{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:22:29Z","timestamp":1760145749744,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Preterm births comprise all pregnancies coming to an end before the gestational age of 37 weeks and remain the leading cause of death in children under 5 years old despite efforts to reduce their occurrence. We aim to analyze all morbidity and mortality data to understand causes and risk factors, helping in prevention efforts. This study includes 140 cases collected during 2018\u20132022. Demographic, maternal, and thanatogenetic data were statistically analyzed. We observed an upward slope of stillborn babies. In the case of live-born premature, the average survival was 301.76 h. The multivariate analysis noted that extremely low birth weight (HR = 5.141) and very low birth weight (HR = 4.177) are risk factors involved in mortality. Increased parity was associated with premature births with low and very low birth weight (p = 0.019). We observed that a mother\u2019s age of over 30 years is predictable for the development of pregnancy-induced hypertension. Cerebral and pulmonary hemorrhages were the most common intermediate morbid conditions, with prematurity and plurivisceral hemorrhages serving as their root causes. We have identified that anthropometric measurements have a high predictability on malformed babies. The identified associations indicate a shared mechanism for certain lesion processes, which can help optimize resources for predicting and preventing preterm neonatal issues.<\/jats:p>","DOI":"10.3390\/clinpract14050144","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T02:25:49Z","timestamp":1725416749000},"page":"1801-1817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is It Possible to Prevent the Thanatogenetic Processes in Premature Babies?"],"prefix":"10.3390","volume":"14","author":[{"given":"Sinziana Andra","family":"Ghitoi","sequence":"first","affiliation":[{"name":"Clinical Service of Pathology, Department of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Deacu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, Department of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constanta, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Aschie","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, Department of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constanta, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Department of Anatomy, Academy of Medical Sciences of Romania, 030171 Bucharest, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), \u201cOvidius\u201d University, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Enciu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, Department of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca Florentina","family":"Mitroi","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), \u201cOvidius\u201d University, 900591 Constanta, Romania"},{"name":"Clinical Service of Pathology, Department of Genetics, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgeta Camelia","family":"Cozaru","sequence":"additional","affiliation":[{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), \u201cOvidius\u201d University, 900591 Constanta, Romania"},{"name":"Clinical Service of Pathology, Department of Genetics, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonela Anca","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, Department of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constanta, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), \u201cOvidius\u201d University, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-3200","authenticated-orcid":false,"given":"Cristian Ionut","family":"Orasanu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, Department of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constanta, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), \u201cOvidius\u201d University, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana Andreea","family":"Ursica","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, Department of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constanta, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9396-2350","authenticated-orcid":false,"given":"Raluca Ioana","family":"Voda","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, Department of Pathology, \u201cSf. 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ICD-10: International Statistical Classification of Diseases and Related Health Problems: Tenth Revision, World Health Organization. [2nd ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S2352-4642(21)00311-4","article-title":"Global, regional, and national causes of under-5 mortality in 2000\u201319: An updated systematic analysis with implications for the Sustainable Development Goals","volume":"6","author":"Perin","year":"2022","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_5","unstructured":"United Nations (2015). The Millennium Development Goals Report 2015, United Nations. Available online: https:\/\/www.un.org\/millenniumgoals\/2015_MDG_Report\/pdf\/MDG%202015%20rev%20(July%201).pdf."