{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:49:13Z","timestamp":1777067353420,"version":"3.51.4"},"reference-count":49,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["304224\/2022-7"],"award-info":[{"award-number":["304224\/2022-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Anima Institute\u2014AI"},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018990","name":"Alfaisal University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018990","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Background\/Objectives: Vitamin D deficiency is prevalent in elderly populations and may impact surgical recovery. Despite the equatorial location, vitamin D insufficiency affects many elderly Ribeirinhos in the Brazilian Amazon. This study investigated whether pre-existing vitamin D supplementation influences postoperative outcomes in elderly Ribeirinhos following femur fracture surgery, while examining metabolic parameters and documenting chronic disease prevalence. Methods: This prospective cohort study enrolled 60 elderly Ribeirinhos patients (\u226565 years) admitted for femur fracture surgery at the Regional Hospital of Lower Amazon. Twenty-two patients had participated in a vitamin D supplementation program (50,000 IU monthly, 3\u20136 months) prior to admission; 38 had not. Primary outcomes were hospitalization duration and serum 25-hydroxyvitamin D levels. Secondary outcomes included ionized calcium, blood glucose, and comorbidity documentation. Results: The supplementation group was associated with significantly shorter hospitalization (14.32 \u00b1 0.79 vs. 22.61 \u00b1 0.88 days, p &lt; 0.0001), representing 37% reduction. Vitamin D levels were markedly higher in supplemented patients (50.26 \u00b1 2.55 vs. 21.74 \u00b1 0.84 ng\/mL, p &lt; 0.0001). Ionized calcium was elevated in the supplementation group (1.29 \u00b1 0.01 vs. 1.08 \u00b1 0.02 mmol\/L, p &lt; 0.001) without hypercalcemia. Blood glucose was lower in supplemented patients (83.8 \u00b1 1.4 vs. 152.2 \u00b1 9.6 mg\/dL, p &lt; 0.001). Medical records revealed that 73.3% had hypertension and 31.7% had diabetes, with 25% having both conditions. Conclusions: Pre-existing vitamin D supplementation was associated with reduced hospitalization duration following femur fracture surgery, though causality cannot be inferred due to observational design. Community-based vitamin D programs may warrant further investigation in vulnerable populations, with randomized trials needed.<\/jats:p>","DOI":"10.3390\/clinpract15100179","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:49:34Z","timestamp":1759142974000},"page":"179","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D and Postoperative Recovery in Elderly Ribeirinhos\u2014Riverside Amazon Communities with Femur Fractures"],"prefix":"10.3390","volume":"15","author":[{"given":"Elca Silvania","family":"da Silva Abreu","sequence":"first","affiliation":[{"name":"Center of Innovation, Technology, and Education (CITE) at Anhembi Morumbi University, Anima Institute, Sao Jose dos Campos Technology Park, S\u00e3o Jos\u00e9 dos Campos 12247-016, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5574-3272","authenticated-orcid":false,"given":"Caroline Oliveira","family":"dos Anjos","sequence":"additional","affiliation":[{"name":"Center of Innovation, Technology, and Education (CITE) at Anhembi Morumbi University, Anima Institute, Sao Jose dos Campos Technology Park, S\u00e3o Jos\u00e9 dos Campos 12247-016, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1255-4401","authenticated-orcid":false,"given":"Zafirah Muhammad","family":"Rahman","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Miyabara","sequence":"additional","affiliation":[{"name":"Center of Innovation, Technology, and Education (CITE) at Anhembi Morumbi University, Anima Institute, Sao Jose dos Campos Technology Park, S\u00e3o Jos\u00e9 dos Campos 12247-016, Brazil"},{"name":"Office of Graduate Studies PROPPEXI, UNINOVAFAPI University Center, Afya, Teresina 64073-505, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-6039","authenticated-orcid":false,"given":"Ovidiu Constantin","family":"Baltatu","sequence":"additional","affiliation":[{"name":"Center of Innovation, Technology, and Education (CITE) at Anhembi Morumbi University, Anima Institute, Sao Jose dos Campos Technology Park, S\u00e3o Jos\u00e9 dos Campos 12247-016, Brazil"},{"name":"College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-1022","authenticated-orcid":false,"given":"Luciana Aparecida","family":"Campos","sequence":"additional","affiliation":[{"name":"Center of Innovation, Technology, and Education (CITE) at Anhembi Morumbi University, Anima Institute, Sao Jose dos Campos Technology Park, S\u00e3o Jos\u00e9 dos Campos 12247-016, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"ref_1","first-page":"e220612pt","article-title":"Invisibilidade das singularidades amaz\u00f4nicas na organiza\u00e7\u00e3o e oferta de servi\u00e7os de Aten\u00e7\u00e3o Prim\u00e1ria \u00e0 Sa\u00fade (APS): Estudo de caso na \u00e1rea rural ribeirinha de Manaus (AM)","volume":"32","author":"Sousa","year":"2023","journal-title":"Saude Soc."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Alves, G.S.B., Herkrath, F.J., Parente, R.C.P., Pinheiro, R.D.d.S., and Vettore, M.V. 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