{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:02:34Z","timestamp":1774022554167,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Background: The purpose of this article is to overview the clinical significance of left supraclavicular adenopathy and review the etiology of inferior vena cava (IVC) thrombosis, starting from a presentation of a rare case of renal cell carcinoma (RCCs) with Xp11.2 translocation involving TFE3 gene fusion. This article also aims to review the literature to understand the characteristics of this rare type of renal tumor. Renal cell carcinoma (RCC) associated with Xp11.2 translocation\/gene fusion TFE3 is a rare subtype of kidney cancer that was classified in 2016 as belonging to the family of renal carcinomas with MiT gene translocation (microphthalmia-associated transcription factor). The prognosis for these kidney cancers is poorer compared to other types. Methods: We present a case of a 66-year-old man with Virchow\u2013Troisier adenopathy during physical examination, which raises the suspicion of infra-diaphragmatic tumor. The echocardiography highlighted a heterogeneous mass in the right cardiac cavities, and the abdominal ultrasound exam revealed a solid mass at the upper pole of the left kidney. Results: Following computed tomography, magnetic resonance imaging, PET-CT, and histopathological and immunohistochemical examinations, the patient was diagnosed with renal carcinoma with Xp11.2 translocation and TFE3 gene fusion. Conclusions: IVC thrombosis is often associated with neoplastic disease due to the procoagulant state of these patients, the most common malignancies related to IVC thrombosis being represented by RCCs (38%), genitourinary cancers (25%), bronchus and lung cancers, retroperitoneal leiomyosarcoma, and adrenal cortical carcinoma. Imaging methods play a crucial role in differential diagnosis, allowing for the localization of the primary tumor and assessment of its characteristics.<\/jats:p>","DOI":"10.3390\/clinpract15010018","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:13:07Z","timestamp":1736835187000},"page":"18","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Relevance of the Virchow Node and Virchow Triad in Renal Cancer Diagnosis"],"prefix":"10.3390","volume":"15","author":[{"given":"Luiza-Roxana","family":"Dorobantu-Lungu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Emergency Institute for Cardiovascular Diseases \u201cC.C. Iliescu\u201d, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Dinca","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Internal Medicine, Col\u021bea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Gegiu","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Internal Medicine, Col\u021bea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Spataru","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Internal Medicine, Col\u021bea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology (ORL), Col\u021bea Clinical Hospital, 030167 Bucharest, Romania"},{"name":"Department of Otorhinolaryngology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luminita","family":"Welt","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, Col\u021bea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela Florentina","family":"Badea","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, Col\u021bea Clinical Hospital, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-7965","authenticated-orcid":false,"given":"Constantin","family":"Caruntu","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Dermatology, \u201cProf. N.C. Paulescu\u201d National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-6393","authenticated-orcid":false,"given":"Cristian","family":"Scheau","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Radiology and Medical Imaging, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilinca","family":"Savulescu-Fiedler","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Internal Medicine, Col\u021bea Clinical Hospital, 030167 Bucharest, Romania"},{"name":"Department of Internal Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108867","DOI":"10.1016\/j.ijscr.2023.108867","article-title":"Metastasis of Incidentally Diagnosed Renal Cell Carcinoma to the Sacrum 7 Years after Partial Nephrectomy: Case Report and Literature Review","volume":"111","author":"Shrateh","year":"2023","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chen, S.-C., and Kuo, P.-L. (2016). Bone Metastasis from Renal Cell Carcinoma. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060987"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0090-4295(97)00329-4","article-title":"Nephrectomy and Vena Caval Thrombectomy in Patients with Metastatic Renal Cell Carcinoma","volume":"50","author":"Slaton","year":"1997","journal-title":"Urology"},{"key":"ref_4","first-page":"1305","article-title":"Natural History of Untreated Renal Cell Carcinoma with Venous Tumor Thrombus","volume":"31","author":"Reese","year":"2013","journal-title":"Urol. Oncol. Semin. Orig. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","article-title":"The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs\u2014Part A: Renal, Penile, and Testicular Tumours","volume":"70","author":"Moch","year":"2016","journal-title":"Eur. Urol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"300060520942095","DOI":"10.1177\/0300060520942095","article-title":"Renal Cell Carcinoma Associated with Xp11.2 Translocation\/Transcription Factor E3 Gene Fusion: An Adult Case Report and Literature Review","volume":"48","author":"Wang","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5858\/2008-0391-RSR.1","article-title":"Xp11.2 Translocation Renal Cell Carcinoma","volume":"134","author":"Armah","year":"2010","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4143\/crt.2012.44.3.215","article-title":"Metastatic Renal Cell Carcinoma in a Supraclavicular Lymph Node with No Known Primary: A Case Report","volume":"44","author":"Choi","year":"2012","journal-title":"Cancer Res. Treat."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13256-022-03261-6","article-title":"Left Supraclavicular (Virchow\u2019s) Node Metastasis Detected before Primary Infradiaphragmatic Tumor: A Case Series","volume":"16","author":"Mochizuki","year":"2022","journal-title":"J. Med. Case Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"102658","DOI":"10.1016\/j.eucr.2024.102658","article-title":"Renal Cell Carcinoma Metastasis without a Primary: A Case Report","volume":"53","author":"Razi","year":"2024","journal-title":"Urol. Case Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/000313481908500711","article-title":"Occult Renal Cell Carcinoma Presenting as a Palpable Supraclavicular Virchow\u2019s Node","volume":"85","author":"Perry","year":"2019","journal-title":"Am. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4081\/rt.2013.e19","article-title":"A Rare Case of Synchronous Renal Cell Carcinoma of the Bladder Presenting with Gross Hematuria","volume":"5","author":"Kruck","year":"2013","journal-title":"Rare Tumors"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/j.semdp.2015.02.006","article-title":"PEComas of the Kidney and of the Genitourinary Tract","volume":"32","author":"Martignoni","year":"2015","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/PAI.0000000000001090","article-title":"Application of TFE3 Immunophenotypic and TFE3 MRNA Expressions in Diagnosis and Prognostication of Adrenal Cortical Neoplasms and Distinction From Kidney Tumors","volume":"31","author":"Wang","year":"2023","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Tampa, M., Georgescu, S.R., Mitran, C.I., Mitran, M.I., Matei, C., Scheau, C., Constantin, C., and Neagu, M. (2020). Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell Carcinoma. J. Clin. Med., 9.","DOI":"10.3390\/jcm9093010"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.32074\/1591-951X-335","article-title":"Epithelioid Angiomyolipoma: A Pathological Entity Discovered in Verona with the Endorsement of Doctor Rosai","volume":"113","author":"Brunelli","year":"2021","journal-title":"Pathologica"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Scheau, C., Draghici, C., Ilie, M.A., Lupu, M., Solomon, I., Tampa, M., Georgescu, S.R., Caruntu, A., Constantin, C., and Neagu, M. (2021). Neuroendocrine Factors in Melanoma Pathogenesis. Cancers, 13.","DOI":"10.3390\/cancers13092277"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/PAT.0b013e32834d7ba4","article-title":"Alveolar Soft Part Sarcoma \u2018Revisited\u2019: Clinicopathological Review of 47 Cases from a Tertiary Cancer Referral Centre, Including Immunohistochemical Expression of TFE3 in 22 Cases and 21 Other Tumours","volume":"44","author":"Rekhi","year":"2012","journal-title":"Pathology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/s41379-019-0283-z","article-title":"Xp11 Translocation Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma with TFE3 Strong Positive Immunostaining: Morphology, Immunohistochemistry, and FISH Analysis","volume":"32","author":"Yang","year":"2019","journal-title":"Mod. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1097\/PAS.0000000000001457","article-title":"Eosinophilic Renal Cell Tumors With a TSC and MTOR Gene Mutations Are Morphologically and Immunohistochemically Heterogenous","volume":"44","author":"Tjota","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<310::AID-PATH525>3.0.CO;2-P","article-title":"Interactions between Cancer Cells and the Endothelium in Metastasis","volume":"190","author":"Orr","year":"2000","journal-title":"J. Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.30683\/1927-7229.2023.12.04","article-title":"Virchow-Troisier\u2019s Node: A Review","volume":"12","author":"Salati","year":"2023","journal-title":"J. Anal. Oncol."