},{"key":"ref_6","unstructured":"UN General Assembly (2024, February 01). Transforming Our World: The 2030 Agenda for Sustainable Development. September 2015. Available online: https:\/\/sustainabledevelopment.un.org\/post2015\/transformingourworld."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Ramaswamy, V.V., Abiramalatha, T., Bandyopadhyay, T., Shaik, N.B., Bandiya, P., Nanda, D., Pullattayil, S.A.K.P., Murki, S., and Roehr, C.C. (2021). ELBW and ELGAN outcomes in developing nations-Systematic review and meta-analysis. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0255352"},{"key":"ref_8","unstructured":"Howson, C.P., Kinney, M.V., and Lawn, J. (2012). 15 million preterm births: Priorities for action based on national, regional and global estimates. Born Too Soon: The Global Action Report on Preterm Birth, World Health Organization."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/S2214-109X(18)30451-0","article-title":"Global, regional, and national estimates of levels of preterm birth in 2014: A systematic review and modelling analysis","volume":"7","author":"Chawanpaiboon","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Santana, D.S., Silveira, C., Costa, M.L., Souza, R.T., Surita, F.G., Souza, J.P., Mazhar, S.B., Jayaratne, K., Qureshi, Z., and Sousa, M.H. (2018). Perinatal outcomes in twin pregnancies complicated by maternal morbidity: Evidence from the WHO Multicountry Survey on Maternal and Newborn Health. BMC Pregnancy Childbirth, 18.","DOI":"10.1186\/s12884-018-2082-9"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1097\/CM9.0000000000000808","article-title":"Systematic management of twin pregnancies to reduce pregnancy complications","volume":"133","author":"Gao","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ijgo.13195","article-title":"Global burden of preterm birth","volume":"150","author":"Walani","year":"2020","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_13","unstructured":"United Nations (2024, February 05). Sustainable Development Goal 3. Ensure Healthy Lives an Promote Well-Being for All at All Ages. Available online: https:\/\/www.un.org\/sustainabledevelopment\/health\/."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Adugna, D.G. (2022). Prevalence and associated risk factors of preterm birth among neonates in referral hospitals of Amhara Region, Ethiopia. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0276793"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhou, J., Ma, Y., Liu, L., Xia, Q., Fan, D., and Ai, W. (2019). Mode of delivery and preterm birth in subsequent births: A systematic review and meta-analysis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0213784"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Fuchs, F., Monet, B., Ducruet, T., Chaillet, N., and Audibert, F. (2018). Effect of maternal age on the risk of preterm birth: A large cohort study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191002"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1824-7288-39-7","article-title":"The origins of health and disease: The influence of maternal diseases and lifestyle during gestation","volume":"39","author":"Capra","year":"2013","journal-title":"Ital. J. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.addr.2020.09.013","article-title":"Diseases and conditions that impact maternal and fetal health and the potential for nanomedicine therapies","volume":"170","author":"Nelson","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E540","DOI":"10.1503\/cmaj.202604","article-title":"The impact of COVID-19 on pregnancy outcomes: A systematic review and meta-analysis","volume":"193","author":"Wei","year":"2021","journal-title":"CMAJ"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ijpam.2020.02.006","article-title":"Late preterm infants\u2014Changing trends and continuing challenges","volume":"7","author":"Karnati","year":"2020","journal-title":"Int. J. Pediatr. Adolesc. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.1016\/j.vaccine.2017.01.049","article-title":"Low birth weight: Case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data","volume":"35","author":"Cutland","year":"2017","journal-title":"Vaccine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.26719\/2013.19.9.775","article-title":"Comparison of maternal characteristics in low birth weight and normal birth weight infants","volume":"19","author":"Nazari","year":"2013","journal-title":"East Mediterr. Health J."},{"key":"ref_23","unstructured":"Eurostat (2023, March 09). How Many Children Were Born in the EU in 2021?. Available online: https:\/\/ec.europa.eu\/eurostat\/web\/products-eurostat-news\/w\/ddn-20230309-1."},{"key":"ref_24","unstructured":"(2023, January 31). UNICEF. Available online: https:\/\/data.unicef.org\/topic\/child-survival\/stillbirths\/."