{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:49:12Z","timestamp":1780584552608,"version":"3.54.1"},"reference-count":34,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031470","name":"sociedad espa\u00f1ola de medicina interna","doi-asserted-by":"crossref","award":["SEMI2021-1"],"award-info":[{"award-number":["SEMI2021-1"]}],"id":[{"id":"10.13039\/100031470","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Background: The clinical characteristics of patients who have a first episode of congestive heart failure (CHF) may have changed in recent years. Methods: A retrospective cohort study was performed on 19,796 patients discharged from medical departments with a diagnosis of CHF between 1 January 2000 and 31 December 2022. Data were drawn from two data sets of the Minimum Basic Data Set-Hospital Data Set (MBDS) of the Lucus Augusti University Hospital (Spain): hospitalizations and patients. Patient characteristics (including the period of their first admission) and the association rules between diseases determined using the Apriori algorithm were studied in five consecutive time periods. Results: The general characteristics of patients on first admission for CHF changed over time. There were increases in mean age (75.9 \u00b1 SD 11.2 vs. 81.6 \u00b1 SD 11.5 years; p &lt; 0.0001), the proportion of women (48.3% vs. 51.4; p = 0.0001), the number of acute diseases (1.1 \u00b1 SD 1.4 to 2.7 \u00b1 SD 2.5; p &lt; 0.0001), and the number of chronic diseases (3.6 \u00b1 SD 1.9 to 6.5 \u00b1 SD 2.6); p &lt; 0.001). Accordingly, the median number of diagnoses (from 3 to 7) and itemsets per patient increased (mean number of items 1.75 vs. 3.4; p &lt; 0.0001), and the associations of diseases leading to CHF became more complex. Conclusions: This single-center study shows that in the last two decades, the characteristics of patients with a first hospital admission for CHF have changed. Patients are older, there is a predominance of women, and they have a greater number of acute and chronic concomitant diseases, making their clinical management more difficult.<\/jats:p>","DOI":"10.3390\/clinpract15100187","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:17:02Z","timestamp":1760617022000},"page":"187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Temporal Evolution of the Profile of Patients Hospitalized with Heart Failure (2000\u20132022)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8091-9791","authenticated-orcid":false,"given":"Teresa","family":"Seoane-Pillado","sequence":"first","affiliation":[{"name":"Rheumatology and Health Research Group, Department of Health Sciences, Faculty of Health Sciences, University of La Coru\u00f1a, Campus de Oza, 15006 La Coru\u00f1a, Spain"},{"name":"Nursing and Health Care Research Group, Biomedical Research Institute of La Coru\u00f1a (INIBIC), Xubias de Arriba 84, 15006 La Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roi","family":"Su\u00e1rez-Gil","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Lucus Augusti University Hospital, C\/Dr. Ulises Romero, s\/n, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"P\u00e9rtega-D\u00edaz","sequence":"additional","affiliation":[{"name":"Rheumatology and Health Research Group, Department of Health Sciences, Faculty of Health Sciences, University of La Coru\u00f1a, Campus de Oza, 15006 La Coru\u00f1a, Spain"},{"name":"Nursing and Health Care Research Group, Biomedical Research Institute of La Coru\u00f1a (INIBIC), Xubias de Arriba 84, 15006 La Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-627X","authenticated-orcid":false,"given":"Juan Carlos","family":"Pi\u00f1eiro-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Lucus Augusti University Hospital, C\/Dr. Ulises Romero, s\/n, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rodriguez-Ameijeiras","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Lucus Augusti University Hospital, C\/Dr. Ulises Romero, s\/n, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Casariego-Vales","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, University Hospital Complex of Santiago, C\/Choupana s\/n, 15076 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1016\/j.amjmed.2019.10.030","article-title":"Risk factors for heart failure in the community: Differences by age and ejection fraction","volume":"133","author":"Chamberlain","year":"2020","journal-title":"Am. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.amjmed.2014.08.024","article-title":"Multimorbidity in heart failure: A community perspective","volume":"128","author":"Chamberlain","year":"2015","journal-title":"Am. