{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:28:11Z","timestamp":1793381291367,"version":"4.5.0"},"reference-count":116,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>The importance of maintaining proper magnesium intake and total body magnesium content in preserving human health remains underappreciated among medical professionals and laymen. This review aimed to show the importance of hypomagnesemia as a modifiable risk factor for developing disease processes. We searched the PubMed database and Google Scholar using the keywords \u2018magnesium\u2019, \u2018diabetes\u2019, \u2018cardiovascular disease\u2019, \u2018respiratory disease\u2019, \u2018immune system\u2019, \u2018inflammation\u2019, \u2018autoimmune disease\u2019, \u2018neurology\u2019, \u2018psychiatry\u2019, \u2018cognitive function\u2019, \u2018cancer\u2019, and \u2018vascular calcification\u2019. In multiple contexts of the search terms, all reviews, animal experiments, and human observational data indicated that magnesium deficiency can lead to or contribute to developing many disease states. The conclusions of several in-depth reviews support our working hypothesis that magnesium and its supplementation are often undervalued and underutilized. Although much research has confirmed the importance of proper magnesium supply and tissue levels, simple and inexpensive magnesium supplementation has not yet been sufficiently recognized or promoted.<\/jats:p>","DOI":"10.3390\/clinpract14020040","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T10:58:02Z","timestamp":1711105082000},"page":"521-535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Magnesium Is a Vital Ion in the Body\u2014It Is Time to Consider Its Supplementation on a Routine Basis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9776-9841","authenticated-orcid":false,"given":"\u00c1kos G\u00e9za","family":"Peth\u0151","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3346-7040","authenticated-orcid":false,"given":"Tibor","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"Medicine Service, Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA"},{"name":"Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronella","family":"Orosz","sequence":"additional","affiliation":[{"name":"Bethesda Children\u2019s Hospital, 1146 Budapest, Hungary"},{"name":"Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mih\u00e1ly","family":"Tapolyai","sequence":"additional","affiliation":[{"name":"Medicine Service, Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA"},{"name":"Department of Nephrology, Szent Margit K\u00f3rhaz, 1032 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00012.2014","article-title":"Magnesium in man: Implications for health and disease","volume":"95","author":"Hoenderop","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"i15","DOI":"10.1093\/ndtplus\/sfr164","article-title":"Regulation of magnesium balance: Lessons learned from human genetic disease","volume":"5","author":"Hoenderop","year":"2012","journal-title":"Clin. 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