{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T11:24:34Z","timestamp":1772537074929,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Background: Internists formulate diagnostic hypotheses and personalized treatment plans by integrating data from a comprehensive clinical interview, reviewing a patient\u2019s medical history, physical examination and findings from complementary tests. The patient treatment life cycle generates a significant volume of data points that can offer valuable insights to improve patient care by guiding clinical decision-making. Artificial Intelligence (AI) and, in particular, Generative AI (GAI), are promising tools in this regard, particularly after the introduction of Large Language Models. The European Federation of Internal Medicine (EFIM) recognizes the transformative impact of AI in leveraging clinical data and advancing the field of internal medicine. This position paper from the EFIM explores how AI can be applied to achieve the goals of P6 Medicine principles in internal medicine. P6 Medicine is an advanced healthcare model that extends the concept of Personalized Medicine toward a holistic, predictive, patient-centered approach that also integrates psycho-cognitive and socially responsible dimensions. An additional concept introduced is that of Digital Therapies (DTx), software applications designed to prevent and manage diseases and disorders through AI, which are used in the clinical setting if validated by rigorous research studies. Methods: The literature examining the relationship between AI and Internal Medicine was investigated through a bibliometric analysis. The themes identified in the literature review were further examined through the Delphi method. Thirty international AI and Internal Medicine experts constituted the Delphi panel. Results: Delphi results were summarized in a SWOT Analysis. The evidence is that through extensive data analysis, diagnostic capacity, drug development and patient tracking are increased. Conclusions: The panel unanimously considered AI in Internal Medicine as an opportunity, achieving a complete consensus on the matter. AI-driven solutions, including clinical applications of GAI and DTx, hold the potential to strongly change internal medicine by streamlining workflows, enhancing patient care and generating valuable data.<\/jats:p>","DOI":"10.3390\/clinpract15110200","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:38:22Z","timestamp":1761759502000},"page":"200","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advancing Toward P6 Medicine: Recommendations for Integrating Artificial Intelligence in Internal Medicine"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4094-5343","authenticated-orcid":false,"given":"Ismael","family":"Said-Criado","sequence":"first","affiliation":[{"name":"Palliative Care Unit, Internal Medicine Department, Pontevedra\u2019s Hospital, Healthcare Research Institute Galicia Sur, 36001 Pontevedra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-0869","authenticated-orcid":false,"given":"Filomena","family":"Pietrantonio","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Medical Area Department, Castelli Hospital, ASL Roma 6, Ariccia, 00040 Rome, Italy"},{"name":"Departmental Faculty of Medicine, Saint Camillus International University of Health Sciences (Unicamillus), 00153 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0907-7640","authenticated-orcid":false,"given":"Marco","family":"Montagna","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-1185","authenticated-orcid":false,"given":"Francesco","family":"Rosiello","sequence":"additional","affiliation":[{"name":"Department of Public Health and Internal Medicine, Sapienza Universit\u00e0 di Roma, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Missikoff","sequence":"additional","affiliation":[{"name":"Department of European, American and Intercultural Studies, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3920-0267","authenticated-orcid":false,"given":"Carlo","family":"Drago","sequence":"additional","affiliation":[{"name":"Department of Economics, Psychology, Communication, Education and Motor Sciences, Niccol\u00f2 Cusano University, 00166 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany I.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Adjunct), Southern Illinois University School of Medicine, Springfield, IL 62794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-7733","authenticated-orcid":false,"given":"Antonio","family":"Vinci","sequence":"additional","affiliation":[{"name":"Doctoral School in Nursing Sciences and Public Health, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-3252","authenticated-orcid":false,"given":"Alessandro","family":"Signorini","sequence":"additional","affiliation":[{"name":"Health Technology Assessment (HTA) Unit, Saint Camillus International University of Health Sciences, 00131 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9909-3555","authenticated-orcid":false,"given":"Ricardo","family":"G\u00f3mez-Huelgas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Regional Universitario de M\u00e1laga, University of M\u00e1laga, 29010 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"ref_1","unstructured":"Walker, H.K., Hall, W.D., and Hurst, J.W. 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