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s00431-021-03984-6","article-title":"Lack of changes in preterm delivery and stillbirths during COVID-19 lockdown in a European region","volume":"180","author":"Arnaez","year":"2021","journal-title":"Eur. J. Pediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.pedneo.2023.08.001","article-title":"Therapeutic trajectory for improving survival and outcomes of very low birth weight (VLBW) preterm in-fants","volume":"64","author":"Chiang","year":"2023","journal-title":"Pediatr. Neonatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.amsu.2020.10.017","article-title":"Assessment and comparison of mortality and short-term outcomes among premature infants before and after 32-week gestation: A cross-sectional analysis","volume":"60","author":"Khasawneh","year":"2020","journal-title":"Ann. Med. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e604","DOI":"10.1016\/S2468-2667(20)30223-1","article-title":"Impact of COVID-19 mit-igation measures on the incidence of preterm birth: A national quasi-experimental study","volume":"5","author":"Been","year":"2020","journal-title":"Lancet Public Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1136\/archdischild-2020-319990","article-title":"Danish premature birth rates during the COVID-19 lockdown","volume":"106","author":"Hedermann","year":"2020","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e003075","DOI":"10.1136\/bmjgh-2020-003075","article-title":"Unprecedented reduction in births of very low birthweight (VLBW) and extremely low birthweight (ELBW) infants during the COVID-19 lockdown in Ireland: A \u2018natural experiment\u2019 allowing analysis of data from the prior two decades","volume":"5","author":"Philip","year":"2020","journal-title":"BMJ Glob. Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1080\/14767058.2020.1759541","article-title":"Coronavirus disease 2019 (COVID-19) and pregnancy: A systematic review","volume":"35","author":"Yang","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ajog.2023.01.019","article-title":"Systematic review and synthesis of stillbirths and late miscarriages following SARS-CoV-2 infections","volume":"229","author":"Alcover","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/humupd\/dmad030","article-title":"COVID-19 in pregnant women: A systematic review and meta-analysis on the risk and prevalence of pregnancy loss","volume":"30","author":"Kostova","year":"2024","journal-title":"Hum. Reprod. Update"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12963-019-0195-7","article-title":"The relationship between the different low birth weight strata of newborns with infant mortality and the influence of the main health determinants in the extreme south of Brazil","volume":"17","author":"Vilanova","year":"2019","journal-title":"Popul. Health Metr."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ballot, D.E., Chirwa, T.F., and Cooper, P.A. (2010). Determinants of survival in very low birth weight neonates in a public sector hospital in Johannesburg. BMC Pediatr., 10.","DOI":"10.1186\/1471-2431-10-30"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1056\/NEJMoa1915075","article-title":"Apgar Score and Risk of Neonatal Death among Preterm Infants","volume":"383","author":"Cnattingius","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Park, J.H., Chang, Y.S., Ahn, S.Y., Sung, S.I., and Park, W.S. (2018). Predicting mortality in extremely low birth weight infants: Comparison between gestational age, birth weight, Apgar score, CRIB II score, initial and lowest serum albumin levels. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192232"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"102670","DOI":"10.1016\/j.midw.2020.102670","article-title":"Maternal factors associated with prematurity in public maternity hospitals at the Brazilian Western Amazon","volume":"85","author":"Santos","year":"2020","journal-title":"Midwifery"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0140-6736(09)61712-8","article-title":"Infection-related stillbirths","volume":"375","author":"Goldenberg","year":"2010","journal-title":"Lancet"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1080\/14767058.2020.1852206","article-title":"Maternal infection and stillbirth: A review","volume":"35","author":"McClure","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Schindler, T., Koller-Smith, L., Lui, K., Bajuk, B., Bolisetty, S., and New South Wales and Australian Capital Territory Neonatal Intensive Care Units\u2019 Data Collection (2017). Causes of death in very preterm infants cared for in neonatal intensive care units: A population-based retrospective cohort study. BMC Pediatr., 17.","DOI":"10.1186\/s12887-017-0810-3"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s10995-008-0348-y","article-title":"The Association Between Major Birth Defects and Preterm Birth","volume":"13","author":"Honein","year":"2009","journal-title":"Matern. Child Health J."