{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:29:47Z","timestamp":1763983787150,"version":"3.45.0"},"reference-count":19,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Urinary bladder hamartoma is an exceptionally rare benign lesion composed of disorganized yet mature tissue elements native to the bladder, including urothelium, fibrous stroma, smooth muscle, and occasionally adipose tissue. Unlike malignant tumors, it lacks cytological atypia, mitotic activity, or necrosis. Patients most often present with lower urinary tract symptoms (LUTS) or hematuria, though some cases are incidental findings. Associations with syndromic conditions such as Peutz\u2013Jeghers, Beckwith\u2013Wiedemann, Goldenhar, and Loeys\u2013Dietz have been reported. Transurethral resection is the preferred treatment and has generally been curative. We report the first case in Germany\u2014and the 16th worldwide\u2014of urinary bladder hamartoma, occurring in a young adult male with bothersome LUTS. Because of its proximity to both ureteral orifices, only partial transurethral resection was performed, which provided durable symptom relief at 14 months of follow-up. This case highlights partial TUR as a pragmatic, organ-preserving alternative when complete resection is anatomically unsafe, while emphasizing that TURBT remains the standard of care. We provide a detailed discussion of the histopathological features, differential diagnosis, treatment considerations, and an updated narrative review of all reported cases.<\/jats:p>","DOI":"10.3390\/clinpract15120218","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T10:24:17Z","timestamp":1763979857000},"page":"218","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary Bladder Hamartoma: Narrative Literature Review of an Exotic Pathology and Rare Cause of LUTS"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1083-707X","authenticated-orcid":false,"given":"Mohammed Rafea","family":"Kanaan","sequence":"first","affiliation":[{"name":"Department of Urology and Urological Oncology, Hanover Medical School (MHH), 30625 Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryem","family":"Akkoyun","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Oncology, Hanover Medical School (MHH), 30625 Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Lafos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hanover Medical School (MHH), 30625 Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus Antonius","family":"Kuczyk","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Oncology, Hanover Medical School (MHH), 30625 Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Tezval","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Oncology, Hanover Medical School (MHH), 30625 Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s003300050624","article-title":"Hamartoma of the urinary bladder: Case report and review of the literature","volume":"9","author":"Brancatelli","year":"1999","journal-title":"Eur. 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Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00428-013-1497-y","article-title":"Nephrogenic adenoma of the urinary tract: Clinical, histological, and immunohistochemical characteristics","volume":"463","author":"Bauleth","year":"2013","journal-title":"Virchows Arch."}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/15\/12\/218\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:26:25Z","timestamp":1763983585000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/15\/12\/218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":19,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["clinpract15120218"],"URL":"https:\/\/doi.org\/10.3390\/clinpract15120218","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]}}}