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/postgradmedj-2020-139361","article-title":"Description of multimorbidity clusters of admitted patients in medical departments of a general hospital","volume":"98","year":"2022","journal-title":"Postgrad. Med. J."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Escobar, C., Palacios, B., Escobar, C., Palacios, B., Gonzalez, V., Guti\u00e9rrez, M., Duong, M., Chen, H., Justo, N., and Cid-Ruzafa, J. (2023). Burden of Illness beyond Mortality and Heart Failure Hospitalizations in Patients Newly Diagnosed with Heart Failure in Spain According to Ejection Fraction. J. Clin. Med., 12.","DOI":"10.3390\/jcm12062410"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cardfail.2024.07.001","article-title":"HF STATS 2024: Heart Failure Epidemiology and Outcomes Statistics an Updated 2024 Report from the Heart Failure Society of America","volume":"31","author":"Bozkurt","year":"2024","journal-title":"J. Card. Fail."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.jchf.2023.06.028","article-title":"Global Variations According to Sex in Patients Hospitalized for Heart Failure in the REPORT-HF Registry","volume":"11","author":"Tromp","year":"2023","journal-title":"JACC Heart Fail."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e031179","DOI":"10.1161\/JAHA.123.031179","article-title":"Temporal Trends in Heart Failure Management and Outcomes: Insights from a Japanese Multicenter Registry of Tertiary Care Centers","volume":"12","author":"Nakamaru","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1002\/ehf2.14915","article-title":"Global trends in heart failure from 1990 to 2019: An age-period-cohort analysis from the Global Burden of Disease study","volume":"11","author":"Liu","year":"2024","journal-title":"ESC Heart Fail."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jjcc.2025.03.012","article-title":"Twelve-year trends of hospitalizations and survival of acute decompensated heart failure: Data from a regional tertiary center","volume":"86","author":"Tsuchida","year":"2025","journal-title":"J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1089\/pop.2018.0190","article-title":"Impactibility Model for Population Health Management in High-Cost Elderly Heart Failure Patients: A Capture Method Using the ACG System","volume":"22","author":"Buja","year":"2019","journal-title":"Popul. Health Manag."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bai, Y., Yao, H., Jiang, X., Bian, S., Zhou, J., Sun, X., Hu, G., Sun, L., Xie, G., and He, K. (2022). Construction of a Non-Mutually Exclusive Decision Tree for Medication Recommendation of Chronic Heart Failure. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.758573"},{"key":"ref_12","unstructured":"R Foundation (2023). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing. Available online: https:\/\/www.R-project.org\/."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v014.i15","article-title":"arules\u2014A Computational Environment for Mining Association Rules and Frequent Item Sets","volume":"14","author":"Hahsler","year":"2005","journal-title":"J. Stat. Softw."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cardfail.2021.08.020","article-title":"Trends in Heart Failure Hospitalizations in the US from 2008 to 2018","volume":"28","author":"Clark","year":"2022","journal-title":"J. Card. Fail."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Gracia Guti\u00e9rrez, A., Moreno-Juste, A., Laguna-Berna, C., Santos-Mej\u00edas, A., Poblador-Plou, B., Gimeno-Miguel, A., and Ruiz Laiglesia, F.J. (2024). Multimorbidity in Incident Heart Failure: Characterisation Impact on 1-Year Outcomes. J. Clin. Med., 13.","DOI":"10.3390\/jcm13133979"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e037973","DOI":"10.1161\/JAHA.124.037973","article-title":"Temporal Trends in Mortality and Hospitalization Risk in Patients with Heart Failure According to the Hospital Frailty Risk Score","volume":"14","author":"Abassi","year":"2025","journal-title":"J. Am. Heart Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e016936","DOI":"10.1161\/JAHA.120.016936","article-title":"Inclusion of Older People Reflective of Real-World Clinical Practice in Cardiovascular Drug Trials","volume":"9","author":"Caughey","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/ejhf.3112","article-title":"The role of multimorbidity in patients with heart failure across the left ventricular ejection fraction spectrum: Data from the Swedish Heart Failure Registry","volume":"26","author":"Tomasoni","year":"2024","journal-title":"Eur. J. Heart Fail."