{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:21Z","timestamp":1760146821384,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Background: Deep or aggressive angiomyxoma is an uncommon neoplasm of the pelvis. Although deep angiomyxoma is a benign tumor, its tendency to infiltrate soft tissues and reach a large size (typically &gt; 10 cm) indicates aggressive biological behavior. It is usually present in female patients, but there have been recent reports of male-aggressive angiomyxoma. While rare, it is an important consideration in patients with a pelvic mass. The clinical presentation is non-specific; patients are either asymptomatic or present with non-specific complaints, such as dull pain, constipation, and dysuria. It is commonly mistaken for an inguinal hernia, hydrocele, testicular cancer, lipoma, and epididymal cyst in male patients, thus misguiding the management of these cases. Hence, preoperative evaluation with imaging studies (ultrasound, computed tomography, magnetic resonance imaging) and biopsy allows for an accurate diagnosis and treatment. Currently, the standard of treatment is surgical resection of the tumor with free margins. The role of hormone therapy is under investigation for patients with deep angiomyxoma positive for estrogen\/progesterone receptors. Regular follow-up is necessary given the high recurrence rate of deep angiomyxoma (9\u201372%). Methods: We present a case of an elderly man who presented with hematuria due to urolithiasis and an asymptomatic inguinal mass mimicking an inguinal hernia. A computed scan (CT) of the abdomen confirmed the presence of the mass, which was removed surgically. Results: The pathologic examination of the tumor was consistent with deep angiomyxoma. Conclusions: The diagnosis of deep angiomyxoma should always be considered in patients with an inguinal mass to avoid delayed treatment and incomplete surgical excision.<\/jats:p>","DOI":"10.3390\/clinpract14060213","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T06:53:39Z","timestamp":1734072819000},"page":"2705-2712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Unusual Cause of Inguinal Mass in a Patient with Urolithiasis: A Case Report of Deep (Aggressive) Angiomyxoma in a Male Patient"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5449-0911","authenticated-orcid":false,"given":"Christodoulos","family":"Chatzigrigoriadis","sequence":"first","affiliation":[{"name":"School of Medicine, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-3888","authenticated-orcid":false,"given":"Vasileios","family":"Tatanis","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-8329","authenticated-orcid":false,"given":"Theodoros","family":"Spinos","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-4506","authenticated-orcid":false,"given":"Angelis","family":"Peteinaris","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Samaras","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios","family":"Thanos","sequence":"additional","affiliation":[{"name":"Mutual Health Fund of National Bank of Greece Personel, 11473 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-9636","authenticated-orcid":false,"given":"Evangelos","family":"Liatsikos","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Kallidonis","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.20344\/amp.9062","article-title":"Aggressive Angiomyxoma: A Rare Tumor of Male Pelvic Cavity","volume":"31","author":"Celik","year":"2018","journal-title":"Acta Med. Port."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/iju5.12470","article-title":"A case of male perineal aggressive angiomyxoma with expressions of female hormone receptors","volume":"5","author":"Hisano","year":"2022","journal-title":"IJU Case Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/(SICI)1097-0142(19960701)78:1<79::AID-CNCR13>3.0.CO;2-4","article-title":"Aggressive angiomyxoma: A clinicopathologic study of 29 female patients","volume":"78","author":"Fetsch","year":"1996","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Angelico, G., Marletta, S., Broggi, G., Vigneri, P., Vecchio, G.M., Salvatorelli, L., and Magro, G. (2022). Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview. Diagnostics, 12.","DOI":"10.3390\/diagnostics12020357"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Cicogna, S., Dellino, M., Miano, S.T., Magazzino, F., Domenici, L., Pignata, S., Mangili, G., and Cormio, G. (2023). Aggressive Angiomyxoma of the Lower Female Genital Tract in Pregnancy: A Review of the MITO Rare Tumors Group. Cancers, 15.","DOI":"10.3390\/cancers15133403"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e1879","DOI":"10.1097\/GOX.0000000000001879","article-title":"Aggressive Angiomyxoma-Report of a Rare Male Buttock Lesion","volume":"6","author":"Hsieh","year":"2018","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4103\/0973-1482.136661","article-title":"Aggressive angiomyxoma of greater omentum with pleural effusion in a young male","volume":"10","author":"Saha","year":"2014","journal-title":"J. Cancer Res. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1515\/med-2021-0317","article-title":"Rare paratesticular aggressive angiomyxoma mimicking an epididymal tumor in an 82-year-old man: Case report","volume":"16","author":"Chen","year":"2021","journal-title":"Open Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"103880","DOI":"10.1016\/j.amsu.2022.103880","article-title":"Aggressive angiomayxoma in men: Case report and systematic review","volume":"79","author":"Sabbagh","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.clinimag.2013.06.007","article-title":"Aggressive angiomyxoma of the scrotum","volume":"37","author":"Gaunay","year":"2013","journal-title":"Clin. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.anndiagpath.2005.09.002","article-title":"Aggressive angiomyxoma of male genital region. Report of 4 cases with immunohistochemical evaluation including hormone receptor status","volume":"10","author":"Idrees","year":"2006","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF00311591","article-title":"Aggressive angiomyxoma occurring in the scrotum: Report of a case","volume":"26","author":"Murakami","year":"1996","journal-title":"Surg. Today"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"105948","DOI":"10.1016\/j.ijscr.2021.105948","article-title":"Deep (aggressive) angiomyxoma of the vagina misdiagnosed as Gartner cyst: A case report","volume":"83","author":"Djusad","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s13256-022-03497-2","article-title":"Aggressive angiomyxoma as a rare cause of scrotum enlargement in a 10-month-old boy: A case report","volume":"16","author":"Nyandwi","year":"2022","journal-title":"J. Med. Case Rep."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chen, Y., Wei, Y., Chang, H., and Yu, C. (2022). Case report and literature review: Rare male aggressive angiomyxoma of the scrotum. Front. Surg., 9.","DOI":"10.3389\/fsurg.2022.955655"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1078\/0344-0338-00025","article-title":"Aggressive angiomyxoma of the spermatic cord. Two unusual cases occurring in childhood","volume":"197","author":"Carlinfante","year":"2001","journal-title":"Pathol. Res. Pract."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1515\/pp-2023-0013","article-title":"Embryological, anatomical and clinical considerations on pleuroperitoneal communication","volume":"8","author":"Chatzigrigoriadis","year":"2023","journal-title":"Pleura Peritoneum"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.3748\/wjg.v29.i26.4214","article-title":"Value of contrast-enhanced ultrasound in deep angiomyxoma using a biplane transrectal probe: A case report","volume":"29","author":"Zhang","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/(SICI)1097-0339(199705)16:5<425::AID-DC8>3.0.CO;2-A","article-title":"Fine-needle aspiration cytology findings in a case of aggressive angiomyxoma: A case report and review of the literature","volume":"16","author":"Layfield","year":"1997","journal-title":"Diagn. Cytopathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/1752-1947-4-396","article-title":"Aggressive angiomyxoma in the inguinal region: A case report","volume":"4","author":"Kondo","year":"2010","journal-title":"J. Med. Case Rep."}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/14\/6\/213\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:53:59Z","timestamp":1760115239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/14\/6\/213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,13]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["clinpract14060213"],"URL":"https:\/\/doi.org\/10.3390\/clinpract14060213","relation":{},"ISSN":["2039-7283"],"issn-type":[{"type":"electronic","value":"2039-7283"}],"subject":[],"published":{"date-parts":[[2024,12,13]]}}}