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Truttmann, A.C., Ginet, V., and Puyal, J. (2020). Current Evidence on Cell Death in Preterm Brain Injury in Human and Preclinical Models. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00027"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1053\/sper.2002.29862","article-title":"Neuropathology associated with stillbirth","volume":"26","author":"Grafe","year":"2002","journal-title":"Semin. Perinatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s13669-013-0041-z","article-title":"Intrauterine Growth Restriction (IUGR): Etiology and Diagnosis","volume":"2","author":"Suhag","year":"2013","journal-title":"Curr. Obstet. Gynecol. Rep."},{"key":"ref_46","first-page":"23","article-title":"Ultrasound Evaluation of Fetal Biometry and Doppler Parameters in the Third Trimester of Pregnancy Suspected of Intrauterine Growth Restriction","volume":"44","author":"Novac","year":"2018","journal-title":"Curr. Health Sci. J."},{"key":"ref_47","first-page":"47","article-title":"Comparison of fetal middle cerebral arteries, umbilical and uterin artery color Doppler ultrasound with blood gas analysis in pregnancy complicated by IUGR","volume":"11","author":"Fardiazar","year":"2013","journal-title":"Iran. J. Reprod. Med."},{"key":"ref_48","unstructured":"Ramanlal, R., and Gupta, V. (2024, February 05). Physiology, Vasodilation. [Updated 2023 Jan 23], StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557562\/."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000438451","article-title":"Brain-Sparing in Intrauterine Growth Restriction: Considerations for the Neonatologist","volume":"108","author":"Cohen","year":"2015","journal-title":"Neonatology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/PDR.0b013e3181c1b176","article-title":"Intraventricular hemorrhage in premature infants: Mechanism of disease","volume":"67","author":"Ballabh","year":"2010","journal-title":"Pediatr. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Zhang, W., and Tian, X. (2022). Analysis of risk factors of early intraventricular hemorrhage in very-low-birth-weight premature infants: A single center retrospective study. BMC Pregnancy Childbirth, 22.","DOI":"10.1186\/s12884-022-05245-2"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41372-019-0471-1","article-title":"Causes of death in preterm neonates (<33 weeks) born in tertiary care hospitals in India: Analysis of three large prospective multicentric cohorts","volume":"39","author":"Jain","year":"2019","journal-title":"J. Perinatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1136\/bmj.329.7472.962","article-title":"Respiratory complications of preterm birth","volume":"329","author":"Fraser","year":"2004","journal-title":"BMJ."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4103\/IJPM.IJPM_461_17","article-title":"An autopsy based descriptive study of the spectrum of pulmonary lesions encountered in fetal deaths at a tertiary care center","volume":"61","author":"Neeha","year":"2018","journal-title":"Indian J. Pathol. Microbiol."},{"key":"ref_55","first-page":"CD003253","article-title":"Cervical stitch (cerclage) for preventing pregnancy loss in women","volume":"2003","author":"Drakeley","year":"2003","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Henderickx, J.G.E., Zwittink, R.D., Renes, I.B., van Lingen, R.A., van Zoeren-Grobben, D., Groot Jebbink, L.J., Boeren, S., van Elburg, R.M., Knol, J., and Belzer, C. (2021). Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-92222-y"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3945\/ajcn.116.142539","article-title":"Impact of human milk pasteurization on gastric digestion in preterm infants: A randomized controlled trial","volume":"105","author":"Bellanger","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Li, D., Li, X., Zheng, A., and Wang, F. (2023). Spontaneous massive fetomaternal hemorrhage: Two case reports and a lit-erature review of placental pathology. BMC Pregnancy Childbirth, 23.","DOI":"10.1186\/s12884-023-05826-9"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/aogs.12762","article-title":"The contribution of massive fetomaternal hemorrhage to antepartum stillbirth: A 25-year cross-sectional study","volume":"94","author":"Walsh","year":"2015","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_60","first-page":"e5789","article-title":"Frequency and Early Complications of Late Preterm Infants: A Descriptive Analysis from Two Secondary-care Hospitals of Karachi","volume":"11","author":"Khowaja","year":"2019","journal-title":"Cureus"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/14\/5\/144\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:47:16Z","timestamp":1760111236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/14\/5\/144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["clinpract14050144"],"URL":"https:\/\/doi.org\/10.3390\/clinpract14050144","relation":{},"ISSN":["2039-7283"],"issn-type":[{"type":"electronic","value":"2039-7283"}],"subject":[],"published":{"date-parts":[[2024,9,2]]}}}