{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:10:55Z","timestamp":1760109055507,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Penetrating aortic injuries represent critical medical emergencies that necessitate immediate intervention to prevent life-threatening consequences. When accompanied by the presence of an enormous right pleural false aneurysm, the clinical scenario becomes exceptionally rare and complex. This case report details the successful management of a patient who presented with a penetrating aortic ulcer and an extensive false aneurysm within the right pleura, employing an interdisciplinary approach involving cardiac surgeons, cardiologists, interventional cardiologists, and radiologists. The pivotal intervention involved the deployment of a covered and bare stent graft into the descending thoracic aorta to seal the aortic rupture. The patient\u2019s clinical condition stabilized postoperatively, with no signs of recurrent hemorrhage. This case underscores the importance of rapid diagnosis, timely intervention, and the collaborative efforts of a specialized medical team in successfully managing such complex vascular injuries. Early recognition and referral to specialized centers are essential for improving patient outcomes in cases of penetrating aortic injuries with associated giant pseudoaneurysms.<\/jats:p>","DOI":"10.3390\/clinpract14020049","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T09:15:20Z","timestamp":1713345320000},"page":"619-628","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Interventional Endovascular Management of Ruptured Penetrating Aortic Ulcer with Associated Enormous Right Pleural False Aneurysm"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-9946","authenticated-orcid":false,"given":"Andrei Emanuel","family":"Grigorescu","sequence":"first","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Research Center of the Institute of Cardiovascular and Heart Disease of Timisoara, 300310 Timisoara, Romania"},{"name":"Division of Cardiovascular Surgery, Institute for Cardiovascular Diseases, 300391 Timisoara, Romania"},{"name":"Doctoral School Medicine\u2014Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Anghel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-8249","authenticated-orcid":false,"given":"Horea","family":"Feier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Research Center of the Institute of Cardiovascular and Heart Disease of Timisoara, 300310 Timisoara, Romania"},{"name":"Division of Cardiovascular Surgery, Institute for Cardiovascular Diseases, 300391 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC Guidelines on the Diagnosis and Treatment of Aortic Diseases: Document Covering Acute and Chronic Aortic Diseases of the Thoracic and Abdominal Aorta of the adultThe Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC)","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/01.CIR.99.10.1331","article-title":"Intimal Tear Without Hematoma: An Important Variant of Aortic Dissection That Can Elude Current Imaging Techniques","volume":"99","author":"Svensson","year":"1999","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/01.CIR.92.6.1376","article-title":"Acute Aortic Dissection and Its Variants: Toward a Common Diagnostic and Therapeutic Approach","volume":"92","author":"DeSanctis","year":"1995","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/CIRCULATIONAHA.121.054710","article-title":"Prognostication of Asymptomatic Penetrating Aortic Ulcers: A Modern Approach","volume":"144","author":"DeCarlo","year":"2021","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00270-018-2114-x","article-title":"Penetrating Aortic Ulcer and Intramural Hematoma","volume":"42","author":"Oderich","year":"2019","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.xjon.2022.03.003","article-title":"Endovascular Treatment of Penetrating Atherosclerotic Ulcers of the Arch and Thoracic Aorta: In-Hospital and 5-Year Outcomes","volume":"10","author":"Murana","year":"2022","journal-title":"JTCVS Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0890-5096(06)60697-3","article-title":"Penetrating Atherosclerotic Ulcers of the Thoracic Aorta: Natural History and Clinicopathologic Correlations","volume":"1","author":"Stanson","year":"1986","journal-title":"Ann. Vasc. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/0002-8703(94)90753-6","article-title":"Penetrating Atherosclerotic Aortic Ulcers","volume":"128","author":"Movsowitz","year":"1994","journal-title":"Am. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/HCO.0000000000000782","article-title":"Penetrating Atherosclerotic Ulcer","volume":"35","author":"Evangelista","year":"2020","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0741-5214(98)70003-5","article-title":"Penetrating Ulcer of the Thoracic Aorta: What Is It? How Do We Recognize It? How Do We Manage It?","volume":"27","author":"Coady","year":"1998","journal-title":"J. Vasc. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.thromres.2019.04.018","article-title":"The Role of von Willebrand Factor in Acute Type A Aortic Dissection and Aortic Surgery","volume":"178","author":"Zindovic","year":"2019","journal-title":"Thromb. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jvs.2020.05.052","article-title":"Results of Cryopreserved Arterial Allograft Replacement for Thoracic and Thoracoabdominal Aortic Infections","volume":"73","author":"Couture","year":"2021","journal-title":"J. Vasc. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e008104","DOI":"10.1161\/JAHA.117.008104","article-title":"Open Repair of Mycotic Abdominal Aortic Aneurysms With Biological Grafts: An International Multicenter Study","volume":"7","author":"Heinola","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/ejcts\/ezy263","article-title":"Twenty-Year Experience with Cryopreserved Arterial Allografts for Vascular Infections","volume":"55","author":"Mestres","year":"2019","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.athoracsur.2014.01.069","article-title":"Cryopreserved Aortic Homograft for In Situ Replacement of Infected Thoracic Stent Graft Associated With Distal Aortic Arch Rupture and Hematemesis","volume":"98","author":"Uzun","year":"2014","journal-title":"Ann. Thorac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.jvs.2010.10.135","article-title":"Open Surgery versus Endovascular Repair of Ruptured Thoracic Aortic Aneurysms","volume":"53","author":"Jonker","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.asjsur.2021.11.040","article-title":"Open Repair versus Thoracic Endovascular Aortic Repair for Treating Traumatic Aortic Injury","volume":"45","author":"Kim","year":"2022","journal-title":"Asian J. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jvs.2008.04.060","article-title":"Meta-Analysis of Endovascular vs Open Repair for Traumatic Descending Thoracic Aortic Rupture","volume":"48","author":"Xenos","year":"2008","journal-title":"J. Vasc. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S0003-4975(02)05028-2","article-title":"Endovascular Repair for Acute Traumatic Rupture of the Thoracic Aorta","volume":"75","author":"Berthet","year":"2003","journal-title":"Ann. Thorac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Rizza, A., Negro, F., Palermi, S., Palmieri, C., Murzi, M., Credi, G., and Berti, S. (2022). Penetrating Aortic Ulceration Treated with Castor Branched Aortic Stent Graft\u2014A Case Series. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19084809"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.athoracsur.2012.03.074","article-title":"Late Outcomes With Repair of Penetrating Thoracic Aortic Ulcers: The Merits of an Endovascular Approach","volume":"94","author":"Patel","year":"2012","journal-title":"Ann. Thorac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Writing Group Members, Hiratzka, L.F., Bakris, G.L., Beckman, J.A., Bersin, R.M., Carr, V.F., Casey, D.E., Eagle, K.A., Hermann, L.K., and Isselbacher, E.M. (2010). 2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease: A Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation, 121, e266\u2013e369.","DOI":"10.1161\/CIR.0b013e3181d4739e"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jvs.2019.09.039","article-title":"Short- and Long-Term Outcomes in Isolated Penetrating Aortic Ulcer Disease","volume":"72","author":"Salim","year":"2020","journal-title":"J. Vasc. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/ejcts\/ezaa480","article-title":"Multicentre Experience with the Frozen Elephant Trunk Technique to Treat Penetrating Aortic Ulcers Involving the Aortic Arch","volume":"59","author":"Kreibich","year":"2021","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"266.e5","DOI":"10.1016\/j.avsg.2010.06.011","article-title":"Hybrid Aortic Arch Repair for a Ruptured and Infected Penetrating Atherosclerotic Ulcer of the Aortic Arch","volume":"25","author":"Canaud","year":"2011","journal-title":"Ann. Vasc. Surg."}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/14\/2\/49\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:29:05Z","timestamp":1760106545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/14\/2\/49"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["clinpract14020049"],"URL":"https:\/\/doi.org\/10.3390\/clinpract14020049","relation":{},"ISSN":["2039-7283"],"issn-type":[{"type":"electronic","value":"2039-7283"}],"subject":[],"published":{"date-parts":[[2024,4,17]]}}}