},{"key":"ref_23","unstructured":"Aghedo, B.O., and Kasi, A. (2024). Virchow Node, StatPearls Publishing."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/1358863X12471967","article-title":"Inferior Vena Cava Thrombosis: A Review of Current Practice","volume":"18","author":"McAree","year":"2013","journal-title":"Vasc. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.thromres.2014.07.012","article-title":"Thrombosis of the Inferior Vena Cava and Malignant Disease","volume":"134","author":"Kraft","year":"2014","journal-title":"Thromb. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.amjcard.2008.05.046","article-title":"Incidence of Vena Cava Thrombosis in the United States","volume":"102","author":"Stein","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1148\/radiographics.12.6.1439022","article-title":"From the Archives of the AFIP. Leiomyosarcoma of the Retroperitoneum and Inferior Vena Cava: Radiologic-Pathologic Correlation","volume":"12","author":"Hartman","year":"1992","journal-title":"RadioGraphics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1464-410X.1997.00370.x","article-title":"Adrenal Cortical Carcinoma Associated with Venous Tumour Thrombus Extension","volume":"80","author":"Figueroa","year":"1997","journal-title":"Br. J. Urol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00000658-199107000-00002","article-title":"Diagnosis and Management of Retroperitoneal Soft-Tissue Sarcoma","volume":"214","author":"Storm","year":"1991","journal-title":"Ann. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1148\/rg.2018180006","article-title":"Retroperitoneal Leiomyosarcoma From the Radiologic Pathology Archives","volume":"38","author":"Marko","year":"2018","journal-title":"RadioGraphics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.3390\/curroncol29090504","article-title":"Updates in Pathology for Retroperitoneal Soft Tissue Sarcoma","volume":"29","author":"Mack","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e6909","DOI":"10.1002\/ccr3.6909","article-title":"Rare Presentation of Retroperitoneal Leiomyosarcoma Mimicking a Myoma in a 46-year-old Woman: A Case Report","volume":"11","author":"Akhavan","year":"2023","journal-title":"Clin. Case Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1102\/1470-7330.2005.0019","article-title":"Retroperitoneal Sarcomas","volume":"5","author":"Francis","year":"2005","journal-title":"Cancer Imaging"},{"key":"ref_34","first-page":"304","article-title":"Buhler\u2019s Arc: An Unexpected Finding in a Case of Chronic Abdominal Pain","volume":"29","author":"Baz","year":"2020","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_35","first-page":"e21603","article-title":"Burned-Out Testicular Tumor Presenting as a Retroperitoneal Mass: A Case Report","volume":"14","author":"Shahrokh","year":"2022","journal-title":"Cureus"},{"key":"ref_36","unstructured":"Kushner, A., West, W.P., Khan Suheb, M.Z., and Pillarisetty, L.S. (2024). Virchow Triad, StatPearls Publishing."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF00391504","article-title":"Procoagulant Activity of Gastric, Colorectal, and Renal Cancer Is Factor VII-Dependent","volume":"114","author":"Bardadin","year":"1988","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_38","first-page":"1","article-title":"Epidemiology, Pathology, and Pathogenesis of Renal Cell Carcinoma","volume":"9","author":"Atkins","year":"2016","journal-title":"UpToDate"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Savulescu-Fiedler, I., Mihalcea, R., Dragosloveanu, S., Scheau, C., Baz, R.O., Caruntu, A., Scheau, A.-E., Caruntu, C., and Benea, S.N. (2024). The Interplay between Obesity and Inflammation. Life, 14.","DOI":"10.3390\/life14070856"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Tseng, C.-H. (2015). Type 2 Diabetes Mellitus and Kidney Cancer Risk: A Retrospective Cohort Analysis of the National Health Insurance. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142480"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1590\/0100-3984.2013.1927","article-title":"Renal Cell Carcinoma: Histological Classification and Correlation with Imaging Findings","volume":"48","author":"Muglia","year":"2015","journal-title":"Radiol. Bras."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s42047-020-00084-x","article-title":"Classification of Renal Cell Tumors\u2014Current Concepts and Use of Ancillary Tests: Recommendations of the Brazilian Society of Pathology","volume":"4","author":"Athanazio","year":"2021","journal-title":"Surg. Exp. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Cali\u00f2, A., Segala, D., Munari, E., Brunelli, M., and Martignoni, G. (2019). MiT Family Translocation Renal Cell Carcinoma: From the Early Descriptions to the Current Knowledge. Cancers, 11.","DOI":"10.3390\/cancers11081110"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s44276-024-00105-2","article-title":"Loss of Vimentin Expression in Preoperative Biopsies Independently Predicts Poor Prognosis, Lymph Node Metastasis and Recurrence in Endometrial Cancer","volume":"2","author":"Hjelmeland","year":"2024","journal-title":"BJC Rep."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Dong, X., Chen, Y., Pan, J., Ma, W., Zhou, P., Chen, M., Guo, H., and Gan, W. (2022). Clinicopathological Features and Prognosis of TFE3-Positive Renal Cell Carcinoma. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1017425"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/PAS.0b013e31824dd972","article-title":"TFE3 Rearrangements in Adult Renal Cell Carcinoma","volume":"36","author":"Sukov","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Liao, G., Li, Y., Zhou, S., Zou, H., and Fernando, S. (2014). Prognostic Value of Carbonic Anhydrase IX Immunohistochemical Expression in Renal Cell Carcinoma: A Meta-Analysis of the Literature. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0114096"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1016\/j.ejca.2010.07.020","article-title":"Carbonic Anhydrase 9 in Clear Cell Renal Cell Carcinoma: A Marker for Diagnosis, Prognosis and Treatment","volume":"46","author":"Tostain","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_49","first-page":"802","article-title":"Carbonic Anhydrase IX Is an Independent Predictor of Survival in Advanced Renal Clear Cell Carcinoma: Implications for Prognosis and Therapy","volume":"9","author":"Bui","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.prp.2013.12.009","article-title":"Clear Cell Papillary Renal Cell Carcinoma: Incidence, Morphological Features, Immunohistochemical Profile, and Biologic Behavior: A Single Institution Study","volume":"210","author":"Alexiev","year":"2014","journal-title":"Pathol. Res. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13000-023-01315-x","article-title":"Clear Cell Renal Cell Carcinoma with Cystic Component Similar to Multilocular Cystic Renal Neoplasm of Low Malignant Potential: A Rare Pattern of Cyst-Dependent Progression from Multilocular Cystic Renal Neoplasm of Low Malignant Potential","volume":"18","author":"Yang","year":"2023","journal-title":"Diagn. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/PAS.0000000000000837","article-title":"Xp11 Translocation Renal Cell Carcinomas (RCCs) With RBM10-TFE3 Gene Fusion Demonstrating Melanotic Features and Overlapping Morphology With t(6;11) RCC","volume":"41","author":"Xia","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Franczyk, B., Rysz, J., \u0141awi\u0144ski, J., Cia\u0142kowska-Rysz, A., and Gluba-Brz\u00f3zka, A. (2023). Cardiotoxicity of Selected Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Renal Cell Carcinoma. Biomedicines, 11.","DOI":"10.3390\/biomedicines11010181"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"P\u0103s\u0103ric\u0103, M.A., Curc\u0103, P.F., Burcea, M., Schmitzer, S., Dragosloveanu, C.D.M., and Grigorescu, A.C. (2023). The Effects of Oncological Treatment on Redox Balance in Patients with Uveal Melanoma. Diagnostics, 13.","DOI":"10.3390\/diagnostics13111907"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","article-title":"Angiogenic Signaling Pathways and Anti-Angiogenic Therapy for Cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/oncolo\/oyac158","article-title":"Efficacy of Cabozantinib in Metastatic MiT Family Translocation Renal Cell Carcinomas","volume":"27","author":"Thouvenin","year":"2022","journal-title":"Oncologist"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1200\/JCO.2021.39.6_suppl.274","article-title":"Efficacy of Cabozantinib in Advanced MiT Family Translocation Renal Cell Carcinomas (TRCC)","volume":"39","author":"Thouvenin","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Guo, W., Zhu, Y., Pu, X., Guo, H., and Gan, W. (2023). Clinical and Pathological Heterogeneity of Four Common Fusion Subtypes in Xp11.2 Translocation Renal Cell Carcinoma. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1116648"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Huang, W., Peng, Y., Zhang, Y., Qiu, Y., Liu, Y., Wang, A., and Kang, L. (2023). Multimodality Imaging of Xp11.2 Translocation\/TFE3 Gene Fusion Associated with Renal Cell Carcinoma: A Case Report. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1266630"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/15\/1\/18\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:28:27Z","timestamp":1759919307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/15\/1\/18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["clinpract15010018"],"URL":"https:\/\/doi.org\/10.3390\/clinpract15010018","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]}}}