},{"key":"ref_19","first-page":"1630","article-title":"Investigation of left ventricular ejection fraction in a Swiss heart failure population: Insights into mortality and sex differences","volume":"12","author":"Muka","year":"2024","journal-title":"ESC Heart Fail."},{"key":"ref_20","unstructured":"Instituto Nacional de Estad\u00edstica (2024, December 18). Esperanza de Vidaen la Comunidad Aut\u00f3noma de Galicia. Available online: https:\/\/www.ine.es\/jaxiT3\/Datos.htm?t=27154#_tabs-grafico."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0140-6736(12)60240-2","article-title":"Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study","volume":"380","author":"Barnett","year":"2012","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/eurheartj\/ehaa071","article-title":"The association of long-term outcome and biological sex in patients with acute heart failure from different geographic regions","volume":"41","author":"Motiejunaite","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_23","first-page":"336","article-title":"Sex differences in clinical course patient-reported outcomes among patients hospitalized for heart failure","volume":"9","author":"Blumer","year":"2021","journal-title":"J. Am. Coll. Cardiol. HF"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s00392-016-1051-4","article-title":"Sex differences in early dyspnea relief between men and women hospitalized for acute heart failure: Insights from the RELAX-AHF study","volume":"106","author":"Meyer","year":"2017","journal-title":"Clin. Res. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.pcad.2020.03.013","article-title":"Sex-specific differences drive temporal trends and outcomes of patients hospitalized for heart failure in Germany","volume":"63","author":"Hobohm","year":"2020","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/JAD-210360","article-title":"Sex and Cardiovascular Function in Relation to Vascular Brain Injury in Patients with Cognitive Complaints","volume":"84","author":"Kuipers","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Appunni, S., Zhang, Y., Khosla, A.A., Rubens, M., Giri, A.R., Saxena, A., Ramamoorthy, V., Doke, M., McGranaghan, P., and Chaparro, S. (2024). Sex disparities in outcomes among hospitalizations for heart failure. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-77109-y"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.26599\/1671-5411.2023.04.005","article-title":"Characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals","volume":"20","author":"Bernal","year":"2023","journal-title":"J. Geriatr. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/clc.22638","article-title":"Trends in hospitalization for congestive heart failure, 1996\u20132009","volume":"40","author":"Munir","year":"2017","journal-title":"Clin. Cardiol."},{"key":"ref_31","first-page":"200306","article-title":"Temporal trends in acute decompensated heart failure outcomes: A single-center 11-year retrospective analysis","volume":"22","author":"Marcus","year":"2024","journal-title":"Int. J. Cardiol. Cardiovasc. Risk Prev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e871","DOI":"10.1016\/S2468-2667(24)00215-9","article-title":"Contemporary epidemiology of hospitalised heart failure with reduced versus preserved ejection fraction in England: A retrospective, cohort study of whole-population electronic health records","volume":"9","author":"Fletcher","year":"2024","journal-title":"Lancet Public Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"132693","DOI":"10.1016\/j.ijcard.2024.132693","article-title":"Temporal trends (2003\u20132018) of in-hospital and 30-day mortality in patients hospitalized with acute heart failure","volume":"419","author":"Marenzi","year":"2025","journal-title":"Int. J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ran, J., Zhou, P., Wang, J., Zhao, X., Huang, Y., Zhou, Q., Zhai, M., and Zhang, Y. (2025). Global, regional, and national burden of heart failure and its underlying causes, 1990\u20132021: Results from the global burden of disease study 2021. Biomark Res., 13.","DOI":"10.1186\/s40364-025-00728-8"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/15\/10\/187\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:11:49Z","timestamp":1761106309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/15\/10\/187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["clinpract15100187"],"URL":"https:\/\/doi.org\/10.3390\/clinpract15100187","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,16]]}}}