{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:16:40Z","timestamp":1792192600814,"version":"4.4.0"},"reference-count":32,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Aims: The purpose of this study was to evaluate survival outcomes and recurrence patterns following curative-intent resection of pancreatic neuroendocrine tumours (PNETs) at a UK tertiary centre. The secondary aims included identifying prognostic clinicopathological factors that influenced survival. Methods: Patients undergoing curative-intent surgical resection for PNETs between August 2010 and March 2024 were retrospectively reviewed. The data collated included demographics, histopathology, recurrence, and survival outcomes. Results: Eighty-six patients were included, with a median age of 61.5 years (IQR: 50\u201371) and an equal sex distribution. Most tumours were solitary (88.4%) and located in the pancreatic tail (57%), with distal pancreatectomy performed in 75% of cases. The median tumour size was 25 mm (IQR: 13\u201340). Lymph node metastases were observed in 23.3% of patients, and R0 resection was achieved in 67%. Most of the PNETs resected were WHO grade 1 tumours (65.1%), followed by grade 2 tumours (26.7%). Postoperative morbidity occurred in 37.2% of cases, while the 30-day postoperative mortality rate was 1.5%. Recurrence was observed in 13.95% of patients, with a median time to recurrence of 36.3 months. The 5-year overall survival (OS) was 83.0%, with a median OS and disease-free survival (DFS) of 143.3 months and 147.0 months, respectively. Multivariable analysis revealed that poorer DFS was associated with larger tumours (p = 0.009), higher tumour grade (p = 0.006), male sex (p = 0.039), vascular invasion (p = 0.003), perineural invasion (p = 0.042) and lymph node metastases (p = 0.015). OS was significantly influenced by the Charlson Comorbidity Index (p &lt; 0.001) and tumour grade (p = 0.025). Conclusions: PNETs are associated with excellent long-term survival following curative-intent resection. However, adverse pathological features are linked to an increased risk of recurrence and a poorer prognosis.<\/jats:p>","DOI":"10.3390\/clinpract15110202","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:48:28Z","timestamp":1761878908000},"page":"202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes Following Surgery for Pancreatic Neuro-Endocrine Tumours: A Single-Centre Experience"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0964-190X","authenticated-orcid":false,"given":"Mina","family":"Fouad","sequence":"first","affiliation":[{"name":"Department of HPB Surgery, Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre, Derby Road, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-9068","authenticated-orcid":false,"given":"Sayed Ali","family":"Almahari","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abed Moeti","family":"Zaitoun","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK"},{"name":"Nottingham Digestive Diseases Centre, Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Queen\u2019s Medical Centre, Derby Road, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2642-0630","authenticated-orcid":false,"given":"Prithvirao","family":"Sonoo","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery, Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre, Derby Road, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5334-2248","authenticated-orcid":false,"given":"Sepand","family":"Malek","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery, Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre, Derby Road, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Sourial","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery, Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre, Derby Road, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7584-3884","authenticated-orcid":false,"given":"Dhanny","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery, Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre, Derby Road, Nottingham NG7 2UH, UK"},{"name":"Nottingham Digestive Diseases Centre, Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Queen\u2019s Medical Centre, Derby Road, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecl.2010.12.005","article-title":"The epidemiology of gastroenteropancreatic neuroendocrine tumors","volume":"40","author":"Lawrence","year":"2011","journal-title":"Endocrinol. 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