Surgery, University of Bari, General Hospital, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Piazzolla","sequence":"additional","affiliation":[{"name":"UOSD Vertebral Surgery, AOU Consorziale Policlinico di Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biagio","family":"Moretti","sequence":"additional","affiliation":[{"name":"Orthopedics Unit, Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, School of Medicine and Surgery, University of Bari, General Hospital, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cger.2010.03.001","article-title":"Epidemiology of Osteoarthritis","volume":"26","author":"Zhang","year":"2010","journal-title":"Clin. 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